Tag: nevin manimala

Int J Palliat Nurs. 2025 Apr 2;31(4):173-180. doi: 10.12968/ijpn.2023.0044.

ABSTRACT

BACKGROUND: Patients with cancer can have problems sleeping. One measure that can help patients with cancer to improve the quality of their sleep is the 5A Self Management Model method.

AIM: This study aimed to determine the effect of the 5A Self Management Model on the quality of sleep of patients with cancer.

METHODS: In this clinical trial, 106 patients with cancer were recruited by convenient sampling, and randomly allocated to experimental and control groups. Data collection tools were a demographic checklist and Pittsburgh Sleep Quality Questionnaire. Patients in the experimental group received a self-management programme with the 5A method for 3 months and the control group obtained the routine intervention. Data were analysed via SPSS 25 software using Wilcoxon, Mann-Whitney U, independent t-test, paired t-test and descriptive statistics.

RESULTS: Before the intervention, the mean scores of sleep quality were 13.41 (1.78) in the experimental group and 9.64 (2.45) in the control group. However, after the intervention, the mean score of sleep quality decreased in the experimental group to 5.07 (1.19) and increased by 12.81 (2.26) in the control group, significantly.

CONCLUSION: The 5A Self Management Model programme improved the quality of sleep of patients with cancer in this trial. It is recommended nurses consider this method as a part of caring for patients with cancer.

PMID:40257767 | DOI:10.12968/ijpn.2023.0044

Int J Palliat Nurs. 2025 Apr 2;31(4):195-204. doi: 10.12968/ijpn.2024.0031.

ABSTRACT

BACKGROUND: Few studies evaluate the satisfaction of patients with cancer receiving palliative care with the nursing care received.

OBJECTIVE: To evaluate satisfaction among patients with cancer in hospitalised palliative care with respect to the nursing care they received.

METHOD: This was a quantitative, descriptive-correlational and cross-sectional study that was reported in accordance with Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. It was carried out in a university hospital in the city of Belém, Brazil. The participants were adults with cancer who were receiving palliative care and who had been hospitalised for more than 72 hours. Data collection took place between December 2022 and September 2023, and instruments were used for bedside interviews.

RESULTS: Patients receiving minimal care reported being satisfied with their nursing care in the technical-professional dimension (p=0.04).

CONCLUSION: The association between patient satisfaction and the degree of dependence is unprecedented in the scientific scenario and has the potential to motivate more in-depth studies in this area.

PMID:40257762 | DOI:10.12968/ijpn.2024.0031

JAMA Pediatr. 2025 Apr 21. doi: 10.1001/jamapediatrics.2025.0528. Online ahead of print.

NO ABSTRACT

PMID:40257760 | DOI:10.1001/jamapediatrics.2025.0528

JMIR Form Res. 2025 Apr 21;9:e68173. doi: 10.2196/68173.

ABSTRACT

BACKGROUND: Previous research has demonstrated a correlation between nursing students’ self-efficacy and their clinical performance, competence, and behavior during clinical practice placements. Assessing students’ self-efficacy in clinical performance could be a valuable method for identifying areas that need reinforcement and for recognizing students who may require additional support during clinical practice placements.

OBJECTIVE: This study aimed to translate the Self-Efficacy in Clinical Performance Scale (SECP) from English into Norwegian and to evaluate the psychometric properties of the Norwegian version.

METHODS: A cross-sectional study design was used. The SECP was translated into Norwegian following a 6-step process: forward translation, forward translation synthesis, backward translation, backward translation synthesis, cognitive debriefing, and psychometric testing. The validity and reliability of the translated version were assessed using confirmatory factor analysis (CFA), Cronbach α, McDonald ω, and composite reliability.

RESULTS: A total of 399 nursing students completed the Norwegian version of the SECP. The CFA goodness-of-fit indices (χ2/df ratio=1.578, comparative fit index=0.98, Tucker-Lewis index=0.98, standardized root mean square residual=0.056, root mean square error of approximation=0.038) indicated an acceptable model fit. Reliability measures, including Cronbach ⍺, McDonald ω, and composite reliability, were high, with factor-level values ranging from 0.94 to 0.98.

