Tag: nevin manimala

Sci Rep. 2024 Nov 25;14(1):29143. doi: 10.1038/s41598-024-80109-7.

ABSTRACT

OBJECTIVES: Investigate the relationship between bone mineral density (BMD) at various body sites and dental caries.

MATERIALS AND METHODS: Based on the National Health and Nutrition Examination Survey (NHANES) database from 2011 to 2016, the correlation between BMD at various body sites and the DMFS index among 7044 adults aged 20-59 years was analyzed. Multiple linear regression, restricted cubic splines (RCS), piecewise linear regression, logistic regression, weighted quantile sum regression (WQS) and mediation effects analysis were integrated to explore the relationship between BMD and dental caries.

RESULTS: Under the linear assumption, except for arm BMD, the BMDs of all other sites are negatively correlated with the DMFS index of dental caries. RCS analysis indicates a U-shaped relationship between head BMD and the DMFS index (p for nonlinear < 0.0001). WQS analysis indicates that mixed BMD is significantly negatively correlated with the DMFS index for dental caries (estimate, – 0.023; 95% CI, – 0.025 ~ – 0.020), and head BMD has the most significant impact on the DMFS index (weight = 91.4%). Simple mediation analysis of the effect of dental caries on BMD levels mediated by inflammation levels showed negative results, suggesting that dental caries may not influence BMD through inflammation levels.

CONCLUSION: Monitoring BMD should be combined with appropriate oral healthcare and caries management strategies to effectively address these interconnected health issues, and particular attention should be paid to the monitoring of head BMD.

PMID:39587203 | DOI:10.1038/s41598-024-80109-7

Sci Rep. 2024 Nov 25;14(1):29155. doi: 10.1038/s41598-024-80790-8.

ABSTRACT

To examine the relationship between age at diagnosis of type 2 diabetes (T2DM) with cardiovascular and all-cause mortality in the U.S. population. Data was used from NHANES 1999 ~ 2018, which were screened to include a total of 8,654 participants with a diagnosis of diabetes for the study. We estimated the association between age at diagnosis and cardiovascular and all-cause mortality using weighted multivariate Cox regression analyses. Subgroup analyses and sensitivity analyses were performed to ensure the robustness of the data analysis. The number of participants diagnosed with diabetes at ages < 40, between 40 and 59, and > 60 are 1,492, 3,970, and 3,192, respectively, with median ages of 44.04, 57.59, and 72.24. Among patients diagnosed with T2DM, the relative risk of all-cause mortality increased with younger age at diagnosis: compared to patients with late-onset diabetes (age at type 2 diabetes diagnosis ≥ 60), the hazard ratio for all-cause mortality was 2.72 (95% CI 1.83-4.05) in those with early-onset diabetes (age at type 2 diabetes diagnosis < 40). Similarly, the risk of cardiovascular disease death was observed to be a higher relative risk with younger age at diagnosis. Exposure-effect analysis indicated that younger age at diagnosis is associated with higher risk of all-cause mortality. Subgroup analysis found that the association between age at diagnosis and cardiovascular and all-cause mortality was stronger in the current smokers and hypertensive population. The results of this study suggest that younger age at diagnosis of T2DM is associated with higher risk of death in patients. Younger patients diagnosed with T2DM had a higher risk of cardiovascular and all-cause mortality. These findings strengthen the understanding of the risk of death from T2DM and emphasize the importance of early prevention of diabetes.

PMID:39587196 | DOI:10.1038/s41598-024-80790-8

Sci Rep. 2024 Nov 25;14(1):29154. doi: 10.1038/s41598-024-80499-8.

