Tag: nevin manimala

J Prosthet Dent. 2026 Mar 9:S0022-3913(26)00142-3. doi: 10.1016/j.prosdent.2026.02.024. Online ahead of print.

ABSTRACT

STATEMENT OF PROBLEM: Comparative studies assessing monolithic zirconia and metal-ceramic for implant-supported fixed prostheses remain limited.

PURPOSE: This retrospective study aimed to compare the survival and success of metal-ceramic and monolithic zirconia implant-supported prostheses using a split-mouth design.

MATERIAL AND METHODS: This study included 112 participants with 302 implant-supported prostheses. All participants had received both metal-ceramic (n=145) and monolithic zirconia (n=157) restorations between January 2018 and January 2024. Mechanical complications were recorded for all restorations. For the split-mouth analysis, the odds ratio was calculated using generalized estimating equations (GEEs). To compare the 5-year cumulative survival rates between groups, the Kaplan-Meier analysis and log-rank test (α=.05) were performed.

RESULTS: The mean follow-up was 36 months. Of the 302 implant-supported prostheses, 12 metal-ceramic and 10 monolithic zirconia restorations failed. The 5-year cumulative survival rates were 90.9% (95% CI, 85.9% to 95.9%) for the metal-ceramic group and 90.0% (95% CI, 81.9% to 98.2%) for the monolithic zirconia group, with no significant difference (P=.653). Similarly, survival rates did not differ significantly for single crown (P=.240) or fixed partial denture (P=.647). According to GEE analysis, the odds ratio for mechanical complications between the groups was 1.11 (95% CI, 0.41 to 2.98). Although complications were more frequent in the metal-ceramic group, the difference was not statistically significant (P=.830).

CONCLUSIONS: In this retrospective split-mouth study, the 5-year cumulative survival rates and the incidence of mechanical complications did not differ significantly between metal-ceramic and monolithic zirconia implant-supported prostheses. Although metal-ceramic showed a higher number of complications, this difference was not statistically significant. Within the limitations of this study, monolithic zirconia may be considered a suitable material for implant-supported prostheses.

PMID:41807167 | DOI:10.1016/j.prosdent.2026.02.024

J Prosthet Dent. 2026 Mar 9:S0022-3913(26)00098-3. doi: 10.1016/j.prosdent.2026.02.012. Online ahead of print.

ABSTRACT

STATEMENT OF PROBLEM: Artificial intelligence (AI) has been applied to crown design and can produce acceptable morphology. However, occlusal morphology and contact area distribution generated by AI may differ from natural teeth. Whether they can approach ideal static and dynamic occlusion remains unknown.

PURPOSE: The purpose of this prospective clinical study was to assess whether using a technique based on the wear facets of antagonist teeth improved the performance of occlusal morphology and contact area distribution of AI generated crowns.

MATERIAL AND METHODS: In the study, 23 participants were enrolled. Four types of crowns for maxillary first molars were analyzed: natural tooth (NA), technician designed crown (TE), AI generated crown (AT), and the Facets Align technique adjusted AT crown (FA). Occlusal morphology was evaluated by cusp inclination and root mean square (RMS). Occlusal contact area distribution was evaluated by area, F1-score, and occlusal contact separation distance. Finite element analysis (FEA) was used to analyze the stress distribution of the crowns. Statistical analysis was performed using the Friedman 2-way rank nonparametric test and Bonferroni post hoc tests (α=.05).

RESULTS: The cusp inclination of AT was lower than that of NA (P<.01) on the distobuccal and distopalatal cusps. The occlusal contact area of AT was smaller than that of NA (P<.01). The occlusal contact separation distance of AT was the shortest during protrusive, working side, and nonworking side lateral movements (P<.01). FA did not differ significantly from NA and AT in cusp inclination. FA had smaller RMS (P<.01) and larger occlusal contact area (P<.001) than AT in several regions. FA improved the occlusal contact separation distance of AT during lateral movement on the working side (P<.05), while no significant difference was observed during protrusive and nonworking side lateral movement. The mean F1-score was 0.60 for FA, and the difference was significant between FA and AT (P<.001). As for finite element analysis (FEA), FA tended to exhibit higher stress and deformation values than AT but remained lower than NA.

CONCLUSIONS: The Facets Align technique optimized AI generated crowns in both static and dynamic occlusion when there were wear facets on the antagonist tooth.

