Tag: nevin manimala

Res Sq [Preprint]. 2025 Sep 24:rs.3.rs-7643216. doi: 10.21203/rs.3.rs-7643216/v1.

ABSTRACT

Background: Substantial variability in individual responses to intermittent theta-burst stimulation (iTBS) limits its clinical efficacy, yet neurophysiological predictors underlying this variability remain unclear. While most machine-learning (ML) studies have focused on modeling behavioral or clinical effects of repetitive transcranial magnetic stimulation (rTMS), the few studies examining neurophysiological outcomes have typically utilized limited feature sets in single-visit settings, which captured only inter-subject variability and most importantly lacked independent validation sets. Methods: To address these gaps, we first employed statistical and reliability analysis to understand the statistical relationship between resting state EEG and responses to iTBS. Next, we employed supervised machine learning models that integrated baseline resting-state EEG (rsEEG) features and transcranial magnetic stimulation (TMS)-evoked measures, including motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs), to predict neurophysiological responses to a single iTBS session applied over the primary motor cortex in two independent test-retest studies of healthy adults. Results: Internal cross-validation within the training cohort yielded promising performance (accuracy: 81%), identifying coarse-grained multiscale distribution entropy of rsEEG as the most robust predictor of local cortical excitability changes indexed by the 100-131ms window of TEPs. However, predictive performance markedly declined upon external validation (accuracy: 69%), reflecting unstable relationships between predictors and outcomes likely driven by substantial intra- and inter-individual variability of iTBS-induced changes in neurophysiological outcomes. Conclusions: These findings emphasize that while EEG complexity measures can capture baseline brain states relevant for neuromodulation to a certain degree, the inherent instability of single-session iTBS effects significantly constrains model generalizability and underscores the necessity of test-retest paradigm to avoid overly optimistic performance estimates. Future studies with multi-session and individualized stimulation protocols are urgently needed to better characterize neurophysiological mechanisms underlying rTMS effects and ultimately enhance its therapeutic potential.

PMID:41041549 | PMC:PMC12486114 | DOI:10.21203/rs.3.rs-7643216/v1

Can J Infect Dis Med Microbiol. 2025 Sep 24;2025:8860382. doi: 10.1155/cjid/8860382. eCollection 2025.

ABSTRACT

Objective: Aimed to analyze the relationship between air pollution and Mycoplasma pneumoniae (MP) infection in children in Chengdu. Method: Data on outpatient and inpatient cases of MP infection among children at Chengdu Women and Children’s Central Hospital from 2019 to 2023 were retrospectively collected. Air pollution and meteorological data from the same period were also obtained. A generalized additive model (GAM) was established using R statistical software to examine the impact of different air pollutant concentrations on MP infection incidence in children. The relationship between pollutant concentrations and MP infection rates was further analyzed by stratifying data by age, sex, and season. Results: From 2019 to 2023, a total of 21,075 outpatient and emergency cases and 6964 inpatient cases of MP infection were reported among children at Chengdu Women and Children’s Central Hospital. A 10-μg/m³ increase in the daily concentration of particulate pollutants (PM_2.5, PM₁₀) had the most significant delayed effect on outpatient MP infection incidence at a 6-day lag (lag 06), although the cumulative lag effect was not statistically significant. When the average daily concentration of gaseous pollutants (SO₂) increased by 10 μg/m³, the strongest lag effects on outpatient and inpatient MP infections were observed at 7-day lags (lag 07 and lag 7, respectively). In the single air pollutant model, age-stratified analysis showed that SO₂ concentration had the most significant correlation with the incidence of outpatient and inpatient MP infections in children under 6 years of age, while nitrogen dioxide (NO₂) concentration had the most significant correlation in children over six. Sex-stratified analysis indicated that SO₂ levels were most significantly associated with MP infection in males, whereas NO₂ were most strongly correlated in females. Among outpatients, SO₂ had the most substantial effect on MP infection incidence across sexes. Seasonal stratification revealed that the impact of air pollution on MP infection was greater in autumn and winter than in spring and summer. Conclusion: Increased air pollution levels in Chengdu from 2019 to 2023 had a measurable impact on MP infection incidence in both inpatient and outpatient children, with notable lag and cumulative lag effects. These effects were more pronounced in autumn and winter, highlighting the need for targeted early warning systems to monitor air pollutant concentrations. Such efforts could play a crucial role in protecting vulnerable populations and reducing MP infection risks in children.

