Tag: nevin manimala

Matern Child Nutr. 2025 Aug 31:e70083. doi: 10.1111/mcn.70083. Online ahead of print.

ABSTRACT

Undernutrition increases the risk of morbidity and mortality, making it essential to identify and address its key determinants. This systematic review and meta-analysis examines the impact of selected child-related, household and hygiene, and sanitation factors on the nutritional status of infants and young children aged 0-59 months in Sub-Saharan Africa. We conducted a comprehensive search of online databases using defined Medical Subject Headings and keyword search terms. Nutritional status was assessed using the WHO child growth Standards Z-scores for stunting, underweight and wasting. A meta-analysis was performed to estimate pooled associations, and heterogeneity was assessed using the Cochrane Q and I² statistic. Sensitivity analyses were conducted, and publication bias was evaluated. Out of 1, 992 articles identified, 49 studies met the inclusion criteria. Our findings indicated that diarrhoea was associated with 77% increased risk of overall undernutrition (odds ratio (OR) = 1.77; confidence interval [Cl] = 1.52, 2.06), and 92% increased risk of wasting (OR = 1.92; 95% Cl = 1.48, 2.48). Low birthweight was linked to a two-fold increased risk of stunting (OR = 2.35; 95% Cl = 1.84, 3.00), while low maternal education was associated with a higher risk of underweight (OR = 1.55; 95% Cl = 1.17, 2.04). These findings highlight the need for targeted interventions to reduce childhood undernutrition in the region.

PMID:40886100 | DOI:10.1111/mcn.70083

Arch Iran Med. 2025 Jul 1;28(7):412-415. doi: 10.34172/aim.33365. Epub 2025 Jul 1.

ABSTRACT

Inpatient falls are a significant health concern, leading to increased hospital stays, costs, and potential severe injuries or death. This study aims to investigate the incidence, risk factors, and challenges of inpatient falls in Firoozgar hospital . This cross-sectional study was conducted in a tertiary care hospital in Tehran, Iran. The study included all patients who experienced a fall incident in Firoozgar hospital between April 2023 and March 2024. We included 90 patients with an average age of 57.49 years. Falls were more prevalent among men, older patients, and individuals with lower education levels. Underlying conditions such as diabetes, heart disease, and addiction significantly increased the risk of falls. Identifying the specific causes of falls in each hospital ward can facilitate the development of targeted preventive strategies. Implementing environmental modifications and fall prevention measures could substantially reduce fall risks, enhance patient safety, and lower healthcare costs.

PMID:40886093 | DOI:10.34172/aim.33365

JAMA Netw Open. 2025 Aug 1;8(8):e2529104. doi: 10.1001/jamanetworkopen.2025.29104.

ABSTRACT

IMPORTANCE: Cardiovascular (CV) disease is the leading cause of death globally for both men and women, yet women remain historically underrepresented in CV clinical trials, despite facing a disproportionately high burden of morbidity and mortality in many forms of CV disease.

OBJECTIVE: To determine the representation of women across a broad range of CV trials.

EVIDENCE REVIEW: The participation of women in CV trials registered on ClinicalTrials.gov from 2017 to 2023 was systematically determined through the extraction of publicly available information. Data were extracted to identify the country of study, disease type, trial size, clinical intervention, and age of the participants. The proportion of women and the ratio of number of female to male participants (F:M ratio) were calculated for each trial. The women’s participation:prevalence ratio (PPR) was estimated for each trial based on the relative prevalence of the disease by sex in the specified region.

FINDINGS: A total of 1079 registered CV trials were identified, including 1 396 104 participants, of whom 571 641 (41.0%) were women. The F:M ratio was significantly lower for studies on arrhythmia (median [IQR], 0.5), coronary heart disease (median [IQR], 0.39 [0.33-0.70]), acute coronary syndrome (median [IQR], 0.32 [0.24-0.51]), and heart failure (median [IQR], 0.51 [0.32-0.87]) but higher for obesity (median [IQR], 1.44 [1.08-4.50]) and pulmonary hypertension (median [IQR], 2.86 [1.50-3.97]) trials. The F:M ratio was higher for trials on lifestyle interventions (median [IQR], 1.51 [0.77-3.24]) than for drug trials. PPRs were low for clinical trials on coronary heart disease (median [IQR], 0.66 [0.50-0.86]), acute coronary syndrome (median [IQR], 0.79 [0.51-0.87]), and stroke (median [IQR], 0.74 [0.61-0.95]). Representation of women in CV trials varied by disease state, region, intervention, and sponsor type.