CONCLUSIONS: The Norwegian version of the SECP demonstrated strong potential as an instrument for assessing self-efficacy in both current and required competencies among nursing students in clinical practice within nursing education. Future research should aim to confirm the factor structure of the SECP and evaluate its test-retest reliability.

PMID:40257751 | DOI:10.2196/68173

Bioinformatics. 2025 Apr 21:btaf182. doi: 10.1093/bioinformatics/btaf182. Online ahead of print.

ABSTRACT

MOTIVATION: The intra-tumor heterogeneity of protein expression is well recognized and may provide important information for cancer prognosis and predicting treatment responses. Analytic methods that account for spatial heterogeneity remain methodologically complex and computationally demanding for single-cell protein expression. For many functional proteins, single-cell expressions vary independently of spatial localization in substantial proportion of the tumor tissues, and incorporation of spatial information may not affect the prognostic value of such protein biomarkers.

RESULTS: We developed a new framework for using the distributions of functional single-cell protein expression levels as cancer biomarkers. The quantile functions of single-cell expressions are used to fully capture the heterogeneity of protein expression across all cancer cells. The quantile index (QI) biomarker is defined as an integral of an unspecified function which may depend linearly or nonlinearly on a tissue-specific quantile function. Linear and nonlinear versions of QI biomarkers based on single-cell expressions of ER, Ki67, TS, and CyclinD3 were derived and evaluated as predictors of progression-free survival or high mitotic index in a large breast cancer dataset. We evaluated performance and demonstrated advantages of non-linear QI biomarkers through simulation studies.

AVAILABILITY: The associated R package Qindex is available at https://CRAN.R-project.org/package=Qindex and R package hyper.gam is available at https://github.com/tingtingzhan/hyper.gam. Examples of R code and detailed instructions could be found in vignette quantile-index-predictor (https://CRAN.R-project.org/package=hyper.gam/vignettes/applications.html#quantile-index-predictor).

SUPPLEMENTARY INFORMATION: Supplementary Material is available at Bioinformatics online.

PMID:40257750 | DOI:10.1093/bioinformatics/btaf182

J Nurs Res. 2025 Apr 22. doi: 10.1097/jnr.0000000000000672. Online ahead of print.

ABSTRACT

BACKGROUND: Children experience fear and anxiety not only during painful procedural interventions but also during painless procedural interventions such as electrocardiography (ECG). Pediatric nurses should be aware of the emotional changes experienced by children during ECG procedures.

PURPOSE: The aim of this single-center, single-blinded, randomized controlled intervention study was to investigate the impact of the undersea-themed examination table cover (UTETC) on the levels of fear and anxiety experienced by children during ECG procedures.

METHODS: This study was conducted between April 1 and July 31, 2022, in the pediatric emergency department of a training and research hospital in Turkey. The participants included 80 children (experimental group = 40, control group = 40) aged 3-12 years. The experimental group underwent the procedure in the ECG room using the UTETC, while the control group underwent the routine procedure in the examination room. The entire process was video-recorded. Video recordings were watched by two nurses who were not otherwise involved in this study, and the data were collected using the Descriptive Data Form, the Children’s Fear Scale, and the Children Emotional Manifestation Scale.

RESULTS: No statistically significant difference was found in the descriptive characteristics of the two groups (p > .05). The experimental group completed the procedure more successfully than the control group with significantly lower levels of procedure-related fear and anxiety (p < .05).

CONCLUSIONS/IMPLICATIONS FOR PRACTICE: The UTETC was found to be effective in reducing fear and anxiety in children aged 3-12 years during ECG procedures in a pediatric emergency department.

PMID:40257748 | DOI:10.1097/jnr.0000000000000672

Eur J Health Econ. 2025 Apr 21. doi: 10.1007/s10198-025-01781-8. Online ahead of print.

