Nevin Manimala

Community Dent Oral Epidemiol. 2022 Feb 14. doi: 10.1111/cdoe.12733. Online ahead of print.

ABSTRACT

OBJECTIVES: This study aimed to perform a systematic review and meta-analysis regarding the prevalence of traumatic dental injuries (TDI) in emergency dental services.

METHODS: Seven electronic and two grey literature databases were searched, up to December 2021, for studies that reported the TDI prevalence among dental emergencies. The Joanna Briggs Institute critical appraisal checklist for prevalence studies, and The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach were used to assess the risk of bias and quality of evidence respectively. The R software was used to perform a proportion meta-analysis on a random-effects model to estimate the pooled prevalence and respective 95% CI.

RESULTS: From a total of 1476 studies identified after excluding duplicates, 38 met the inclusion criteria, and another five were identified through hand searching, summing 43 included observational studies with a total sample of 209099 individuals searching for emergency dental care. The overall pooled prevalence of TDI was 15.4% (95% CI: 11%-21%, I² = 100%). Paediatric dental emergency services and age group from 0 to 21 years presented the highest prevalence, 29% (95% CI: 22%-38%, I² = 99.5%) and 24% (95% CI: 15%-35%, I² = 98%) respectively.

CONCLUSIONS: The overall pooled prevalence of TDI in emergency dental services was 15.4%, and 24% in the age group under 21 years. Considering the impact of prompt and correct emergency care in the long-term prognosis of TDI, such knowledge is relevant to organize emergency healthcare and support public policies in this area.

PMID:35165912 | DOI:10.1111/cdoe.12733

Stat Med. 2022 Feb 14. doi: 10.1002/sim.9344. Online ahead of print.

ABSTRACT

A rate ratio (RR) is an important metric for comparing cancer risks among different subpopulations. Inference for RR becomes complicated when populations used for calculating age-standardized cancer rates involve sampling errors, a situation that arises increasingly often when sample surveys must be used to obtain the population data. We compare a few strategies of estimating the standardized RR and propose bias-corrected ratio estimators as well as the corresponding variance estimators and confidence intervals that simultaneously consider the sampling error in estimating populations and the traditional Poisson error in the occurrence of cancer case or death. Performance of the proposed methods is evaluated empirically based on simulation studies. An application to immigration disparities in cancer mortality among Hispanic Americans is discussed. Our simulation studies show that a bias-corrected RR estimator performs the best in reducing the bias without increasing the coefficient of variation; the proposed variance estimators for the RR estimators and associated confidence intervals are fairly accurate. Finding of our application study are both interesting and consistent with the common sense as well as the results of our simulation studies.

PMID:35165903 | DOI:10.1002/sim.9344

Planta Med. 2022 Feb 14. doi: 10.1055/a-1770-7581. Online ahead of print.

ABSTRACT

Essential oils are often utilized for therapeutic purposes and are composed of complex structural molecules, including sesquiterpenes, with high molecular weight and potential for stereochemistry. A detailed study on the properties of selected sesquiterpenes was conducted as part of a broader investigation on the effects of sesquiterpenes on the central nervous system. A set of 18 sesquiterpenes, rigorously selected from an original list of 114, was divided into 2 groups i.e., the training and test sets, with each containing 9 compounds. The training set was evaluated for the sedative activity in mice through inhalation, and all compounds were sedatives at any dose in the range of 4 × 10-4-4 × 10-2 mg/cage, except for curzerene. Molecular determinants of the sedative activities of sesquiterpenes were evaluated using quantitative structure-activity relationship (QSAR) and structure-activity relationship (SAR) analyses. An additional test set of six compounds obtained from the literature was utilized for validating the QSAR model. The parental carbonyl cation and an oxygen-containing groups are possible determinants of sedative activity. The QSAR study using multiple regression models could reasonably predict the sedative activity of sesquiterpenes with statistical parameters such as the correlation coefficient r² = 0.82 > 0.6 and q²_LOO = 0.71 > 0.5 obtained using the leave-one-out cross-validation technique. Molar refractivity and the number of hydrogen bond acceptors were statistically important in predicting the activities. The present study could help predict the sedative activity of additional sesquiterpenes, thus accelerating the process of drug development.

PMID:35158383 | DOI:10.1055/a-1770-7581

Dermatology. 2022 Feb 14:1-10. doi: 10.1159/000522053. Online ahead of print.

ABSTRACT

BACKGROUND: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT) is an aggressive lymphoma variant. Anthracycline-based chemotherapy with rituximab is recommended as first-line treatment. Radiotherapy (RT) has been considered as a therapeutic option for local disease control in patients with solitary or localized lesions.

METHODS: We report the results of a retrospective analysis of PCDLBC, LT patients treated either with RT alone or with physician’s decision as first-line treatment, aiming to assess disease progression and/or first recurrence in these treatment groups.