CONCLUSIONS AND RELEVANCE: These findings highlight both progress and persistent challenges in representation of women within CV trials. These gaps not only limit the generalizability of trial outcomes but also perpetuate inequities in evidence-based care for women with CV conditions.

PMID:40886088 | DOI:10.1001/jamanetworkopen.2025.29104

Knee Surg Sports Traumatol Arthrosc. 2025 Aug 31. doi: 10.1002/ksa.70018. Online ahead of print.

ABSTRACT

PURPOSE: Evidence on injury incidence on artificial turf for female footballers is conflicting. Some studies have found no difference in injury rates, while others have suggested increased knee injury risk. The aim of this study was to compare match injury incidences between artificial turf and natural grass in the Finnish female premier division of football.

METHODS: All teams in the Finnish female premier division of football were invited to participate in a five-season prospective cohort study, and eight to ten teams took part depending on the season. Injuries were reported by players in weekly questionnaires and categorised by anatomical region, recurrence, contact, severity, and playing position. Individual match exposure was tabled, and incidences per 1000 h of match exposure and incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were calculated for both surface types.

RESULTS: A total of 517 league matches (401 on artificial turf and 116 on natural grass) were played during the five-season follow-up. In that time, 237 sudden-onset injuries (184 on artificial turf and 53 on natural grass) were reported. The overall injury incidence rate was 19.6/1000 match hours on artificial turf and 19.3/1000 match hours on natural grass (IRR 1.0, 95% CI 0.7-1.4). No statistical difference was observed for risk in knee injuries or other subcategories.

CONCLUSIONS: This study found no evidence of a difference in match injury risk between artificial turf and natural grass for elite level female footballers. Research with modern non-filler surfaces will be needed as pitches containing microplastic pollution are banned in the European Union.

LEVEL OF EVIDENCE: Level II.

PMID:40886078 | DOI:10.1002/ksa.70018

HGG Adv. 2025 Aug 30:100499. doi: 10.1016/j.xhgg.2025.100499. Online ahead of print.

ABSTRACT

In studies of individuals of primarily European genetic ancestry, common and low- frequency variants and rare coding variants have been found to be associated with the risk of bipolar disorder (BD) and schizophrenia (SZ). However, less is known for individuals of other genetic ancestries or the role of rare non-coding variants in BD and SZ risk. We performed whole genome sequencing (∼27X) of African American individuals: 1,598 with BD, 3,295 with SZ, and 2,651 unaffected controls (InPSYght study). We increased power by incorporating 14,812 jointly called psychiatrically unscreened ancestry-matched controls from the Trans-Omics for Precision Medicine (TOPMed) Program for a total of 17,463 controls (∼37X). To identify variants and sets of variants associated with BD and/or SZ, we performed single-variant tests, gene-based tests for singleton protein truncating variants, and rare and low-frequency variant annotation-based tests with conservation and universal chromatin states and sliding windows. We found suggestive evidence of BD association with single-variants on chromosome 18 and of lower BD risk associated with rare and low-frequency variants on chromosome 11 in a region with multiple BD GWAS loci, using a sliding window approach. We also found that chromatin and conservation state tests can be used to detect differential calling of variants in controls sequenced at different centers and to assess the effectiveness of sequencing metric covariate adjustments. Our findings reinforce the need for continued whole genome sequencing in additional samples of African American individuals and more comprehensive functional annotation of non-coding variants.

PMID:40886051 | DOI:10.1016/j.xhgg.2025.100499

J Orthop Surg Res. 2025 Aug 30;20(1):807. doi: 10.1186/s13018-025-06241-w.

ABSTRACT

BACKGROUND: This study aimed to investigate the utility of shear wave elastography (SWE) as a noninvasive diagnostic tool for assessing anterior compartment intracompartmental pressure (ICP) in patients with tibial plateau fractures, facilitating early detection of high compartment pressure (HCP) to mitigate acute compartment syndrome (ACS) risks.