ABSTRACT

OBJECTIVE: As European healthcare systems struggle with increasing workload and sustainability issues, it is estimated that 20% of their production is ineffective. One potential strategy to reduce this excess is by minimizing the use of unnecessary laboratory tests. The aim of this review was to investigate the effect of presenting physicians in Europe with the cost of laboratory tests at the time of ordering on the quantities and expense of laboratory tests as well as to identify knowledge gaps on this matter.

METHODS: Following PRISMA guidelines, a systematic search in PubMed and EMBASE was conducted in February 2025. Studies were included if written in English and conducted in Europe. There were no restrictions on year of publication. Study quality was evaluated using a modified Downs and Black checklist.

RESULTS: Of the 2185 publications identified, five met the inclusion criteria. All included studies were published 2002-2021 and found a reduction in order cost and/or volume of laboratory test, following price display (four with statistically significant results). The reduction in order costs were greater than the reduction in order volume. Additionally, the impact of price display diminished over time as the intervention period continued. None of the studies included patient safety measures.

CONCLUSIONS: Price display is a simple yet potentially impactful intervention as it is likely to reduce both the cost and volume of tests, thereby decreasing the workload and enhancing the sustainability of the healthcare systems. Further high-quality studies are needed to determine if price display is a patient-safe intervention.

PMID:40257741 | DOI:10.1007/s10198-025-01781-8

Sports Med. 2025 Apr 21. doi: 10.1007/s40279-025-02217-2. Online ahead of print.

ABSTRACT

BACKGROUND: In response to exercise, protein kinases and signaling networks are engaged to blunt homeostatic threats generated by acute contraction-induced increases in skeletal muscle energy and oxygen demand, as well as serving roles in the adaptive response to chronic exercise training to blunt future disruptions to homeostasis. High-intensity interval training (HIIT) is a time-efficient exercise modality that induces superior or similar health-promoting skeletal muscle and whole-body adaptations compared with prolonged, moderate-intensity continuous training (MICT). However, the skeletal muscle signaling pathways underlying HIIT’s exercise intensity-specific adaptive responses are unknown.

OBJECTIVE: We mapped human muscle kinases, substrates, and signaling pathways activated/deactivated by an acute bout of HIIT versus work-matched MICT.

METHODS: In a randomized crossover trial design (Australian New Zealand Clinical Trials Registry number ACTRN12619000819123; prospectively registered 6 June 2019), ten healthy male participants (age 25.4 ± 3.2 years; BMI 23.5 ± 1.6 kg/m²; $\dot{V}{\text{O}}_{2}max$ 37.9 ± 5.2 ml/kg/min, mean values ± SD) completed a single bout of HIIT and MICT cycling separated by ≥ 10 days and matched for total work (67.9 ± 10.2 kJ) and duration (10 min). Mass spectrometry-based phosphoproteomic analysis of muscle biopsy samples collected before, during (5 min), and immediately following (10 min) each exercise bout, to map acute temporal signaling responses to HIIT and MICT, identified and quantified 14,931 total phosphopeptides, corresponding to 8509 phosphorylation sites.

RESULTS: Bioinformatic analyses uncovered exercise intensity-specific signaling networks, including > 1000 differentially phosphorylated sites (± 1.5-fold change; adjusted P < 0.05; ≥ 3 participants) after 5 min and 10 min HIIT and/or MICT relative to rest. After 5 and 10 min, 92 and 348 sites were differentially phosphorylated by HIIT, respectively, versus MICT. Plasma lactate concentrations throughout HIIT were higher than MICT (P < 0.05), and correlation analyses identified > 3000 phosphosites significantly correlated with lactate (q < 0.05) including top functional phosphosites underlying metabolic regulation.

CONCLUSIONS: Collectively, this first global map of the work-matched HIIT versus MICT signaling networks has revealed rapid exercise intensity-specific regulation of kinases, substrates, and pathways in human skeletal muscle that may contribute to HIIT’s skeletal muscle adaptations and health-promoting effects. Preprint: The preprint version of this work is available on medRxiv, https://doi.org/10:1101/2024.07.11.24310302 .

PMID:40257739 | DOI:10.1007/s40279-025-02217-2

J Magn Reson Imaging. 2025 Apr 21. doi: 10.1002/jmri.29796. Online ahead of print.

