Tag: nevin manimala

BMC Pediatr. 2025 Oct 10;25(1):798. doi: 10.1186/s12887-025-05832-0.

ABSTRACT

BACKGROUND: Autism Spectrum Disorder (ASD) is characterized by physical, communication, and behavioral challenges that often require comprehensive interventions. This study aimed to evaluate the combined efficacy of physiotherapy, occupational and speech therapies in improving physical and behavioral outcomes among children with ASD.

MATERIALS AND METHODS: This assessor-blinded randomized clinical trial was conducted at Proyash (Institute of Special Education), Jashore, Bangladesh, involving seventy children with ASD. Outcomes were assessed using the modified SF-36 for physical status and GARS-3 for behavioral status at baseline and after six weeks of intervention. Data were analyzed using SPSS version 25.0, with descriptive statistics (median and IQR) and inferential tests (Mann-Whitney U and Wilcoxon signed-rank), maintaining a 95% confidence level.

RESULTS: The average age of participants was 10.66 ± 3.28 years in Group A and 9.17 ± 2.83 years in Group B. Group A had a higher BMI of 21.86 ± 7.96 kg/m² compared to 19.53 ± 4.85 kg/m² in Group B. Post-intervention analysis revealed significant improvements in both physical and behavioral outcomes. Between-group comparisons yielded p-values < 0.01 for both measures. Within-group analysis showed significant improvements in Group A (p < 0.01), whereas changes in Group B were not statistically significant.

CONCLUSION: The combined rehabilitation program demonstrated significant improvements in physical and behavioral outcomes and showing greater effectiveness overall. These findings emphasize the importance of customized rehabilitation approaches in enhancing both physical and behavioral health, particularly when tailored to specific participant profiles.

TRIAL REGISTRATION: CTRI/2024/07/070209 (Prospectively Registered).

PMID:41068726 | DOI:10.1186/s12887-025-05832-0

BMC Public Health. 2025 Oct 9;25(1):3427. doi: 10.1186/s12889-025-24439-9.

ABSTRACT

BACKGROUND: The Vital Capacity Weight Index (VCWI) serves as a pivotal indicator of cardiopulmonary function among children and adolescents, reflecting their tissue oxygenation capacity and athletic potential. This study delves into the influence of environmental greenness and physical activity on VCWI in children residing in China’s economically prosperous provinces, who are exposed to air pollutants, namely PM_2.5 and O₃.

METHODS: We performed a cross-sectional analysis using data from the 2019 Chinese National Survey on Students’ Constitution and Health (CNSSCH), involving 62,987 students from the top eight provinces by GDP. Exposure to PM_2.5 and O₃ was estimated using data from the Tracking Air Pollution in China (TAP) platform. Greenness surrounding schools was assessed based on the China Land Cover Dataset (CLCD). Daily physical activity duration was used to classify participants into moderate or vigorous activity groups. Associations with VCWI were examined using univariate and multivariate logistic regression models. Interaction effects between air pollution and greenness or physical activity were assessed using additive models.

RESULTS: Higher concentrations of PM_2.5 and O₃ were significantly associated with lower VCWI. In contrast, greater greenness coverage and engagement in vigorous physical activity were linked to better VCWI outcomes. Interaction analysis showed that increased greenness may enhance the protective effect of lower air pollution levels on VCWI, while the interaction between physical activity and air pollution was not statistically significant.

CONCLUSIONS: These findings highlight the potential of green environments and active lifestyles in buffering the negative respiratory effects of air pollution among children. The results provide evidence to inform integrated urban planning and public health initiatives aimed at improving children’s lung health.

PMID:41068724 | DOI:10.1186/s12889-025-24439-9

BMC Public Health. 2025 Oct 9;25(1):3423. doi: 10.1186/s12889-025-24588-x.

ABSTRACT

BACKGROUND: Childhood vaccination coverage in Sierra Leone remains unsatisfactory despite multiple efforts made by health authorities to enhance collective immunity of the population, especially for children aged 12 to 23 months. This study aimed at identifying the factors associated with incomplete vaccination or non-vaccination among children aged 12 to 23 months in Sierra Leone in 2019.

