Nevin Manimala

Appl Physiol Nutr Metab. 2021 Aug 25. doi: 10.1139/apnm-2021-0390. Online ahead of print.

ABSTRACT

This study examined associations between child food involvement and food fussiness. Analyses used survey data from 62 children ages 1.5 to 5.9 years who participated in the Guelph Family Health Study Pilot. Overall involvement (β = -0.51, p = 0.02), involvement in meal preparation (β = -0.42, p = 0.009), and involvement in grocery shopping (β = -0.29, p = 0.04) were inversely associated with food fussiness. Experimental research including larger, more diverse samples is needed to test whether food involvement reduces food fussiness among young children. Novelty: • Our study identified significant, inverse associations between child food involvement and food fussiness.

PMID:34432990 | DOI:10.1139/apnm-2021-0390

Rural Remote Health. 2021 Aug;21(3):6348. doi: 10.22605/RRH6348. Epub 2021 Aug 25.

ABSTRACT

INTRODUCTION: Immunization is one of the most cost-effective methods for reducing mortality and morbidity rates in children. Children being fully vaccinated helps prevent diseases that would have great societal costs otherwise. Incomplete vaccination poses public health risks and challenges. This study examines the issue of incomplete vaccination in Indonesia. The objectives were to quantify the association between child level, parent level and community level determinants and child immunization coverage in Indonesia.

METHODS: Data were from the 2017 Indonesian Demographic Health Survey; this study included 4753 children aged 12-24 months. The survey implemented multistage random sampling. The data were examined using descriptive statistics and multilevel logistic regression analysis.

RESULTS: The survey found that in Indonesia, country-wide, 58.22% of children were fully vaccinated. A multilevel logistic regression model after adjusting for household wealth and proportion of public healthcare centers (PHCs) showed that children of first birth order had significantly lower likelihood of being fully immunized than children of second order and higher. The parent level factors, such as age of mother at delivery, mother’s education, father’s occupation, antenatal care (ANC) and region, significantly influenced the completeness of child immunization. At the community level, the presence of a PHC significantly improved immunization coverage.

CONCLUSION: The findings indicate that there is a wide range of inequality in immunization throughout the region due to socioeconomic and demographic factors. Findings revealed that complete immunization status was significantly associated with birth order, age of mother at delivery, mother’s education, father’s occupation, ANC, region, and proportion of PHCs. This study emphasizes the need to increase healthcare centers in each community with the objective to reduce disparities in maternal and child health services.

PMID:34432982 | DOI:10.22605/RRH6348

S D Med. 2021 Apr;74(4):154-157.

ABSTRACT

BACKGROUND: There is little data available that examines the activation of the cervical paraspinal muscles that occurs during the bench press. It is intuitive that activation of these muscles may lead to increased loads across the cervical spine and may increase the risk of injury to the intervertebral disks of the cervical spine.

HYPOTHESIS: The hypothesis of this study is that by supporting the cervical spine with the “Bench Rite” cervical spine orthosis, there will be less muscular activation of the cervical paraspinal muscles as determined by electromyography when performing the bench press.

STUDY DESIGN: Comparative electromyographic study – Level of evidence III (case-control study).

METHODS: Fifteen healthy subjects performed two sets (with and without the cervical orthosis) of five repetitions of a 60 percent maximum repetition on the bench press for each muscle group tested (pectoralis major, deltoid, C5 paraspinal, trapezius). Electromyography was used to determine the maximum isometric contraction and concentric contraction of each muscle with and without the cervical orthosis. The concentric contraction of each muscle group was reported as a percentage of maximum voluntary isometric contraction.

RESULTS: The use of the “Bench Rite” cervical spine orthosis resulted in a statistically significant decrease in muscle activation in the C5 paraspinal (37 percent; p=0.0001) and deltoid muscles (9.8 percent; p=0.001) and a significant increase in trapezius muscle activation (9.3 percent; p=0.03). No differences were found in muscle activation of the pectoralis major with or without the use of the cervical spine orthosis (0.8 percent; p=0.90).

CONCLUSIONS: Weightlifters may consider utilizing the “Bench Rite” cervical orthosis while performing the bench press to decrease cervical paraspinal muscle activation without impacting the muscle activation of the pectoralis major.