PMID:41807165 | DOI:10.1016/j.prosdent.2026.02.012

Acad Radiol. 2026 Mar 9:S1076-6332(26)00117-0. doi: 10.1016/j.acra.2026.02.029. Online ahead of print.

ABSTRACT

RATIONALE AND OBJECTIVES: This retrospective study compared thermal ablation (TA) and surgical resection (SR) in treating hepatocellular carcinoma (HCC) based on multiparametric gadoxetic acid-enhanced MRI features, with an emphasis on the impact of tumor location, size, and liver function reserve.

MATERIALS AND METHODS: Patients with early-stage HCC treated with either TA or SR at our hospital from January 2016 to August 2021 were included. Propensity score matching (PSM) with a 1:1 nearest-neighbor algorithm was employed to balance nineteen predefined covariates across treatment groups. Standardized imaging protocols and blinded consensus review were implemented. Survival outcomes, including overall survival (OS) and disease-free survival (DFS), were analyzed using Kaplan-Meier curves and Cox proportional hazards regression. Subgroup analyses stratified by tumor topography, size, and albumin-bilirubin grade were performed.

RESULTS: Initially, 92 patients in the TA group and 181 patients in the SR group were included. After PSM, a balanced cohort of 50 patients in each group was achieved. No significant differences in OS (log-rank p = 0.822) or DFS (log-rank p = 0.268) were found between the TA and SR groups. The subgroup analyses after matching demonstrated no statistically significant differences in OS or DFS across the stratified groups (all p > 0.05). Further Cox analysis revealed that elevated alpha-fetoprotein (hazard ratio = 1.88, 95% CI: 1.04-3.39, p = 0.037) was an independent risk factor affecting DFS in the ablation group.

CONCLUSION: This study indicates that TA and SR offer similar therapeutic outcomes in early-stage HCC, with comparable survival outcomes for patients.

PMID:41807162 | DOI:10.1016/j.acra.2026.02.029

Mov Disord. 2026 Mar 10. doi: 10.1002/mds.70264. Online ahead of print.

ABSTRACT

BACKGROUND: Emerging evidence indicates that dysregulation of monounsaturated fatty acids (MUFAs), synthesized by the enzyme stearoyl-coenzyme A desaturase (SCD), impacts on α-synuclein pathology in the Parkinson’s disease (PD) brain.

OBJECTIVE: The objective of this study was to analyze SCD and MUFA-enriched lipids in the periphery of patients with sporadic PD compared with healthy control subjects.

METHODS: Serum SCD protein was quantified using enzyme-linked immunosorbent assay in patients with PD (n = 40) and control subjects (n = 41). Lipidomic profiling was performed using liquid chromatography-mass spectrometry and LipidSearch software. Statistical analyses included Mann-Whitney U tests and Welch’s t tests with false discovery rate (FDR) correction.

RESULTS: SCD levels were higher in PD (mean = 1702 pg/ml) compared with control subjects (1158 pg/ml; P = 2.2 × 10^-4; Cohen’s d = 0.73). Lipidomics showed elevated MUFA content in four lipid classes: methylphosphatidylcholine, phosphatidylcholine, dihexosylceramide, and triglycerides (FDR < 0.05).

CONCLUSIONS: Increased SCD and MUFA-enriched lipids indicate altered membrane and sphingolipid metabolism in PD, consistent with central disease pathology, that present a potential for novel biomarker development for PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

PMID:41807087 | DOI:10.1002/mds.70264

Musculoskeletal Care. 2026 Mar;24(1):e70202. doi: 10.1002/msc.70202.

ABSTRACT

BACKGROUND: Chronic low back pain is a highly prevalent and disabling condition that impairs physical function and has a broad social impact. This study aimed to assess the effects of manipulative techniques on static, quasi-static, and dynamic balance in individuals with chronic low back pain, and to compare these outcomes between an experimental group and a placebo group. The study is justified by the high prevalence of low back pain, the economic burden associated with treatment and work absence, and the need to clarify the effectiveness of therapeutic approaches.

METHODS: A randomized, controlled, longitudinal, pre/post-intervention clinical trial was conducted with 30 participants (18-59 years), of both sexes, all experiencing chronic low back pain. Individuals with other musculoskeletal, neurological, cognitive, cardiorespiratory, or balance-affecting conditions were excluded. Participants were randomly allocated to an experimental group, which received global spinal manipulation in the thoracolumbar and lumbopelvic regions, or a placebo group. Assessments included the modified Sensory Organization Test (SOT), the Star Excursion Balance Test (SEBT), and pain pressure threshold algometry, applied before and after the intervention.

