Tag: nevin manimala

ACS Sens. 2025 Apr 4. doi: 10.1021/acssensors.4c03260. Online ahead of print.

ABSTRACT

Raman spectroscopy in biological applications faces challenges due to complex spectra, characterized by peaks of varying widths and significant biological background noise. Convolutional neural networks (CNNs) are widely used for spectrum classification due to their ability to capture local peak features. In this study, we introduce a multiscale CNN designed to detect weak biomolecule signals and differentiate spectra with features that cannot be statistically distinguished. The approach is further enhanced by a new visualization technique tailored for multiscale spectral analysis, providing clear insights into classification results. Using the classification of cholera toxin B subunit (CTB)-treated versus untreated cell membrane samples, whose spectra cannot be statistically differentiated, the optimized multiscale CNN achieved superior performance compared to traditional machine learning methods and existing multiscale CNNs, with accuracy (99.22%), sensitivity (99.27%), specificity (99.16%), and precision (99.20%). Our new visualization method, based on gradients of activation maps with respect to class scores, generates saliency scores that capture sample variations, with decision-making relying on consistently identified peak features. By visualizing the effects of different kernel sizes, Grad-AM highlights features at varying scales, aligning closely with spectral features and enhancing CNN interpretability in complex biomolecular analysis. These advancements demonstrate the potential of our method to improve spectral analysis and reveal previously hidden peaks in complex biological environments.

PMID:40184533 | DOI:10.1021/acssensors.4c03260

Adv Skin Wound Care. 2025 Apr 4. doi: 10.1097/ASW.0000000000000306. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate the effects of extra-virgin olive and almond oils on maintaining skin integrity in neonates admitted to the neonatal ICU.

METHODS: This was a semiexperimental study. The sample comprised 120 term (37-42 weeks) neonates treated in a state hospital in Istanbul, Turkey (May-August 2023), who met the sample criteria (olive oil: 60, almond oil: 60). The data were collected using a newborn identification form, the Neonatal Skin Condition Score, and the DMM Skin Moisture Meter.

RESULTS: The neonates’ sex, gestational age, postnatal age, birth weight, length, and head circumference measurements were similar, suggesting no significant differences between the groups (Ps > .05). A statistically significant difference was found between the mean skin hydration levels of neonates treated with almond oil and extra-virgin olive oil on the first, second, and third days of the application, where a higher skin hydration was determined in the extra-virgin olive oil group (P = .024, P = .004, P = .020). However, no statistically significant difference was found between the Neonatal Skin Condition Score scores of neonates treated with almond oil and extra-virgin olive oil before and on all days of the application (1-5 days, P > .05).

CONCLUSIONS: Both extra-virgin olive oil and almond oil increased the stratum corneum hydration in term neonates. The application of extra-virgin olive oil and almond oil did not result in any adverse effects on neonatal skin conditions of neonates admitted to the neonatal ICU.

PMID:40184517 | DOI:10.1097/ASW.0000000000000306

Adv Skin Wound Care. 2025 Apr 2. doi: 10.1097/ASW.0000000000000300. Online ahead of print.

ABSTRACT

OBJECTIVE: To explore the application of telemedicine in patients with an ostomy and assess the current research status.

DATA SOURCES: The authors searched PubMed, EMBASE, Web of Science, Ovid, CINAHL (Cumulative Index to Nursing and Allied Health Literature), China Biology Medicine, China National Knowledge Infrastructure, WanFang, and VIP (Chinese Scientific Journals Database) databases from the inception of each database to March 2024.

STUDY SELECTION: A total of 41 articles comparing telemedicine and standard care in ostomy patients were included.

DATA EXTRACTION: Information was extracted from full-text articles, including author(s), year, country, study design, ostomy type, sample characteristics, intervention type, duration, and outcomes.

