Tag: nevin manimala

J Hazard Mater. 2024 Aug 4;478:135431. doi: 10.1016/j.jhazmat.2024.135431. Online ahead of print.

ABSTRACT

Recently, there has been increasing concern regarding the emergence of bisphenol S analogues (BPSs) due to their potential toxicity. However, their exposure levels and associated health risks in susceptible populations remain unknown. In our study, we analyzed bisphenol A (BPA), along with 11 common BPA analogues (BPAs), and nine emerging BPSs in urine samples collected from 381 pregnant women in South China. All nine BPSs were first detected in pregnant women’s urine. In addition to BPA, two BPAs, three BPSs including Diphenylsulfone (DPS), Bis(phenylsulfonyl)phenol (DBSP) and Bis(3-allyl-4-hydroxyphenyl)sulfone (TGSA), were identified as the predominant bisphenols, with detection frequencies ranging from 53-100 %. BPA still exhibited the highest median concentration at 0.624 ng/mL, followed by DPS (0.169 ng/mL), BPS (0.063 ng/mL) and DBSP (0.023 ng/mL). Importantly, mothers with higher levels of BPA, DBSP, DPS, and TGSA in their urine are statistically more likely to give birth to premature infants with shorter lengths at birth or smaller head circumference (p < 0.05). Although the median exposure to 21 bisphenols did not exceed the tolerable daily intake (TDI) of BPA, it did surpass the recently proposed BPA TDI (0.2 ng/kg bw/day) by a factor ranging from 1.1-99 times. This study signifies the first report unveiling the prevalence of multiple bisphenols, particularly emerging BPSs, in the urine of pregnant women in South China.

PMID:39128146 | DOI:10.1016/j.jhazmat.2024.135431

Turk J Gastroenterol. 2024 Mar;35(3):178-185. doi: 10.5152/tjg.2024.23210.

ABSTRACT

BACKGROUND/AIMS: This study is aimed to compare the effects of nutrition which has been enriched with different amounts of gluten to gluten-free diets on weight gain, diabetogenic state, hematological, and biochemical parameters.

MATERIALS AND METHODS: A total of 40 newly weaned male Wistar albino rats used in the study were randomized into 4 different groups based on the gluten rations they were given. Following 12 weeks of diet they were killed and intracardiac blood samples were collected. Groups were identified as group 1 (n = 10): control group; normal rat ration containing wheat, group 2 (n = 10): gluten-free diet, group 3 (n = 10): ration containing medium level of gluten (normal rat diet+6% vital gluten) and group 4 (n = 10): ration containing high level of gluten (normal rat diet+12% vital gluten).

RESULTS: In groups 3 and 4, high-density lipoprotein was found to be higher than the other 2groups. However, when group 2 results were compared to the other groups; the highest T3, T4, creatinine and B12 levels and the lowest gluten-specific IgE level were observed. alanine aminotransferase and aspartate aminotransferase levels were found to be higher in group 1 compared to the other 3 groups. No statistically significant difference was detected between the groups in terms of other parameters.

CONCLUSION: This study provides evidence that a gluten-containing diet does not cause weight gain, has no diabetogenic effect, and also does not adversely affect general health in relation to hematological, biochemical, and various endocrinological parameters.

PMID:39128121 | DOI:10.5152/tjg.2024.23210

Turk J Gastroenterol. 2024 Mar;35(3):168-177. doi: 10.5152/tjg.2024.22850.

ABSTRACT

BACKGROUND/AIMS: The purpose of this study was to investigate whether computed tomography enterography can be used to predict the presence of perianal fistula in Crohn’s disease patients.

MATERIALS AND METHODS: According to the presentation of perianal fistula or not, this study divided retrospectively included Crohn’s disease patients into 2 groups. The disease duration, incidence of involved intestinal segments, and scoring of the activity of the lesions in all patients were statistically analyzed to explore significant factors between the 2 groups. The statistically significant findings identified in the univariate analysis were incorporated into the multivariate analysis. Logistic regression models were subsequently constructed to assess the predictive factors associated with the occurrence of perianal fistula in individuals with Crohn’s disease.The contribution of each factor to the outcome variable was confirmed by the nomogram. The clinical utility of the nomogram was confirmed by calibration and decision curves.