RESULTS: Results indicated that a single session of spinal manipulation did not produce significant changes in static, quasi-static, or dynamic balance variables. Additionally, comparisons between pre- and post-intervention (immediate, 24 h, and 1 week follow-up) revealed no statistically significant differences were found.

CONCLUSION: These findings suggest that a single session of spinal manipulation may not be sufficient to induce measurable changes in balance parameters in this population.

PMID:41807085 | DOI:10.1002/msc.70202

Stat Med. 2026 Mar;45(6-7):e70476. doi: 10.1002/sim.70476.

ABSTRACT

Modeling dynamic heterogeneity is essential for revealing the distinct longitudinal trajectories of individual change. Dynamic heterogeneity analysis of semi-continuous longitudinal data is commonly difficult due to the semi-continuity of longitudinal responses. The hidden semi-Markov model is a powerful tool that can reveal the longitudinal dependency structure and the dynamic heterogeneity of the observation process by introducing the sojourn time distribution. To address the challenge of modeling dynamic heterogeneity in semi-continuous longitudinal data, this study develops a two-part hidden semi-Markov mixed-effects model. The proposed model mainly consists of two parts: a discrete binary indicator model to estimate the probability of a zero outcome for the semi-continuous longitudinal response, and a continuous hidden semi-Markov model to fit the positive values of semi-continuous longitudinal responses. In order to accurately obtain the state of each individual at different observation times, a set of likelihood ratio test state iteration algorithms is developed. Bayesian methods are used to estimate the regression coefficients and state parameters of the proposed model. The proposed methodology is applied to analyze the dataset of the Health and Retirement Study conducted by the University of Michigan. Simulation studies are conducted to assess the flexibility of the proposed model under various scenarios.

PMID:41807079 | DOI:10.1002/sim.70476

Trends Neurosci Educ. 2026 Mar;42:100278. doi: 10.1016/j.tine.2026.100278. Epub 2026 Jan 29.

ABSTRACT

BACKGROUND: This study is the first to examine the prevalence of neuromyth beliefs among parents of primary school students in Turkey, the sources of these beliefs, their relationship with educational level, and their predictive effect on attitudes toward neuroscience and purchase intentions.

METHOD: A total of 311 Turkish parents with children in primary school participated in the study. The prevalence of parents’ neuromyth beliefs, their sources (e.g., TV news, social media), attitudes toward neuroscience, and purchase intentions for brain development products were measured using scales. Frequency analyses, simple linear regression analysis, and multiple regression analyses were used to analyze the data.

RESULTS: The analyses revealed that neuromyth beliefs are prevalent among Turkish parents and that TV news and social media are the main sources of these beliefs. Statistical analyses showed that neuromyth belief levels decreased significantly as parents’ education level increased. Furthermore, regression analysis revealed that belief in neuromyths significantly predicted attitudes toward neuroscience.

CONCLUSION: This study shows that parents’ belief in neuromyths is widespread in the Turkish context and is disseminated particularly through popular media channels. The fact that belief in neuromyths positively predicts attitudes toward neuroscience indicates that parents are interested in neuroscientific topics, albeit with misconceptions. These results suggest that science-based awareness campaigns targeting parents should consider differences in media use and educational levels.

PMID:41807074 | DOI:10.1016/j.tine.2026.100278

Can J Physiol Pharmacol. 2026 Mar 10. doi: 10.1139/cjpp-2025-0085. Online ahead of print.

ABSTRACT

Ionizing radiation is a known risk factor for the occurrence and development of cardiovascular diseases, particularly in patients receiving thoracic radiotherapy. This exposure leads to oxidative stress and inflammation, which can damage cardiac tissue and vascular endothelium. Molecular hydrogen (H2) has been recognized for its therapeutic potential, including antioxidant effects. In this study, male Wistar rats were irradiated with a dose of 10 Gy (X-rays) in the chest area. Two and nine days post-irradiation, significant increases in lactate dehydrogenase (LDH), catalase, glutathione peroxidase activity, malondialdehyde, superoxide, and tumor necrosis factor alpha levels were observed in the rat blood plasma or heart tissue. Administration of H2 either via drinking H2-rich water (min. 4 mg/L) or inhaling H2 in air (4%), effectively decreased oxidative stress, LDH, and inflammatory proteins to normal levels. H2 also normalized the nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associating protein 1 (Nrf2/Keap1) pathway, an important antioxidative response regulator activated by irradiation. Based on these results, we can conclude that H2 administration through both routes mitigated heart damage caused by irradiation after two and nine days. The mitigating effect exerted more pronounced trend with H2 gas inhalation, but further research is needed for statistically relevant data and mechanistic insights.

