Tag: nevin manimala

Orv Hetil. 2025 Mar 9;166(10):377-384. doi: 10.1556/650.2025.33243. Print 2025 Mar 9.

ABSTRACT

Bevezetés: A COVID–19-világjárvány előtt a digitális egészségügyi megoldások elterjedését szabályozási és stratégiai hiányosságok is akadályozták, a pandémia idején azonban a digitális eszközök gyors bevezetése szükségszerűvé vált. Ezen időszak után már rendelkezésre állnak a szabályozási feltételek Magyarországon is, amelyek a digitális egészségügyi megoldások használatát támogatják, ugyanakkor az alkalmazásuk iránti kényszer csökkent. Célkitűzés: Két országos reprezentatív lakossági kutatásunkban arra kerestük a választ, hogy a COVID–19-járvány milyen hatással volt a lakosság digitális egészségügyi megoldásokkal kapcsolatos használati szokásaira, attitűdjeire és igényeire. Módszerek: Két országos reprezentatív lakossági felmérés eredményeit hasonlítjuk össze. Az első felmérést 2021 októberében, a COVID–19-járvány idején végeztük 1500 fő telefonon történő megkérdezésével, míg a második felmérést 2024 februárjában 1000 fő online kérdőíves megkeresésével. Mind a két minta nem, kor, iskolai végzettség és településtípus szerint reprezentálja a magyar felnőtt lakosságot. Az adatgyűjtést mindkét felmérés esetében az Ipsos Zrt. végezte. Eredmények: A két lakossági felmérés eredményei alapján az internetes egészségügyi információkeresés gyakorisága és módja jelentős változásokon ment keresztül. Azok aránya, akik egyáltalán nem keresnek információt az interneten, tovább csökkent. Az egészségügyi célú internethasználat során a weboldalak népszerűsége nőtt, míg a blogok, a podcastok és a közösségi platformok iránti érdeklődés csökkent. A digitális egészséggel kapcsolatos lehetőségek ismertsége és használata szintén növekedett, különösen az online időpontfoglalás, az egészségügyi adatok megosztása és a közösségi média használata terén. Az ellátás hatékonyságával kapcsolatos pozitív vélemények enyhén csökkentek, míg a technológiai frusztrációval kapcsolatos aggodalmak enyhültek. Következtetés: A COVID–19-járvány elmúltával megjelentek a digitális egészségüggyel kapcsolatos szabályozások, a lakosság körében pedig megszokottá vált a digitális egészségügyi technológiák használata. A digitális technológiák ismertsége és használata szignifikánsan növekedett, különösen az online időpontfoglalás, az e-recept és a viselhető eszközök esetében. A digitális eszközök használatának potenciális hátrányai iránti aggodalmak mérséklődtek, míg az előnyök iránti elvárások nem változtak jelentősen, ami reálisabb megítélést jelez. A páciensek digitalizációs igénye mára az ellátás szerves részévé vált, támogatva a tudatosabb, aktívabb szerepvállalást a gyógyulási folyamatban. Orv Hetil. 2025; 166(10): 377–384.

PMID:40057836 | DOI:10.1556/650.2025.33243

Exp Hematol Oncol. 2025 Mar 8;14(1):32. doi: 10.1186/s40164-025-00622-x.

ABSTRACT

Cancer remains the leading cause of mortality worldwide, and the emergence of drug resistance has made the identification of new therapeutic targets imperative. Lactate, traditionally viewed as a byproduct of glycolysis with limited ATP-producing capacity, has recently gained recognition as a critical signaling molecule. It plays a key role not only in cancer cell metabolism but also in shaping the tumor microenvironment (TME). Histone lysine lactylation, a newly identified post-translational modification, has been shown to influence a range of cellular processes in cancer. Current research focuses on the mechanisms and functions of histone lactylation in cancer, including its role in gene expression regulation, signal transduction, and protein synthesis. However, despite these advancements, there are still plenty of barriers in the quest to unravel the mechanisms of lactylation modification. The emergence of single-cell and spatial transcriptomics may offer valuable insights for selecting targets. This review provides a comprehensive summary of the mechanisms and the applications of lactylation modification in clinical settings. Through a detailed analysis, we identify the key challenges and limitations that exist in the current research landscape. These insights lay the groundwork for future studies by highlighting promising research directions.