RESULTS: We retrospectively analyzed 20 patients treated either with RT alone (n = 8) or with investigator’s choice treatment (n = 12), which included chemotherapy alone or combined with local therapy (RT and wide local excision). Complete response (CR) was achieved in 8 patients from the first group and 9 patients from the second group, with 1 treatment failure. Six patients treated with RT alone progressed with a median time to progression (TTP) of 12.5 months. In the second group, 5 patients progressed with a median TTP of 5.2 months. RT showed good local disease control in both groups without any skin relapses during the follow-up period.

CONCLUSION: RT as first-line monotherapy followed by watchful waiting did not significantly improve the overall risk of disease progression but resulted in good local disease control. After progression, RT could still easily be combined with systemic treatment. The strength of this analysis needs to be evaluated in a larger patient cohort.

PMID:35158362 | DOI:10.1159/000522053

Kidney Blood Press Res. 2022;47(2):81-93. doi: 10.1159/000518866. Epub 2022 Jan 11.

ABSTRACT

INTRODUCTION: Diabetic kidney disease (DKD) remains the leading cause of chronic kidney disease. Dysregulation of circulating miRNAs has been reported, suggesting their pathological roles in DKD. This study aimed to investigate differentially expressed miRNAs in the sera of type 2 diabetes mellitus (T2DM) patients with and without albuminuria in a selected Malaysian population.

METHOD: Forty-one T2DM patients on follow-up at a community clinic were divided into normo-(NA), micro-(MIC), and macroalbuminuria (MAC) groups. Differential levels of miRNAs in 12 samples were determined using the pathway-focused (human fibrosis) miScript miRNA qPCR array and was validated in 33 samples, using the miScript custom qPCR array (CMIHS02742) (Qiagen GmbH, Hilden, Germany).

RESULTS: Trends of upregulation of 3 miRNAs in the serum, namely, miR-874-3p, miR-101-3p, and miR-145-5p of T2DM patients with MAC compared to those with NA. Statistically significant upregulation of miR-874-3p (p = 0.04) and miR-101-3p (p = 0.01) was seen in validation cohort. Significant negative correlations between the estimated glomerular filtration rate (eGFR) and miR-874-3p (p = 0.05), miR-101-3p (p = 0.03), and miR-145-5p (p = 0.05) as well as positive correlation between miR-874-3p and age (p = 0.03) were shown by Pearson’s correlation coefficient analysis.

CONCLUSION: Upregulation of previously known miRNA, namely, miR-145-5p, and possibly novel ones, namely, miR-874-3p and miR-101-3p in the serum of T2DM patients, was found in this study. There was a significant correlation between the eGFR and these miRNAs. The findings of this study have provided encouraging evidence to further investigate the putative roles of these differentially expressed miRNAs in DKD.

PMID:35158353 | DOI:10.1159/000518866

Ophthalmologica. 2022 Feb 14. doi: 10.1159/000522527. Online ahead of print.

ABSTRACT

Objective and purpose: To explore the relation between retinal neurodegenerative changes and vessel closure (VC) in individuals with non-proliferative diabetic retinopathy (NPDR) in a follow-up period of 3 years.

DESIGN: 3-year prospective longitudinal study with four annual visits.

PARTICIPANTS: 74 individuals with type 2 diabetes, NPDR and ETDRS grades from 10 to 47, one eye/person. An age-matched healthy control population of 84 eyes was used as control group.

METHODS: Participants were annually examined by color fundus photography (CFP), spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Vessel closure was assessed by OCTA vessel density maps. SD-OCT segmentations was performed to access central retinal thickness (CRT) and retinal neurodegeneration considered as thinning of the ganglion cell plus inner plexiform layer (GCL+IPL).

RESULTS: Type 2 diabetic individuals presented significantly higher CRT (p=0.001), GCL+IPL thinning (p=0.042), and decreased vessel density at the superficial capillary plexus (p<0.001) and full retina (p=0.001). When looking at changes occurring over the 3-year period of follow up (Table 2), there were statistically significant decreases in GCL+IPL thickness (-0.438 µm/year; p=0.038), foveal avascular zone circularity (-0.009; p=0.047), and vessel density, in superficial capillary plexus (-0.172 mm-1/year; p<0.001), deep capillary plexus (-0.350 mm-1/year; p<0.001) and full retina (-0.182 mm-1/year; p<0.001). A statistically significant association was identified between GCL+IPL thinning and decrease in deep capillary plexus vessel density (β = 0.196 [95% CI 0.037, 0.355], z = 2.410, p = 0.016), after controlling for age, gender, diabetes duration, hemoglobin A1c level, and CRT.

CONCLUSIONS: Retinal neurodegenerative changes show a steady progression during a 3-year period of follow-up in eyes with NPDR and appear to be directly associated with progression in decreased vessel density including vascular closure through preferential involvement of the deep capillary plexus. Our findings provide evidence that retinal neuropathy is linked with microvascular changes occurring in diabetic patients.

PMID:35158351 | DOI:10.1159/000522527

J Phys Condens Matter. 2022 Feb 14. doi: 10.1088/1361-648X/ac54e3. Online ahead of print.

