Tag: nevin manimala

J Orthop. 2024 Mar 13;54:76-80. doi: 10.1016/j.jor.2024.03.019. eCollection 2024 Aug.

ABSTRACT

BACKGROUND: Septic arthritis of the hip joint (septic hip) is the bacterial infection of the hip. Delayed treatment increases the risk of extensive joint damage, systemic infection, prolonged recovery, higher healthcare costs, and long-term disability. This study explores the repercussions of delayed surgical treatment in pediatric septic hip.

METHODS: In this observational study, pediatric patients diagnosed with septic hip between 2012 and 2021 were retrospectively selected from a major referral center in Shiraz, Iran. We collected clinical and radiological data, including Kocher score and determined Choi classification in follow-up radiographs. Multivariate logistic regression analysis was used to assess the impact of delay to surgery on the development of clinical sequelae and radiological deformities in the presence of potential confounders of age and Kocher criteria.

RESULTS: Out of 49 children with delayed presentation, 46 survived and entered the study. Mean delay from symptom presentation to admission was 12.67 ± 10.51 days, and mean delay from admission to surgery was 5.33 ± 6.47 days. Of the 46 patients, 28.26% developed clinical sequelae. The Choi classification revealed that 54.35% of patients developed no residual deformity. A multivariate logistic regression analysis indicated a statistically significant association between delay to surgery and the development of radiological deformities (adjusted odds ratio: 1.36, 95% CI: 1.14-1.64, p = 0.001). Additionally, a separate analysis revealed that each additional day of delay was associated with a 12% increase in the odds of clinical sequelae (adjusted odds ratio: 1.12, 95% CI: 1.03-1.22, p = 0.006). Sensitivity analyses confirmed the relationship of delay from admission to surgery in developing both outcomes.

CONCLUSION: Delay in medical care and surgical management remains the most important factor affecting the outcomes of septic hip. The study underscores the critical role of timely surgical intervention in reducing complications in pediatric septic hip patients.

PMID:39036808 | PMC:PMC11259651 | DOI:10.1016/j.jor.2024.03.019

J Natl Cancer Cent. 2020 Dec 17;1(1):2-11. doi: 10.1016/j.jncc.2020.12.001. eCollection 2021 Mar.

ABSTRACT

BACKGROUND: National Cancer Center (NCC) updated nationwide cancer statistics using population-based cancer registry data in 2015.

METHODS: 501 cancer registries submitted data, among which 368 registries with high quality data were included in analysis. Numbers of nationwide new cancer cases and deaths were estimated using incidence and mortality rates and corresponding national population stratified by area, sex, age group and cancer site. The world Segi’s population was applied for the calculation of age-standardized rates.

RESULTS: About 3,929,000 new cancer cases were diagnosed. The crude incidence rate was 285.83/100,000 and the age-standardized incidence rate by world standard population (ASIRW) was 186.39/100,000. ASIRW was higher in urban areas than in rural areas. South China had the highest ASIRW while Southwest China had the lowest ASIRW. Age-specific incidence rate was higher in males for population younger than 20 years or over 49 years. From 2000 to 2015, the ASIRWs for esophageal cancer, gastric cancer and liver cancer decreased significantly. The ASIRWs for colorectal cancer in whole population and for lung cancer, breast cancer, cervix cancer, uterus cancer and thyroid cancer in females increased significantly. 2,338,000 cancer deaths were reported. The crude mortality rate was 170.05/100,000 and the age standardized mortality rate by world standard population (ASMRW) was 105.84/100,000. ASMRW was higher in rural areas than in urban areas. Central China had the highest ASMRW while North China had the lowest ASMRW. Age-specific mortality rates in males were higher than that in females in every age group. From 2000 to 2015, the ASMRWs for esophageal cancer, gastric cancer, liver cancer and lung cancer decreased significantly. The ASMRWs for colorectal cancer, pancreas cancer and prostate cancer in males and for breast cancer, cervix cancer and thyroid cancer in females increased significantly.

