Br J Anaesth. 2025 Jan 6:S0007-0912(24)00724-4. doi: 10.1016/j.bja.2024.11.033. Online ahead of print.
NO ABSTRACT
PMID:39765404 | DOI:10.1016/j.bja.2024.11.033
Tag: nevin manimala
Pancreatology. 2025 Jan 1:S1424-3903(24)00848-2. doi: 10.1016/j.pan.2024.12.020. Online ahead of print.
ABSTRACT
BACKGROUND/OBJECTIVES: Loss-of-function chymotrypsin C (CTRC) variants increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC activity. Variants in the 5′ upstream region that includes the promoter might affect CTRC expression but have not been investigated to date. The aim of the present study was to address this knowledge gap.
METHODS: We analyzed ∼1.4 kb of the 5′ region of the CTRC gene in 293 patients with chronic pancreatitis of alcoholic and non-alcoholic etiology and 402 controls from the Hungarian National Pancreas Registry by direct Sanger sequencing.
RESULTS: We identified 14 gene variants, which included 11 novel variants and 3 previously reported variants. When allele frequencies were considered, none of the variants were significantly overrepresented in CP cases or controls. Genotype distribution of the frequently occurring variant c.-913A>G showed a statistically significant enrichment of the homozygous GG genotype (versus the AA genotype) in CP cases versus controls (OR 1.67, 95 % CI 1.2-2.4, P 0.0053). However, the disease association was driven by the linkage disequilibrium with the known CTRC risk variant c.180C>T.
CONCLUSIONS: We found no significant association between variants in the 5′ region of the CTRC gene and CP risk.
PMID:39765393 | DOI:10.1016/j.pan.2024.12.020
Arab J Gastroenterol. 2025 Jan 6:S1687-1979(24)00127-8. doi: 10.1016/j.ajg.2024.11.003. Online ahead of print.
ABSTRACT
BACKGROUND AND STUDY AIMS: This study was aimed to validate the correlation of circular RNA HIPK3 (CircHIPK3) expression in serum and tissues with the progression of liver fibrosis (LF) and liver cirrhosis (LC).
PATIENTS AND METHODS: Serum CircHIPK3 expressions were detected in 120 patients with LF/LC and 120 healthy controls (HCs). CircHIPK3 expression in tissues was detected in 120 fibrotic liver tissues and compared to 57 healthy liver tissues from patients with hepatic hemangioma. The expressions of CircHIPK3, TGF-β1, and CollA1 mRNAs were assessed by qRT-PCR. The Child-Pugh (CP) classification was used to evaluate disease severity. The Ishak score was applied to assess LF/LC in liver biopsy samples. The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also investigated. Receiver operating characteristic (ROC) analysis was conducted to assess the diagnostic value of CircHIPK3 expressions in serum and tissues.
RESULTS: CircHIPK3 expressions in serum and tissues were upregulated in patients with LF/LC compared to HCs. The patient group comprised 39 with CP class A (CP-A), 45 with CP class B (CP-B), and 36 with CP class B (CP-C). Patients with CP-C had markedly increased serum and local CircHIPK3 levels compared to those with CP-B and CP-A. Patients with CP-B showed upregulated CircHIPK3 expressions in serum and tissues compared to CP-A with statistical significance. ROC curve analysis indicated that CircHIPK3 expressions in both serum and tissues may serve as potential diagnostic indicators for the progression of LF/LC. Moreover, serum CircHIPK3 expressions were positively associated with serum ALT and AST levels. Tissue CircHIPK3 expressions were positively correlated with tissue TGF-β1 and CollA1 mRNA expressions. In addition, both serum and tissue CircHIPK3 expressions were positively associated with the Ishak score.
CONCLUSIONS: For the first time, this study demonstrated the positive correlation of CircHIPK3 expressions in both serum and tissues with the progression of LF/LC, regardless of etiology. CircHIPK3 might play a significant role in the development of LF/LC and act as a potential therapeutic target for these conditions.
PMID:39765392 | DOI:10.1016/j.ajg.2024.11.003
Nutr Metab Cardiovasc Dis. 2024 Dec 25:103842. doi: 10.1016/j.numecd.2024.103842. Online ahead of print.