ABSTRACT

The Kohn-Sham density functional theory (KS-DFT) with the long-range corrected (LC) functional is applied to the benchmark dataset of 401 valence ionization potentials (IP) of 63 small molecules of Chong, Gritsenko and Baerends (the CGB set). The vertical ionization potentials (IP) of the CGB set are estimated as negative orbital energies within the context of the Koopmans’ prediction using the LCgau-core range-separation scheme in combination with PW86-PW91 exchange-correlation functional. The range separation parameterμof the functional is tuned to minimize the error of the negative HOMO orbital energy from experimental IP. The results are compared with literature data, including ab initio IP variant of the equation-of-motion coupled cluster theory with singles and doubles (IP-EOM-CCSD), the negative orbital energies calculated by KS-DFT with the statistical averaging of orbital potential (SAOP), and those with the QTP family of functionals. The optimally tuned LC functional performs better than other functionals for the estimation of valence level IP. The mean absolute deviations (MAD) from experiment and from IP-EOM-CCSD are 0.31 eV (1.77 %) and 0.25 eV（1.46 %）, respectively. LCgau-core performs quite well even with fixedμ(not system-dependent). Aμvalue around 0.36 bohr^-1gives MAD of 0.40 eV (2.42%) and 0.33 eV (1.96%) relative to experiment and IP-EOM-CCSD, respectively. The LCgau-core-PW86-PW91 functional is efficient alternative to IP-EOM-CCSD and it is reasonably accurate for outer valence orbitals. We have also examined its application to core ionization energies of C(1s), N(1s), O(1s) and F(1s). The C(1s) core ionization energies are reproduced reasonably (MAD of 46 cases is 0.76 eV (0.26 %)) but N(1s), O(1s) and F(1s) core ionization energies are predicted less accurately.

PMID:35158348 | DOI:10.1088/1361-648X/ac54e3

Eur J Oncol Nurs. 2022 Feb 1;57:102098. doi: 10.1016/j.ejon.2022.102098. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to investigate the influence of type D personality on quality of life in patients with lung cancer.

METHODS: A correlational, cross-sectional research design was used. A convenience sample of 136 patients with lung cancer were recruited from an outpatient pulmonology clinic. Data collection was performed using a structured questionnaire between July and August 2019. Data analyses included descriptive statistics, an independent t-test, a one-way ANOVA, the χ² test, an ANCOVA, Pearson’s correlation coefficients, and hierarchical regression analysis, which were performed using the SPSS WIN 25.0 program.

RESULTS: Type D personality was identified in 18.4% of the participants. Patients with type D personality had poorer quality of life and experienced more cancer stigma and more severe symptoms. Type D personality had the strongest association with quality of life among patients with lung cancer, followed by cancer stigma and symptoms. Poor quality of life was associated with non-married status and higher Eastern Cooperative Oncology Group grade.

CONCLUSIONS: Type D personality, stigma, symptoms, and demographic and clinical factors should be considered when assessing quality of life in patients with lung cancer. Interventions that reflect these factors, including type D personality, may help enhance quality of life for patients with lung cancer in oncology nursing practice.

PMID:35158321 | DOI:10.1016/j.ejon.2022.102098

Seizure. 2022 Feb 5;96:79-85. doi: 10.1016/j.seizure.2022.01.019. Online ahead of print.

ABSTRACT

BACKGROUND: Super-refractory status epilepticus (SRSE) is extremely difficult to control and associated with poor outcomes. Ketogenic diet (KD) has been increasingly used for SRSE treatment. Enteral ketosis induction in SRSE is sometimes unfeasible, leading to the use of parenteral KD which has limited data among children.

OBJECTIVES: To assess the effectiveness of KD and compare parenteral and enteral ketosis induction as treatment options in pediatric SRSE patients.

METHODS: This study is a retrospective medical record review of children < 15 years old diagnosed with SRSE who received KD as one of the treatment modalities during 2007-2021 at King Chulalongkorn Memorial Hospital, Thailand.

RESULTS: KD was used in 14 (77.8%) of the 18 pediatric SRSE cases whose age ranged from 2 months to 13.5 years. The leading etiologies of SRSE were immune-mediated encephalitis, infectious encephalitis, and epilepsy. Ketosis was induced via enteral route (kEN) in 8/14 and parenteral route (kPN) in 6/14 cases. The median time from the onset of SRSE to KD initiation was 6 days (IQR 4.8-9.3) with no demonstrable difference between groups. The median time to achieve significant ketosis was significantly shorter in the kPN (2 days; IQR 1.8-4) compared to the kEN group (5 days (3.3-7.8)). Nonetheless, the median time after ketosis induction to SRSE termination when anesthetic infusion was stopped was not statistically difference between the kPN (14 days; IQR 8.5-18) and the kEN group (10.5 days (5.5-15.3)). Hypertriglyceridemia was found more in the kPN (6/6, 100%) compared to the kEN group (3/8, 37.5%). All survivors (12/14) were seizure free at discharge.

CONCLUSION: Parenteral ketosis induction achieved the target ketosis quicker than enteral induction but showed no difference in efficacy and duration for SRSE termination in our study. The adverse effects were minimal and controllable. Both parenteral and enteral KD could be considered early during SRSE treatment.

PMID:35158320 | DOI:10.1016/j.seizure.2022.01.019