ABSTRACT

Three-dimensional (3D) marker-based motion capture is the current gold standard to assess and monitor pathological gait in a clinical setting. However, 3D markerless motion capture based on pose estimation is advancing into the field of gait analysis. This study aims at evaluating the lower-body 3D gait kinematics and kinetics from synchronously recorded Theia3D markerless and CAST marker-based systems. Twelve healthy individuals and 34 clinical patients aged 8-61 years walked at self-selected speed over a 13 m long walkway. Similarity between models was statistically analysed using inter-trial variability, root mean square error, Pearson’s correlation coefficient and Statistical Parametric Mapping. Inter-trial variability was on average higher for clinical patients in both models. Overall, the markerless system demonstrated similar gait patterns although hip and knee rotations were non-comparable. Pelvic anterior tilt was significantly underestimated. Significant differences especially in peak values at specific phases of the gait cycle were observed across all planes for all joints (more so for clinical patients than healthy subjects) as well as in the sagittal powers of the hip, knee and ankle. Theia3D markerless system offers great potential in gait analysis. This study brings awareness to potential clinical users and researchers where they can have confidence, as well as areas where caution should be exercised.

PMID:39587194 | DOI:10.1038/s41598-024-80499-8

Sci Rep. 2024 Nov 26;14(1):29266. doi: 10.1038/s41598-024-80340-2.

ABSTRACT

Earthquakes cause severe destruction in the region where they occur. Children and adolescents are the group most affected group by earthquakes, and Post-Traumatic Stress Disorder is most common in this group. The age-related increase in Grip Strength varies between childhood and early adolescence. The purpose of the present study was to investigate the relationship between Post Traumatic Stress Disorder and Hand Grip and Hand Measurements of children exposed to the Kahramanmaraş-centered earthquake on February 6, 2023. The “Post-Traumatic Stress Disorder Response Scale for Children” was administered to 116 children who in children between the ages of 8 and 12 groups, and consent was obtained from the participants. Morphometric measurements of the hands of the children were measured with a digital caliper. Children’s hand Grip Strength measurements were made by using a digital hand dynamometer. The analysis of study data was performed with the SPSS (Statistical Program in Social Sciences) 25 software. Positive and statistically significant relationships were detected between right and left-hand Grip Strength and right and left-hand measurements of females and males (p < 0.05). Statistically significant and negative relationships were detected between PTSD and right and left-hand Grip Strength and right and left-hand measurements in females and males (p < 0.05).In the present study, it was detected that as post-traumatic stress disorder increases, hand Grip Strength decreases. We think that these findings will guide future prospective studies.

PMID:39587186 | DOI:10.1038/s41598-024-80340-2

Sci Rep. 2024 Nov 25;14(1):29197. doi: 10.1038/s41598-024-79800-6.

ABSTRACT

To evaluate the value of suspension and suturing technique in the prevention of anastomotic leakage of rectal cancer following double stapling technique. We performed a cohort study between August 2018 and December 2021 and analyzed the patients with rectal cancer underwent radical resection and double stapling technique at the department of general surgery. 324 patients were recruited in this research. There were 124 patients in control group and 200 patients in study group. There was a total of 19 patients present with anastomotic leakage. The incidence of anastomotic leakage was 5.8%. 12 patients were in control group and 7 in study group. The incidence of anastomotic leakage in control group was 9.7%. while the incidence of anastomotic leakage in study group was 3.5%, which was significantly lower than that in control group (p = 0.021). There were 4 patients present with anastomotic bleeding in control group (3.2%) while there were 6 cases with anastomotic bleeding in study group (3%) with no statistical differences. The average operation time of patients with anastomotic leakage was longer than that of patients without anastomotic leakage (p = 0.048). The intraoperative blood loss of patients with anastomotic leakage was more (p = 0.003) and the proportion of diabetes in anastomotic leakage group was larger (p = 0.003). Suspension and suturing technique could reduce the incidence of anastomotic leakage of patients with rectal cancer underwent double stapling technique. It is safe, simple, and easy to perform. Operation time, intraoperative blood loss, and diabetes may be high-risk factors of anastomotic leakage.

PMID:39587181 | DOI:10.1038/s41598-024-79800-6

Sci Rep. 2024 Nov 25;14(1):29233. doi: 10.1038/s41598-024-80876-3.