CONCLUSIONS: Cancer has become a major life-threatening disease in China. Disease burdens differed across areas. Disease burdens for esophageal cancer, gastric cancer and liver cancer have decreased, while disease burdens for colorectal cancer, female breast cancer, cervix cancer and thyroid cancer have increased over the last 15 years. National and regional initiative for cancer prevention and control should be prioritized.

PMID:39036787 | PMC:PMC11256613 | DOI:10.1016/j.jncc.2020.12.001

IEEE Trans Inf Theory. 2024 Jan;70(1):509-531. doi: 10.1109/tit.2023.3305538. Epub 2023 Aug 15.

ABSTRACT

Motivated by applications in single-cell biology and metagenomics, we investigate the problem of matrix reordering based on a noisy disordered monotone Toeplitz matrix model. We establish the fundamental statistical limit for this problem in a decision-theoretic framework and demonstrate that a constrained least squares estimator achieves the optimal rate. However, due to its computational complexity, we analyze a popular polynomial-time algorithm, spectral seriation, and show that it is suboptimal. To address this, we propose a novel polynomial-time adaptive sorting algorithm with guaranteed performance improvement. Simulations and analyses of two real single-cell RNA sequencing datasets demonstrate the superiority of our algorithm over existing methods.

PMID:39036782 | PMC:PMC11257605 | DOI:10.1109/tit.2023.3305538

Gates Open Res. 2021 May 19;4:20. doi: 10.12688/gatesopenres.13100.2. eCollection 2020.

ABSTRACT

Background: The prevalence of contraception among married women, evaluated at 23%, is low in Cameroon. Maternal death rates, estimated at 782 deaths per 100,000 live births, are very worrying. The National Strategic Plan for Reproductive, Maternal, Newborn and Child Health (2015-2020) and the Health Sector Strategy (2016-2027) focuses on increasing modern contraceptive prevalence as a means to reduce maternal death. This paper identifies women’s bargaining power as a factor that may stimulate contraceptive use. The objective of this study is to analyze the association between women’s bargaining power within couples and modern contraceptive use. Methods: The data used come from the fifth Demographic and Health Survey (DHS) conducted in 2018. Women’s bargaining power within couple is measured by a Woman Bargaining Power Composite Index (WBPCI) built through a multiple correspondence analysis. The logistic regression model was used to analyze the relationship between WBPCI and modern contraceptive use. Results: The results of the descriptive statistics show that women’s bargaining power is higher among women who use contraception than for those who do not. The results of the logistic regression model show that an increase of WBPCI was significantly associated with higher chances of using a modern contraceptive method (OR = 1.352; 95% CI: 1.257, 1.454; p <0.01). The education of women is also a key determinant since educated women were at least two times more likely to use a modern contraceptive method than uneducated women. Conclusions: To reduce high maternal death rates in Cameroon, public health policies should not only focus on the health system itself, but should also focus on social policies to empower women in the household.

PMID:39036780 | PMC:PMC11259594 | DOI:10.12688/gatesopenres.13100.2

Contin Educ. 2024 Jul 15;5(1):100-110. doi: 10.5334/cie.118. eCollection 2024.

ABSTRACT

Lessons conducted in hospitals ensure school continuity for hospitalized children unable to attend regular school. Hospital-based school (HS) provides a tailored experience that ensures normality for children through education. The objective of this study is to evaluate the effects of the proposed lessons in reducing negative emotions, distress, and pain in children, as well as fostering positive affects. The study was conducted with 32 hospitalized children, aged 8-12 years, in the Onco-Hematology and Pediatric Unit of Meyer Children’s Hospital IRCCS (Florence, Italy). Positive and negative emotions were measured using the Positive and Negative Affect Scale for Children; distress was measured using the Physiological Hyperarousal for Children; pain was measured using the Visual Analogue Scale for children. Variables were assessed before (T0) and after (T1) lessons, for three times; for each variable, collected data were averaged at both T0 and T1. Statistical analyses showed a significant increase in positive emotions in hospitalized children and a significant decrease in negative emotions, distress, and pain; nevertheless, only for pain the significant correlation between its scores before and after the HS lessons indicated that the detected change occurred for all participants in much the same way. These preliminary results suggest that HS lessons can promote hospitalized children’s well-being, at least as far as pain reduction is concerned.

