Tag: nevin manimala

Aesthetic Plast Surg. 2025 Sep 4. doi: 10.1007/s00266-025-05191-2. Online ahead of print.

ABSTRACT

OBJECTIVE: The aim of this study is to compare the radiological measurements of patients who underwent rhinoplasty using a piezo device with those of patients who underwent rhinoplasty using a classical osteotome.

METHODS: A total of 60 patients were included in the study: 30 rhinoplasty patients who underwent piezosurgical osteotomy and 30 who underwent classical osteotomy. Preoperative and postoperative functional and aesthetic outcomes were compared using NOSE and ROE scores. Four anthropometric parameters were measured radiologically before and after surgery: nasofrontal angle (NFA), nasal bone length (NL), pyramidal angle (PA) and the closest distance between the nasolacrimal canal and the rhinoplasty fracture line (N-R). The pyramidal angle (PA) was measured separately at two levels: at the nasal root (PA-R) and at the tip of the nasal bone (PA-T).

RESULTS: The two groups were similar in terms of age, gender, and follow-up period (p > 0.05). The operative time was significantly longer in the Piezo group (p < 0.001). Preoperative and postoperative ROE values, as well as preoperative NOSE values, were comparable between the two groups (p > 0.05). However, postoperative NOSE values were statistically significantly lower in the Piezo group compared to the Osteotome group (p = 0.004). Surgery significantly affected both NOSE and ROE values in each group (p < 0.001). No statistically significant differences were found between the groups in terms of preoperative and postoperative NFA, PA-R, and PA-T values (p > 0.05). Preoperative NL values were also similar between the groups; however, postoperative NL values were significantly shorter in the Piezo group (p < 0.001). A statistically significant difference was observed in both right and left side N-R values between the groups (right: p = 0.025; left: p = 0.010), with the N-R distance being shorter in the Piezo group.

CONCLUSION: The long-term aesthetic outcomes of the piezosurgery and conventional osteotomy groups were similar; however, the piezosurgery group demonstrated better functional results. The safe margin for the nasolacrimal canal was narrower when osteotomy was performed using piezosurgery. This finding warrants caution regarding potential complications in the lacrimal system.

LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

PMID:40908317 | DOI:10.1007/s00266-025-05191-2

Sci Rep. 2025 Sep 2;15(1):32321. doi: 10.1038/s41598-025-11152-1.

ABSTRACT

Effective sample design has a major role in the quality of parameter estimation in statistical parameter estimation issues. The ranking set sampling (RSS) strategy is effective and a less costly option than simple random sampling (SRS). A novel mixture continuous lifetime distribution that has been proposed recently is the power Chris-Jerry distribution (PC-JD). It is useful for modeling a number of real data sets. This paper investigates the RSS approach for estimating the PC-JD’s parameters. There are roughly sixteen different techniques of estimation that are used, such as the maximum likelihood method, the percentiles method, some methods based on minimum distance, the Kolmogorov method, and some methods based on minimum and maximum spacing distances. In comparison to a SRS, the simulation research assesses the performance of the suggested RSS-based estimates in terms of some measures of accuracy. To identify the optimal estimating strategy, the partial and overall ranks of many estimates are shown. According to numerical results, the maximum likelihood approach seems to be quite beneficial in evaluating the estimated quality of RSS and SRS. RSS is a more effective sampling approach than SRS owing to its better efficiency. Additionally, the different estimation techniques with survival data for both sampling techniques are examined.

PMID:40908291 | DOI:10.1038/s41598-025-11152-1

Orthop Surg. 2025 Sep 4. doi: 10.1111/os.70166. Online ahead of print.

ABSTRACT

BACKGROUND: Lumbar spondylolisthesis (LS) is a spinal disorder that often necessitates surgical intervention. However, evidence on the comparative clinical value of robot-assisted full-endoscopic transforaminal lumbar interbody fusion (RA FE-TLIF) versus conventional FE-TLIF in early-grade (Grades I and II) LS remains limited, leaving uncertainty about its true clinical value in this patient population. This study aims to compare the clinical efficacy and safety of FE-TLIF with RA FE-TLIF in patients with Grade I and II LS.

METHODS: A retrospective analysis was conducted on 47 patients who underwent surgical treatment for LS between April 2022 and April 2023 at our hospital. Patients were divided into two groups: 22 underwent RA FE-TLIF, and 25 underwent FE-TLIF. Key outcomes measured included operative time, intraoperative blood loss, postoperative recovery time, fusion rate, screw placement accuracy, Visual Analogue Scale (VAS), the Japanese Orthopaedic Association (JOA) scores, and the incidence of postoperative complications. Statistical analyses were performed using the independent-sample t test for continuous variables and the chi-square test for categorical variables, with a significance threshold of p < 0.05.