DATA SYNTHESIS: In the 41 studies, telemedicine intervention tools encompass social and conference software, mobile healthcare apps, and remote devices. Intervention durations ranged from 4 weeks to 3 years. The intervention content can be categorized into seven key aspects: health guidance, health counseling, psychological care, peer support, medical appointment scheduling, information statistics, and remote visits. Evaluation of these interventions involves measuring outcomes in 10 areas, including quality of life, ostomy knowledge, self-efficacy, self-care ability, stoma complications, participant satisfaction, psychology, coping and adaptation, burden, and health condition.

CONCLUSIONS: The implementation of telemedicine for patients with an ostomy has had a profound impact. As internet technology evolves, optimization of platforms and longer interventions are needed. Healthcare professionals should enhance their training in online communication. In addition, researchers should design specific, specialized measurement scales based on the characteristics of patients with stomas.

PMID:40184509 | DOI:10.1097/ASW.0000000000000300

Eur J Endocrinol. 2025 Apr 4:lvaf060. doi: 10.1093/ejendo/lvaf060. Online ahead of print.

ABSTRACT

BACKGROUND: Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) affects approximately 1 in 15,000 individuals. We leveraged the power of multicentre registry data to assess the trend and predictors of blood pressure (BP) within children and young persons with 21OHD to inform monitoring strategies.

METHOD: Data from the International CAH Registry in patients younger than 20 years was compared to normative values. Values of BP were modelled to create reference curves, multiple change point analysis applied to quantify the difference with normative data. Covariate adjustment was informed by a directed acyclic graph, prior to joint outcome regression modelling to accurately assess predictors of BP.

RESULTS: A total of 6436 visits within 554 patients (52.5% females) showed BP-Standard deviation scores (SDS) were higher at younger ages. Patients under five years had systolic BP-SDS of 1.6 (Q1:0.6-Q3:2.7) decreasing to 1.0 (Q1:0.2-Q3:1.8) over five years, equating to 31.0% over the 95th centile decreasing to 15.0%. Higher doses of fludrocortisone were associated with a small increase in systolic BP equivalent to 1.2mmHg with every 100 micrograms extra fludrocortisone. Renin of 100µU/ml was associated with 4.6mmHg lower systolic BP than a renin of 1µU/ml, higher 17OH-progesterone and androstenedione also predicted lower systolic and diastolic BP (p<0.05).

CONCLUSION: Higher BP in children with 21OHD is common and particularly pronounced at a younger age, but may not be attributable to excessive mineralocorticoid replacement. There is a need to improve our understanding of the determinants of this raised BP as well as its long-term effects.

PMID:40184493 | DOI:10.1093/ejendo/lvaf060

Gynecol Endocrinol. 2025 Dec;41(1):2487498. doi: 10.1080/09513590.2025.2487498. Epub 2025 Apr 4.

ABSTRACT

To date, there remains a paucity of prospective studies examining the association between premature ovarian insufficiency (POI) and cardiovascular diseases (CVD). The objective of this study was to investigate the potential association between POI and CVD utilizing the method of Mendelian randomization (MR). MR analyses utilized summary statistics from the most extensive genome-wide association studies (GWAS) on POI and CVD extracted from European ancestry cohorts and the FinnGen biobank. The inverse variance-weighted (IVW) method was the primary MR analysis technique. Supplementary analyses were performed using MR-Robust Adjusted Profile Score (MR-RAPS). Cochran’s Q statistic, MR-Egger, and weighted median MR models were employed to further assess heterogeneity and horizontal pleiotropy. Causal effects of POI on coronary heart disease (odds ratio [OR] = 1.048, 95% confidence interval [CI]: 1.006-1.091; p = 0.023)] and ischemic stroke (OR = 1.010, 95% CI: 1.000-1.020; p = 0.0498) were found. However, we did not observe a significant correlation between POI and hypertension (OR = 0.999, 95% CI: 0.994-1.004, p = 0.691), heart failure (OR = 1.009, 95% CI: 0.999-1.020, p = 0.0725), atrial fibrillation (OR = 0.995, 95% CI: 0.986-1.004, p = 0.3035), and myocardial infarction (OR = 1.002, 95% CI: 0.991-1.013, p = 0.7061). POI was causally associated with coronary heart disease and ischemic stroke, with no apparent impact on hypertension, heart failure, atrial fibrillation, or myocardial infarction. The causal relationship between POI and CVD underscores the imperative for proactive cardiovascular risk management in individuals with POI.