ABSTRACT
BACKGROUND AND AIM: The relationship between socio-economic inequalities (SEIs) and early life malnutrition with muscle health remains unclear. This study aims to examine the effects of SEIs and early life exposure to famine on relative hand grip strength (rHGS).
METHODS AND RESULTS: We analyzed data of 37,008 individuals from the China National Health Survey. SEI were assessed using the Population Attributable Fraction (PAF), the Relative Index of Inequality (RII), and the Slope Index of Inequality (SII). The propensity score matching and cohort size shrinkage index were used to examine the impact of famine on low rHGS. The RII for education- and income-based SEI was 1.17 (95 % CI: 1.09 to 1.27) and 1.20 (95 % CI: 1.11 to 1.29) in men, and 1.20 (95 % CI: 1.12 to 1.28) and 1.06 (95 % CI: 0.99 to 1.13) in women, respectively. The SII per 100,000 persons for education- and income-based SES was 609 (207-1011) and 912 (481-1343) in men, compared to 909 (580-1237) and 218 (-134 to 570) in women. The stimulation analysis showed that both RII and SII increased with a higher proportion of individuals at the highest income level, exhibiting a sex-differential pattern. Early-life exposure to famine was significantly associated with decreased rHGS. The PAFs of low rHGS attributed to famine ranged from 2.5 % to 4.6 % in men and 5.8 %-9.6 % in women.
CONCLUSIONS: SEI and early life malnutrition increased the risk of low rHGS. These findings are valuable for informing policymaking aimed at healthy aging.
PMID:39765377 | DOI:10.1016/j.numecd.2024.103842
J Pediatr Surg. 2024 Dec 31:162128. doi: 10.1016/j.jpedsurg.2024.162128. Online ahead of print.
NO ABSTRACT
PMID:39765367 | DOI:10.1016/j.jpedsurg.2024.162128
Dent Mater. 2025 Jan 7:S0109-5641(24)00366-X. doi: 10.1016/j.dental.2024.12.010. Online ahead of print.
ABSTRACT
OBJECTIVE: To analyze the impact of the translucency/opacity of two commercial brands of resin cements and different translucency of lithium disilicate on the masking ability of saturated substrates.
METHODS: 120 samples (n = 5) were prepared using 0.5 mm lithium disilicate (IPS e.max CAD) in three translucencies (HT, MT, LT). These were cemented onto A1 and A4 resin substrates using two brands of resin cements: Allcem Veneer (FGM) in Trans (T) and Opaque White (OW), and Variolink Esthetic LC (Ivoclar Vivadent) in Neutral (N) and Light+ (L+), with a thickness of 100 µm. Color analysis was performed using reflectance measurements with a CM-3700d spectrophotometer (Konica Minolta). The Relative Translucency Parameter (RTP) and the Color Difference (∆E00) were calculated using the CIEDE2000 formula, with Perceptibility Threshold (PT) of ∆E00 = 0.8 and Acceptability Threshold (AT) of ∆E00 = 1.8. Statistical analyses were conducted using three-way ANOVA followed by Tukey’s tests (α=0.05).
RESULTS: For ∆E00 between substrates saturation (A1 VS A4), the isolated fixed factors and their interaction were statistically significant (p < .001) and showed ∆E00 > 1.8 for all groups. ∆E00 between resin cements colors of the same brand reveals significant factors (p < .001) but a non-significant statistical interaction (p = 0.072). The RTP of the resin cement were N(47.64) > T(47.47) > Ow(42.02)>L+ (23.39). For restorative set RTP, a non-significant interaction (p > 0.05) and groups cemented with L+ reveal lower RTP values than those cemented with OW.
SIGNIFICANCE: The ceramic translucency, the resin cement brand and color were influential on ability to mask substrates of different saturations. The opaquest resin cement contributes to reduce the influence of the ceramic on restoration final color. Resin cement brand and color influences restoration esthetics.
PMID:39765364 | DOI:10.1016/j.dental.2024.12.010
Zhonghua Xue Ye Xue Za Zhi. 2024 Dec 14;45(12):1085-1090. doi: 10.3760/cma.j.cn121090-20240613-00222.