PMID:34432961

PM R. 2021 Aug 25. doi: 10.1002/pmrj.12698. Online ahead of print.

ABSTRACT

INTRODUCTION: Difficulty descending stairs is common in persons with knee osteoarthritis (OA). Clinically, it is important to know if and how this is explained by objectively measured difficulty to descend stairs, muscle weakness, pain, fear of movement, or knee joint status.

OBJECTIVE: Identify the potential of these factors to explain self-reported difficulty descending stairs DESIGN: Cross sectional, case-control SETTING: Hospital outpatient and physiotherapy clinic PARTICIPANTS: 28 men and women with knee OA (age 62.2 SD 5.9 years) and 31 controls (age 50.0 SD 8.5 years).

INTERVENTION: Not applicable MAIN OUTCOME MEASURES: Using multivariate statistics, group comparisons were made for lower extremity kinematics (incorporating hip-, knee-, and ankle- angles) and stance time in stair-descent and lower extremity muscle-strength. Then, a stepwise linear regression analysis was performed within the OA-group to explain self-reported difficulties in stair descent where pain, kinesiophobia, radiographic signs, and outcomes that differed from controls for stair-descent kinematics and muscle-strength were independent variables.

RESULTS: Multivariate statistics showed that the OA-group displayed different all-over lower extremity kinematics (F_{8, 42,} = 2.44 p = 0.029, η² = 0.32) and a longer stance time (F_{3, 50,} = 6.46; p = 0.001, η² = 0.28) in stair descent, and lower muscle strength (F_{7, 47,} = 2.39; p = 0.035, η² = 0.26) compared to controls. Regression analysis within the OA-group for explaining self-rated difficulties to descend stairs showed that the strongest association with kinesiophobia (ß = 0.607, p=0.001) that combined with pain last week and radiographic signs explained almost 100 % (ß = 0.972). Stair descent kinematics and strength variables that differed between groups did not explain self-rated difficulties to descend stairs.

CONCLUSION: Kinesiophobia and pain rather than stair-descent kinematics and reduced muscle-strength explained self-rated difficulties in stair descent in the OA-group. This article is protected by copyright. All rights reserved.

PMID:34432951 | DOI:10.1002/pmrj.12698

Mol Syst Biol. 2021 Aug;17(8):e10240. doi: 10.15252/msb.202110240.

ABSTRACT

Advancements in mass spectrometry-based proteomics have enabled experiments encompassing hundreds of samples. While these large sample sets deliver much-needed statistical power, handling them introduces technical variability known as batch effects. Here, we present a step-by-step protocol for the assessment, normalization, and batch correction of proteomic data. We review established methodologies from related fields and describe solutions specific to proteomic challenges, such as ion intensity drift and missing values in quantitative feature matrices. Finally, we compile a set of techniques that enable control of batch effect adjustment quality. We provide an R package, “proBatch”, containing functions required for each step of the protocol. We demonstrate the utility of this methodology on five proteomic datasets each encompassing hundreds of samples and consisting of multiple experimental designs. In conclusion, we provide guidelines and tools to make the extraction of true biological signal from large proteomic studies more robust and transparent, ultimately facilitating reliable and reproducible research in clinical proteomics and systems biology.

PMID:34432947 | DOI:10.15252/msb.202110240

J Appl Clin Med Phys. 2021 Aug 25. doi: 10.1002/acm2.13401. Online ahead of print.

ABSTRACT

BACKGROUND AND PURPOSE: The efficacy of clinical trials and the outcome of patient treatment are dependent on the quality assurance (QA) of radiation therapy (RT) plans. There are two widely utilized approaches that include plan optimization guidance created based on patient-specific anatomy. This study examined these two techniques for dose-volume histogram predictions, RT plan optimizations, and prospective QA processes, namely the knowledge-based planning (KBP) technique and another first principle (FP) technique.

METHODS: This analysis included 60, 44, and 10 RT plans from three Radiation Therapy Oncology Group (RTOG) multi-institutional trials: RTOG 0631 (Spine SRS), RTOG 1308 (NSCLC), and RTOG 0522 (H&N), respectively. Both approaches were compared in terms of dose prediction and plan optimization. The dose predictions were also compared to the original plan submitted to the trials for the QA procedure.