PMID:40184471 | DOI:10.1080/09513590.2025.2487498

PLoS One. 2025 Apr 4;20(4):e0321177. doi: 10.1371/journal.pone.0321177. eCollection 2025.

ABSTRACT

OBJECTIVE: The Chinese version of Dietary Sodium Restriction Questionnaire (DSRQ) was adapted to evaluate its reliability and validity for measuring adherence to a sodium-restricted diet in peritoneal dialysis (PD) patients.

METHODS: Specific items related to peritoneal dialysis were added to create a PD version of the DSRQ (PD-DSRQ), which was administered to 135 patients undergoing PD. Item analysis was performed using the critical ratio and homogeneity tests. The reliability of the questionnaire was determined by assessing the internal consistency. Content validity was evaluated using the expert evaluation method, and construct validity was assessed via exploratory and confirmatory factor analyses.

RESULTS: The item analysis revealed correlation coefficients (R-values) ranging from 0.311 to 0.745 for each item, with statistically significant differences between the high and low subgroups for all items. The Cronbach’s α coefficients for the overall PD-DSRQ and the attitude, subjective norm, and perceived behavioral control subscales were 0.805, 0.892, 0.794, and 0.889, respectively. The item-level content validity index ranged from 0.83 to 1.00, and the scale-level content validity index/universal agreement was 0.9894. Exploratory factor analysis identified a three-factor structure consistent with the original DSRQ, except for Question 18. The three factors had eigenvalues of 5.302, 4.179, and 1.290, which explained 64.32% of the variance. The average variance extracted for each dimension was 0.5777, 0.5654, and 0.5259, and the composite reliability values were 0.8864, 0.7956, and 0.8802, respectively, demonstrating good convergent and discriminant validity.

CONCLUSION: The PD-DSRQ encompasses general information and three dimensions: attitude, subjective norms, and perceived behavioral control. The questionnaire demonstrated strong reliability and validity, making it a reliable tool for assessing adherence to sodium-restricted diets in patients undergoing PD.

PMID:40184402 | DOI:10.1371/journal.pone.0321177

PLoS One. 2025 Apr 4;20(4):e0320795. doi: 10.1371/journal.pone.0320795. eCollection 2025.

ABSTRACT

Youth unemployment in the East Gojjam Zone is a critical issue. This study focuses on identifying the factors that influence unemployment duration and evaluating the impact of job creation programs on the well-being of youth in this region. We employed Cox regression to analyze the determinants of unemployment duration and used propensity score matching to assess the welfare effects of job creation initiatives. Our multistage cluster sampling revealed a youth unemployment rate of 33.3% (95% CI: 27.3-39.3). Over half of the unemployed youth transitioned to employment within four years, with 25% securing jobs within two years. Participation in job creation programs led to an average earnings increase of 1,069.716 birr, though retention in these programs was low at 49%. The findings reveal a connection between prolonged unemployment, skill mismatches, financial constraints, limited work experience, weak social networks, low income, and a preference for public-sector employment. To effectively address these challenges, interventions must focus on improving job accessibility, aligning vocational training with labor market needs, promoting financial inclusion, and enhancing social support systems.

PMID:40184397 | DOI:10.1371/journal.pone.0320795

PLoS One. 2025 Apr 4;20(4):e0321471. doi: 10.1371/journal.pone.0321471. eCollection 2025.