ABSTRACT

This article investigates the interrelationships and interdependencies inherent in the integrated use of the territory’s social, resource, and environmental potential to achieve its sustainable development. The basic hypotheses formulated during this study were as follows: Sustainable development of the territory’s resource and ecological potential cannot be achieved if its social potential is reduced; Sustainable development of the territory’s ecological and social potential can be achieved only if it is economically feasible, that is if it contributes to the sustainable development of the territory’s resource potential; Sustainable development of the territory’s resource and social potential cannot be achieved while its ecological potential deteriorates; Ensured sustainable development of territories in today’s world is only possible with simultaneous integrated use of the territory’s social, resource, and environmental potential. The aim of this research is to investigate the interrelationships among these three components and to determine their impact on the overall development of the regions. A comprehensive multi-stage research project based on the analysis of statistical information and survey results was designed and applied to meet the research objective. Methodologically, the study was based on a quantitative approach, which led to the integrated use of economic-statistical and econometric data processing methods. All these hypotheses were tested and found to be true in the Kizilsu Kyrgyz Autonomous Prefecture of the People’s Republic of China. The results indicate a direct and stable relationship between the development of resource potential, ecological potential, and social potential of the territories. Specifically, regions with high resource potential exhibit better social indicators, while ecological investments contribute to the improvement of public health and quality of life. The originality of this study lies in its comprehensive approach to examining the interconnections among resources, social aspects, and ecological sustainability, thereby contributing to the international literature in the field of sustainable development. These results can be of use to state and municipal government experts when planning territorial development, as well as to academic researchers, including to identify promising avenues for later research.

PMID:39587180 | DOI:10.1038/s41598-024-80876-3

Sci Rep. 2024 Nov 25;14(1):29208. doi: 10.1038/s41598-024-80404-3.

ABSTRACT

Residual histograms can provide meaningful statistical information in low-level visual research. However, the existing image denoising methods do not deeply explore the potential of alternate multiple residual histograms for overall optimization constraints. Considering this deficiency, this paper presents a novel unified framework of the alternating multiple residual Wasserstein regularization model (AMRW), which can tactfully embrace multiple residual Wasserstein constraints and different image prior information for image denoising. Specifically, AMRW focuses on solving the practical and meaningful problem of restoring a clean image from multiple frame degraded images. Utilizing the Wasserstein distance in the optimal transport theory, the residual histograms of the multiple degraded images are as close as possible to the referenced Gaussian noise histogram to enhance the noise estimation accuracy. Further, the proposed concrete AMRW combines the triple residual Wasserstein distance with the image total variation prior information for Gaussian image denoising. More importantly, through the alternating implementation of residual Wasserstein regularization from different image frames, the beneficial information of the image is essentially transmitted in each cycle, continuously improving the quality of the output image. Synchronously, the alternate iterative algorithm of histogram matching and Chambolle dual projection has high implementation efficiency. AMRW provides a new research idea for other visual processing tasks such as image inpainting and image deblurring. Finally, extensive numerical experiments substantiate that our AMRW can greatly boost the subjective and objective performance of the restored images compared with some popular image denoising algorithms in recent years.

PMID:39587177 | DOI:10.1038/s41598-024-80404-3

Sci Rep. 2024 Nov 25;14(1):29228. doi: 10.1038/s41598-024-79862-6.