RESULTS: For the RTOG 0631 (Spine SRS) and RTOG 0522 (H&N) plans, the dose predictions from both techniques have correlation coefficients of >0.9. The RT plans that were re-optimized based on the predictions from both techniques showed similar quality, with no statistically significant differences in target coverage or organ-at-risk sparing. The predictions of mean lung and heart doses from both methods for RTOG1308 patients, on the other hand, have a discrepancy of up to 14 Gy.

CONCLUSIONS: Both methods are valuable tools for optimization guidance of RT plans for Spine SRS and Head and Neck cases, as well as for QA purposes. On the other hand, the findings suggest that KBP may be more feasible in the case of inoperable lung cancer patients who are treated with IMRT plans that have spatially unevenly distributed beam angles.

PMID:34432946 | DOI:10.1002/acm2.13401

J Spec Pediatr Nurs. 2021 Aug 25:e12356. doi: 10.1111/jspn.12356. Online ahead of print.

ABSTRACT

PURPOSE: Current routine circumcision rates declined indicating a procedure reduction and because of this, nurses will encounter more intact male patients. Best practices are needed to provide appropriate, safe nursing care. The research aim was to understand what American nurses presently know about intact care and if any knowledge deficits exist.

DESIGN AND METHODS: The research was conducted using a cross-sectional survey design. American nurses currently in practice were invited to participate in a survey distributed via social media groups for nursing professionals. No incentive was offered for participation. An author-developed instrument was used to assess knowledge levels regarding intact care. Analysis was performed using descriptive statistics as there was no intervention.

METHODS: American nurses currently in practice were invited to participate in a survey distributed via social media groups for nursing professionals. No incentive was offered for participation. An author-developed instrument was used to assess knowledge levels regarding intact care. Analysis was performed using descriptive statistics as there was no intervention.

RESULTS: A convenient sample of 345 nursing professionals participated indicating an intact care knowledge deficit across the lifespan. Fourteen percent of respondents did not indicate that replacing the foreskin back over the glans was necessary with adult genital hygiene for intact patients. In pediatrics, 41.7% answered yes to the item statement “Do you retract the foreskin of an infant male child for catheter placement.”

PRACTICE IMPLICATIONS: The results indicate a knowledge deficit among American nurses regarding genital hygiene, particularly for pediatric patients. Practicing without knowledge of intact care that scientifically based can endanger the caring relationship between nurse and patient, resulting in physical harm and may open themselves and their health systems to legal liability.

PMID:34432945 | DOI:10.1111/jspn.12356

J Vet Emerg Crit Care (San Antonio). 2021 Aug 25. doi: 10.1111/vec.13099. Online ahead of print.

ABSTRACT

OBJECTIVES: To determine the impact of age on survival in horses with colitis and to elucidate whether a lower type-1/type-2 cytokine ratio or an exaggerated inflammatory state contribute to reduced survival in aged horses.

DESIGN: Part 1: Retrospective cohort analysis. Part 2: Analytic observational study.

ANIMALS: Part 1: One hundred twenty-four adult horses with colitis. Part 2: Twenty-nine adult horses with new diarrhea onset while hospitalized.

MEASUREMENTS AND MAIN RESULTS: Part 1: Patient signalment, select clinicopathological data, diagnoses, treatment, hospitalization length, and invoice were compared between survivors (n = 101) and nonsurvivors (n = 23). Only age and plasma transfusion retained statistical significance in the final multivariate outcome model, with 8.5 times lower odds of survival in transfused horses (95% confidence interval [CI], 2.6-27.2%). Additionally, the likelihood of nonsurvival increased by 11.8% (95% CI, 4-20.2%) for every year the horse aged (P = 0.002). Similarly, geriatric horses (≥20 years) were 15.2 times more likely to die than young-adults (2-12 years, P = 0.03), independent of financial investment, documented comorbidities, and duration of hospitalization. Part 2: Select cytokine analyses were performed on serum collected from hospitalized horses within 1 hour of diarrhea onset (T0) and 6 hours later. At T0, all recorded clinicopathological variables were comparable between geriatric and young-adult horses, suggesting a similar degree of systemic illness. The median concentration of type-2 cytokines interleukin-4 and interleukin-10, and type-1 cytokine interferon-γ did not differ between age groups. Inflammatory cytokines interleukin-6 and tumor necrosis factor-α were significantly higher in geriatric compared to young-adult horses at both sampling time points.

