Nevin Manimala

Food Chem. 2025 Nov 5;496(Pt 3):146926. doi: 10.1016/j.foodchem.2025.146926. Online ahead of print.

ABSTRACT

Tea storage is a critical determinant in determining the quality of tea products. This study systematically investigated the quality alterations of instant green tea during storage and developed an intelligent evaluation method by integrating computer vision, electronic nose, and electronic tongue with machine learning. Quantitative chemical profiling established statistically significant correlations between conventional quality indicators and multi-sensor intelligent features. Machine learning models effectively classified the storage duration of instant green tea, with the electronic tongue achieving a classification accuracy exceeding 98 % for storage time prediction. Furthermore, data fusion combined with feature selection algorithms enhanced the predictive accuracy for both storage duration and key quality content. The integration of intelligent sensing technologies provides a robust methodology for rapid shelf-life prediction and quality discrimination of instant tea, establishing a scientific foundation for quality control and authenticity assurance in the tea industry.

PMID:41202358 | DOI:10.1016/j.foodchem.2025.146926

Aging Ment Health. 2025 Nov 7:1-14. doi: 10.1080/13607863.2025.2575025. Online ahead of print.

ABSTRACT

OBJECTIVES: This randomized controlled trial compared flywheel-based resistance training with traditional resistance training on depressive symptoms in sedentary older women.

METHOD: Twenty-nine women aged ≥60 years without clinical depression were randomized (blocks of 2 and 4) to flywheel (n = 14) or traditional resistance training (n = 15) for 8 weeks (six exercises, twice weekly) at the Federal University of Viçosa, Brazil. Flywheel devices provide inertial resistance and eccentric overload by storing and releasing kinetic energy. Depressive symptoms were the primary outcome. Allocation was concealed with sealed envelopes; outcome assessors and the principal investigator were blinded.

RESULTS: Twenty-eight participants completed the protocol; one dropout in the traditional group required multiple imputation. Adjusted depressive symptom scores were 2.7 ± 2.7 in the flywheel group (↓2.5 points) and 2.0 ± 2.8 in the traditional group (↓2.0 points), with no between-group difference (p = 0.193). The effect size was small (ηp² = 0.03) and statistical power was low (1-β = 0.25). All adverse events were mild (grade 1); no serious events occurred.

CONCLUSION: Both flywheel and traditional resistance training showed potential to reduce depressive symptoms in sedentary older women. Larger trials are warranted.

TRIAL REGISTRATION: ClinicalTrials.gov NCT05910632.

PMID:41202328 | DOI:10.1080/13607863.2025.2575025

Am J Speech Lang Pathol. 2025 Nov 7:1-12. doi: 10.1044/2025_AJSLP-25-00036. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to examine the Turkish version of the Short Behavioral Inhibition Scale (SBIS-TR) and to investigate its validity and reliability.

METHOD: The original Short Behavioral Inhibition Scale (SBIS) was translated into Turkish in accordance with the prescribed procedures for the cross-cultural adaptation of self-report measures. This translated version was administered to 227 children and their parents, including children who stutter (CWS) and children who do not stutter (CWNS). After 7-14 days, a random sample of 98 children completed the SBIS again. Reliability and validity were assessed using statistical analyses. Reliability was assessed using Cronbach’s alpha and the test-retest method. Validity was evaluated through confirmatory factor analysis, mean score comparisons between CWS and CWNS, and correlations with the Behavioral Inhibition Questionnaire Parent Form-Turkish version (BIQ-TR) and the Communication Attitude Test for Preschool and Kindergarten Children Who Stutter-Turkish version (KiddyCAT-TR).

RESULTS: SBIS-TR demonstrated high internal consistency, with a Cronbach’s alpha of .86 and a test-retest correlation coefficient of .96. Structural validity analysis confirmed that the single-factor model fits the data well, with all fit indices meeting the accepted thresholds. SBIS-TR scores showed significant negative correlations with BIQ-TR and KiddyCAT-TR scores. No significant difference was found in SBIS-TR scores between CWS and CWNS groups (p = .235), with a median SBIS score of 15 for both groups.

CONCLUSION: The SBIS-TR demonstrated strong reliability and evidence of convergent validity; however, the results did not fully support its construct validity due to the absence of the predicted group differences between CWS and CWNS.

PMID:41202306 | DOI:10.1044/2025_AJSLP-25-00036

JMIR Form Res. 2025 Nov 7;9:e75056. doi: 10.2196/75056.