PMID:41041510 | PMC:PMC12488315 | DOI:10.1155/cjid/8860382

Phys Imaging Radiat Oncol. 2025 Aug 21;35:100827. doi: 10.1016/j.phro.2025.100827. eCollection 2025 Jul.

ABSTRACT

BACKGROUND AND PURPOSE: Subcutaneous implantable cardioverter defibrillators (S-ICDs) are increasingly used to prevent sudden cardiac death. Due to their placement near the left lateral and apical myocardium, S-ICDs can present technical challenges for stereotactic arrhythmia radioablation (STAR) of ventricular tachycardia. This study aimed to evaluate the feasibility of STAR in patients with S-ICDs.

MATERIALS AND METHODS: Previously acquired cardiac computed tomography data from ten S-ICD patients were retrospectively analyzed. Organs at risk, S-ICD components, and hypothetical planning target volumes (PTV) for segments 8 (septal), 11 (lateral), and 17 (apical) were contoured. For each patient and segment, two treatment plans were calculated with a prescribed PTV dose of 25 Gy: one plan sparing the S-ICD from the primary radiotherapy beam (‘spared’) and one without this constraint (‘non-spared’).

RESULTS: The S-ICD was successfully spared from the primary beam in 27 out of 30 plans, with D _0.035cm ³ < 1 Gy. In three spared plans (PTV segment 11) with a distance between PTV and S-ICD <4 cm, D _0.035cm ³ exceeded 1 Gy. Spared plans for PTV segment 11 showed significant higher dose/volume metrics and reduced plan quality compared to non-spared plans (p < 0.05), although 9/10 plans remained clinically acceptable. For PTV segment 8 and segment 17, no clinical or statistical differences were observed.

CONCLUSIONS: The presence of an S-ICD is not a contraindication for STAR, although plan quality may decrease with PTVs in lateral segments. Rare cases with a distance between PTV and S-ICD <4 cm may complicate radiation treatment planning.

PMID:41041508 | PMC:PMC12486173 | DOI:10.1016/j.phro.2025.100827

Prog Rehabil Med. 2025 Oct 2;10:20250025. doi: 10.2490/prm.20250025. eCollection 2025.

ABSTRACT

OBJECTIVES: Assessment of quality of life (QOL) is essential in evaluating rehabilitation outcomes for individuals with lower limb amputation (LLA). However, there are few longitudinal studies of QOL over extended periods. This study reports the findings of a third QOL survey conducted in 2021 using the Japanese version of the Prosthetic Evaluation Questionnaire (PEQ-J), following previous surveys in 2003 and 2011.

METHODS: The survey targeted 254 individuals with LLA who had received prosthetic limbs from our center. Questionnaires were mailed, and responses were analyzed using the PEQ-J. Results were compared with those from previous surveys. The Mann-Whitney U test was used to assess statistical significance.

RESULTS: Responses were received from 129 participants (response rate: 51%): 101 males and 28 females, with a mean age of 62.8 ± 14.8 years. Causes of amputation were trauma (n=83), disease (n=44), and others (n=2). The present survey had more older participants than the previous surveys. Fifty-seven individuals responded to both the 2011 and 2021 surveys. The most notable changes were observed in psychological domains. Sex-based differences in “Perceived Response” observed in 2011 were not present in 2021. Moreover, differences in “Frustration” and “Social Burden” related to time since amputation were no longer observed.

CONCLUSIONS: Our findings suggest that psychological adaptation may evolve over time, reducing disparities previously associated with sex and amputation duration. Advanced prosthetics and the Tokyo 2020 Paralympic Games may have effected improvements in QOL in individuals with LLA.

PMID:41041507 | PMC:PMC12484563 | DOI:10.2490/prm.20250025

J Food Sci Technol. 2025 Nov;62(11):2132-2142. doi: 10.1007/s13197-024-06154-2. Epub 2024 Dec 13.