METHODS: This was a cross-sectional study that used the 2019 Sierra Leone Demographic and Health Survey data. Descriptive statistics was performed to describe the sample, ascending hierarchical classification following a multiple correspondence analysis was employed to establish the profile of children with incomplete vaccination or non-vaccination status, and a binary logistic regression was used to identify the factors associated with incomplete vaccination or non-vaccination.

RESULTS: Of the 966 children aged 12 to 23 months involved in the study, 42.9% (95% CI[39.2; 46.6]) were incompletely vaccinated or unvaccinated, of which, 43.5% (95% CI[37.9; 49]) among male children and 42.4% (95% CI[37.3; 47.4]) among their female counterparts. The Northern (AOR 1.683, 95% CI[1.131; 2.503]) and the North Western (AOR 1.847, 95% CI[1.208; 2.825]) survey regions, delivery in a place other than a health facility (AOR 1.404, 95% CI[1.001; 2.042]), the mother’s age group 35 to 49 years (AOR 0.437, 95% CI[0.251; 0.762]) and the child’s birth order 7th or higher (AOR 2.640, 95% CI[1.452; 4.800]) turned out to be significant factors of incomplete vaccination or non-vaccination.

CONCLUSION: Incomplete vaccination or non-vaccination among children was high in Sierra Leone in 2019. In order to increase childhood vaccine uptake, we recommend the development of initiatives geared towards optimizing facility-based service delivery, intensifying health education focusing more on vaccination, enhancing community engagement, addressing barriers to vaccine access, establishing and ensuring proper functioning of immunization defaulter tracking systems.

PMID:41068721 | DOI:10.1186/s12889-025-24588-x

BMC Pregnancy Childbirth. 2025 Oct 9;25(1):1057. doi: 10.1186/s12884-025-08245-0.

ABSTRACT

BACKGROUND: Incomplete antenatal care (ANC) follow-up remains a significant public health issue, especially in low- and middle-income countries, where it poses serious risks to both maternal and fetal health. Although ANC plays a critical role in improving maternal and child health outcomes, data on regional disparities and high rates of incomplete ANC follow-up in Ethiopia are limited. Understanding the local factors contributing to these geographic variations is essential for targeted public health interventions. This study aimed to assess the spatial variation and determinants of incomplete ANC follow-up in Ethiopia.

METHODS: This study utilized data from the 2019 Ethiopian Mini Demographic and Health Survey (EMDHS), employing a stratified, two-stage cluster sampling design. A total of 3,926 women gave their consent and were included in the study. Spatial analysis, including hotspot analysis, interpolation, and spatial statistics (SaTScan), was conducted using ArcGIS 10.8, SaTScan 9.6, and STATA 17. Additionally, spatial regression analyses, including ordinary least squares regression and geographically weighted regression (GWR), were performed to identify hotspot areas and geographical predictor variables.

RESULTS: The study found that 56.75% (95% CI: 54.32%, 59.14%) of pregnant women had incomplete ANC follow-up. Spatial autocorrelation analysis revealed a Global Moran’s I value of 0.660 (p < 0.001), indicating significant spatial clustering of incomplete ANC follow-up across Ethiopia. Hotspot areas were identified in the Southern, Somali, Gambela, Afar, and Oromia regions. GWR analysis indicated that being from rural areas, in the poorest wealth index, and lacking formal education were significant positive determinants of spatial variation in incomplete ANC follow-up.

CONCLUSION: This study revealed that over half of pregnant women in Ethiopia had incomplete ANC follow-up, with significant spatial clustering observed across the country. The GWR analysis also indicated that rural residence, low household wealth, and lack of formal education were spatially varying determinants associated with incomplete ANC follow-up. These findings suggest that targeted interventions in the identified hotspot areas and addressing the spatially varying determinants may help improve ANC follow-up.

PMID:41068716 | DOI:10.1186/s12884-025-08245-0

BMC Public Health. 2025 Oct 9;25(1):3431. doi: 10.1186/s12889-025-24662-4.

