Tag: nevin manimala

J Nutr Educ Behav. 2025 Oct 28:S1499-4046(25)00427-0. doi: 10.1016/j.jneb.2025.09.004. Online ahead of print.

ABSTRACT

OBJECTIVE: To describe the intervention and research methods of the Teacher Education and Classroom Habits (TEACH) study, a social cognitive theory-based virtual nutrition intervention program for Montessori teachers to enhance teachers’ personal and classroom nutrition beliefs and behaviors.

DESIGN: This 12-week study will employ a cluster-randomized control design with a delayed intervention for the control group.

SETTING: Montessori schools across the US with early childhood programs.

PARTICIPANTS: Early childhood teachers will be recruited from approximately 29 Montessori schools across the US and randomized at the school level.

INTERVENTION: The TEACH study will provide culturally focused nutrition education for Montessori teachers over 6 weeks, consisting of 4 program components, including an interactive online platform, live virtual education sessions, a Montessori-based nutrition curriculum, and parent education handouts.

MAIN OUTCOME MEASURES: Using validated survey measures, changes in teachers’ nutrition knowledge, nutrition self-efficacy, nutrition teaching self-efficacy, cultural competence, classroom eating behaviors, classroom food practices, nutrition teaching practices, and teacher-parent communication will be assessed at 3 timepoints (i.e., baseline, week 6, and week 12).

ANALYSIS: Stepwise linear regressions will be used to assess relationships between baseline variables. Multilevel modeling will be used to determine the impact of the intervention. Statistical significance set at P ≤ 0.05.

PMID:41159997 | DOI:10.1016/j.jneb.2025.09.004

J Hand Surg Am. 2025 Oct 28:S0363-5023(25)00473-3. doi: 10.1016/j.jhsa.2025.08.017. Online ahead of print.

ABSTRACT

PURPOSE: Open reduction and internal fixation (ORIF) of distal humerus fractures (DHFs) has nearly identical work relative value unit (wRVU) compensation compared with distal radius fractures (DRFs). The purpose of this study was to compare perioperative work effort, surgical times, complications, and the frequency of postoperative follow-up care for ORIF DRF and DHF cases.

METHODS: All isolated cases of ORIF DHF and intra-articular DRF in adult patients between 2010 and 2024 from a single, large health care system were reviewed. Baseline demographics, surgical characteristics, complications/reoperations, and postoperative visits/communication were recorded. Work relative value units per minute of surgery (wRVU/min) were calculated for each case relative to their current procedural terminology (CPT) codes and assigned wRVUs: (1) CPT 24545: ORIF extra-articular DHF (13.15 wRVU), (2) CPT 24546: ORIF intra-articular DHF (14.91wRVU), (3) CPT 25608: ORIF intra-articular DRF, two fragments (11.07 wRVU), and (4) CPT 25609: ORIF intra-articular DRF, ≥3 fragments (14.38 wRVU). A 1:1 matched cohort was constructed to make comparisons between groups.

RESULTS: A total of 75 DHF and 74 DRF cases were included. Baseline demographics were similar. Distal humerus fractures had significantly longer mean surgical times (183 minutes) compared with DRFs (92 minutes). Distal humerus fracture cases had a mean wRVU/min of 0.093/min compared with DRF (0.154/min), and this difference was statistically significant. Distal humerus fracture cases also demonstrated significantly higher complication/reoperation rates (23% and 21%) compared with DRFs (6.8% and 6.8%). Both groups had similar frequencies of postoperative visits (mean = 3.0), and ORIF DHF cases had significantly more postoperative phone calls (mean = 2.6) compared with DRF cases (mean = 1.0).

CONCLUSIONS: Considering the longer surgical times and complication rates, upper-extremity surgeons are not proportionally compensated from a wRVU perspective for DHF management compared with DRFs.

CLINICAL RELEVANCE: These data should be used in future analyses and advocacy efforts related to wRVU adjustments for DHFs.

PMID:41159988 | DOI:10.1016/j.jhsa.2025.08.017

Microbiol Resour Announc. 2025 Oct 29:e0017425. doi: 10.1128/mra.00174-25. Online ahead of print.

ABSTRACT

We report an updated draft genome sequence of Streptomyces sp. isolate H28, a melanin-producing bacterium recovered from the sediments of Meycauayan River, Philippines. The improvement in sequencing methodology is reflected in the reported statistics. The new sequence data is highly useful for future exploration given the melanogenesis of the bacterium.