PMID:39036770 | PMC:PMC11259103 | DOI:10.5334/cie.118

Prostate Int. 2024 Jun;12(2):70-78. doi: 10.1016/j.prnil.2024.01.002. Epub 2024 Feb 7.

ABSTRACT

INTRODUCTION: Although the clinical benefits of pelvic lymph node dissection (PLND) at the time of radical prostatectomy for prostate cancer remain uncertain, major guidelines recommend PLND based on risk profile. Thus, the objective of this study was to examine the association between PLND and survival among patients undergoing RP stratified by Gleason grade group (GG) with the aim of allowing patients and physicians to make more informed care decisions about the potential risks and benefits of PLND.

MATERIALS AND METHODS: From the SEER-17 database, we examined overall (OS) and prostate cancer-specific (PCSS) survival of prostate cancer patients who underwent RP from 2010 to 2015 stratified by GG. We applied propensity score matching to balance pre-operative characteristics including race, age, PSA, household income, and housing status (urban/rural) between patients who did and did not undergo PLND for each GG. Statistical analyses included log-rank test and Kaplan-Meier curves.

RESULTS: We extracted a matched cohort from 80,287 patients with GG1-5 who underwent RP. The median PSA value was 6.0 ng/mL, and the median age was 62-years-old. 49,453 patients underwent PLND (61.60%), while 30,834 (38.40%) did not. There was no difference in OS and PCSS between patients who received PLND and those who did not for all Gleason GG (OS-GG1: P = 0.20, GG2: P = 0.34, GG3: P > 0.05, GG4: P = 0.55, GG5: P = 0.47; PCSS-GG1: P = 0.11, GG2: P = 0.96, GG3: P = 0.81, GG4: P = 0.22, GG5: P = 0.14).

CONCLUSIONS: In this observational study, PLND at the time of RP was not associated with improved OS or PCSS among patients with cGS of 3 + 3, 3 + 4, 4 + 3, 4 + 4, 4 + 5, and 5 + 4. These findings suggest that until definitive clinical trials are completed, prostate cancer patients who have elected RP should be appropriately counseled on the potential risks and lack of proven survival benefit of PLND.

PMID:39036758 | PMC:PMC11255894 | DOI:10.1016/j.prnil.2024.01.002

Prostate Int. 2024 Jun;12(2):110-115. doi: 10.1016/j.prnil.2024.04.001. Epub 2024 Apr 19.

ABSTRACT

BACKGROUND: Epidemiological reports indicate a potential association between androgenic alopecia (AGA) and increased prostate cancer (PC) prevalence, but conflicting reports also exist. This study aims to elucidate the causality of AGA on PC risk using Mendelian randomization (MR) analysis.

MATERIALS AND METHODS: Two-sample MR analyses utilized public genome-wide association studies summary data for single-nucleotide polymorphisms associated with AGA. Four statistical methods were used: inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode, with IVW as the preliminary estimation method. Additionally, sensitivity analyses were conducted to address pleiotropic bias.

RESULTS: Genetically proxied AGA did not demonstrate a causal effect on PC risk (IVW P > 0.05). Consistently, complementary methods yielded results aligned with IVW.

CONCLUSIONS: Our MR analysis indicates no causal relationship between genetically predicted AGA and PC risk, suggesting that observed associations in epidemiological studies may not be causal.

