Nevin Manimala

J Natl Cancer Inst. 2021 Jul 28:djab147. doi: 10.1093/jnci/djab147. Online ahead of print.

ABSTRACT

BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers.

METHODS: 483 BRCA1 and 1,318 BRCA2 European ancestry male carriers were available from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). A 147-single nucleotide polymorphism (SNP) prostate cancer PRS (PRSPC) and a 313-SNP breast cancer PRS were evaluated. There were three versions of the breast cancer PRS, optimized to predict overall (PRSBC), estrogen-receptor (ER) negative (PRSER-) or ER-positive (PRSER+) breast cancer risk.

RESULTS: PRSER+ yielded the strongest association with breast cancer risk. The odds ratios (ORs) per PRSER+ standard deviation estimates were 1.40 (95% confidence interval [CI] =1.07-1.83) for BRCA1 and 1.33 (95% CI = 1.16-1.52) for BRCA2 carriers. PRSPC was associated with prostate cancer risk for both BRCA1 (OR = 1.73, 95% CI = 1.28-2.33) and BRCA2 (OR = 1.60, 95% CI = 1.34-1.91) carriers. The estimated breast cancer ORs were larger after adjusting for female relative breast cancer family history. By age 85 years, for BRCA2 carriers, the breast cancer risk varied from 7.7% to 18.4% and prostate cancer risk from 34.1% to 87.6% between the 5th and 95th percentiles of the PRS distributions.

CONCLUSIONS: Population-based prostate and female breast cancer PRS are associated with a wide range of absolute breast and prostate cancer risks for male BRCA1 and BRCA2 carriers. These findings warrant further investigation aimed at providing personalized cancer risks for male carriers and to inform clinical management.

PMID:34320204 | DOI:10.1093/jnci/djab147

Eur J Orthod. 2021 Jul 28:cjab048. doi: 10.1093/ejo/cjab048. Online ahead of print.

ABSTRACT

OBJECTIVES: This controlled study aimed to evaluate the effects of Herbst therapy on the trabecular structure of the condyle and angulus mandible using fractal dimension analysis (FD-A) accompanied by skeletal cephalometric changes.

MATERIAL AND METHOD: The panoramic and cephalometric radiographs of 30 patients with skeletal Class II malocclusion treated with the Herbst appliance (C II-H group, mean age: 15.23 ± 1.08), 30 patients with skeletal Class II malocclusion that received fixed orthodontic treatment (C II-C group, mean age: 15.73 ± 1.38), and 30 patients with skeletal Class I malocclusion (C I-C group, mean age: 15.90 ± 1.30) were selected. FD-A was performed on the superoposterior region (C-SP) and centre of the condyles (C-C) and the mandibular angulus (Ang) on the panoramic radiographs taken at the pretreatment (T0), intermediate stage of treatment (T1), and posttreatment (T2) timepoints just like cephalometric analysis.

RESULTS: Herbst therapy provided a statistically significant increase in SNB, ANS-Me, Na-Me, S-Go, Co-Gn and a decrease in ANB and overjet (P < 0.05). All skeletal changes remained stable during the fixed appliance treatment after Herbst. The FD values in C-C increased (P < 0.05), and C-SP values decreased (P < 0.05) during Herbst therapy, while after removal of the Herbst appliance, no significant change was observed despite an increase in C-SP. The Ang value did not change during Herbst treatment, but then increased significantly (P < 0.05). There was no significant change in the FD values of the C I-C and C II-C groups at any stage of treatment. The C-C and C-SP changes at T1-T0 period, C-SP and Ang changes at T2-T1 period, and C-C, C-SP, and Ang values at T2-T0 period were found higher in C II-H group compared with the C II-C group significantly (P < 0.05).

CONCLUSION: Herbst therapy changed the trabecular structure of the condyles in different directions at the superoposterior and central regions of the condyles, while the structural complexity of the angulus mandible, which did not change during the Herbst treatment, increased during the fixed orthodontic treatment after Herbst.

PMID:34320187 | DOI:10.1093/ejo/cjab048

Nucleic Acids Res. 2021 Jul 28:gkab637. doi: 10.1093/nar/gkab637. Online ahead of print.

ABSTRACT

Whole genome bisulphite sequencing (WGBS) permits the genome-wide study of single molecule methylation patterns. One of the key goals of mammalian cell-type identity studies, in both normal differentiation and disease, is to locate differential methylation patterns across the genome. We discuss the most desirable characteristics for DML (differentially methylated locus) and DMR (differentially methylated region) detection tools in a genome-wide context and choose a set of statistical methods that fully or partially satisfy these considerations to compare for benchmarking. Our data simulation strategy is both biologically informed-employing distribution parameters derived from large-scale consortium datasets-and thorough. We report DML detection ability with respect to coverage, group methylation difference, sample size, variability and covariate size, both marginally and jointly, and exhaustively with respect to parameter combination. We also benchmark these methods on FDR control and computational time. We use this result to backend and introduce an expanded version of DMRcate: an existing DMR detection tool for microarray data that we have extended to now call DMRs from WGBS data. We compare DMRcate to a set of alternative DMR callers using a similarly realistic simulation strategy. We find DMRcate and RADmeth are the best predictors of DMRs, and conclusively find DMRcate the fastest.