PMID:41159971 | DOI:10.1128/mra.00174-25

Eur J Psychotraumatol. 2025 Dec;16(1):2571252. doi: 10.1080/20008066.2025.2571252. Epub 2025 Oct 29.

ABSTRACT

Background: Forced displacement is globally increasing, with children and adolescents being particularly affected. Exposure to armed conflict, the flight itself and challenges of settling in new environments put them at risk of experiencing potentially traumatic events and developing mental health problems, such as post-traumatic stress disorder (PTSD) and depression. Still, limited information is available regarding the traumatic experiences, psychological stress and treatment goals of treatment-seeking refugee children and adolescents.Methods: This cross-sectional study evaluated data from refugee minors seeking treatment at an Outpatient Health Care Center for Refugee Children in Germany. The standard diagnostic procedure included assessing sociodemographic characteristics, traumatic experiences before, during and after flight and mental health problems, including the diagnosis of PTSD and depression. Treatment goals were also examined.Results: From October 2016 to December 2023, a total of 716 refugee minors participated in the study. They were on average 15.13 years old, 56.3% of the sample were unaccompanied, and 72.1% were male. Most participants were from Afghanistan and Syria. Repeated interpersonal violence was frequently experienced in the home country (65.5%), during flight (59.3%), and in Germany (13.7%). The majority of children and adolescents fulfilled the diagnostic criteria of PTSD (57.8%), and the prevalence of depressive episodes was 44.2%, with a comorbidity rate of 35.9%. The majority of refugee minors identified specific treatment goals, particularly for reducing trauma-related symptoms such as negative thoughts, sleep issues, and nightmares.Conclusions: Our findings provide novel data on the mental health problems, pre-, peri- and post-migration traumatic experiences and treatment expectations in a treatment-seeking sample of refugee minors. The findings highlight the importance of developing trauma-focused interventions and improving clinicians’ skills to address effects of complex, potentially ongoing, traumatic experiences and to tailor treatment to personal treatment goals. This is essential for providing high quality care for refugee minors.

PMID:41159958 | DOI:10.1080/20008066.2025.2571252

Eur J Public Health. 2025 Oct 29:ckaf175. doi: 10.1093/eurpub/ckaf175. Online ahead of print.

ABSTRACT

Dental and periodontal infections can lead to serious systemic complications through bacterial dissemination. While global awareness of these risks is increasing, data on the incidence and outcomes of such complications remain limited. This study aims to quantify the incidence of serious extraoral infectious complications associated with dental infectious foci, using dental procedures as markers of active oral infection, in the Czech Republic between 2010 and 2022. A retrospective analysis was conducted using data from the National Register of Reimbursed Health Services. Patients who underwent invasive dental procedures indicating active dental/periodontal infection and were hospitalized for severe infectious conditions within 7 days were identified. This temporal criterion captured both cases where dental procedures preceded systemic spread and cases where dental foci were identified during workup for serious infections. Descriptive statistics and linear regression analysed incidence rates and temporal trends. Among 15 098 093 dental procedures over 13 years, annual hospitalizations for associated infectious complications ranged from 855 to 1252 cases. Overall incidence was 12.82 per 100 000 population annually. Oral region complications (cellulitis, abscesses, osteomyelitis) were most common (9.48 per 100 000), followed by systemic complications (sepsis and endocarditis) (2.89 per 100 000). Significant increasing trends were observed for jaw periostitis (P = .006), endocarditis (P < .001), and central nervous system abscesses (P = .027), while acute sinusitis declined (P < .001). This population-based analysis reveals a substantial incidence of serious infectious complications associated with dental infectious foci, with concerning increasing trends in potentially life-threatening conditions. These findings emphasize the importance of preventive dental care and early intervention strategies.

PMID:41159935 | DOI:10.1093/eurpub/ckaf175

Aging Male. 2025 Dec 11;28(1):2568729. doi: 10.1080/13685538.2025.2568729. Epub 2025 Oct 29.

ABSTRACT

OBJECTIVE: To systematically compare the efficacy and safety of medications in elderly with overactive bladder.

METHODS: Pubmed, Embase, Web of Science, and the Cochrane Register of Clinical Trials databases were systematically searched from database inception to July 25, 2023, and randomized, controlled, double-blind trials for overactive bladder in the elderly were screened according to the protocol. Data were analyzed using Stata17.0.