ABSTRACT

BACKGROUND: The Break Method is a structured, behavior-based emotional reconditioning program designed to help individuals gain insight into patterns of emotional dysregulation and reprogram behavioral responses rooted in past experiences. Although it has been widely adopted in private and small-group settings, empirical evidence supporting its effectiveness remains limited. With increasing interest in accessible, scalable, and personalized mental health interventions, evaluating the outcomes of such programs is essential for informing future implementation and research.

OBJECTIVE: This pilot study aimed to evaluate changes in self-reported mental health status before and after participation in the Break Method program. Specifically, we sought to examine (1) overall trends in mental health improvement, (2) associations between specific reasons for joining the program and changes in mental health outcomes, and (3) latent clusters of participant motivations based on symptom profiles.

METHODS: Data were collected from 175 unique participants, yielding 195 total survey responses (as 15 participants completed the program more than once). Participants rated their mental health status on a 5-point Likert scale both before and after the program (this was not a validated clinical measure, limiting the interpretability and comparability of results). Descriptive statistics and paired 2-tailed t tests were used to assess pre- and postprogram differences in Likert scores. McNemar tests were conducted to compare categorical mental health status (Likert score ≥4 vs <4) before and after participation. Analyses of covariance examined score changes across groups stratified by reported reasons for joining. Multiple correspondence analysis was used to explore latent symptom clusters.

RESULTS: Before program participation, 186 of 195 (95.4%) responses reported Likert scores below 4. Following the program, 157 (80.5%) responses reported scores of 4 or higher. A significant improvement in mental health status was observed (preprogram mean score 2.07 SD 0.82, postprogram mean score 3.92 SD 0.73; P<.001). Significant, positive changes were associated with reasons including anxiety (β=0.332, 95% CI 0.073-0.591), obsessive-compulsive disorder (β=0.455, 95% CI 0.061-0.850), and a history of self-harm or suicidal ideation (β=0.511, 95% CI 0.091-0.931). The multiple correspondence analysis identified three clusters of participants based on symptom profiles: (1) low self-image (eg, depression, self-sabotage, and relationship issues); (2) life-development goals (eg, self-discovery and future planning); and (3) obsessive-compulsive disorder-related symptoms. The first cluster was significantly associated with improved mental health outcomes (β=0.348, 95% CI 0.060-0.636).

CONCLUSIONS: The Break Method appears to be a promising intervention for improving mental health, particularly among individuals reporting anxiety, low confidence, or a history of self-sabotage. However, due to the single-group, preprogram-postprogram design without a control group, causality cannot be inferred, and these findings should be interpreted as preliminary associations rather than confirmed efficacy. Future studies should incorporate standardized clinical tools, control groups, and longitudinal designs to validate these results and explore long-term outcomes across diverse populations.

PMID:41202293 | DOI:10.2196/75056

JMIR Hum Factors. 2025 Nov 7;12:e69305. doi: 10.2196/69305.

ABSTRACT

BACKGROUND: Telepsychiatry has gained considerable attention, particularly during the COVID-19 pandemic. Although various factors influence the choice between online and offline modalities, differences among populations remain underexplored.

OBJECTIVE: This study aims to compare adults seeking mental health support online and offline in private clinics.

METHODS: In this cross-sectional study, we assessed differences in sociodemographic factors, internet accessibility and usability, previous help-seeking history, personality traits assessed using the Arabic Big Five Personality Inventory, and levels of self-stigma measured using the Self-Stigma of Seeking Help Scale.

RESULTS: In total, 259 participants were included (136 online and 123 offline). The online group had a higher proportion of university graduates (P=.02), employed individuals (P<.001), and those with better internet access (P=.03) and higher internet usability (P=.001). The offline group showed higher levels of conscientiousness (P=.003). The primary reasons for choosing online therapy were ease of access and time-saving. Logistic regression identified previous use of online psychiatry as the strongest factor associated with choosing online services (odds ratio [OR] 28.90, 95% CI 11.739-71.165; P<.001). Employment (OR 5.01, 95% CI 1.781-14.080; P=.002), better internet usability (OR 1.69, 95% CI 1.069-2.664; P=.03), and agreeableness (OR 1.16, 95% CI 1.001-1.351; P=.05) were also significant factors. In contrast, previous in-person visits (OR 0.11, 95% CI 0.048-0.269; P<.001), openness (OR 0.85, 95% CI 0.748-0.975; P=.02), and conscientiousness (OR 0.86, 95% CI 0.758-0.971; P=.02) were negatively associated with online preference.

CONCLUSIONS: This study highlights key differences between online and offline mental health help seekers, enhances our understanding of treatment modality preferences, and paves the way for future research.