RESULTS: The RA FE-TLIF group exhibited significantly shorter operative times and lower intraoperative blood loss compared to the FE-TLIF group (p < 0.05). Postoperative recovery, as measured by hospital stay, was also shorter in the RA FE-TLIF group (p = 0.001). VAS and JOA scores indicated greater pain relief and functional improvement in the RA FE-TLIF group, with statistically significant differences observed at both 1 month and final follow-up (p < 0.05). The incidence of postoperative complications was lower in the RA FE-TLIF group, though this difference was not statistically significant (p = 0.144). Complete fusion rates were 95.45% in the RA FE-TLIF group and 88.00% in the FE-TLIF group, with no significant difference (p > 0.05). Screw placement accuracy was higher in the RA FE-TLIF group (97.73%) than in the FE-TLIF group (89.00%), with a significant difference (p < 0.05).

CONCLUSION: RA FE-TLIF demonstrates superior clinical outcomes compared to FE-TLIF in the treatment of LS. These findings support the broader adoption of RA FE-TLIF as a preferred surgical technique for this condition.

PMID:40908279 | DOI:10.1111/os.70166

J Ayurveda Integr Med. 2025 Sep 3;16(5):101198. doi: 10.1016/j.jaim.2025.101198. Online ahead of print.

ABSTRACT

BACKGROUND: Metabolic syndrome (MetS) is a major side-effect of antipsychotic and antidepressant medications that increases risk for cardiac and neurological disorders and hinders long-term adherence to treatment. Integrated Yoga and Ayurveda (IYA) intervention can potentially aid in counteracting these side effects.

OBJECTIVE: To evaluate the efficacy and safety of Integrated Yoga and Ayurveda (IYA) intervention in psychotropic associated metabolic syndrome (MetS) in patients with severe mental disorders MATERIALS AND METHODS: A single-arm exploratory observational trial was conducted in an outpatient setting at a major tertiary mental healthcare hospital in South India. The study included 29 consenting patients(11 females and 18 males) with severe mental disorders (SMDs) stable on anti-psychotic and antidepressant medications diagnosed with MetS (NCEP-ATP III criteria). A 45-day IYA intervention comprising an Ayurveda herbal formulation (Triphala choorna 6 gm per dose) with warm water twice daily and a 10-min specific yoga program was administered. Assessments were performed at the baseline and after 45 days for the following variables: anthropometry, blood pressure, lipid profile, fasting blood sugar, and safety profile consisting of Renal Function and Liver Function tests. Seventeen patients completed the study. Data on changes in anthropometry and biochemical markers was analyzed using paired samples t-test.

RESULTS: A statistically significant reduction was observed in the following variables: body weight (p < 0.001), BMI (p < 0.001), Total cholesterol (p < 0.05), and triglycerides (p < 0.05). None of the patients reported any side effects of IYA. Clinical assessment at the end of 45 days did not reveal any worsening of psychotic symptoms.

CONCLUSION: IYA may serve as a safe and potentially effective adjuvant in addressing MetS in patients with SMDs who are on psychotropics.

PMID:40907137 | DOI:10.1016/j.jaim.2025.101198

J Electrocardiol. 2025 Aug 26;93:154097. doi: 10.1016/j.jelectrocard.2025.154097. Online ahead of print.

ABSTRACT

BACKGROUND: Hypertensive crisis (HC) is recognized as a contributing factor in the development of cardiac arrhythmias. This study aims to assess Tp-e interval, Tp-e/QT (TQR), and Tp-e/QTc (TQcR) ratios in patients experiencing hypertensive urgency and emergency, in order to evaluate the potential risk of ventricular arrhythmias.

METHODS: A prospective study was conducted involving HC patients admitted to a tertiary hospital’s emergency department between June 1, 2022, and June 30, 2024. Patients were categorized into three groups: hypertensive emergency, hypertensive urgency, and control group. Data collected included demographic characteristics, vital signs, laboratory results, and electrocardiography (ECG) parameters such as Tp-e interval, TQR, and TQcR.