ABSTRACT
Objective: This study aimed to summarize the clinical characteristics and prognosis of patients with bone marrow invasive follicular lymphoma (FL) and discuss the treatment modalities. Methods: This study included 183 consecutive patients with FL accompanied by bone marrow invasion and receiving regular treatment at the Hospital of Hematology, Chinese Academy of Medical Sciences, from January 2013 to December 2022. Clinical data were retrospectively collected and analyzed, and single and multifactorial analyses of survival prognosis were conducted with the Kaplan-Meier method and Cox regression model. Results: The median age was 48 (range: 19 – 78) years, and the male-to-female ratio was 0.9∶1. All of the patients had bone marrow invasion, 27.8% had increased lactate dehydrogenase levels, 42.1% had lymphocyte counts of >5×10(9)/L, 18.4% had abnormal chromosomal karyotypes, and 48.6% had Ki-67 index of ≥30% in lymphoid tissue. Comparison of different subgroups: lymphocyte counts of >5×10(9)/L, number of lymph nodes of ≥5 involved, and proportion of bone marrow chromosomal abnormalities occurring were higher in the anthracycline-intensive treatment group than in the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) protocol and the nucleoside analog (including CD20 monoclonal antibody in combination with fludarabine and bendamustine) groups (all P<0.05). The complete remission rate was 39.1% in the conventional R-CHOP group, which was lower and statistically significant than that in the intensive treatment group (55.1%) and the nucleoside analog group (62.5%) (P=0.042). The multivariate analysis for survival analysis revealed high risk of FLIPI (HR= 1.910, 95% CI 1.036 – 3.522, P=0.036), chromosomal abnormalities karyotype (HR=2.666, 95% CI 1.333-5.331, P=0.006), and conventional R-CHOP treatment (HR=2.287, 95% CI 1.140-4.591, P=0.020) were the independent adverse prognostic factors affecting progression-free survival (PFS), whereas POD24 was the only independent adverse prognostic factor affecting overall survival (OS) adverse prognostic factor (HR=9.581, 95% CI 3.000 – 30.593, P<0.001) . Conclusions: The clinical presentations of patients with bone marrow invasive FL were easy to combine the clinical features, including increased lymphocyte count, chromosomal abnormalities, and Ki-67 index in lymphoid tissues. The FLIPI score, chromosomal abnormal karyotype, and high-lymphoid-tissue Ki-67 index were the poor prognostic factors influencing PFS. R-CHOP therapy demonstrated a poor prognosis in this group of patients.
PMID:39765348 | DOI:10.3760/cma.j.cn121090-20240613-00222
Zhonghua Xue Ye Xue Za Zhi. 2024 Dec 14;45(12):1078-1084. doi: 10.3760/cma.j.cn121090-20240701-00240.
ABSTRACT
Objective: This study aimed to investigate the clinical characteristics of oral mucositis (OM) in patients with hematological diseases who received secondary allogeneic hematopoietic stem cell transplantation (allo-HSCT) . Methods: This study retrospectively analyzed data on 58 patients with hematological diseases who underwent secondary allo-HSCT at the Peking University People’s Hospital from January 2018 to December 2023. The control group included 116 randomized patients after primary allo-HSCT during this period (1:2 ratio) with matched gender, age, and diagnosis. The incidence of OM and overall survival (OS) were compared between the two groups. Results: The secondary allo-HSCT and control groups reported 17 (29.31%) and 16 (13.79%) cases that developed OM (P=0.014), whereas 10 (17.24%) and 7 (6.03%) developed grade ≥3 OM (P=0.019). The median time for OM to occur was 4 days (1-9 days) and 5 days (1-10 days) posttransplantation in the secondary allo-HSCT and control groups, respectively. The multivariate analysis revealed that the use of whole-body radiation therapy as the main pretreatment regimen was an independent risk factor for OM occurrence (P=0.019). Among patients with OM, an age of <55 years is a risk factor for developing grade 3-4 OM (P=0.028). All patients who underwent the secondary allo-HSCT received granulocyte implantation. The median time of granulocyte implantation in 17 patients with OM was 14 days posttransplantation, whereas the median time of granulocyte implantation in patients without OM was 12 days posttransplantation. The difference was not statistically significant (P=0.721). The presence of OM did not affect the occurrence of acute graft-versus-host disease (P=0.938). No statistically significant difference was observed in the 2-year OS rate between patients with and without OM during the secondary allo-HSCT (51.9% vs 50.4%, P=0.943). No statistically significant difference was observed in the 2-year OS rate between patients with OM undergoing the secondary allo-HSCT and those undergoing the primary allo-HSCT (51.9% vs 81.3%, P=0.185) . Conclusions: The proportion of patients with concurrent OM was significantly increased in the secondary allo-HSCT, and the severity was more severe. Whether or not to merge OM does not affect granulocyte implantation, acute graft-versus-host disease incidence, and 2-year OS rate.