PMID:34320181 | DOI:10.1093/nar/gkab637

Am J Clin Nutr. 2021 Jul 28:nqab251. doi: 10.1093/ajcn/nqab251. Online ahead of print.

ABSTRACT

BACKGROUND: The 2019 Canada’s Food Guide recommends the consumption of lower fat dairy products to reduce saturated fat (SFA) intakes.

OBJECTIVES: The objective of this study was to assess the impact of such recommendation on SFA intake at a population level in Canada.

METHODS: Analyses were conducted based on dietary intakes from the nationally representative 2015 Canadian Community Health Survey-Nutrition (unweighted n = 20,103). Dietary intake was assessed using 24-h dietary recalls. Food-based substitution modeling analyses were conducted by replacing all regular-fat dairy products reported by an equal amount of a corresponding lower fat dairy product. Regular-fat dairy products included milks ≥2% fat, cheeses >25% fat, and yogurts ≥2% fat. Corresponding lower fat replacement products were 1% fat milks, 10-25% fat cheeses, and <2% fat yogurts. The National Cancer Institute method was used to account for within-person variation in dietary intakes.

RESULTS: Replacing all regular-fat dairy products consumed by Canadians (ages ≥2 y) by a corresponding lower fat product reduced the population’s SFA intake from 10.8% of total energy intake (%E; 95% CI: 10.7%, 11.0%) to 10.0%E (95% CI: 9.8%, 10.2%). This reduction was mostly attributable to the milk and cheese substitutions (mean SFA reductions of -0.3%E each). The proportion of the population with an SFA intake <10%E was 34.7% (95% CI: 31.2%, 38.2%) before substitution and 51.5% (95% CI: 47.5%, 55.5%) after substitution.

CONCLUSIONS: This food-based substitution modeling analysis suggests that SFA intakes at a population level are slightly reduced if all regular-fat dairy products consumed by Canadians were replaced by a lower fat dairy product. Approximately half of the population would still consume SFAs in excess of 10%E even if all regular-fat dairy consumed were replaced by lower fat dairy.

PMID:34320157 | DOI:10.1093/ajcn/nqab251

Rev Bras Enferm. 2021 Jul 26;74(6):e20210125. doi: 10.1590/0034-7167-2021-0125. eCollection 2021.

ABSTRACT

OBJECTIVE: To evaluate the impact of implementing the SafeCare clinical supervision model on nurses’ job satisfaction and emotional competence profile.

METHODS: This is a quasi-experimental study, with a sample of 28 nurses from a hospital in northern Portugal. A self-administered questionnaire was applied, used as pre and post-test, which included: sociodemographic and professional characterization; “Job Satisfaction Scale”; and “Veiga Emotional Competence Scale”. We conducted descriptive statistical analysis and the Wilcoxon Test.

RESULTS: A significant decrease in the nurses’ satisfaction with hierarchical superior was observed in the post-test. No significant differences were found in the nurses’ job satisfaction and emotional competence after the implementation of the SafeCare Model.

CONCLUSION: The SafeCare Model needs improvement, suggesting increasing the amount of training time administered to nurses and strengthening the healthcare institution’s link to the Model.

PMID:34320147 | DOI:10.1590/0034-7167-2021-0125

Rev Bras Enferm. 2021 Jul 26;74(6):e20210061. doi: 10.1590/0034-7167-2021-0061. eCollection 2021.

ABSTRACT

OBJECTIVE: To analyze the factors associated with sex without the use of condoms in consumers of sexually explicit media (SEM).

METHODS: Cross-sectional study, with a sample of 172 participants selected and collected through social media. To assess the predictors of unprotected sexual practices, the Poisson regression model was used. Values were expressed as a robust prevalence ratio (PR) with their respective confidence intervals.

RESULTS: There was a statistically significant association between, the use of condoms and the type of scenes that the participants prefer (p = 0.03), the preference for films with scenes involving unprotected sex or even those that do not care about protection (p = 0.02), the type of pornography watched influencing sexual relations (p = 0.017), and the number of scenes seen per week (p = 0.05).

CONCLUSIONS: The lack of condom use was associated with the access to erotic scenes.

PMID:34320146 | DOI:10.1590/0034-7167-2021-0061

Rev Bras Enferm. 2021 Jul 26;74(6):e20210044. doi: 10.1590/0034-7167-2021-0044. eCollection 2021.

ABSTRACT

OBJECTIVE: to analyze the relationship between exposure to workloads and presenteeism among nursing workers in the socio-environmental context of university hospitals.

