J Pediatr Gastroenterol Nutr. 2023 Jul 25. doi: 10.1097/MPG.0000000000003895. Online ahead of print.
ABSTRACT
Genetic variations, in specific COMT, OPRM1 and MAO-A polymorphisms, have been associated with hypnotizability in adults. The aim of this exploratory study was to investigate whether these polymorphisms are also associated with response to hypnotherapy (HT) in children. Patients (8-18 years, n=260) diagnosed with a functional abdominal pain disorder (FAPDs) from a previous trial assessing HT efficacy were approached for participation and 144 agreed to collect a buccal sample. Primary aim was to explore the association between COMT, OPRM1 and MAO-A polymorphisms with treatment success after 3-month HT. Additionally, associations between these polymorphisms and adequate relief, anxiety, depression, quality of life, somatization, hypnotic susceptibility, expectations, pain beliefs, and coping strategies were evaluated. Participants with different variations of COMT, MAO-A and OPRM1 achieved similar treatment success levels (p > .05). No associations were found between these polymorphisms and secondary outcomes. This suggest that in pediatric patients with FAPDs, COMT, OPRM1 and MAO-A polymorphisms do not predict HT response.
PMID:37490618 | DOI:10.1097/MPG.0000000000003895