ABSTRACT

Respiratory health and chronic disease risks are prevalent concerns in agricultural communities in Northern Thailand, prompting an assessment of these issues among residents in Chiang Mai. A cross-sectional study involving 145 participants was conducted in San Pa Tong District from October to December 2023, utilizing structured questionnaires and spirometry tests to evaluate lung function and chronic health disease risk. The study found that education and income significantly impacted lung function, with better FVC% and FEV1/FVC% predicted values observed in those with primary education and lower income. Lower DM risk was associated with better lung function (P = 0.023). Logistic regression showed a significant increase in lung function impairment among participants with high to very high DM risk (aOR 9.06, p < 0.05). High CV and COPD risk levels also correlated with lung function impairment, though not all results were statistically significant. The results emphasize the intricate interplay between socioeconomic factors, chronic disease risks, and lung function, advocating for public health interventions that holistically address population respiratory and metabolic health.

PMID:40184396 | DOI:10.1371/journal.pone.0321471

PLoS One. 2025 Apr 4;20(4):e0309751. doi: 10.1371/journal.pone.0309751. eCollection 2025.

ABSTRACT

Additive friction stir deposition (AFSD) is a novel solid-state additive manufacturing technique that circumvents issues of porosity, cracking, and properties anisotropy that plague traditional powder bed fusion and directed energy deposition approaches. However, correlations between process parameters, thermal profiles, and resulting microstructure in AFSD still need to be better understood. This hinders process optimization for properties. This work employs a framework combining supervised machine learning (SML) and physics-informed neural networks (PINNs) to predict peak temperature distribution in AFSD from process parameters. Eight regression algorithms were implemented for SML modeling, while four PINNs leveraged governing equations for transport, wave propagation, heat transfer, and quantum mechanics. Across multiple statistical measures, ensemble techniques like gradient boosting proved superior for SML, with the lowest MSE of 165.78. The integrated ML approach was also applied to classify deposition quality from process factors, with logistic regression delivering robust accuracy. By fusing data-driven learning and fundamental physics, this dual methodology provides comprehensive insights into tailoring microstructure through thermal management in AFSD. The work demonstrates the power of bridging statistical and physics-based modeling for elucidating AM process-property relationships.

PMID:40184386 | DOI:10.1371/journal.pone.0309751

Res Q Exerc Sport. 2025 Apr 4:1-10. doi: 10.1080/02701367.2025.2471880. Online ahead of print.

ABSTRACT

The purpose of the present study was to compare the ratings of perceived exertion (RPE), affective (Feeling Scale), and remembered enjoyment (Physical Activity Enjoyment Scale) responses following different exercise intensities/patterns and to investigate possible associations with physiological parameters in active adults. In a randomized crossover trial, 16 active adults (29.9 ± 3.2 years; 8 males/8 females) performed three different conditions: moderate continuous exercise (MCE) at 70% lactate threshold (LT), heavy continuous exercise (HCE) at 10% of the difference between LT and VO₂ peak, and heavy interval exercise (HIE) wherein intensity matched HCE but performed as 1-minute on:off with stationary rest in between. RPE (CR10) and affect were evaluated during exercise while remembered enjoyment was assessed at the end of each exercise session. Average RPE was significantly different (p = .001; η_p² = .744) between all three exercise modalities (MCE = 2.6 ± 0.8, HCE = 5.1 ± 1.0; HIE = 3.5 ± 0.9; p ≤.001). Average affect during exercise was also significantly different (p = .001; η_p² = .427) with post hoc testing revealing lower affect for HCE compared to MCE (p = .002) and HIE (p = .008). Similar results were observed for affect nadir (lowest affect during exercise; MCE = 3.1 ± 1.3; HCE = 1.2 ± 1.7; HIE = 2.4 ± 1.6; p = .001; η_p² = .470). Remembered enjoyment was not statistically different between modalities (MCE = 98 ± 18; HCE = 96 ± 17; HIE = 100 ± 16; p = .468; η_p² = .049), but more people preferred HCE (10/16; 62.5%) compared with both HIE (4/16; 25%) and MCE (2/16; 12.5%) (p = .039): Despite the higher average RPE and lower affect during HCE, no difference was observed for remembered exercise enjoyment, and active individuals seem to prefer this exercise modality compared with HIE or MCE.

PMID:40184203 | DOI:10.1080/02701367.2025.2471880