RESULTS: In terms of reducing Micturitions, the interventions were ranked: trospium chloride (TRO), fesoterodine (FES) 4/8 mg, vibegron (VIB), mirabegron (MIR) 25/50 mg, tolterodine ER (TOL) 4 mg, placebo (PBO), of which only TOL showed no significant difference compared to placebo; Forsafety, the TEAE of TOL 4/8 mg had the highest incidence and was significantly different from others; MIR, VIB, and FES 4mg were well-tolerated regarding dry mouth and constipation; TOL 4 mg, FES 4/8 mg, and VIB showed a statistically increase from placebo for headache and FES 4/8mg and MIR 25 mg showed a statistically increase for dizziness.

CONCLUSIONS: TRO 60 mg has the best efficacy in reducing micturitions, but increases the incidence of dry mouth and constipation; VIB and MIR are well tolerated in dry mouth and constipation, but may increase the risk of headache or dizziness.

PMID:41159930 | DOI:10.1080/13685538.2025.2568729

J Health Organ Manag. 2025 Oct 30:1-19. doi: 10.1108/JHOM-10-2024-0416. Online ahead of print.

ABSTRACT

PURPOSE: To determine the relationship between nursing care satisfaction levels and nursing image perceptions of patients hospitalized in inpatient units of a university hospital.

DESIGN/METHODOLOGY/APPROACH: This is a descriptive, correlational and cross-sectional study. The study data were collected from 610 patients hospitalized in the inpatient units of a university hospital with the Introductory Information Form, Patient Perception of Hospital Experience with Nursing Care and the Nursing Image Scale. Descriptive analyses, independent groups t-test, one-way analysis of variance, Mann-Whitney U test, Kruskal-Wallis test and Spearman correlation analysis were employed in the analysis of the data.

FINDINGS: It was determined that the Nursing Image Scale scores differed statistically significantly according to the participants’ age, education level, state of thinking that they received quality nursing care and nursing image perception of the participants. It can be stated that the satisfaction of the patients participating in the study with the nursing care provided is high, and the nursing image they perceive is at a high level and positive. A positive and significant relationship was found between the participants’ nursing care satisfaction levels and their perceptions of nursing image (r = 0.502, p < 0.01).

ORIGINALITY/VALUE: The results of the study are very important in terms of showing the effect of the image of nursing not only in terms of the development of the profession but also on the perception of the care provided. It is recommended that health institutions and managers determine more strategies in this regard because it affects the preferability of their institutions and the satisfaction of the care provided.

PMID:41159922 | DOI:10.1108/JHOM-10-2024-0416

Expert Rev Proteomics. 2025 Oct 29. doi: 10.1080/14789450.2025.2580647. Online ahead of print.

ABSTRACT

INTRODUCTION: Recent advances in multi-omic technologies and computational tools have enabled comprehensive studies of cancer that integrate proteomics, genomics, transcriptomics, and metabolomics to improve disease understanding and outcomes.

AREAS COVERED: 1. Recent improvements in throughput and decreasing sample mass requirements have enabled deep analysis of hundreds of human samples in multi-omic studies, increasing the statistical rigor of these studies and facilitating comparisons across clinical and demographic categories.2. Despite advances in statistical modeling, machine learning, and pathway-aware analysis, the principal outcome from these observational studies remains correlational – strong statistical associations between omic features and clinical characteristics, including clinical outcomes.3. Demonstration of causal relationships requires multi-pronged mechanistic experiments involving techniques in molecular and cellular biology that are distinct from the analytical and computational skills needed to generate these datasets.Database used: National Library of Medicine PubMed database.

EXPERT OPINION: True clinical utility depends on the demonstration of causal relationships between candidate targets and the biomedical process of interest. Enhanced collaboration with molecular and cellular biologists skilled in the use of modern tools of genetic manipulation and engineered model systems is required to realize the full translational potential of even the most comprehensive multi-omic studies.

PMID:41159901 | DOI:10.1080/14789450.2025.2580647

J Periodontol. 2025 Oct 29. doi: 10.1002/JPER.24-0707. Online ahead of print.

ABSTRACT

BACKGROUND: A self-reported questionnaire developed by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) has demonstrated adequate reliability for evaluating periodontal status in national surveillance surveys–which has been translated and validated in multiple languages–but has not yet been tested in Thai. Therefore, this cross-sectional study evaluated the validity of the CDC/AAP self‑report questionnaire for periodontitis in a Thai population.