ABSTRACT

BACKGROUND: Axillary lymph node burden(ALNB) is a critical factor in determining treatment strategies for clinical T₁-T₂ (cT₁-T₂) stage breast cancer. However, as ALNB assessment relies on invasive procedures, exploring non-invasive methods is essential.

PURPOSE: To develop and validate a habitat radiomics model for assessing ALNB in cT₁-T₂ breast cancer, incorporating radiogenomic data to improve interpretability.

STUDY TYPE: Retrospective.

POPULATION: 468 patients with cT₁-T₂ stage breast cancer from two institutions and The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA)-Breast Invasive Carcinoma (BRCA) were included. The cohort was divided into training (n = 173), internal validation (n = 58), external validation (n = 130), and TCGA-BRCA sets (n = 107). Patients were categorized into high nodal burden (HNB; > 3 positive lymph nodes) and non-HNB (≤ 3 positive lymph nodes) groups.

FIELD STRENGTH/SEQUENCE: 1.5-T MRI and 3.0-T MRI, and three-dimensional dynamic contrast-enhanced T1-weighted gradient-echo sequences.

ASSESSMENT: Two logistic regression models were developed using habitat-based and clinical features. Model performance was evaluated using the AUC. SHapley Additive exPlanations (SHAP) analysis was employed to identify key features. Radiogenomic analysis, including gene set enrichment and drug sensitivity assessments, was conducted using transcriptomic data from the TCGA-BRCA set.

STATISTICAL TESTS: Pearson correlation, Mann-Whitney U, genetic algorithm, logistic regression, AUC analysis, delong test, and SHAP analysis. A p-value < 0.05 was considered statistically significant.

RESULTS: The Habitat model outperformed the Clinical model (AUCs: 0.840-0.932 vs. 0.558-0.673). The SHAP analysis was used to rank feature importance, with subregion 3 showing the highest average SHAP value. Radiogenomic analysis indicated upregulation of the KEGG ribosome pathway in the HNB group and identified differential drug sensitivity profiles among risk groups.

DATA CONCLUSION: The Habitat model has the potential to assess ALNB in cT₁-T₂ breast cancer and assist radiologists in axillary diagnosis, which may help reduce the need for unnecessary ALN dissection.

EVIDENCE LEVEL: 3. Technical Efficacy: Stage 2.

PMID:40256826 | DOI:10.1002/jmri.29796

Diabetes Technol Ther. 2025 Apr 21. doi: 10.1089/dia.2025.0064. Online ahead of print.

ABSTRACT

Background: Potatoes are a staple food, especially in pediatric populations, but they pose distinct challenges for individuals with type 1 diabetes (T1D). This study evaluated glycemic responses in youth with T1D using a second-generation automated insulin delivery system after consuming potatoes prepared by two methods: fried and boiled. Methods: The study was conducted during a 5-day school camp for unaccompanied youth with T1D, aged 11-17 years, who had been using the Tandem t:slim X2™ Control-IQ insulin pump for at least 6 months. On two separate days, participants consumed a standardized meal containing 240 g of either fried or boiled potatoes, considered as 38 g of carbohydrates. Continuous glucose monitoring (CGM) data were collected and analyzed for all participants. Results: Our study population consisted of 31 children and adolescents (mean age 14.2 ± 1.7 years). Time in range was slightly higher after consuming boiled potatoes compared with fried potatoes, though the difference was not statistically significant (73.7% vs. 67.8%; P = 0.225). Mean glucose changes from pre-meal to 3-h post-meal were comparable between groups (-34.3 vs. -25.4 mg/dL; P = 0.517). Similarly, no significant differences were observed in the area under the curve of glucose levels. However, the percentage of bolus insulin within the 3-h post-meal period tended to be higher after fried potato consumption (20.7% vs. 11.9%; P = 0.075). Conclusions: Despite differences in glycemic index and fat content, the Tandem t:slim X2 Control-IQ system effectively maintained satisfactory glucose control within the 3-h post-meal period for both fried and boiled potatoes.

PMID:40256802 | DOI:10.1089/dia.2025.0064