ABSTRACT

BACKGROUND: The mediation effect of 24-hour physical activities on the association between type 2 diabetes and mortality is unclear. Additionally, Little evidence was found on the isotemporal substitution effect of 24-hour physical activities components on changing Life expectancy among patients with type 2 diabetes diagnosed. To address the abovementioned research gap, the study has a two-fold aims: first, to examine the mediation effect of 24-hour physical activities in type 2 diabetes and mortality; and second, to address how reallocating time on different daily activities would affect life expectancy.

METHODS: Analysis was conducted on the accelerometer data of 103,359 participants in the UK Biobank, with a median age of 57 years (range 39 to 70). Compositional mediation cox model was conducted to analyze the mediating effects of 24-hour physical activities. Additionally, the cohort Life table method was utilized to estimate the changes of Life-years over the next 10 years resulting from the substitution effect of different physical activities.

RESULTS: During a mean follow-up of 13.95 (range 2.95-16.28) years, 2,649 deaths were recorded. Diabetes was significantly associated with increased time spent engaging in sedentary behavior (SB), and reduced time spent on moderate-to-vigorous physical activity (MVPA) and light-intensive physical activity (LPA), thereby demonstrating an association with higher mortality risk. The indirect effect of physical activity (HR = 1.27, 95% CI 1.23-1.30) accounted for 41.9% of the total effect of diabetes on mortality. Furthermore, the Life expectancy gains with a maximum of 1.32 years over the next 10 years was found when reallocating SB time to MVPA.

CONCLUSION: The results revealed that 24-hour physical activities might mediate the association between diabetes and mortality. Therefore, promoting participation in MVPA and reducing sedentary activities among diabetes patients was expected to have a positive effect on Life expectancy over the next 10 years.

PMID:41068706 | DOI:10.1186/s12889-025-24662-4

BMC Nurs. 2025 Oct 9;24(1):1252. doi: 10.1186/s12912-025-03910-3.

ABSTRACT

BACKGROUND: The way of Foley insertion and required cares after that are key factors to prevent catheter-associated urinary tract infection. Nurses play the main role in catheter placement and care, so their knowledge and performance are important. This study aims to determine Correlation Between Nurses’ Knowledge and Practices in prevention of catheter-associated urinary tract infection with Urinary Tract Infection Incidence in Intensive Care Unit.

METHODS: This correlational study was conducted with the cross-sectional method. 105 nurses from five Intensive Care Unit wards was selected with census sampling. The data about nurses’ knowledge and practice to prevent catheter-associated urinary tract infection was collected through standard questionnaires with self-reporting. The incidence of Urinary Tract Infection in the last six months according to statistics recorded by the hospital infection control center was considered. The descriptive results of nurses’ knowledge, their practice, Urinary Tract Infection prevalence, and the correlation between these factors was examined.

RESULTS: The average work experience of nurses was 2.90 ± 1.57 years. Only 16.20% of nurses had taken part in workshops related to Urinary Tract Infection prevention. The average score of knowledge was 73.26, and for practice was 2.85 ± 0.37, which both were in a low level. The overall incidence of Urinary Tract Infection in the mentioned period was 2.99%. Urinary Tract Infection prevalence had an inverse and significant correlation with nurses’ knowledge and practice, 0.461 and 0.491 respectively.

CONCLUSION: Nurses’ knowledge and practice to prevent catheter-associated urinary tract infection were at poor level. Therefore, considering the negative and significant correlation of these variables with incidence of Urinary Tract Infection in this study, it is required that nurses be trained about specialized trainings related to urinary catheter care.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:41068702 | DOI:10.1186/s12912-025-03910-3

BMC Ophthalmol. 2025 Oct 9;25(1):557. doi: 10.1186/s12886-025-04321-3.

ABSTRACT

OBJECTIVE: To do the differential expression of long noncoding RNAs (lncRNAs) in pterygium was screened by gene chip technology, and the differentially expressed lncRNAs HOTTIP and RP1-261G23.7 were studied to explore their possible mechanisms in the pathogenesis of pterygium.