METHODS: The Thai version of CDC/AAP self-reported questionnaire was developed. Full-mouth periodontal examinations were performed, and periodontitis was diagnosed using CDC/AAP 2012 or European Federation of Periodontology (EFP)/AAP 2018 case definition. Association between questionnaire responses and a periodontitis diagnosis was assessed using multiple regression modeling. Several predictive models were constructed and their validity assessed using receiver operating characteristic curves.

RESULTS: The study included 250 participants resided in Chiang Mai, Thailand, aged 20-82 years, with 83.6% and 84.4% diagnosed with periodontitis based on CDC/AAP 2012 and EFP/AAP 2018 case definitions, respectively. CDC/AAP questions revealed a satisfactory performance in predicting CDC/AAP-defined severe periodontitis and EFP/AAP-defined stage III/IV periodontitis. Additional questions regarding demographic data and periodontal risk factors improved the performance. Reduced model constructed using stepwise regression yielded sensitivity versus specificity of 57.8% versus 84.0% and 79.4% versus 81.4% for predicting CDC/AAP-defined severe periodontitis and EFP/AAP-defined stage III/IV periodontitis, respectively.

CONCLUSIONS: The questionnaire in Thai version demonstrated better performance in predicting advanced stages of periodontitis when combined with demographic variables and periodontal risk factors. Our findings highlight the potential utility of this tool in diverse populations.

PLAIN LANGUAGE SUMMARY: Despite being one of the most common diseases in humans, periodontal disease diagnosis is not easy at the individual and surveillance levels. Efforts have been made to assemble tools to ease the process, and questionnaires are an auspicious tool. This study aimed to validate the self-reported questionnaire developed by the US Centers for Disease Control and Prevention in collaboration with the American Academy of Periodontology for predicting periodontal disease in the Thai population. The validity of the questionnaires was assessed by comparing the self-reported responses to the data collected through a full-mouth examination by a third-year resident from the Periodontology Residency Training Program. In our study, questions related to signs of the disease showed promising validity as a predictive variable for periodontitis, especially its severe form, and the questionnaires performed better when used together with other questions, such as age and education level.

PMID:41159894 | DOI:10.1002/JPER.24-0707

J Infect Dis. 2025 Oct 29:jiaf544. doi: 10.1093/infdis/jiaf544. Online ahead of print.

ABSTRACT

BACKGROUND: Schistosomiasis and malaria are major poverty-related parasitic infectious diseases. They are often co-endemic and affect similar target populations. Mass drug administration and intermittent preventive treatment programs are commonly used for their control. From a programmatic perspective the conception of preventive treatment programs targeting both diseases simultaneously would be a great advantage. While there is preliminary evidence that certain anti-malarial drugs exert a clinically important effect on Schistosomes, little is known on whether praziquantel (PZQ), the only licensed drug to treat schistosomiasis, has activity against Plasmodium parasites. Therefore, the CORMA-MAL study was conducted to evaluate anti-malarial activity of PZQ.

METHODS: This double-blinded, randomized, placebo-controlled phase IIb trial was conducted in Lambaréné, Gabon and recruited semi-immune adults with an asymptomatic P. falciparum parasitemia. Participants were randomized (1:1) to receive placebo or 40mg/kg PZQ once daily for three days and followed up for a total of seven days.

RESULTS: 44 participants were recruited. Analytical models indicated a highly significant hourly reduction of microscopically-determined parasitemia in the PZQ arm and a non-significant decreasing trend in the placebo group (regression slopes of log10-transformed parasitemia: β=-0.006 [p<0.001] and β=-0.0013 [p=0.3], respectively). However, in total only 9/22 (41%) in the PZQ arm compared to 6/22 (27%) in the placebo arm reached parasite clearance by D7.

CONCLUSIONS: Findings demonstrate a statistically significant anti-malarial activity of PZQ; however, the observed effect is only moderate compared to current first-line anti-malarial treatments. Future research should investigate the synergistic potential of combining PZQ and antimalarial drugs in malaria and schistosomiasis control.

TRIAL REGISTRATION: The trial was registered in the Pan African Clinical Trials Registry (PACTR); Registration number: PACTR202206584817951; Date of Approval: 10/JUN/2022; URL: https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=22586).

PMID:41159886 | DOI:10.1093/infdis/jiaf544