ABSTRACT

A cross-sectional survey research design was chosen to explore the degree of acceptance of Malaysian consumers from various demographic backgrounds towards migratory locust-based food products by using the Food Neophobia Scale (FNS), Insect Phobia Scale (IPS), and Willingness to Consume (WTC) migratory locust-based food products scale. This study chose migrant locusts (Locusta migratoria) due to their high protein content and potential to obtain Halal certification and sustainable production. In this study, 326 questionnaires were distributed online using non-probability sampling methods among Malaysian consumers. The results showed that average mean values for total FNS, IPS, and WTC scores were 35.73 out of 70, 31.05 out of 42, and 4.27 out of 7, respectively. In addition, the correlations between FNS and IPS scores towards WTC scores showed a negative correlation, with the IPS-WTC (- 0.399) correlation being stronger than FNS-WTC (- 0.216). Regarding demographic background, statistically significant variables for total FNS and IPS scores were limited to age group and gender. Overall, it can be concluded that most respondents hold a neutral stance towards introducing migratory locust-based food products in Malaysia, with entomophobia being the most probable reason for consumers’ rejection of migratory locust-based food products.

PMID:41041494 | PMC:PMC12484482 | DOI:10.1007/s13197-024-06154-2

Int J Cardiol Cardiovasc Risk Prev. 2025 Aug 19;27:200493. doi: 10.1016/j.ijcrp.2025.200493. eCollection 2025 Dec.

ABSTRACT

INTRODUCTION: Pheochromocytoma is a catecholamine-producing tumor, that may alter cardiovascular activity. Conveniently, sympathovagal activity can be measured non-intrusively and pain-free through heart rate variability (HRV).

OBJECTIVE: To conduct a systematic review and meta-analysis on the impact of pheochromocytoma on HRV parameters.

METHODS: PubMed, Cochrane, Embase and Google Scholar were searched until October 10, 2024 for articles reporting HRV parameters in pheochromocytoma patients. Random-effects meta-analysis were conducted on each HRV parameters stratified on pheochromocytoma patients and controls and then comparing these two groups: RR intervals (or Normal-to-Normal intervals-NN), SDNN (Standard Deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50 ms of variation), LF (low-frequency) and HF (high-frequency), and LF/HF.

RESULTS: We included six studies for a total of 178 patients: 94 with pheochromocytoma and 84 controls. Compared to controls, pheochromocytoma patients had higher vagal activity with higher HF (ES = 0.50, 95CI 0.04 to 0.96) and rMSSD (1.22, 0.09 to 2.35), and a tendency for higher pNN50 (1.14, -0.14 to 2.41). The sympathovagal balance tended to be higher in pheochromocytoma patients compared to controls with a tendency for a decreased LF/HF (-0.97, -2.03 to 0.09). Pheochromocytoma patients also tended to have lower RR-intervals than controls (-0.39, -0.86 to 0.07). Sympathetic activity (LF and SDNN) did not differ between pheochromocytoma and controls.

CONCLUSION: Paradoxically, pheochromocytoma patients have higher HRV. The sympathovagal balance may be explained by a desensitization of beta-adrenergic receptors consecutive to chronic high levels of catecholamine.

PMID:41041488 | PMC:PMC12485537 | DOI:10.1016/j.ijcrp.2025.200493

Front Oral Health. 2025 Sep 17;6:1539018. doi: 10.3389/froh.2025.1539018. eCollection 2025.

ABSTRACT

INTRODUCTION: Effective pain management techniques are fundamental for enhancing patients’ adherence to various pediatric dental procedures.

OBJECTIVE: This study aims to evaluate the effectiveness of virtual reality (VR) on pain perception during dental procedures in children.

METHODOLOGY: Children aged between 5 and 12 years were recruited from a pediatric dental clinic. Ethical approval and informed consent were obtained from all parents or guardians. The need for different dental procedures was determined for each child based on the outcome of a clinical examination. Some of these procedures require local anesthesia (LA) administration, while others do not. The children were randomly assigned to either a VR or a non-VR group. Three behavioral scales, the Visual Analogue Scale (VAS), the Wong-Baker FACES Pain Rating Scale, and the “Face, Legs, Activity, Cry, and Consolability” (FLACC) Scale, were used to assess the pain level during dental procedures.

RESULTS: A total of 154 children were recruited and evenly divided into VR and non-VR groups (77 each). The results of the study indicated that utilizing VR during dental procedures resulted in a significant reduction in pain perception (p < 0.05) and doubled the level of relaxation experienced by patients (70.31%), irrespective of anesthesia requirements. Statistical analysis revealed a significant difference between the VR and anesthesia groups across all VAS and Wong-Baker FACES variables.