RESULTS: There were 40 cases with perianal Crohn’s disease and 58 without perianal Crohn’s disease. After univariate and multivariate analysis, disease duration (early stage of Crohn’s disease), ascending colon, and rectum were identified as the independent predictive factors for perianal fistula in Crohn’s disease patients. The clinical utility of the nomogram was effective, which implied potential benefits for Crohn’s disease patients.

CONCLUSION: Computed tomography enterography can be used to predict the presence of perianal fistula in Crohn’s disease patients by analyzing the location and the stage of the disease.

PMID:39128117 | DOI:10.5152/tjg.2024.22850

J Int Adv Otol. 2024 Mar;20(2):127-134. doi: 10.5152/iao.2024.231140.

ABSTRACT

BACKGROUND: The aim of this study was to survey the knowledge and treatment management practices for single-sided deafness (SSD) among different subspecialties of otolaryngology.

METHODS: A questionnaire was sent via Google Sheets to members of the Turkish and Egyptian Otorhinolaryngology Societies between December 2021 and February 2022. For the statistical analysis, the respondents were divided into 3 groups as otologists, non-otologists, and residents at the department of otolaryngology-head and neck department.

RESULTS: There were no statistically significant differences between otologists and non-otologists in radiological imaging (child P = .469, adult P = .140) and preferred treatment method (child P = .546, adult P = .106). However, otolaryngologists showed significant differences in radiological evaluation (P <.001), vestibular evaluation (P = .000), and frequency of treatment options recommended for pediatric and adult SSD patients (P = .000).

CONCLUSION: There were no significant differences in SSD diagnosis, treatment, and rehabilitation between otologists and non-otologists. However, when comparing pediatric and adult patients, there was a difference in the treatment management of SSD patients.

PMID:39128116 | DOI:10.5152/iao.2024.231140

Turk J Gastroenterol. 2024 Mar;35(3):161-167. doi: 10.5152/tjg.2024.22733.

ABSTRACT

BACKGROUND/AIMS: Gastroenterologists have an important role in the treatment and management of comorbidities related to obesity. Assessment of gastroenterologists’ perception and attitude toward obesity was aimed in this study.

MATERIALS AND METHODS: Survey questions were determined for the study. An online questionnaire was prepared afterward. Participants were invited via e-mail by providing them with information about the study. It was ensured that those who accepted the study could access the questionnaire form with the relevant link. Participants who answered all questions were included in the study.

RESULTS: Totally 117 gastroenterologists were included in the study. The proportion of gastroenterologists who thought that obesity complicates the management of gastroenterological diseases and those who thought obesity as a factor that negatively affects the prognosis of gastroenterological diseases was determined as 88.9% and 95.7%, respectively. Among the obese patients, the proportion of those who applied diet therapy, exercise, pharmacotherapy, and endoscopic methods was 94%, 91.5%, 35%, and 37.6%, respectively. The rates of intragastric balloon therapy and intragastric botulinum toxin A injection were 30% and 21.4%, respectively. The proportion of those who agreed that obese patients lost a significant amount of weight with the treatment methods applied was 47.2%. The proportion of participants who agreed that long-term maintenance of weight loss was impossible for most obese patients was 59.8%.

CONCLUSION: To our knowledge, this is the first study that evaluates the perception and attitude of gastroenterologists toward obesity. Our study results show that gastroenterologists think that obesity is a chronic disease and that gastroenterologists should be involved in management of obesity.

PMID:39128109 | DOI:10.5152/tjg.2024.22733

Turk J Gastroenterol. 2024 Apr;35(4):343-349. doi: 10.5152/tjg.2024.23250.

ABSTRACT

BACKGROUND/AIMS: Congenital sucrase-isomaltase deficiency is an autosomal recessive inherited disaccharidase deficiency characterized by chronic osmotic diarrhea. In this study, the genotype-phenotype relationships of close relatives of an index case with congenital sucrase-isomaltase deficiency were investigated.

