Nevin Manimala

Arthritis Res Ther. 2025 Nov 4;27(1):204. doi: 10.1186/s13075-025-03666-w.

ABSTRACT

BACKGROUND: Although patients with idiopathic inflammatory myopathy (IIM) have a higher cancer risk than the general population, this risk varies among IIM patients based on clinical factors such as IIM subtype, clinical features, and autoantibody profiles. This study aimed to establish a risk-stratification system to identify those with high-risk for cancer in patients with IIM.

METHODS: This study included 481 patients with IIMs from four independent cohorts in South Korea. The primary outcome was myositis-associated cancer, defined as cancers occurring within 3 years before or after the diagnosis of IIM. Logistic regression with Least Absolute Shrinkage and Selection Operator (LASSO) regularization was used to select predictors from 24 prespecified factors for the multivariable model. A scoring system, entitled the SCRIM score, was established based on the β coefficient of each predictor in the final model. A conditional inference tree analysis was used to identify the optimal cut-off point for group classifications. The cancer risk of each group compared to that of the general population was assessed using standardized incidence ratio (SIR), which was calculated using the 2022 age-matched general population in South Korea as the reference.

RESULTS: In the study population, 12.9% (n = 62) had myositis-associated cancer. The LASSO regression identified older age, male sex, current smoking status, dermatomyositis, and anti-TIF1γ as high-risk factors for cancer; however, anti-synthetase syndrome, overlap myositis, arthritis, and interstitial lung disease were associated with a lower cancer risk. The SCRIM score based on these factors showed excellent performance (AUROC 0.852 [95% CI 0.796-0.907]). Patients were stratified into the low-risk, intermediate-risk, and high-risk groups based on the SCRIM score, and the incidence of myositis-associated cancer increased significantly in a stepwise manner across groups. Patients in the low-risk group had a cancer incidence comparable to that of the general population (SIR 0.79), whereas those in the intermediate-risk (SIR 2.28) and high-risk (SIR 15.30) groups had significantly higher cancer incidences.

CONCLUSION: The SCRIM score precisely stratified the risk of myositis-associated cancer for patients with IIM, which can be an important basis for establishing an evidence-based screening cancer strategy.

PMID:41188999 | DOI:10.1186/s13075-025-03666-w

BMC Chem. 2025 Nov 4;19(1):296. doi: 10.1186/s13065-025-01655-3.

ABSTRACT

MnCeO_x/TiO₂ composite catalysts were synthesized and characterized to investigate their photocatalytic efficiency in methyl orange decolorization. Structural and textural analyses revealed mesoporous architectures with specific surface areas ranging from 31.38 to 68.46 m² g^-1, pore volumes of 0.252-0.505 cm³ g^-1, and average pore diameters of 14.75-29.50 nm. FT-IR, XRD, and UV-Vis/DRS confirmed successful MnCeOx incorporation and band gap tuning (2.87-3.46 eV), indicating enhanced charge transfer capabilities. Photocatalytic experiments demonstrated that MO decolorization is highly sensitive to solution pH, temperature, MnCeO_x/TiO₂ weight ratio, and reaction time. Optimal conditions-pH = 3, temperature ≈ 39.6 °C, MnCeO_x/TiO₂ = 0.31, and reaction time = 35 min-achieved a maximum photo decolorization efficiency of 41.93%. Kinetic studies revealed pseudo-first-order behavior (k = 0.04927 min^-1 for MCT-0.1), with performance strongly influenced by surface charge interactions and active site accessibility. A Response Surface Methodology-Central Composite Design model was developed, demonstrating excellent predictability (R² = 0.99, Pred R² = 0.96) and a desirability score of 0.97. ANOVA confirmed the significance of main effects and binary interactions, particularly between pH, MnCeO_x/TiO₂ ratio, and reaction time, on MO PDE.

PMID:41188994 | DOI:10.1186/s13065-025-01655-3

BMC Psychol. 2025 Nov 4;13(1):1223. doi: 10.1186/s40359-025-03510-5.

ABSTRACT

BACKGROUND: In parallel with developing technologies, university students may experience digital burnout and postpone their academic tasks because of the need to be in digital environments. This study aimed to examine the relationship between digital burnout and academic procrastination and the mediating roles of life satisfaction and fatigue in this relationship. For this purpose, the direct relationships between the variables and the indirect effects of digital burnout on academic procrastination through the mediating variables were tested.