PMID:39765347 | DOI:10.3760/cma.j.cn121090-20240701-00240
Int Neurourol J. 2024 Dec;28(4):294-301. doi: 10.5213/inj.2448372.186. Epub 2024 Dec 31.
ABSTRACT
PURPOSE: While pump manipulation is rarely problematic in male patients with artificial urinary sphincters (AUSs), the situation may differ in female patients due to anatomical or cultural factors. This study aimed to evaluate the prevalence of difficulties in pump manipulation among female AUS patients, identify associated risk factors, and explore management strategies for this challenging issue.
METHODS: Data were collected from all female patients who underwent a robotic AUS implantation at a single academic center between 2014 and 2022. The primary endpoint was temporary difficulties, defined by at least one other short hospitalization to learn pump manipulation.
RESULTS: Out of the 88 female AUS patients included in the study, 20 experienced initial difficulties manipulating the pump, accounting for 22.7% of the group. Temporary difficulties were reported by 16 patients (18.2%), while 4 patients (4.5%) had their devices permanently deactivated. Surgical reoperations to reposition the pump were necessary for 5 patients, representing 5.6% of the sample. The only variables significantly associated with temporary difficulties were longer operative time (183.4 minutes vs. 159.1 minutes, P=0.04) and the overall experience of the center (32 vs. 50, P=0.04). The sole variable significantly linked to serious difficulties was the overall experience of the center (11 vs. 47, P=0.004). Although the median age and body mass index were higher in the group with temporary difficulties, these differences were not statistically significant.
CONCLUSION: Difficulties in manipulating the pump are relatively common among female AUS patients. Most of these difficulties can be resolved through repeated patient education and careful follow-up. However, some may lead to serious complications. Raising awareness of this issue, along with ongoing patient education and meticulous follow-up, may help to minimize these consequences.
PMID:39765342 | DOI:10.5213/inj.2448372.186
Int Neurourol J. 2024 Dec;28(4):270-277. doi: 10.5213/inj.2448348.174. Epub 2024 Dec 31.
ABSTRACT
PURPOSE: This study aimed to compare and analyze the feasibility and long-term efficacy of prostatic capsule-sparing (PCS) and nerve-sparing (NS) radical cystectomy in the treatment of bladder cancer.
METHODS: From June 2004 to December 2021, our institution treated and followed 145 patients who underwent radical cystectomy with neobladder reconstruction for over a year. These patients were divided into 2 groups: PCS (n=74) and NS (n=71). To minimize potential biases, 1:1 propensity score matching was utilized to compare oncological outcomes, functional outcomes, and complications between the groups. Additionally, Kaplan-Meier analysis and the log-rank test were used to evaluate survival differences between the PCS and NS groups.
RESULTS: The median follow-up durations for PCS and NS were 155 and 122 months, respectively. After adjusting for propensity scores, a total of 96 patients (48 in each group) were included for further analysis. Kaplan-Meier curves showed no statistically significant differences in metastasis-free probability (P=0.206), cancer-specific survival (P=0.091), and overall survival (P=0.208). The daytime urinary control (UC) rate at 3, 6, and 12 months postoperatively was 72.9%, 91.7%, and 97.9% in the PCS group and 47.9%, 79.2%, and 91.7% in the NS group, respectively (P=0.012, P=0.083, and P=0.362). The nocturnal UC rate was 54.2%, 85.4%, and 95.8% in the PCS group, and 31.3%, 60.4%, and 83.3% in the NS group, respectively (P=0.023, P=0.006, and P=0.091). Regarding erectile function recovery, 62.5% of patients in the PCS group and 22.9% in the NS group returned to preoperative levels (P<0.001).
CONCLUSION: PCS outperformed NS in restoring UC and sexual function and did not affect oncological outcomes. However, PCS was associated with a higher risk of complications linked to bladder-neck obstruction.
PMID:39765339 | DOI:10.5213/inj.2448348.174