METHODS: Collected 40 specimens from June 2016 to May 2017 that underwent surgery in the Ophthalmology Department of Yanjishan Hospital of Wannan Medical College, including 20 pterygium tissue specimens (6 males and 14 females, aged 47-84 years, mean age 68.1 years), 20 cases of normal nasal bulbar conjunctival tissue in patients with strabismus (9 males and 11 females, aged 41-88 years, mean age 61.6 years). Four samples from each group were randomly selected to detect lncRNA expression by high-throughput gene chip detection technology; lncRNA HOTTIP, RP1-261G23.7 and corresponding target genes HOXA13, VEGFA were screened by quantitative real time polymerase chain reaction (qRT-PCR) to verify whether there is a significant difference between the two groups, and to analyze the correlation between the expression of the target genes HOXA13 and VEGFA.

RESULTS: (1) SPSS17.0 software was used for data processing in the experimental group and the control group. Gender and age were analyzed by the chi-square test. The statistical results were all P > 0.05, and there was no significant difference in statistics, (2) A total of 8271 differential lncRNAs were detected by high-throughput gene chip detection and compared with normal nasal bulbar conjunctival tissue in patients with strabismus. Among them, lncRNAs with a P-value < 0.05 and log fold change > 2 and Benjamini-Hochberg FDR correction (FDR < 0.05) had 612 upregulated genes and 743 downregulated genes. (3) The two highly differential lncRNAs were selected and verified by qRT-PCR. The results showed that lncRNAs HOTTIP and RP1-261 G23.7 and the corresponding target genes HOXA13 and VEGFA were highly consistent and highly expressed in the control group.

CONCLUSIONS: (1) LncRNAs are differentially expressed in pterygium; (2) Key lncRNA HOTTIP, RP1-261G23.7 may be new gene targets for pterygium.

PMID:41068700 | DOI:10.1186/s12886-025-04321-3

BMC Med Educ. 2025 Oct 9;25(1):1386. doi: 10.1186/s12909-025-07854-9.

ABSTRACT

BACKGROUND: Artificial intelligence (AI) is rapidly transforming healthcare, including dentistry, through its applications in diagnosis, prosthetic planning, and oral disease detection. As future professionals, dental students play a vital role in integrating AI into clinical practice. However, little is known about their attitudes toward AI, particularly in low-resource settings such as Palestine.

METHODS: A cross-sectional survey was conducted among 305 dental students from four Palestinian universities using a validated 22-item questionnaire. Data were analyzed using descriptive statistics and chi-square tests (p < 0.05).

RESULTS: Among the 305 participants (232 females, 73 males), 77% reported basic knowledge of AI, with social media being the most common source (66.2%). Female students were significantly more likely than males to believe that AI will bring major advancements to dentistry (p = 0.04), and that it can be used for diagnostic (p = 0.030), prognostic (p = 0.045), and treatment planning purposes (p = 0.015), as well as in postgraduate training (p = 0.017). Those with prior AI knowledge or awareness of its dental applications showed greater enthusiasm for its diagnostic use (p = 0.004) and integration into dental education (p = 0.004 and p = 0.009, respectively).

CONCLUSION: Palestinian dental students demonstrate strong awareness and positive attitudes toward the use of AI in dentistry. Gender-based differences and ethical concerns emphasize the need for structured, inclusive, and responsible AI training within dental curricula.

PMID:41068696 | DOI:10.1186/s12909-025-07854-9

BMC Surg. 2025 Oct 9;25(1):468. doi: 10.1186/s12893-025-03202-2.

ABSTRACT

BACKGROUND: To study the medical history, diagnosis, management, and treatment results of piriformis syndrome (PS).

METHODS: Articles published between 1980 and 2024 reporting cases of PS or piriformis muscle sciatica (PMs) case/case series were included. We excluded articles that did not report anagraphic data for singular cases, diagnostic procedure, therapy, and outcome for each case. We searched PubMed database and we retrieved articles from references. We used the Preferred Reporting Items of Systematic Reviews (PRISMA) guidelines to conduct a systematic review of the literature to identify all published cases of PS or piriformis muscle sciatica (PM). Data for all cases were collected in a database and analysed using statistical software (Statistical Package for the Social Sciences for Windows).