METHODS: A total of 277 sport sciences students participated in the study conducted with the relational survey model. The Personal Information Form, Digital Burnout Scale, Satisfaction with Life Scale, Calder Fatigue Scale, and Academic Procrastination Scale were used as data collection tools. Descriptive statistics, Pearson correlation, SEM and mediation analysis were used in the analysis of the data. Mediation analysis is a popular statistical procedure for testing hypotheses about the mechanisms by which a causal effect operates. Path analysis of the research model was conducted.

RESULTS: References numbered 53 in Question 7 and 107 and 126 in Question 10 were retrieved from the Turkish National Thesis Center, where the corresponding thesis titles can be located through the database search function. Additionally, Reference 116 is available as an open-access source provided by the University of Alabama. As no specific citation guidelines for theses were supplied, these references have been formatted in accordance with the available information. I look forward to your response and any suggestions you may have. Sincerely,The results revealed that digital burnout had a negative effect on life satisfaction, a positive effect on fatigue and academic procrastination, and that life satisfaction and fatigue had positive and significant effects on academic procrastination. It was concluded that digital burnout had a positive and significant effect on academic procrastination in the absence of other mediating variables and that life satisfaction and fatigue had a partial mediating effect on the effect of digital burnout on academic procrastination.

CONCLUSIONS: Negative and significant relationships were found between digital burnout and life satisfaction, as well as between life satisfaction and academic procrastination. In contrast, positive and significant relationships were observed between digital burnout and fatigue, and between digital burnout and academic procrastination. Furthermore, both digital burnout and fatigue were found to increase academic procrastination. The analyses indicated that life satisfaction and fatigue played a partial mediating role in the relationship between digital burnout and academic procrastination. Future research may investigate potential strategies to reduce the effects of digital burnout on academic procrastination (e.g., social activities, sports). Additionally, longitudinal data could be used in various disciplines to examine differences in mediation effects across demographic variables, and cultural differences could be explored in samples from diverse cultural contexts.

PMID:41188990 | DOI:10.1186/s40359-025-03510-5

BMC Psychol. 2025 Nov 3;13(1):1219. doi: 10.1186/s40359-025-03540-z.

ABSTRACT

BACKGROUND: Amid China’s rapid urbanization and demographic aging, the population of migrant grandparents who relocate to cities to provide intergenerational care has been steadily expanding. This group is particularly vulnerable to depressive symptoms due to the accumulation of multiple stressors, and they face an elevated risk of intergenerational family conflict. This study aims to examine the relationship between depression among migrant grandparents and intergenerational conflict within families, with a particular focus on the mediating role of hostile attribution bias and the moderating role of collective family efficacy.

METHODS: Using the Short Form of the Center for Epidemiological Studies Depression Scale (CES-D), the Collective Family Efficacy Questionnaire, the Hostile Attribution Bias Scale, and the Multidimensional Intergenerational Relationship Quality Scale, a questionnaire survey was conducted among 432 representative migrant grandparents in Zhengzhou, China, between March and May 2023. Data analysis included descriptive statistics, correlation analysis, and moderated mediation modeling.

RESULTS: (1) Depressive symptoms were found to be positively and significantly associated with intergenerational family conflict (β = 0.336, 95%CI[0.253,0.418]). Hostile attribution bias demonstrated a significant mediating effect in the relationship between depressive symptoms and intergenerational family conflict (β = 0.175, 95%CI[0.097,0.257]). (2) Furthermore, collective family efficacy moderated the mediating role of hostile attribution bias. When collective family efficacy was at a low level, the mediating pathway of hostile attribution bias was significant (β = 0.486, 95%CI[0.374,0.597]); when collective family efficacy was at a high level, the mediating pathway was no longer significant (β = 0.058, 95%CI[-0.063,0.179]).

CONCLUSION: Within the co-residential, multi-generational caregiving arrangements involving migrant grandparents in China, hostile attribution bias mediates the relationship between depressive symptoms and intergenerational family conflict, while collective family efficacy moderates the mediating pathway of hostile attribution bias on intergenerational family conflict. The findings provide a theoretical basis for designing targeted preventive interventions. Future interventions are recommended to focus on reducing hostile attribution bias and enhancing collective family efficacy to mitigate the negative relationship between depressive symptoms and intergenerational family conflict, thereby promoting the intergenerational well-being of migrant grandparents.

PMID:41188972 | DOI:10.1186/s40359-025-03540-z

J Orthop Surg Res. 2025 Nov 4;20(1):951. doi: 10.1186/s13018-025-06408-5.

ABSTRACT

BACKGROUND: Gait analysis of patients with spinal disorders at different walking speeds helps clinicians diagnose conditions and investigate treatment/rehabilitation effectiveness. A subject-specific database for trunk muscle forces and lumbar spine loads of healthy individuals during different walking speeds is therefore useful.