PMID:41806364 | DOI:10.1139/cjpp-2025-0085

Adv Sci (Weinh). 2026 Mar 10:e22313. doi: 10.1002/advs.202522313. Online ahead of print.

ABSTRACT

Machine-learned interatomic potential (MLIP) has become a powerful tool to combine the accuracy of quantum mechanics with the efficiency of molecular dynamics in the era of artificial intelligence. However, a key open question persists: what physical mechanism is behind the atomic model that generates the MLIP and what physical information determines the final outputs? To address this problem, we use molten Na₂WO₄ as a representative system and fine-tune a pretrained deep potential model (DPA2) with ab initio molecular dynamics data of Na₂WO₄. We find a strong correlation between the model’s final output and the projected density of states (PDOS) in energy regions exhibiting high electron density and distinct local atomic environments. This result indicates that a well-constructed neural network inherently captures the quantum-mechanical information and its predictions represent meaningful physicochemical interactions rather than purely statistical patterns. Importantly, the mechanistic insights gained in this work-which links model’s outputs to electronic structure descriptors- are general in nature. It provides an electronic-structure-informed metric for feature learning and a general strategy for building interpretable, transferable MLIPs across diverse material systems.

PMID:41806340 | DOI:10.1002/advs.202522313

Addiction. 2026 Mar 10. doi: 10.1111/add.70380. Online ahead of print.

ABSTRACT

BACKGROUND AND AIMS: Evidence regarding the impacts of supervised drug consumption services (SDC) remains mixed, and few evaluations have used individual-level, linkable health data to examine service withdrawal. In September 2024, the Red Deer overdose prevention site (OPS) in Alberta, Canada, was scheduled for closure, with operations ceasing on 31 March 2025. This study examined: (1) changes in weekly opioid agonist therapy (OAT) dispensing among identifiable OPS clients associated with the closure announcement and subsequent service cessation; and (2) changes in acute healthcare utilization and mortality.

DESIGN: Retrospective cohort study using linked provincial administrative health data from 30 June 2024 to 6 months after the Red Deer site closure (27 September 2025). A segmented difference-in-differences interrupted time-series (DID-ITS) design compared Red Deer OPS clients with clients from a continuously operating OPS in Lethbridge. Within-site interrupted time-series (ITS) models were applied for Red Deer-only analyses.

SETTING: Two provincially regulated OPS programs in Alberta, Canada. The Red Deer OPS closure was publicly announced on 24 September 2024 and implemented on 31 March 2025. The Lethbridge OPS remained operational throughout.

PARTICIPANTS: OPS clients with a linked personal health number (PHN) and at least one consumption event at the Red Deer (n = 381) and Lethbridge sites (n = 300).

MEASUREMENTS: Primary outcome: weekly proportion of clients receiving ≥1 OAT dispensing.

SECONDARY OUTCOMES: weekly emergency department (ED) visits, inpatient (IP) admissions, suspected opioid-related emergency medical services (EMS) events and mortality.

FINDINGS: Prior to the closure announcement, baseline weekly OAT proportions were lower in Red Deer (9.9%) than in Lethbridge (12.0%), with broadly similar pre-announcement trends. After the closure, the proportion of clients on OAT in Red Deer exceeded those in Lethbridge (16.1% versus 14.4%, respectively; P < 0.021). After closure, there was no statistically significant difference in the number of ED visits or suspected opioid-related EMS events in both the Red Deer only ITS models or in the proportion of these outcomes in the DID-ITS model comparing Red Deer and Lethbridge. Mortality events were rare during the follow-up period, and no statistically detectable increase was observed over the available follow-up.

CONCLUSIONS: The announcement and subsequent closure of the Red Deer overdose prevention site in Alberta, Canada, were associated with increased opioid agonist therapy dispensing among identifiable site users. Short-term effects on acute healthcare utilization and mortality appear stable but remain inconclusive due to the limited 26-week follow-up period and low event counts.

PMID:41806310 | DOI:10.1111/add.70380