MATERIALS AND METHODS: A 23-month-old female patient with a sucrase-isomaltase gene c.317G>A (p.C106Y) homozygous mutation was diagnosed as an index case and her pedigree analysis was performed subsequently. The family members with and without sucrase- isomaltase gene mutations were compared in terms of clinical symptoms.

RESULTS: The study included 109 cases [mean age ± SD: 22.6 ± 17.2 years (0.1-75 years), 61 males (56%)] of 130 family members of the index case. Sucrase-isomaltase gene c.317G>A (p.C106Y) heterozygous mutation was detected in 27 cases (24.7%); 14 (51.9%) were male and had a mean age of 23.2 ± 18.3 years. The most common complaints of 12 (44.4%) symptomatic patients with mutations were abdominal pain (37%), gas irritability (33.3%), bloating (22.2%), and foul-smelling stools (18.5%). Compared with the cases without mutation, a statistically significant difference was observed in the incidence of gas irritability, foul-smelling stool, ≥2 gastrointestinal symptoms, postprandial complaints, and food allergy (P = .005, P = .047, P = .049, P = .017, P = .021, respectively). Sacrosidase enzyme replacement was applied to 7 patients whose symptoms did not improve with dietary elimination. Clinical response was obtained after enzyme treatment.

CONCLUSION: Despite its autosomal recessive inheritance, congenital sucrase-isomaltase deficiency can also be symptomatic in heterozygous individuals. Further studies are required to clarify the genotype-phenotype relationship and management of the disease.

PMID:39128102 | DOI:10.5152/tjg.2024.23250

J Int Adv Otol. 2024 May;20(3):247-254. doi: 10.5152/iao.2024.231269.

ABSTRACT

BACKGROUND: Fibromyalgia syndrome (FMS) is a chronic pain condition that may be associated with dysfunction in the central nervous system.

OBJECTIVE: The aim of this study was to assess the vestibulo-spinal reflex (VSR) and vestibulo-ocular reflex (VOR) in FMS using the cervical vestibular evoked myogenic potential (cVEMP) and ocular vestibular evoked myogenic potential (oVEMP) tests, respectively, and to evaluate their relation to disease severity.

METHODS: This study included 30 female FMS patients and 30 well-matched healthy controls. They underwent full history taking and assessment of the severity of dizziness/vertigo using the Dizziness Handicap Inventory; assessment of the severity of FMS symptoms using the Revised Fibromyalgia Impact Questionnaire; bedside examination of the dizzy patient; videonystagmography, cVEMP, and oVEMP tests; basic audiologic evaluation; and uncomfortable loudness level (UCL) testing.

RESULTS: Dizziness was reported in 46.6% and vertigo in 11.1% of patients. Abnormalities in cVEMP (50%) and oVEMP (63.3%) were mostly unilateral, irrespective of FMS severity. Disease duration affected only the oVEMP amplitude. Fibromyalgia syndrome patients had a statistically significant lower UCL and narrower dynamic range compared to controls.

CONCLUSION: The VSR and VOR are commonly affected in FMS patients, and findings suggest central sensitization involving the brain stem. We recommend routine cVEMP and oVEMP testing to assess brainstem function in FMS patients.

PMID:39128093 | DOI:10.5152/iao.2024.231269

Eurasian J Med. 2024 Jun;56(2):114-120. doi: 10.5152/eurasianjmed.2024.23281.

ABSTRACT

BACKGROUND: The aim of the present study was to examine the findings of the intraoral examinations of the 12-16 years old novice (control) and elite athletes across the winter sports branches, which were alpine discipline skiing, snowboarding, biathlon, ski jumping, and ice hockey. Besides, the study aimed to determine the intra- and inter-group relationships by comparing the athletes salivary stress biomarker levels at precompetition, during-match, and post-competition stages.

METHODS: Ninety-one athletes (71 elite, 20 novice) participated in our study. Oral health status of the athletes were evaluated. In addition, cortisol levels in the saliva samples obtained at pre-competition (rested before the competition), during-match (just before the start), and post-competition (competition ending moment) stages were measured. The data were analyzed statistically with a significance level of 0.05.