ABSTRACT

The objective of this study is to assess the impact of dietary intake and supplementation of total magnesium, iron, zinc and selenium on pulmonary function in middle-aged to elderly individuals diagnosed with chronic obstructive pulmonary disease (COPD). This study utilized publicly available data from NHANES, focusing on the 2007-2012 cycles to include participants aged 50 and above with COPD. The definition of COPD followed the 2024 Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. Dietary mineral intake was assessed through two 24-h dietary recall surveys. Pulmonary function assessments included parameters such as forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), forced mid-expiratory flow (FEF 25-75%), and peak expiratory flow (PEF). Sex-specific associations of total magnesium, iron, zinc, and selenium intakes with pulmonary function parameters were assessed using multivariable regression models adjusted by potential covariates. The study sample had a mean age of 64.56 ± 8.26 years, with 35% being female. The median intakes of total magnesium, iron, zinc, and selenium for males were 312.8 mg, 15.6 mg, 14.4 mg, and 127.9 mcg, respectively, while for females, they were 257.5 mg, 12.8 mg, 11.4 mg, and 96.2 mcg. In males, higher total magnesium and iron intake were significantly associated with increased FEV1, FVC, and PEF (P < 0.05), while in females, only total zinc intake showed a positive association with PEF (P < 0.05). Participants meeting the recommended dietary allowance for total magnesium also exhibited significantly better lung function outcomes in both sexes. This study highlights the importance of adequate dietary mineral intake in managing pulmonary health among COPD patients. Enhancing mineral consumption, particularly magnesium, and iron, may be a viable strategy for improving lung function and overall health in this population, especially in men.

PMID:39587155 | DOI:10.1038/s41598-024-79862-6

Sci Rep. 2024 Nov 25;14(1):29245. doi: 10.1038/s41598-024-80487-y.

ABSTRACT

Little is known about the optimal measure of handgrip strength for predicting all-cause mortality and whether this association is modified by age or sex. We used data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES), 9,583 adults aged ≥ 20 years were included. Equal-length grip strength was measured using a digital handheld Takei dynamometer. We defined five measurements of grip strength, i.e., the average of handgrip strength (HGS), maximum of grip strength (MGS), HGS/body mass index (BMI), HGS/height (HT)², and MGS/weight, and three indicators of low grip strength, namely, low reference grip strength, lowest 20% grip strength, and low grip strength in sarcopenia. Information on deaths were obtained through linkage to National Death Index (NDI). Cox regression was used to assess the association of grip strength with mortality risk. HGS, MGS, HGS/BMI, HGS/HT², and MGS/weight were all inversely associated with all-cause mortality, with HGS or HGS/HT² (the area under the curve (AUC) = 0.714) being the optimal predictor of mortality, followed by MGS (AUC = 0.712). Participants with low grip strength showed increased risk of mortality regardless of which indicator was used, and the highest effect size was seen for lowest 20% grip strength group (hazard ratio (HR) = 2.20 for men, 2.52 for women). The above-mentioned correlations were consistently found in people of different ages and sexes. This study suggests the simplest measure of absolute grip strength (HGS, MGS) was the optimal index for predicting all-cause mortality, followed by HGS/HT². Keeping an adequate level of handgrip strength may be beneficial to reduce the risk of mortality.

PMID:39587152 | DOI:10.1038/s41598-024-80487-y

Sci Rep. 2024 Nov 26;14(1):29269. doi: 10.1038/s41598-024-75320-5.

ABSTRACT

The Indian summer monsoon (ISM) is a complex and multiscale interacting climate system, which is responsible for major contribution in India’s annual rainfall. Understanding the spatial and temporal variability of ISM rainfall is critical for managing water resources, which directly impact and regulate the functioning of India’s socio-economic conditions and subsequently, sustenance of over a billion people. This study evaluates the suitability of various gridded precipitation data products with different spatiotemporal resolutions, essential requirement for hydrologic modeling, disaster mitigation, irrigation allocation and agricultural application. Hence, we evaluate the performance of seven gridded datasets in generating time-matched characteristic event occurrences and their respective magnitudes using gauge-based Indian Meteorological Department (IMD) gridded data as reference. We observe that reanalysis datasets underperform compared to satellite and hybrid products in identifying both normal and extreme precipitation events. We develop a performance measure, called ‘rank score’ that considers deviations from IMD data in magnitude, statistical moments, and rain event detectability for a robust assessment and identifying best-suited dataset. Results indicate that APHRODITE, MSWEP, and CHIRPS (in descending order) are the most suitable data products across India. Additionally, region-specific evaluations provide valuable insights into the applicability of these datasets in different climatic and homogeneous rainfall zones.

PMID:39587150 | DOI:10.1038/s41598-024-75320-5