METHODS: In this cross-sectional study conducted from January 2024 to March 2025 at a tertiary hospital in China, 170 patients aged 18-65 years with tibial plateau fractures diagnosed within 48 h were enrolled. Demographic data, injury mechanisms, Schatzker classification, and laboratory parameters were collected. shear wave velocity (SWV) was measured via SWE on both injured and contralateral anterior compartment muscles, alongside invasive ICP monitoring. Statistical analyses encompassed Spearman’s correlations, stepwise logistic regression for a multivariate model incorporating SWV, age, and fracture type, and receiver operating characteristic (ROC) curves for diagnostic performance.

RESULTS: Among participants (57.1% male, median age 45 years), 44 exhibited HCP (ICP ≥ 30 mmHg). Injury-side SWV and SWV differential showed strong positive correlations with ICP (ρ = 0.704 and 0.535, respectively; both P < 0.001). Significant SWV disparities were observed between HCP and non-HCP groups (P < 0.001). The multivariate model yielded an AUC of 0.880, with 93.2% sensitivity and 71.4% specificity, demonstrating consistent performance across gender subgroups. Adjusted odds ratios highlighted injury-side SWV (aOR 5.99) and Schatzker Ⅳ-Ⅵ fractures (aOR 4.14) as key predictors.

CONCLUSION: Our study results indicate that SWE can reliably and noninvasively detect HCP in tibial plateau fractures, providing superior diagnostic accuracy and clinical applicability.

PMID:40886029 | DOI:10.1186/s13018-025-06241-w

J Orthop Surg Res. 2025 Aug 30;20(1):803. doi: 10.1186/s13018-025-06199-9.

ABSTRACT

BACKGROUND: The spine, pelvis, and joints maintain sagittal balance, which is often disrupted in lumbar degenerative diseases. While preoperative changes in sagittal alignment are well studied, postoperative adaptations, particularly following spinal fixation extending to the pelvis, are less understood. Therefore, the present study aimed to examine sagittal changes in the spine, pelvis, and joints in sitting and standing positions after short- or long-segment posterior spinal fixation extending to the pelvis.

METHODS: This cross-sectional study analyzed patients who underwent long- or short-segment instrumented fusion to the pelvis for lumbar degenerative disease at our hospital from June 2018 to October 2019. Patients were grouped based on the number of internal fixation segments, both short and long. Sagittal parameters were measured in standing and sitting positions and matched for sex, gender, height, weight, and other related parameters. Statistical analysis was performed using t-tests and Mann-Whitney U tests.

RESULTS: A total of 98 patients were included, of whom 55 were included in the long-segmengroup (31 men, 24 women; mean age of 63.1 ± 8.5 years). In the long-segment group, no significant changes were observed between standing and sitting positions (P > 0.05). In the short-segment group, significant changes were observed in the sacral vertical axis, pelvic tilt, sacral slope, thoracic kyphosis, lumbar lordosis, T1 pelvic angle, T1 spinopelvic inclination, acetabular tilt, and pelvic-femoral angle between the two positions (P < 0.05). The difference in pelvic femoral angle changes between the groups was also significant (P < 0.05).

CONCLUSIONS: In the short-segment group, transitioning from standing to sitting leads to greater sagittal changes, including decreased lumbar lordosis and forward trunk lean, with smaller hip joints than in the long-segment internal fixation group.

PMID:40886027 | DOI:10.1186/s13018-025-06199-9

J Orthop Surg Res. 2025 Aug 30;20(1):800. doi: 10.1186/s13018-025-06222-z.

ABSTRACT

BACKGROUND: In this study, we investigated the bidirectional causal relationship between spondyloarthritis (SpA)/ankylosing spondylitis (AS) and intervertebral disc degeneration (IVDD).

METHODS: Genome-wide association study (GWAS) statistics for SpA, AS, and IVDD were obtained exclusively from the FinnGen consortium. The instrumental variables (IVs) were identified under genome-wide significance thresholds (P < 5 × 10^-8) with linkage disequilibrium clumping removed. An F-value exceeding 10 was deemed a robust association between IVs and exposure. The inverse-variance weighted (IVW) method was prioritized to infer causal relationships between SpA/AS and IVDD. To robustly evaluate reverse causality, reverse MR analyses were systematically implemented. Heterogeneity across single-nucleotide polymorphisms (SNPs) was quantified by conducting Cochran’s Q test and Rucker’s Q test; horizontal pleiotropy was assessed via MR-Egger intercept analysis.