PMID:40057816 | DOI:10.1186/s40164-025-00622-x

Arthritis Res Ther. 2025 Mar 8;27(1):54. doi: 10.1186/s13075-025-03522-x.

ABSTRACT

PURPOSE: Quercetagetin, a flavonoid derived from the natural herb Flos eriocauli, is used in traditional Chinese medicine for its fire-purging (anti-inflammation) and wind-expelling (pain-alleviating) properties. However, its potential effects concerning rheumatoid arthritis (RA) remain underexplored. This study was designed to elucidate the potential associations between Quercetagetin and RA, establishing the therapeutic potential of Quercetagetin and related mechanisms in RA treatment.

METHODS: Network pharmacology was conducted to decipher related targets and signaling pathways between Quercetagetin and RA. In vitro assays were then conducted to explore the effects of Quercetagetin on osteoclast cell behaviors and corresponding signaling pathways. In vivo study further validated the therapeutic effect of Quercetagetin in collagen antibody-induced arthritis (CAIA) mice.

RESULTS: The network pharmacological analysis indicated an intimate correlation of Quercetagetin with RA-related inflammatory osteolysis treatment. Pertaining to biological validations, 2 µM of Quercetagetin successfully inhibited LPS-driven osteoclast differentiation and function. qPCR assay and Western blot analyses denoted parallel changes in osteoclastic marker genes and proteins. Further mechanism study uncovered the effect of Quercetagetin in stimulating the Nrf2/Keap1 signaling pathway and moderating the Pten/AKT/Nfatc1 axis in osteoclasts. In vivo study revealed 40 mg/kg Quercetagetin every day could significantly relief joint destruction in CAIA mice.

CONCLUSIONS: Our study presents Quercetagetin ‘s therapeutic potential in treating RA, outlining its effects and potential mechanisms in suppressing LPS-induced osteoclast activity, and alleviating inflammatory bone destruction in CAIA model, thereby laying the groundwork for further translational research on Quercetagetin and Flos eriocauli in RA treatment.

PMID:40057805 | DOI:10.1186/s13075-025-03522-x

BMC Nurs. 2025 Mar 8;24(1):262. doi: 10.1186/s12912-025-02924-1.

ABSTRACT

BACKGROUND: Nursing internship play a crucial role in cultivating nursing students. However, nursing interns often face challenges of career anxiety, which can have negative impacts on their professional development and work quality. Therefore, understanding the factors influencing career anxiety among nursing interns is important.

OBJECTIVES: The purpose of this study was to investigate the serial multiple mediating effect of perceived stress and self-control in the relationship between neuroticism and career anxiety among nursing interns in China.

DESIGN: A cross-sectional study.

METHODS: A total of 499 nursing interns from five tertiary hospitals in Xi’an, China, participated. Neuroticism, perceived stress, self-control, and career anxiety among nursing interns were assessed. Serial mediation analysis was conducted using the PROCESS Macro in SPSS. Statistical analyses included descriptive analysis, t-tests, ANOVA, Pearson correlation, and regression with bootstrapping.

RESULTS: (1)Career anxiety was significantly and positively correlated with neuroticism (r = 0.384, p < 0.001) and perceived stress (r = 0.460, p < 0.001), and negatively correlated with self-control (r = -0.570, p < 0.001). (2) Neuroticism positively predicted perceived stress (β = 0.385, p < 0.001). Both perceived stress and neuroticism, negatively predicted self-control (β = -0.237; β = -0.355, p < 0.001). Self-control negatively predicted career anxiety (β = -0.401, p < 0.001), while neuroticism and perceived stress positively predicted it (β = 0.149; β = 0.173, p < 0.001). (3) In the model of neuroticism → perceived stress → self-control → career anxiety, the total indirect effect was 0.216. The mediating effect of perceived stress accounted for 18.1% of the total effect (0.066), while self-control accounted for 26.0% (0.095). The serial mediation effect of perceived stress and self-control contributed 15.1% (0.055) to the total effect.

CONCLUSION: Neuroticism significantly predicts career anxiety, mediated by perceived stress and self-control. Higher neuroticism leads to increased stress, reduced self-control, and greater career anxiety. Interventions focusing on stress reduction and self-control enhancement may help mitigate career anxiety among nursing interns.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:40057794 | DOI:10.1186/s12912-025-02924-1

BMC Palliat Care. 2025 Mar 8;24(1):59. doi: 10.1186/s12904-025-01697-3.