RESULTS: Of the 235 articles screened, 97 were included. Data from 212 patients (117 females and 95 males, mean age 43.6 ± 14.8) were collected. 38.2% of the patients in this study had a history of blunt / indirect pelvic trauma or piriform muscle (PM) stress due to vigorous physical activity/sport. 9.0% (19/212) of the patients had previously failed lumbar spine surgery. Before treatment, the diagnosis of PS/PMs was corroborated in 29.7% of patients by intrapelvic magnetic resonance imaging (MRI); 50.5% of the patients had a PS clinical diagnosis. Conservative treatments were effective in treating PS/PMs in 41.1% of patients; 58.9% of patients required surgical treatments. In the group of patients with PS diagnosis made without instrumental finding, the OR of surgical treatment failure occurrence was 5.3. After treatment, the most frequent causes of PS/PMs identified by intraoperative or instrumental findings were the anatomical variant of PM or SN (12.7%) followed by pyomyositis (9.4%) and PM hypertrophy (7.5%). 47.6% of the patients had no instrumental or intraoperative findings.

CONCLUSIONS: Intrapelvic MRI was the instrumental examination most frequently used to confirm the diagnosis of PS/PMs prior to treatment. The PS causes most frequently identified were the anatomical variant of PM or SN. In the group of patients with PS diagnosis made without instrumental finding, the OR of surgical treatment failure occurrence was 5.3. To reduce the number of cases of persistent pain after treatment for suspected PS, it is advisable to support the clinical diagnosis through all available instrumental diagnostic procedures. However, considering all the risks that SN surgery can cause, all nonsurgical treatments should be encouraged prior to surgery. TRIAL REGISTRATION: PROSPERO Reg. No. CRD42025641061.

PMID:41068685 | DOI:10.1186/s12893-025-03202-2

BMC Psychiatry. 2025 Oct 9;25(1):957. doi: 10.1186/s12888-025-07445-4.

ABSTRACT

BACKGROUND: Although antidepressant monotherapy is recommended for patients with major depressive disorder (MDD), they often do not respond to it, necessitating alternatives such as electroconvulsive therapy (ECT). However, maintenance pharmacotherapy after ECT has remained unestablished. This study, conducted at 240 facilities throughout Japan, aimed to explore maintenance pharmacotherapy after ECT for 3,749 inpatients with MDD.

METHODS: The patients were divided into two groups, one that underwent ECT (ECT group, N = 521) and another that did not (non-ECT group, N = 3,273), for the comparison of clinical characteristics and prescription details at discharge. The primary outcome of this study was the prescription rate of antidepressant monotherapy at discharge, while the secondary outcomes included prescription rates of specific combination regimens, such as antidepressant plus lithium.

RESULTS: We identified 198 prescription patterns involving antidepressants in the ECT group. Analysis by drug category revealed distinctive patterns: there was no statistically significant difference in prescription rates for antidepressant monotherapy between the ECT and non-ECT groups (N = 118, 22.6% vs. N = 932, 28.4%). In contrast, the prescription rate for the combination of antidepressant and antipsychotic medications was significantly higher in the ECT group (N = 188, 36.0% vs. N = 941, 28.7%). The combination of antidepressant and mood stabilizer was also more frequent in the ECT group (N = 35, 6.7% vs. N = 130, 3.9%), although this difference did not reach statistical significance after Bonferroni correction. At the drug level, additional distinctive patterns emerged: among antidepressant monotherapies, nortriptyline use was significantly more common in the ECT group (N = 9, 1.7% vs. N = 11, 0.3%). For mood stabilizers, restricting the analysis to lithium revealed a markedly higher rate in the ECT group (N = 30, 5.7% vs. N = 35, 1.0%).

CONCLUSIONS: These findings highlight the complexity of treatment decisions managing of MDD after ECT and emphasize the need for structured prospective research on the effectiveness of specific maintenance pharmacotherapies after ECT.

PMID:41068670 | DOI:10.1186/s12888-025-07445-4