METHOD: this is a quantitative, cross-sectional and analytical study with 355 nursing workers from two university hospitals in southern Brazil. Data were collected from November 2019 to February 2020. The Workload Scale in Nursing Activities and the Work Limitations Questionnaire were used. Descriptive statistics, variance analysis and Pearson’s correlation test were used.

RESULTS: there was a significant correlation between chemical loads and time management; biological loads and time management, physical demand and productivity loss; physiological loads and mental and interpersonal demand, production demand and loss of productivity; psychological loads and production demand.

CONCLUSIONS: there is a relationship between workloads and nursing presenteeism, verified by limitations and loss of productivity.

PMID:34320145 | DOI:10.1590/0034-7167-2021-0044

Rev Esc Enferm USP. 2021 Jul 26;55:e03757. doi: 10.1590/S1980-220X2020019503757. eCollection 2021.

ABSTRACT

OBJECTIVE: To analyze factors associated with diabetic foot risk in patients with diabetes mellitus assisted in Primary Care.

METHOD: Observational, analytic, and transversal study took place in Teresina, Piauí, with diabetic patients who are assisted in Primary Care. Data collection took place through interviews, foot clinical exams, and medical record analysis. We used the Mann-Whitney, Pearson’s Chi-square and multiple logistic regression statistics tests to analyze the data. The association power among categorical variables was measured by Odds Ratio .

RESULTS: 322 patients participated. Marital status with a partner presented a protection factor (p = 0.007). Risk factors for the development of the diabetic foot are: arterial hypertension (p = 0.045), obesity (p = 0.011), smoking (p = 0.027), not being submitted to follow ups (p = 0.046), inadequate control of capillary blood glucose (p < 0.001), indisposition to the care of the foot (p=0.014), and foot self-exam less frequently (p = 0.040).

CONCLUSION: Sociodemographic, clinical, and self-care aspects interfere in diabetic foot development, highlighting the necessity of effective follow up tracking and educational interventions for patients with diabetes mellitus in Primary Care.

PMID:34320142 | DOI:10.1590/S1980-220X2020019503757

Codas. 2021 Jul 23;33(5):e20200197. doi: 10.1590/2317-1782/20202020197. eCollection 2021.

ABSTRACT

PURPOSE: To analyze which method of judgment, auditory- perceptual (PAJ) of audios or perceptual-visual judgment (PVJ) (ultrasound images), is more sensitive to detect gradual productions between the class of deaf coronal fricatives and check if there is a correlation between these forms of judgment.

METHOD: Audio and video files of language ultrasound (LUS) related to the production of the words “frog” and “key”, of 11 children, between 6 and 12 years old, with atypical speech production, were selected from a bank data and edited for judgments. After instruction and prior training, 20 judges should choose, immediately upon presentation of the stimulus (auditory or visual), one of three options arranged on the computer screen. In PAJ the options were: correct, incorrect or gradient production, while in PVJ the options were images corresponding to the production of [s], [∫] or undifferentiated. The presentation time of the stimuli and the reaction time were automatically controlled by the PERCEVAL software.

RESULTS: PVJ provided a higher percentage of identification of gradient stimuli and a shorter reaction time in performing the task compared to PAJ, both statistically significant. Spearman’s correlation test did not show statistical significance between PAJ and PVJ responses, nor for reaction time.

CONCLUSION: PVJ using US images proved to be the most sensitive method for detecting gradient production in the production of fricatives [s] and [∫], and can be used as a complementary method to PAJ in speech analysis.

PMID:34320140 | DOI:10.1590/2317-1782/20202020197

Codas. 2021 Jul 23;33(5):e20200174. doi: 10.1590/2317-1782/20202020174. eCollection 2021.

ABSTRACT

PURPOSE: To identify and correlate vocal fatigue and voice-related quality of life in university professors and verify possible differences between genders.

METHODS: This is a cross-sectional, observational, and analytical study approved by the Research Ethics Committee of the institution under number 1,708,786. The Voice Fatigue Index (VFI) and the Voice Related Quality of Life (VRQOL) were applied to 126 university professors, 71 women and 55 men, with an average age of 43 years. Scores were calculated using the formula for each protocol and statistical analysis was performed using Spearman’s Correlation.

RESULTS: Regarding the VFI, the average score found for factors 1, 2 and 3 were 13.78, 4.05 and 7.93, respectively. As for VRQOL, professors had an average global score of 91.90; 88.49 for the physical domain and 97.02 for the socioemotional domain. There was a negative weak to strong correlation between the protocols. There was no statistical difference between genders for both VFI and VRQOL.

CONCLUSION: University professors have good levels of voice related quality of life, but self-reported vocal fatigue, with no differences between genders. The lower the vocal fatigue is, the higher is the voice related quality of life, and vice versa.

PMID:34320139 | DOI:10.1590/2317-1782/20202020174