ABSTRACT

BACKGROUND: The negative impact of over-treatment in end-of-life individuals has led to attention to the value of death. Reassessing the attitude of death and dying can improve care and improve the quality of life. Therefore, the use of multidimensional tools to comprehensively assess the attitudes of individuals on dying and death, identify attitude tendencies and causes meaningful, and evaluate the effectiveness of the tools is an important prerequisite.

OBJECTIVES: We aimed to obtain MODDI-F-C through cross-cultural translation and to evaluate its psychometric characteristics among mainland China participants.

METHODS: In order to obtain MODDI-F-C, a cross-cultural translation of MODDI- F/eng was performed using the Brislin model. The items quality, factor structure, reliability and validity were assessed among 2105 participants from mainland China. The concurrent validity was assessed using the Chinese version of DAP-R for the first time.

RESULTS: MODDI-F-C consists of 27 items, and five common factors were identified through factor analysis, accounting for 56.79% of the overall variance.The total consistency coefficient was 0.949.The correlation coefficient between DAP-R-C-Z and the overall scale was 0.55 (p < 0.001), between DAP – R-C – Z and the subscale 0.37-0.56 (p < 0.001).Most of the methods used for psychometric evaluation meet acceptable criteria.

CONCLUSIONS: Our research has initially confirmed that MODDI-F-C is an effective tool to evaluate the fear dimension of death and dying attitude, which can identify individuals’ tendencies and causes related to dying and death. However, the acceptance dimension needs further assessment.

PMID:40057793 | DOI:10.1186/s12904-025-01697-3

AIDS Res Ther. 2025 Mar 8;22(1):31. doi: 10.1186/s12981-025-00726-8.

ABSTRACT

BACKGROUND: Vaccine acceptance among People Living with HIV (PLWH) is crucial for managing and mitigating the spread of infectious diseases, including Mpox. This systematic review and meta-analysis assess the rate of vaccine acceptance for Mpox among PLWH and identify factors influencing these rates.

METHODS: We searched major databases including PubMed, Embase, and Web of Science up to 30 August 2024 for observational studies involving PLWH that reported on mpox vaccine acceptance rates. A random-effects model was employed for the meta-analysis, utilizing R software version 4.4. Heterogeneity among the studies was quantified using the I² statistic, and the methodological quality of each study was assessed using a modified version of the Newcastle-Ottawa Scale.

RESULTS: Out of 1,123 articles identified, 17 studies met the inclusion criteria and included 7,248 participants. The pooled estimate of the Mpox vaccine acceptance rate was 61.1% (95% CI: 44.2-75.7%), with high heterogeneity (I² = 99%). Additionally, a pooled vaccine hesitancy prevalence was 13.2%, (95% CI: 2.4-48.6%), reflecting substantial variability and had high heterogeneity (I² = 98%).

CONCLUSION: This systematic review and meta-analysis reveal moderate Mpox vaccine acceptance and considerable hesitancy among PLWH. To further increase vaccine uptake and address any remaining hesitancy in this at-risk population, targeted public health strategies and ongoing research are necessary. Strengthening vaccine acceptance is critical to safeguarding PLWH against emerging infectious diseases such as Mpox.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:40057788 | DOI:10.1186/s12981-025-00726-8

Syst Rev. 2025 Mar 8;14(1):57. doi: 10.1186/s13643-025-02760-z.

ABSTRACT

BACKGROUND: Double gloving is recommended for protecting surgical personnel from infections, but it is not a universal practice, especially in low- and middle-income countries where risk is very high. Evidence for double gloving is still only moderate, and for indicator double gloves, it is even rare. This systematic review and meta-analysis includes recent trials to analyse outcomes like glove perforations (inner/outer/matched/intraoperatively detected) and hand contamination rates for single versus double including indicator double-gloved conditions and identify factors to be considered for deciding double gloving.