CONCLUSIONS: Outcome of colitis was less favorable in aging horses and patients receiving a plasma transfusion. Although an exaggerated inflammatory state, based on increased interleukin-6 and tumor necrosis factor-α concentrations, in geriatric horses may contribute to reduced survival, a lower type-1/type-2 cytokines ratio was not identified in our geriatric population.

PMID:34432936 | DOI:10.1111/vec.13099

PLoS One. 2021 Aug 25;16(8):e0256669. doi: 10.1371/journal.pone.0256669. eCollection 2021.

ABSTRACT

We study geographical epidemic scales and patterns and positivity trends of SARS-CoV-2 pandemics in mass antigen testing in Slovakia in 2020. The observed test positivity was exponentially distributed with a long scale exponential spatial trend, and its characteristic correlation length was approximately 10 km. Spatial scales also play an important role in test positivity reduction between two consecutive testing rounds. While test positivity decreased in all counties, it increased in individual municipalities with low test positivity in the earlier testing round in a way statistically different from a mean-reversion process. Also, non-residents testing influences the mass testing results as test positivity of non-residents was higher than of residents when testing was offered only in municipalities with the highest positivity in previous rounds. Our results provide direct guidance for pandemic geographical data surveillance and epidemic response management.

PMID:34432845 | DOI:10.1371/journal.pone.0256669

PLoS One. 2021 Aug 25;16(8):e0256598. doi: 10.1371/journal.pone.0256598. eCollection 2021.

ABSTRACT

INTRODUCTION: Internationally, countries have reacted to the COVID-19 outbreak by introducing key public health non-pharmaceutical interventions to protect vulnerable population groups. In response to COVID-19, the Government of Ethiopia has been taking a series of policy actions beyond public health initiatives alone. Therefore, this study was aimed to assess the applicability of basic preventive measures of the pandemic COVID-19 and associated factors among the residents of Guraghe Zone from 18th to 29th September, 2020.

METHODS: Community based cross sectional study was conducted at Guraghe Zone from 18th to 29th September, 2020. Systematic random sampling method was applied among the predetermined 634 samples. Variables which had p-value less than 0.25 in bivariate analysis were considered as candidate for multivariable logistic regression model. P-value <0.05 was used as a cutoff point to determine statistical significance in multiple logistic regressions for the final model.

RESULT: In this study, 17.7% (95% CI: 14.7, 20.5) of the respondents apply the basic preventive measures towards the prevention of the pandemic COVID-19. In addition, being rural resident (AOR: 4.78,; 95%CI: 2.50, 8.90), being studied grade 1-8 (AOR: 3.70; 95%CI: 1.70, 7.90), being a farmer (AOR: 4.10; 95%CI: 1.25, 13.35), currently not married (AOR: 2.20, 95%CI: 1.24, 4.06), having family size 1-3(AOR: 6.50; 95%CI: 3.21, 3.35), have no diagnosed medical illness (AOR: 6.40; 95%CI: 3.85, 10.83) and having poor knowledge (AOR: 3.50; 95%CI: 1.60, 7.40) were factors which are statistically significant in multivariable logistic regression model.

CONCLUSION: Despite the application of preventive measures and vaccine delivery, the applicability of the pandemic COVID-19 preventive measures was too low, which indicate that the Zone is at risk for the infection. Rural residents, those who have lower educational level, farmers, non-marrieds, those who have lower family size, those who have diagnosed medical illnesses and those who have poor knowledge were prone to the infection with the pandemic COVID-19 due to the lower practice of applying the basic preventive measures. In addition, awareness creation should be in practice at all levels of the community especially lower educational classes and rural residents.

PMID:34432844 | DOI:10.1371/journal.pone.0256598