CONCLUSION: This research has confirmed that using virtual reality (VR) as a distraction technique effectively reduces pain during dental procedures for children. VR is a safe, non-invasive, and user-friendly technique that has gained interest as a non-pharmacological option for pain management. As a result, this promising approach has the potential to be used in clinical practice and should be further researched.

PMID:41041487 | PMC:PMC12486600 | DOI:10.3389/froh.2025.1539018

Front Med (Lausanne). 2025 Sep 17;12:1644446. doi: 10.3389/fmed.2025.1644446. eCollection 2025.

ABSTRACT

INTRODUCTION: National Regulatory Authorities have the responsibility of ensuring that pharmaceutical manufacturers comply with Good Manufacturing Practices (GMP) to ensure that medicinal products are consistently produced according to quality standards. Since July 2016, the EAC National Medicines Regulatory Authorities (NRAs) have been collaborating to conduct joint Good Manufacturing Practice (GMP) inspections. This study was conducted to (a) assess the joint GMP inspection procedure, (b) determine key milestones and target timelines, (c) identify areas of improvement and opportunities for capacity building, and (d) identify the contribution of the EAC joint GMP inspections in the operationalization of the African Medicines Agency (AMA).

METHODS: A retrospective review of the timelines for joint GMP inspections conducted from 2016 to 2022 was performed using data recorded in the EAC metric tool. Data is captured based on key milestones, including screening, scheduling joint GMP inspections, planning for joint GMP inspections, conducting physical inspections, reviewing GMP documentation, writing inspection reports, peer reviewing inspection reports, reviewing CAPAs, communicating with applicants, and issuing GMP compliance certificates. JMP was used as the statistical software to analyze the main milestones of the EAC joint GMP inspection process. The study also looked into the twinning model and joint inspections for capacity building among NRAs.

RESULTS: Results indicated that a total of 37 pharmaceutical manufacturing facilities, located in Africa, Asia, and Europe, were jointly inspected (35 physical inspections and two desk reviews) between 2016 and 2022. The inspected facilities manufacture vaccines, non-beta-lactam tablets/capsules, sterile products, and other biologicals. Of the 37 facilities inspected, 65% (24) met EAC GMP standards and received a certificate of compliance, valid for 3 years. 8% (3) of the facilities inspected between 2018 and 2022 failed to meet GMP standards and were advised to apply for reinspection. Two facilities have not submitted corrective and preventive action (CAPA) since 2016, and three facilities have not submitted one since 2022. The study further revealed that one facility is pending joint inspection, one has been awaiting CAPA review since 2019, and one with a CAPA is still under review. Two facilities scheduled for physical inspection in 2020 could not be inspected due to COVID-19 travel restrictions. Timelines for key milestones of the joint GMP inspection process showed that overall scheduling of joint GMP inspections took more than 14 workdays, such as 57 days in 2018, 24 days in 2019, 43 days in 2020, and 28 days in 2022. Median times for planning EAC joint GMP inspections aligned with the set timelines of 30 days; however, in 2017, the median duration was 40 days. All physical inspections conducted between 2016 and 2022 were completed within the median timeline of 3 days. Nonetheless, the median time for GMP report writing in 2016 was 16 days, slightly exceeding the established timeline of 14 days. Findings also indicated that manufacturing facilities (Applicants) take a lengthy time to submit CAPA, which should be done within 90 days. Median submission times for CAPA were 135 days in 2018 and 125 days in 2019. In 2022, notable improvements were observed, with applicants submitting CAPA in a median time of 49 days.

DISCUSSION: EAC GMP inspections have served as a model for building capacity in lessresourced NRAs through the twinning program. The joint inspections are carried out by two inspectors from more experienced National Regulatory Authorities (NRAs) and one inspector from less-resourced NRAs. These NRAs benefit from learning and gaining practical skills, while also building confidence and trust among themselves. This model is suitable for adoption at the continental level by the African Medicines Agency and the African Medicines Regulatory Harmonization Programme to support reliance, convergence, and harmonization. The study identified several gaps, including incomplete data in the metric tool and a lack of monitoring and recording timelines for joint GMP desk assessments. Based on the findings, the EAC region needs to establish an annual planning mechanism for joint GMP inspections and update the metric tool to include key milestones and timelines for the joint GMP desk assessment process. Enhancing the stakeholders’ feedback mechanism is also essential for reducing delays in submitting corrective and preventive actions (CAPA) from facilities and shortening timelines for the joint regulatory inspection process.