RESULTS: MR analyses demonstrated a significant causal effect of SpA on IVDD (IVW: OR = 1.04, 95% CI: 1.02-1.05, P_adjust = 2.76E-05). Similarly, AS exhibited a robust causal association with IVDD (OR = 1.03, 95% CI: 1.02-1.04, P_adjust = 2.08E-05). The reverse analyses revealed that IVDD significantly increased susceptibility to SpA (OR = 1.26, 95% CI: 1.14-1.40, P_adjust = 7.07E-05) and AS (OR = 1.32, 95% CI: 1.14-1.52, P_adjust = 8.10E-04). Neither significant heterogeneity nor horizontal pleiotropy was detected.

CONCLUSIONS: SpA/AS significantly increased the risk of IVDD, whereas reverse MR analyses revealed that IVDD increased susceptibility to SpA/AS. Further experimental studies are required to confirm the bidirectional causal relationship between SpA/AS and IVDD.

PMID:40886020 | DOI:10.1186/s13018-025-06222-z

J Orthop Surg Res. 2025 Aug 30;20(1):802. doi: 10.1186/s13018-025-06231-y.

ABSTRACT

BACKGROUND: Multi-limb amputations are extremely rare and devastating injuries, particularly in the context of civilian disasters. The 2023 Türkiye earthquake resulted in a significant number of complex traumatic injuries, including multiple limb amputations. This study aims to investigate early mortality, surgical complications, and functional outcomes at two-year follow-up in civilian patients who underwent two or more limb amputations following the disaster.

METHODS: A retrospective analysis was conducted on 22 patients who sustained multiple limb amputations after the earthquake. Demographic data, amputation levels, surgical interventions, complications, and outcomes at two-year follow-up were recorded. The primary outcomes were mortality, the number and type of reoperations, and functional recovery at two years.

RESULTS: Among the cohort, two-limb amputations were performed in 17 patients, three-limb amputations in 4 patients, and four-limb amputation in 1 patient. Twenty patients required at least one additional surgical procedure during hospitalization, most commonly surgical debridement for soft tissue infection. Eight patients died, of whom five had undergone amputation of three or more limbs. Sepsis was the leading cause of death. Follow-up data at two years were available for 14 survivors. Of these, only 3 patients were able to ambulate independently using prosthetic devices. Phantom limb pain was reported in 6 patients, and all received medical management. The average hospital stay exceeded 80 days in patients with bilateral amputations.

CONCLUSIONS: This study presents one of the largest case series of multi-limb amputees following a civilian earthquake. The findings highlight the high rate of reoperation, substantial mortality, and limited functional recovery at two-year follow-up in this population. Early multidisciplinary rehabilitation strategies should be prioritized to improve outcomes in future mass-casualty settings.

PMID:40886017 | DOI:10.1186/s13018-025-06231-y

AIDS Res Ther. 2025 Aug 30;22(1):86. doi: 10.1186/s12981-025-00776-y.

ABSTRACT

OBJECTIVES: The diversity of HIV-1 genotypes among Men who have sex with men (MSM) globally has changed considerably. The purpose of this study to assess the global prevalence of HIV-1 genotypes among MSM.

METHODS: PubMed, Embase, Scopus, and Web of Science were systematically searched to identify the articles. Pooled prevalence of HIV-1 genotypes was calculated and subgroup analyses were performed to examine the prevalence estimates across time and locations.

RESULTS: A total of 95 studies were included in the final analysis, including 84,622 successfully genotyped samples. The predominant strains were CRF01_AE (34.46%), subtype B (31.16%), and CRF07_BC (24.72%). In subgroup analyses, Subtype B and C showed a declining trend over the years. However, CRF07_BC exhibited a consistent year-on-year increase, while CRF01_AE experienced a slight reduction after 2018. Notably, both subtypes currently account for more than 35% of the total. In addition, the distribution of HIV-1 subtypes in this population shown a clear regional distribution. Regionally, subtype B predominated in Latin America and Europe, CRF01_AE and CRF07_BC in Asia and China, while subtype C and CRF02_AG were dominant in Africa and the Middle East.

CONCLUSIONS: Global and regions MSM HIV-1 subtypes are becoming more complex over time and the prevalence of recombinant viruses is increasing. Ongoing and effective surveillance of the global and regional molecular epidemiology of HIV-1 in MSM is critical for developing targeted preventive control measures against HIV.

PMID:40886010 | DOI:10.1186/s12981-025-00776-y