PMID:39036755 | PMC:PMC11255885 | DOI:10.1016/j.prnil.2024.04.001

Prostate Int. 2024 Jun;12(2):96-103. doi: 10.1016/j.prnil.2024.03.003. Epub 2024 Mar 26.

ABSTRACT

BACKGROUND: The relationship between obesity, sexual behavior, and prostate cancer (PCa) has been widely debated, contributing to a lack of understanding of its potential mechanisms and hindering the development of effective prevention measures.

PURPOSE: The aim of this study was to examine the causal effect of body mass index (BMI), age at first sexual intercourse (AFS), and bioavailable testosterone levels on PCa while also quantifying the potential roles of mediators.

METHOD: We conducted a Mendelian randomization (MR) study using summary statistics from genome-wide associations of BMI (152,893 European males), AFS (182,791 European males), bioavailable testosterone (184,205 European males), and PCa (79,148 cases, 61,106 controls, European ancestry). Inverse-variance weighted method, weighted median method, MR-Egger regression, Least Absolute Shrinkage and Selection Operator (LASSO), and outlier test were used for MR analyses. Reverse MR and mediation analysis were performed. Data analyses were conducted from December 2022 to July 2023.

RESULTS: The results showed that genetic liability to BMI was protective of PCa (OR, 0.82; 95% CI: 0.74-0.91; P = 3.29 × 10^-4). Genetic liability to later AFS (OR, 1.28; 95% CI: 1.08-1.53; P = 5.64 × 10^-3) and higher bioavailable testosterone levels (OR = 1.11, 95% CI: 1.01-1.24, P = 0.04) were associated with an increased risk of PCa. All of these potential causal effects could only be forwarded and were not affected by prostate specific antigen (PSA) screening. After controlling for bioavailable testosterone levels, the causal impact of BMI and AFS on PCa was no longer significant. The mediation analysis suggested that the causal influence of AFS/BMI on PCa relied on bioavailable testosterone levels.

CONCLUSION: In conclusion, the difference between the univariable and multivariable MR results suggested that the causal influence of BMI and AFS on PCa relied on bioavailable testosterone levels. Further work is needed to identify other risk factors and to elucidate the specific mechanisms that underlie this causal pathway.

PMID:39036754 | PMC:PMC11255935 | DOI:10.1016/j.prnil.2024.03.003

JAAD Int. 2024 May 24;16:189-191. doi: 10.1016/j.jdin.2024.05.004. eCollection 2024 Sep.

NO ABSTRACT

PMID:39036739 | PMC:PMC11260329 | DOI:10.1016/j.jdin.2024.05.004

J Undergrad Neurosci Educ. 2022 Oct 1;20(3):A391-A396. doi: 10.59390/FULX3501. eCollection 2022 Spring.

ABSTRACT

Neuroscience students often seem more responsive to laboratory exercises that involve human brains. Here we describe a lab that utilizes human brain MRIs to evaluate a long-standing debate over the presence of sex differences in the human brain, specifically the corpus callosum. Students at both Widener and UCLA measured corpus callosum subregions that were already marked-off as described by Witelson (1989) or by Hofer and Frahm (2006). Statistical analyses revealed sex differences using both schemes after correcting for the size of the midsagittal cortex. Widener students, however, uncovered more sex differences than the UCLA students. Lab instruction for UCLA students occurred during the COVID-19 pandemic. So, lab sessions were completely online. In contrast, Widener students had the benefit of in-person lab instruction. Nonetheless, both the data obtained from the images of the corpus callosi as well as measures of pedagogical efficacy were similar between the two institutions, suggesting that distance learning may be a valuable and viable option. Further, when in person learning is not an option, such as during a pandemic, digital databases serve as invaluable resources for online learning. When these databases are utilized in a hypothesis driven research setting, they can serve as the basis for course-based undergraduate research experiences (CUREs), which are known to benefit students-improving retention in science fields.

PMID:39036716 | PMC:PMC11256376 | DOI:10.59390/FULX3501