PMID:41041458 | PMC:PMC12484000 | DOI:10.3389/fmed.2025.1644446

Front Med (Lausanne). 2025 Sep 17;12:1671323. doi: 10.3389/fmed.2025.1671323. eCollection 2025.

ABSTRACT

BACKGROUND: Red cell distribution width (RDW) has been investigated as a clinical predictor in different study populations. However, its prognostic usefulness in medical and surgical intensive care units remains unknown. This study investigates the role of RDW as a prognostic factor in this specific patient population.

OBJECTIVE: This study examined the relationship between red cell distribution width and other blood parameters as a prognostic indicator among patients treated in medical and surgical ICU.

METHODS: This study is observational in type and its sample consisted of n = 197 patients treated in the medical and surgical ICU (msICU) of a public hospital of Istanbul and during 2023. In this study, personal characteristics (age, gender etc.), clinical characteristics (comorbidity, presence of catheters, length of stay etc.) and clinical/laboratory blood parameters (the RDW coefficient of variation (CV), C reactive protein (CRP), albumin, platelet (PLT) etc.) of msICU patients were analyzed. The relationship between clinical/laboratory parameters was examined using the Pearson correlation test, and changes in RDW values according to patient characteristics were examined using ANOVA and independent sample t-tests.

RESULTS: In this study a positive, strong and statistically significant relationship existed between RDW and lactate (r = 0.704, p = 0.004) and CRP (r = 0.759, p = 0.026), and creatinine (r = 0.729, p = 0.001). It was reported that a negative, weak and statistically significant relationship existed between RDW and albumin (r = -0.172, p = 0.015) and PLT (p = -0.169, p = 0.011). The patient characteristics such as inotropic and vasopressor use, multiple comorbidities, APACHE II score, and surgical experience were factors that increased RDW levels (p < 0.05). Patients in the postoperative period and patients with pressure sores had higher RDW values and these differences were statistically significant (p < 0.05).

CONCLUSION: As a result of this study, RDW level was associated with levels of lactate, CRP, albumin, platelet and creatinine among patients in the medical and surgical ICU. The patients with chronic wounds, comorbidities, and/or certain medications and in deceased patients, were associated with increased RDW. RDW may be a useful marker as a prognostic criterion to validate clinical status.

PMID:41041442 | PMC:PMC12484200 | DOI:10.3389/fmed.2025.1671323

Orthop Rev (Pavia). 2025 Sep 29;17:144737. doi: 10.52965/001c.144737. eCollection 2025.

ABSTRACT

BACKGROUND: Osteogenesis Imperfecta (OI) is a rare genetic bone disorder that has attracted increasing scientific attention. Bibliometric analysis offers insights into the intellectual structure and evolution of this field. This study aimed to identify and evaluate the most highly cited articles on OI to highlight influential contributors, leading journals, and major research trends.

METHODS: A bibliometric search was conducted in the Web of Science Core Collection using the terms “Osteogenesis Imperfecta” and “Brittle Bone Disease.” The search was restricted to English- language original and review articles published between 2000 and 2024. The 50 most cited articles were selected and analyzed based on citation metrics, journal impact factors, author contributions, institutional affiliations, and collaboration patterns. Statistical analyses were performed using SPSS version 25.0.

RESULTS: The United States produced the highest number of publications, followed by the United Kingdom and Germany. The most cited article, published by Rauch et al. (2004), received 950 citations. The Journal of Bone and Mineral Research and The American Journal of Human Genetics were the most prolific journals in this domain. Observational studies and genetic investigations dominated the top-cited works. Collaboration networks revealed strong interconnections among North American and European institutions, while keyword analysis highlighted growing research interest in gene therapy, molecular diagnostics, and precision medicine.

CONCLUSION: This bibliometric analysis identified the most influential contributions in OI research, underscoring the role of key authors, journals, and international collaborations. It also revealed major trends in genetic and clinical studies while highlighting emerging areas such as gene therapy and precision medicine as promising directions for future research.

PMID:41041436 | PMC:PMC12488073 | DOI:10.52965/001c.144737