METHODS: Ten healthy participants walked at three speeds (slow, normal, and fast) while motion and force-plate data were collected. Force in trunk muscles and loads on the lumbar spine discs were estimated using subject-specific musculoskeletal simulations in OpenSim. Model predictions at different walking speeds were statistically compared.

RESULTS: The time-dependent subject-specific force in all major trunk muscles and compression/shear loads at all lumbar spine discs (T12-S1) were reported for all walking speeds. Significant differences were observed in the average of peak compression between the fast and both slow/normal walking speed conditions across all lumbar discs (p < 0.001). With the exception of the L4-S1 discs, significant differences in the average of peak anterior-posterior and medio-lateral shear loads were also found between the fast and both slow/normal walking speed conditions. Significant differences (p < 0.007) in the average of peak muscle forces were generally found between the fast and both slow/normal walking speed conditions.

CONCLUSIONS: This study presents a normative, subject-specific database of lumbar loading and muscle forces during walking at multiple speeds. These data provide a useful reference for future research in spinal biomechanics and musculoskeletal modeling. Furthermore, the database may serve as a baseline for assessing altered gait patterns and spinal loads in individuals with spinal disorders, supporting future clinical applications.

PMID:41188961 | DOI:10.1186/s13018-025-06408-5

Nutr Metab (Lond). 2025 Nov 4;22(1):131. doi: 10.1186/s12986-025-01027-7.

ABSTRACT

BACKGROUND: Metabolic Syndrome (MetS) involves several cardiovascular risk factors, with hypertension being a critical component that significantly impacts cardiovascular outcomes. As guidelines support blood pressure control in populations with high cardiovascular risk factors, we evaluated BP control in MetS patients.

METHODS: We conducted a cross-sectional analysis of probability samples of adults aged ≥ 18 years with MetS from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020 to assess changes in BP control. MetS was identified by meeting at least three of the following criteria: (1) waist circumference ≥ 102 cm in men and ≥ 88 cm in women; (2) fasting glucose ≥ 100 mg/dl; (3) BP ≥ 130/85 mmHg; (4) triglycerides ≥ 150 mg/dl; and (5) high-density lipoprotein cholesterol (HDL-C) < 40 mg/dl in men and < 50 mg/dl in women. BP control was defined as systolic BP < 130 mmHg and diastolic BP < 80 mmHg. All analyses accounted for differences between survey years, complex sampling design, and survey weights.

RESULTS: From 1999-2002 to 2015-2020, the prevalence of MetS increased from 19% to 24% (P < 0.001). Among MetS patients, the proportion of those self-reporting hypertension or taking BP medications increased from 65% in 1999-2002 to 72% in 2015-2020 (P = 0.001). Over time, both the use and quantity of antihypertensive medications increased significantly, and according to current guidelines, BP control among MetS patients has improved significantly. Similar trends were observed across subgroups stratified by gender, diabetes status, and CKD status.

CONCLUSION: BP management in MetS patients showed significant improvement from 1999 to 2020, with increasing control rates despite fluctuations.

PMID:41188950 | DOI:10.1186/s12986-025-01027-7

BMC Glob Public Health. 2025 Nov 4;3(1):98. doi: 10.1186/s44263-025-00220-3.

NO ABSTRACT

PMID:41188943 | DOI:10.1186/s44263-025-00220-3

Orphanet J Rare Dis. 2025 Nov 4;20(1):559. doi: 10.1186/s13023-025-04091-7.

ABSTRACT

INTRODUCTION: Autoimmune nodopathy (AN) is a recently recognized, rare immune-mediated neuropathy characterized by autoantibodies targeting nodal and paranodal proteins such as neurofascin-155 and contactin-1. Since its classification as a distinct entity in 2021 by European Academy of Neurology/Peripheral Nerve Society, scientific interest in AN has rapidly increased. This study aimed to conduct a comprehensive bibliometric analysis to identify research trends, influential publications, leading authors, institutions, and collaboration networks in the field of AN between 2005 and 2025.

METHODS: A literature search was performed in the Web of Science Core Collection using AN-related keywords. A total of 109 original English-language articles were included based on defined inclusion and exclusion criteria. VOSviewer and CiteSpace were used for network visualization and citation burst analysis. Descriptive statistics and trend projections were conducted using SPSS and Microsoft Excel.

RESULTS: A marked increase in publications was observed after 2021, coinciding with the formal definition of AN. The most productive countries were France, Germany, Spain, and Japan. Querol Luis, Sommer Claudia, and Doppler Kathrin emerged as leading authors. Highly cited articles focused on the pathogenesis and antibody profiles of AN. Keywords such as “neurofascin,” “IgG4,” and “autoimmune nodopathy” dominated the thematic clusters.