PMID:41202289 | DOI:10.2196/69305

J Neurosurg Spine. 2025 Nov 7:1-9. doi: 10.3171/2025.6.SPINE25376. Online ahead of print.

ABSTRACT

OBJECTIVE: Paraspinal involvement has been consistently reported as a negative predictor of local control following stereotactic body radiation therapy (SBRT) for spinal metastases. The aim of this study was to investigate the characteristics of paraspinal disease and determine the impact on outcomes.

METHODS: Patients who underwent SBRT for spinal metastases with paraspinal involvement, identified from a single-institutional prospective database, were retrospectively reviewed. Those with prior radiation therapy/surgery were excluded. The treated clinical target volume (CTV) was segmented into paraspinal (CTV_PS), neuroforaminal (CTV_NF), epidural (CTV_EP), and osseous bone (CTV_bone) components. The extent of extraosseous disease was classified according to the involvement of rib, neuroforamina, and muscle. Volume and dosimetric parameters were collected and dichotomized using recursive binary partitioning. The outcomes of interest were the cumulative incidence of local failure (LF), overall survival (OS), and reirradiation rates.

RESULTS: One hundred fourteen patients with 125 treated spinal sites were identified. There were 38% (47/125), 66% (82/125), and 19% (24/125) treated spinal sites with involvement of rib, neuroforamina, and muscle, respectively. The median follow-up duration of the cohort was 17.34 months (IQR 7.79-40.11 months). The 12-month and 24-month cumulative incidence rates of LF were 19.5% (95% CI 12.6%-27.4%) and 29.8% (95% CI 21.4%-38.7%), respectively. The 12-month cumulative incidence rates of LF were 12.0% (95% CI 5.9%-20.5%) and 36.3% (95% CI 20.2%-52.6%) for patients with CTV_PS < 42.9 mL and those with ≥ 42.9 mL (p < 0.001), respectively, and 55.6% (95% CI 28.7%-75.8%) and 12.2% (95% CI 6.5%-19.9%) for patients with and without muscle invasion (p = 0.001), respectively. In the multivariable analysis, only CTV_PS remained statistically associated with LF. CTV_PS ≥ 42.9 mL was associated with 2.3 times (95% CI 1.13-4.83, p = 0.02) increased risk of LF compared with CTV_PS < 42.9 mL. The 12-month and 24-month OS rates were 56% (95% CI 47%-65%) and 41% (95% CI 32%-50%), respectively. Patients with an Eastern Cooperative Oncology Group performance status score < 1 and oligometastatic disease (≤ 5 metastases) were associated with better OS in the multivariable analysis. The 12-month and 24-month reirradiation rates were 7.3% (95% CI 3.4%-13.3%) and 16.5% (95% CI 10.2%-24.1%), respectively.

CONCLUSIONS: Spinal metastases with high-volume paraspinal involvement were associated with increased risk of LF following SBRT, and strategies to optimize local control are required.

PMID:41202272 | DOI:10.3171/2025.6.SPINE25376

J Speech Lang Hear Res. 2025 Nov 7:1-12. doi: 10.1044/2025_JSLHR-25-00336. Online ahead of print.

ABSTRACT

PURPOSE: Intensive comprehensive aphasia programs (ICAPs) are a novel service delivery model incorporating best practice principles in aphasia rehabilitation. Despite increased evidence, adoption of this model into health care services remains limited. This study evaluated the feasibility and effectiveness of the comprehensive, high-dose aphasia treatment (CHAT) program, a modified-ICAP, when implemented by a public rehabilitation facility in Brisbane, Australia.

METHOD: A nonrandomized, Type II hybrid clinical implementation and effectiveness study design was employed. The CHAT program includes 50 hr of goal-directed aphasia rehabilitation, delivered over 8 weeks. Sixty-seven adults with poststroke aphasia consented to the study. Feasibility was evaluated using service statistics (i.e., referrals, adherence, dose) and analyzed using descriptive statistics. Effectiveness evaluated changes in participants’ language impairment, communication activity and participation, and quality of life at posttherapy and 3-month follow-up. Group-level data were analyzed using linear mixed models and Cohen’s d effect sizes. Minimal detectable change (MDC₉₀) was used to determine changes at the individual participant level.

RESULTS: Fourteen cohorts of CHAT were delivered from February 2021 to December 2023. Sixty-five participants completed CHAT, with an average dose of 46.6 hr of therapy. Group-level analyses revealed significant improvements in participants’ language impairment, communication activity and participation, and quality of life (p < .05) at posttherapy and 3-month follow-up. Most participants (89%) demonstrated significant improvements on at least one outcome measure.