RESULTS: Among the 235 eligible patients, 57 % were female and 43 % male. The hypertensive urgency group included 130 patients, the emergency group 45, and the control group 60. Statistically significant differences in Tp-e, TQR, and TQcR values were observed across all groups (p < 0.001). These metrics demonstrated moderate positive correlations with both systolic and diastolic blood pressures.

CONCLUSION: Increased Tp-e, TQR, and TQcR values identified in HC patients suggest a heightened risk for ventricular arrhythmias. These findings support the routine evaluation of these ECG.

PMID:40907074 | DOI:10.1016/j.jelectrocard.2025.154097

Vaccine. 2025 Sep 3;64:127645. doi: 10.1016/j.vaccine.2025.127645. Online ahead of print.

ABSTRACT

The estimand framework as outlined in ICH E9(R1) has been extensively discussed and implemented in clinical trials of therapeutic products. However, there is limited literature on the application of the framework in preventive vaccine trials, which has many unique characteristics, including emphasis on estimating the per-protocol or “biological” effect. We provide a comprehensive review of the application of the framework to preventive vaccine trials evaluating clinical outcome and immunogenicity, focusing on commonly encountered intercurrent events including but not limited to: noncompliance with vaccination schedule and blood sampling window, infection not meeting protocol definition, death, and use of prohibited products. We discuss various considerations in choosing strategies to handle intercurrent events in terms of their utility in addressing the scientific questions. Finally, we provide considerations and examples for summarizing study estimands and data handling which may be incorporated into the protocol and statistical analysis plan.

PMID:40907068 | DOI:10.1016/j.vaccine.2025.127645

Can J Microbiol. 2025 Sep 4. doi: 10.1139/cjm-2025-0021. Online ahead of print.

ABSTRACT

Syphilis cases have been consistently rising since its near elimination in the late 1990s. This resurgence, along with increasing rates of macrolide resistance and congenital syphilis, has triggered renewed efforts to better understand and control the disease. We analyzed 827 T. pallidum genomes and created a new genome-based hierarchical lineage framework, recapitulating the major T. pallidum lineages and characterizing sub-lineages. An updated pangenome was constructed, revealing that T. pallidum subsp. pallidum lineages are determined by a single hypothetical major outer sheath C-terminal domain-containing gene while no significant genetic difference was observed between T. pallidum subsp. pertenue and T. pallidum subsp. endemicum. This study introduces an integrated genomic approach to characterize T. pallidum and highlights the significance of pangenomes in supporting public health.

PMID:40907038 | DOI:10.1139/cjm-2025-0021

Int J Oral Maxillofac Implants. 2025 Sep 4;0(0):1-28. doi: 10.11607/jomi.11454. Online ahead of print.

ABSTRACT

PURPOSE: The objective of this study was to conduct a comparative evaluation of the clinical and radiographic findings of definitive two-piece abutments placed at secondary surgery following submerged healing and definitive abutments used in standard prosthetic treatments.

MATERIALS AND METHODS: The study was designed as a prospective, split-mouth, randomised, parallel-design, blinded clinical trial. The study comprised two groups: a test group and a control group. The test group received a two-piece abutment, while the control group received a standardized healing abutment. The study analyzed a total of 10 patients and 20 implants. Clinical and radiographic measurements were obtained at baseline (T0), 6 months (T1), 12 months (T2) and 36 months follow-up (T3). Radiographic measurements were calculated on standardized periapical radiographs, with the aim of determining marginal bone level changes (ΔMBL) at different time points, emergence angles, and emergence profiles in mesially and distally.

RESULTS: A significant difference was found between the groups in mesial, distal, and mean ΔMBL at T0-T1 and distal and mean ΔMBL at T0-T3 values. (p<0.05) Emergence angle values were found to be below 30 degrees both mesially and distally in both groups. (p>0.05) A statistically significant correlation was found between healing/definitive abutment disconnection/reconnection and distal ΔMBL T0-T3. (p<0.05) Conclusion: Within the limitations of the study, although the sample size was limited, with the study design and minimizing confounding factors, it was concluded that two-piece definitive abutment application may have significant effects in terms of reducing ΔMBL changes in both the short and long term. However, further studies with a larger sample size are needed. The study was prospectively registered on the international Clinicaltrials.com registry (NCT05592821).

PMID:40907027 | DOI:10.11607/jomi.11454

JMIR Res Protoc. 2025 Sep 4;14:e74266. doi: 10.2196/74266.

ABSTRACT

BACKGROUND: The past decade has seen a substantial increase in the number of people experiencing unsheltered homelessness. The unsheltered population faces heightened health and social risks, yet research on their experiences remains limited.