METHOD: Six databases PubMed, EBESCO, Embase, CINAHL, Scopus, Web of Science, and CENTRAL were searched up to May 2024. The quality of included trials was assessed using Cochrane risk-of-bias tool (version 5.1.0). Heterogeneity among trials was estimated using the chi-squared (I²) test. RevMan 5.3 was used for meta-analysis and subgroup analysis. Odds ratio at 95% confidence interval was used as statistical measure to compare outcomes and calculate effect size. Publication bias was assessed through a funnel plot.

RESULT: A review of these total of 18 randomized controlled trials showed that deep/major/emergent surgeries, primary surgeons, and longer surgical duration are prone to have higher glove perforations. Impaired dexterity is not a constraint for double gloving and has no impact on glove perforations. Meta-analysis of outcomes suggests that double gloving (standard or indicator) provides significant protection against infections compared to single gloves in terms of reduced inner (OR = 0.2, 95% CI 0.14-0.31) and matched glove perforations (OR = 0.1, 95% Cl 0.07-0.13) and lower incidences of hand contamination (OR = 0.28, 95% Cl 0.14-0.54). Standard double gloves were more effective in reducing matched glove perforations than indicator double gloves. But for detecting glove perforations intraoperatively, only the indicator double glove (OR = 8.64, 95% Cl 4.78-15.61) was effective.

CONCLUSION: Double gloving is recommended over single gloving for better safety of surgical personnel and indicator gloves for better detection of perforations during surgery so that it can be changed timely, but it does not provide any additional protection. In the future, there should be high-quality trials for specific surgeries, surgical personnel, and different surgical durations taking into consideration the cost-effectiveness of indicator gloving over standard double gloving so that specific recommendations can be made.

PMID:40057774 | DOI:10.1186/s13643-025-02760-z

Alzheimers Res Ther. 2025 Mar 8;17(1):58. doi: 10.1186/s13195-025-01708-8.

ABSTRACT

BACKGROUND: The influence of duration of type 2 diabetes mellitus (T2DM) on the likelihood of developing new-onset dementia in post-stroke population is not well understood. Therefore, we aimed to clarify the relationship between the duration of T2DM and the risk of developing dementia in the post-stroke population.

METHODS: Leveraging the Korean National Health Insurance Database, this study included 118,790 individuals with a history of stroke but no previous dementia diagnosis. We classified diabetes status into five categories: normoglycemia, impaired fasting glucose (IFG), newly diagnosed T2DM, and established T2DM with durations of less than 5 years and 5 years or more. The primary endpoint was the incidence of all-cause dementia.

RESULTS: Among 118,790 participants (average age 64.26 ± 9.95 years, 48% male), 16.7% developed dementia during an average follow-up of 7.3 ± 2.3 years. Participants with a history of T2DM for less than five years at cohort entry had a 26.7% higher risk of developing all-cause dementia compared to those with normoglycemia. Those with T2DM for five years or longer had a 46.7% increased risk, with an adjusted hazard ratio (aHR) of 1.466 (95% confidence interval [CI], 1.408-1.527). Specifically, the risk of developing Alzheimer’s disease (AD) and vascular dementia (VaD) rose by 43.4% and 51.4%, respectively, for individuals with T2DM lasting more than five years (aHR 1.434, 95% CI 1.366-1.505; aHR 1.514, 95% CI 1.365-1.679, respectively).

CONCLUSIONS: Our findings demonstrated a significant association between an extended duration of T2DM and an increased risk of developing all-cause dementia, including AD and VaD in post-stroke population. These results emphasize proactive dementia prevention approaches in stroke survivors, particularly those with longstanding T2DM.

PMID:40057772 | DOI:10.1186/s13195-025-01708-8

J Health Popul Nutr. 2025 Mar 8;44(1):71. doi: 10.1186/s41043-025-00774-w.

ABSTRACT

BACKGROUND: Like other Sub-Saharan Africa (SSA) countries, Tanzania is undergoing socio-economic changes that impact lifestyles and dietary choices. Traditionally, differences in dietary habits between rural and urban areas in Tanzania and other SSA countries were prominent. However, recent research indicates converging lifestyles and dietary choices associated with increased risk of cardiometabolic diseases. The objective of the current study was hence to investigate differences and similarities in dietary patterns, energy, and food groups intake in urban and rural Tanzania.