CONCLUSION: This is first bibliometric analysis to systematically examine the scientific landscape of AN. Despite growing research interest, there remains a significant gap in large-scale epidemiological studies and randomized controlled trials. Our findings provide a roadmap for future research, highlighting the importance of international collaboration and antibody-based stratification in the diagnosis and treatment of AN.

PMID:41188921 | DOI:10.1186/s13023-025-04091-7

BMC Health Serv Res. 2025 Nov 4;25(1):1440. doi: 10.1186/s12913-025-13613-9.

ABSTRACT

BACKGROUND: The medicines’ pathway in nursing homes (NHs) is complex and challenging, resulting in processes that are prone to medication errors and lack person-centredness. There is a clear need for quality improvement initiatives, for which a systems approach – rather than isolated interventions – is considered more effective. In this context, the Process Optimization Of the Medicines’ pAthway in nursing Homes (POOMAH) study was established. The study aims to evaluate the effectiveness of different formats and intensities of support provided to NHs to improve the quality of the medicines’ pathway.

METHODS: The intervention includes four arms, each offering a different level of support: access to toolbox, intervision meetings, external coaching and integration of a coordinating pharmacist. In total, 100 NHs participate in this study, with stratified randomization used to allocate them to the intervention arms. The primary outcome is the overall quality of the medicines’ pathway, through the calculation of performance scores. The key secondary outcome is the number of (psychoactive) medications used by NHRs. Other secondary outcomes include the quality of specific processes and KAs of the medicines’ pathway, represented by process-specific and activity-specific performance scores, and the number of falls and hospitalizations of NHRs. A comprehensive process evaluation will also be conducted. Both quantitative and qualitative data will be collected and analyzed using (generalised) linear mixed models and content/thematic analysis, respectively.

DISCUSSION: The POOMAH study will assess and compare the effectiveness of four support levels aimed at improving the quality of the medicines’ pathway in NHs. The findings will contribute to the evidence base on quality improvement in this context and inform future strategies, including the role of pharmacists in optimizing medication management.

CLINICAL TRIAL NUMBER: Not applicable. Although this study was not classified as a clinical trial by the ethics committee, it was retrospectively registered in the ISRCTN registry (ISRCTN17231220) on 07 May 2025 ( https://www.isrctn.com/ISRCTN17231220 ).

PMID:41188918 | DOI:10.1186/s12913-025-13613-9

Respir Res. 2025 Nov 4;26(1):306. doi: 10.1186/s12931-025-03378-4.

ABSTRACT

BACKGROUND: There is limited real-world evidence on the use and positioning of inhaled long-acting muscarinic antagonists (LAMAs) for treating severe asthma.

OBJECTIVE: We aimed to assess the differences in clinicians’ perspectives on prescribing LAMA for severe asthma across Europe.

METHODS: Within the Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) network, we conducted a multi-country survey of 470 respiratory clinicians in 2023-24.

RESULTS: Most participants were pneumonologists (83%). 68% reported using specific criteria for prescribing LAMA for severe asthma, primarily fixed bronchial obstruction (68%), frequent asthma exacerbations (65%), and a history of smoking (53%). Improved quality of life, lung function improvement, and reduction of asthma exacerbations were the three expected outcomes of LAMA treatment that showed the largest agreement across clinicians (85-95%). As compared to non-severe asthma specialists (about 50% of the sample), severe asthma specialists were more likely to report always prescribing LAMA before biologics (54 vs. 41%) and before oral corticosteroids (OCS) (51 vs. 40%). Approximately 90% of participants prioritised tapering or discontinuing OCS before stopping LAMA. Overall, participants in Northern (n = 73) and Western Europe (n = 71) appeared less prone to prescribe LAMA and less confident in their benefits compared to those from Eastern (n = 88) and Southern Europe (n = 238). In particular, most participants from Latvia (91%) and Lithuania (67%) reported that LAMAs are not reimbursed for severe asthma in their countries. Most participants who expressed their opinion favoured triple therapy (n = 236) over single inhaler therapy (n = 91).

CONCLUSION: Our findings show that barriers and heterogeneous approaches still limit LAMA prescription for severe asthma in Europe, potentially leading to the underuse of this treatment option. Establishing a clear role for LAMA within a precision medicine framework is crucial; this aspect is not yet firmly supported by current international recommendations.

PMID:41188910 | DOI:10.1186/s12931-025-03378-4