OBJECTIVE: This paper presents the protocol for the Periodic Assessment of Trajectories of Housing, Homelessness, and Health Study (PATHS), a longitudinal study that leverages mobile phone technology and web-based surveys to track the housing and health trajectories of people experiencing unsheltered homelessness in Los Angeles County.

METHODS: Participants were recruited from the Los Angeles County Homeless Count Demographic Survey, an annual representative survey of the county’s unsheltered population. Eligibility criteria included being aged ≥18 years, having stayed in an unsheltered location or homeless shelter for at least 1 night in the past month, and residing in Los Angeles County. The study uses a web-based survey platform accessible via mobile phones and provides electronic gift card incentives for participation. Data on housing, health, and social outcomes are collected monthly using trauma-informed, equity-sensitive surveys, designed for diverse literacy levels with a user-friendly interface that includes buffers for sensitive topics.

RESULTS: Since the study launched in December 2021, a total of 2058 individuals have been screened and found eligible. In total, 57.43% (n=1182) of participants completed the baseline survey, of whom 75.47% (n=892) completed at least 1 monthly survey. By December 2024, participants had contributed 7585 monthly surveys (average of 8.5, SD 8.36 per respondent and median of 6, IQR 2-11). Compared to the unsheltered population of Los Angeles County, the PATHS sample overrepresents younger adults aged <40 years (641/1182, 54.23% vs 38.64%) and female participants (507/1182, 42.89% vs 27.74%). Furthermore, the PATHS cohort reports a high burden of health risks relative to the housed population, with 47.3% (422/892) reporting symptoms of anxiety (vs 19.1%), 45.1% (402/892) reporting symptoms of depression (vs 16.4%), 35% (312/892) reporting a disability (vs 12.9%), and 69.4% (619/892) experiencing food insecurity (vs 15.7%).

CONCLUSIONS: PATHS offers an innovative platform for real-time monitoring of the housing, health, and service needs of people experiencing unsheltered homelessness in Los Angeles County. By leveraging continuous, in-depth data collection via mobile surveys, PATHS provides valuable insights into the evolving challenges faced by this population. Addressing critical gaps in longitudinal research, PATHS has the potential to drive more informed policy decisions and interventions that improve outcomes for this population considered vulnerable.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/74266.

PMID:40907020 | DOI:10.2196/74266

JMIR Res Protoc. 2025 Sep 4;14:e66085. doi: 10.2196/66085.

ABSTRACT

BACKGROUND: Despite the increasing options for public and private health care providers in the Lao People’s Democratic Republic (Lao PDR), choosing a high-quality provider or facility is difficult because timely and reliable information about providers is not readily available. Additionally, only 28% described their most recent visit to a health care provider as high quality, suggesting that while options for care are expanding, people may need support in finding providers that meet their quality needs. To inform efforts to improve access to high-quality care, evidence is needed on mechanisms that empower people to identify and use such care. The rapid adoption of mobile phones in Lao PDR, particularly in urban areas, offers opportunities to enhance access to timely, reliable information about health care facilities.

OBJECTIVE: This study aims to conduct an unblinded randomized controlled experiment using mobile phones to study whether routinely collected information on quality of care can improve access to high-quality care and patient satisfaction.

METHODS: Mothers with at least one child under 2 years of age who are already enrolled in the Vientiane Multigenerational Birth Cohort (VITERBI) will be invited to participate during in-person visits by the research staff. Participants will be randomly assigned in equal numbers to the control and intervention groups. The intervention group will receive a URL with facility ratings for pediatric health care services every 2 weeks via WhatsApp; the control group will not receive any messages. WhatsApp will also be used to administer biweekly surveys to both groups to assess the quality of care received in the past 2 weeks. The web page shared with the intervention group will display results from these surveys and from the pilot study. Research staff will conduct baseline and endline surveys with all participants during in-person visits, 3 months apart.

RESULTS: The trial is currently underway and scheduled for completion in 2025.

CONCLUSIONS: This study will use a demand-side intervention to increase demand for high-quality child health care among mothers in Vientiane Capital. We will assess whether information on the quality of health care facilities-generated by study participants during the study period-influences mothers to change their preferred providers for nonurgent conditions.

TRIAL REGISTRATION: ClinicalTrials.gov NCT06304831; https://www.clinicaltrials.gov/study/NCT06304831.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/66085.

PMID:40907019 | DOI:10.2196/66085