METHODS: Dietary habits were assessed by use of a Food Frequency Questionnaire (FFQ) for 442 respondents aged 44-65 years in urban (Ubungo -Dar es Salaam) and rural (Kilindi- Tanga) districts of Tanzania. Dietary patterns were determined using Principal Components Analysis (PCA). Bivariate analyses identified determinants of dietary patterns in urban and rural Tanzania.

RESULTS: Two dietary patterns, a “mixed pattern” characterized by whole grains, potatoes, fruits, vegetables, meat, fried potatoes and tubers, alcohol, sugar-sweetened beverages (SSB), sugar and sweets, and added oils and a “plant-rich pattern” characterized by whole grains, fruits, pulses and peas, seasoning vegetables and salads, SSB, sugar and sweets, and added oils were identified. Urban residents contributed more to the mixed pattern, while rural residents had a higher contribution to the plant-rich pattern. Overall, dietary diversity was greater in urban than rural Tanzania. The estimated median daily energy intake was 2,902 kcal (IQR: 1449.2) with a lower energy intake in rural (2,817 kcal, IQR: 1,274) as compared to urban residents (3,052 kcal, IQR: 1558) (p = 0.021). The percent contribution to the median average daily energy intake for grains, fruits, and milk was higher in rural than urban participants. No differences were observed for meat, poultry and eggs.

CONCLUSION: We identified two distinct dietary patterns: a “mixed pattern” prominent in urban and a “plant-rich pattern” more common in rural. Urban diets were more diverse with slightly higher energy intake. These findings underscore the effects of urbanization on diets and the need for targeted nutritional intervention for both rural and urban populations.

PMID:40057768 | DOI:10.1186/s41043-025-00774-w

Virol J. 2025 Mar 8;22(1):66. doi: 10.1186/s12985-025-02668-z.

ABSTRACT

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19), which is a huge global health threat. Interleukin27 (IL-27) gene is a cytokine that produces antiviral proteins in an IFN-independent manner and stimulates both pro- and anti-inflammatory responses. Interferon induced transmembrane protein 3 (IFITM3) inhibits SARS-CoV2 infection by blocking SARSCoV-2 spike proteins which facilitate viral entrance and cell-to-cell fusion. The association between genetic variants and COVID-19 in Egyptians is still unclear. Hence, we sought to investigate the impact of the single nucleotide polymorphism of IL-27P28 rs153109 and IFITM3 rs12252 on the susceptibility and severity of SARS-CoV-2 in Egyptian patients.

METHODS: Our study included 242 SARS-CoV-2 patients were recruited from Main University Hospital, Alexandria University, Egypt, and 187 healthy controls. We subdivided the patient group into two subgroups: group A comprised mild/moderate cases (N = 42) (17.4%), and group B included severe/critical cases (N = 200) (82.6%). Genomic DNA was extracted from blood samples using the QIAamp DNA Blood Mini kit, then the PCR products of IL27 and IFITM3 were cut by FastDigest XhoI and MScI, respectively, for detection of SNPs of IL-27P28 rs153109 (-964A/G) and IFITM3 rs12252 (T>C).

RESULTS: The present study found a significant association between IL27 rs153109 (-964A/G) and SARS-CoV-2 infection susceptibility after adjusting for the risk factor (advanced age), IL27 rs153109 (-964A/G) AG genotype (OR = 2.791, 95% CI: 1.237-6.295, P = 0.013), AA genotype (OR = 2.385, 95% CI: 1.075-5.291, P = 0.033), and (AG+AA vs. GG) genotypes (OR = 2.558, 95% CI: 1.186-5.517, P = 0.017). On the other hand, the IFITM3 rs12252(T>C) CT genotype (OR = 1.419, 95% CI: 0.843-2.391, P = 0.188), CC genotype (OR = 2.132, 95% CI: 0.436-10.415, P = 0.350), and (C/T+C/C vs. TT) genotypes (OR = 1.466, 95% CI: 0.884-2.432, P = 0.138) did not show a statistically significant association with either susceptibility or the severity of SARS-CoV-2.

CONCLUSION: IL27P28 rs153109 AG and AA genotypes of IL27 may be associated with the susceptibility of SARS-CoV-2 infection but not the severity. Concerning the IFITM3 rs12252 SNP, we could not confirm its influence on either susceptibility or the severity of SARS-CoV-2 in this Egyptian population.

PMID:40057761 | DOI:10.1186/s12985-025-02668-z