RESULTS: Ice hockey athletes were the most affected by untreated dental caries (27.3%). No signs of dental trauma caused by sports activities were found in the winter sports branches. Basic erosive wear examination scores of the ice hockey athletes were similar to the ski jumping athletes and lower than other groups (P=.034). The mean cortisol values between sports branches were listed as: biathlon <snowboarding > alpine skiing < ice hockey < ski jumping (P < .001). Test results of the winter sports athletes’ saliva samples revealed that their salivary stress levels might vary in accordance with the sports branches, and there was a negative relationship between the levels of salivary stress biomarkers in competitions and oral health.

CONCLUSION: In winter sports activities, measures for improving oral health should be disseminated.

PMID:39128091 | DOI:10.5152/eurasianjmed.2024.23281

Turk J Gastroenterol. 2024 Jul;35(7):523-531. doi: 10.5152/tjg.2024.23205.

ABSTRACT

BACKGROUND/AIMS: This study aimed to investigate the possible positive effects of arbutin in a trinitrobenzene sulfonic acid (TNBS)- induced experimental colitis model, to compare it with mesalazine, which is used in treating inflammatory bowel disease and to observe the effect of its concomitant use.

MATERIALS AND METHODS: Forty Wistar albino species male rats were randomized into 5 groups as control, colitis, colitis+arbutin (Arb), colitis+mesalazine (Mes), and colitis+mesalazine+arbutin (M+A). Proinflammatory cytokines [interleukin (IL)-6, IL-1β, tumor necrosis factor alpha (TNF-α)] and oxidant/antioxidant parameters [malondialdehyde (MDA), superoxide dismutase inhibition (SOD) inhibition, myeloperoxidase (MPO), and catalase, glutathione peroxidase (GPx)] were processed from the samples. Histopathological evaluation evaluated goblet cell reduction, cellular infiltration, and mucosal loss.

RESULTS: When the treatment groups and the TNBS group were compared, statistical significance was achieved in MDA, MPO, SOD inhibition, GPx values, IL-6, IL-1β and TNF-α levels. Histopathological evaluation revealed a statistically significant decrease in the mucosal loss value in the group where mesalazine and arbutin were used together compared to the TNBS group.

CONCLUSION: Our study’s results elaborated that using arbutin alone or in combination with mesalazine produced positive effects in colitis-induced rats.

PMID:39128087 | DOI:10.5152/tjg.2024.23205

Eurasian J Med. 2024 Jun;56(2):86-90. doi: 10.5152/eurasianjmed.2024.23110.

ABSTRACT

BACKGROUND: Viral hepatitis is still a common and important public health problem for health-care workers around the world and in our country. This study was aimed at determining the immunity status of hepatitis B and hepatitis A in order to vaccinate non-immune workers.

METHODS: The population of this cross-sectional descriptive study, which was conducted retrospectively, consists of all health-care workers who applied to the Occupational Health and Safety Department of the hospital between September 1, 2022, and December 31, 2022, for periodic examination. The files of 1652 health-care workers were examined without selecting the sample and these individuals were included in the study. “Annex 2 form,” which was delivered to the employees, was used as a data source in the research. Statistical analyses were performed by Statistical Package for the Social Sciences Statistics software (SPSS Inc.; Chicago, IL, USA), version 15.0.

RESULTS: In our study, the immunity against hepatitis B in the 18-29 age group, women, singles, and university graduates was statistically significantly higher, and the immunity against hepatitis A of the participants aged 50 and over, men, and primary school graduates was statistically significant and was found to be significantly higher (P <.05).

CONCLUSION: The fact that 90.2% of the participants were immune to hepatitis B and 85.0% of the participants were immune to hepatitis A seems to be related to the success of vaccination programs for health-care workers in our country. It is very important that the immunization status of health-care workers, who are in the high-risk group in terms of infectious diseases, is at the desired level.

PMID:39128071 | DOI:10.5152/eurasianjmed.2024.23110