CONCLUSIONS: The CHAT program was feasibly delivered within a public, health care context and resulted in positive and enduring changes in participants’ language impairment, communication function, and quality of life.

SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.30522767.

PMID:41202268 | DOI:10.1044/2025_JSLHR-25-00336

Phys Rev Lett. 2025 Oct 24;135(17):173401. doi: 10.1103/nkm3-1725.

ABSTRACT

Recent experiments have shown that raising the temperature of a dipolar gas under certain conditions leads to a transition to a supersolid state. Here, we employ the path integral Monte Carlo method, which exactly accounts for both thermal and correlation effects, to study that phenomenology in a system of ^{162}Dy atoms in the canonical ensemble. Our microscopic description allows the quantitative characterization of the emergence of spatial order and superfluidity, the two ingredients that define a supersolid state. Our calculations prove that temperature on its own can promote the formation of a supersolid in a dipolar system. Furthermore, we bridge this exotic phenomenology with the more usual melting of the supersolid at a higher temperature. Our results offer insight into the interplay between thermal excitations, the dipole-dipole interaction, quantum statistics, and supersolidity.

PMID:41202245 | DOI:10.1103/nkm3-1725

Hum Vaccin Immunother. 2025 Dec;21(1):2585544. doi: 10.1080/21645515.2025.2585544. Epub 2025 Nov 7.

ABSTRACT

Diabetes mellitus (DM) predisposes individuals to respiratory tract infections (RTIs), making vaccination an essential preventive measure; however, evidence regarding vaccination awareness, uptake, and barriers among DM patients in Saudi Arabia is limited. This study aimed to assess the awareness, uptake, and barriers related to influenza, pneumococcal, and COVID-19 vaccinations among adults with DM in Saudi Arabia. A cross-sectional survey was conducted between December 2023 and March 2025 among 1,556 adults with type 1 and type 2 DM attending endocrinology clinics across three sites. A structured questionnaire evaluated awareness, uptake, and barriers, and data were analyzed using descriptive statistics and chi-square tests. Uptake rates were 60.8% for influenza, 88.7% for COVID-19, and 27.1% for pneumococcal vaccines, with pneumococcal vaccination lower in type 1 than type 2 DM (23.2% vs. 28.5%; p = .002) and COVID-19 vaccination higher in type 2 DM (90.1% vs. 84.6%; p = .001). Influenza infection was more common in type 2 DM (58.6% vs. 52.4%; p = .030), while pneumonia was less frequent in type 1 DM (10.2% vs. 16.3%; p = .003). Overall, 82.6% recognized the purpose of vaccination and 70.4% agreed that DM patients should be vaccinated, though misconceptions persisted, especially regarding pneumococcal vaccine efficacy. Healthcare providers were the main information source for influenza (45.6%) and pneumococcal vaccines (23.6%), while social media predominated for COVID-19 (49.1%). Despite reasonable awareness, vaccine uptake remains suboptimal, highlighting the need for targeted education and stronger healthcare provider engagement.

PMID:41202216 | DOI:10.1080/21645515.2025.2585544

J Am Chem Soc. 2025 Nov 7. doi: 10.1021/jacs.5c11854. Online ahead of print.

ABSTRACT

Herein, we report a ligand-controlled chemodivergent bismuth-catalyzed coupling between arylboronic acids and N-fluorosulfonimide derivatives that enables the selective formation of either C(sp²)-N or C(sp²)-O bonds. Selectivity is achieved by the modulation of the electronic and steric properties of a common ligand framework for bismuth, thus establishing an unusual ligand-controlled chemodivergent platform in main group catalysis. Specifically, the use of an electron-enrich sulfone ligand led to the major formation of sulfonimide with selectivities ranging from 2:1 to more than 20:1. Conversely, a bismuth catalyst supported by an electron-deficient sulfoximine predominantly promoted the sulfonimidate product with ratios ranging between 5:1 and 15:1. To understand the underlying principles that control the selectivity, a comprehensive mechanistic investigation was conducted by combining experimental stoichiometric studies, DFT calculations, and statistical modeling. These studies support a catalytic high-valent bismuth redox cycle, where Bi(V) intermediates dictate product selectivity through either a three- or five-membered reductive elimination-ligand coupling event. By means of statistical modeling, we identified that the charge of the coordinating heteroatom through hypervalency, together with a steric parameter around the bismuth, is the key parameter responsible for the stabilization of the relevant transition states that lead to control over the reductive elimination process.

PMID:41202213 | DOI:10.1021/jacs.5c11854