Tag: nevin manimala

Nanomedicine (Lond). 2025 Dec 12:1-17. doi: 10.1080/17435889.2025.2582466. Online ahead of print.

ABSTRACT

INTRODUCTION: This meta-analysis examined the antibacterial efficacy of Cerium Oxide Nanoparticles (CeO₂ NPs) through statistical analysis of published data.

METHOD: Following a comprehensive literature search and systematic screening, data were extracted and analyzed using STATA software to calculate pooled standard mean differences and effect sizes.

RESULTS: Analysis of data from 58 articles (218 experiments) demonstrated significant antibacterial activity. Analysis of 189 agar diffusion tests showed substantial effect (EF = 15.04; 95% CI = 14.793-15.277; p < 0.0001). Subgroup analysis revealed greater efficacy for particles larger than 50 nm and rod-shaped nanoparticles. CeO₂ NPs were effective against both Gram-positive (EF = 18.194) and Gram-negative (EF = 14.049) bacteria, including Escherichia coli and Staphylococcus aureus. Compared to conventional antibiotics, CeO₂ NPs were generally less effective (SMD = -2.846, p < 0.0001) but performed comparably to Amoxicillin, Streptomycin, Linezolid, and Clindamycin. MIC and CFU tests confirmed significant growth-inhibitory effects across multiple bacterial species.

CONCLUSION: CeO₂ NPs demonstrate significant broad-spectrum antibacterial activity, suggesting potential against antibiotic-resistant bacteria. Future research should explore synergistic effects with standard antibiotics.

PMID:41384286 | DOI:10.1080/17435889.2025.2582466

Res Rep Urol. 2025 Dec 6;17:481-493. doi: 10.2147/RRU.S568396. eCollection 2025.

ABSTRACT

PURPOSE: To evaluate survival outcomes and identify prognostic factors among bladder cancer patients.

PATIENTS AND METHODS: A total of 488 bladder cancer patients admitted between 2007 and 2017 were followed until December 31, 2020, using both active and passive follow-up. The Kaplan-Meier method was used to estimate observed survival (OS), with group comparisons performed using the Log rank test. Variables included sex, age group, number of hospital admissions, TNM stage, and geographic origin.

RESULTS: Of 488 patients, 485 (99.38%) were successfully followed. The majority were male (80.21%) with a mean age of 66.5 years. The average number of hospital admissions was 1.81. Overall 1-, 3-, 5-, and 10-year OS rates were 79.95%, 63.50%, 56.32%, and 45.54% for males, and 69.79%, 58.33%, 56.01%, and 56.01% for females, respectively (P = 0.697). Age significantly affected prognosis (P < 0.01), with 5-year OS declining from 66.67% (age ≤34) to 29.53% (≥80). Patients with ≥3 admissions had worse survival (44.87%) than those with one (61.93%) or two admissions (58.97%) (P < 0.01). TNM stage was strongly with survival: 5-year OS rates were 86.43% (Stage I), 55.48% (Stage II), 38.25% (Stage III), and 13.85% (Stage IV) (P < 0.01). Regional differences were not statistically significant (P > 0.05).

CONCLUSION: Advanced age and late-stage diagnosis were associated with poorer survival, while early-stage detection correlated with better outcomes. These findings underscore the importance of early screening, timely treatment, and comprehensive care strategies to improve bladder cancer survival, especially in resource-limited settings. Limitations include single-center design and absence of multivariate adjustment.

PMID:41384284 | PMC:PMC12691630 | DOI:10.2147/RRU.S568396

J Innov Card Rhythm Manag. 2025 Nov 15;16(11):6509-6519. doi: 10.19102/icrm.2025.16114. eCollection 2025 Nov.

ABSTRACT

Patients with heart failure (HF) may experience depression or anxiety due to various reasons associated with their or caregivers’ characteristics. The purpose of this study was to explore patients’ and caregivers’ characteristics associated with hospitalized HF patients’ anxiety and depression. A total of 300 hospitalized HF patients with their caregivers were enrolled in the study. Data were collected using the Hospital Anxiety and Depression Scale, which also included patients’ and caregivers’ characteristics. The statistical significance level was set at P < .05. A statistically significant association was observed between patients’ anxiety and age (P = .044), level of education (P = .015), type of diagnosis (P = .001), New York Heart Association (NYHA) class (P = .001), prior hospitalization within the current year (P = .013), current smoking (P = .001), frequency of physical exercise (P = .001), and their self-reported ability for symptom management after hospital discharge (P = .001). A statistically significant association was observed between patients’ depression and age (P = .018), type of diagnosis (P = .001), NYHA class (P = .001), prior hospitalization within the current year (P = .004), current smoking (P = .001), occasional alcohol consumption (P = .026), frequency of physical exercise (P = .001), and their self-reported ability for symptom management after hospital discharge (P = .001). In terms of caregivers’ characteristics, a statistically significant association was observed between patients’ anxiety/depression and the relationship with caregivers (P = .006 and P = .001, respectively), whether caregivers declared added responsibilities among family members (P = .041 and P = .002, respectively), and whether they felt uncertain about patients’ clinical outcome (P = .001 and P = .001, respectively). Finally, a statistically significant association was observed between patients’ depression and the occupation of their caregivers (P = .038). Patients’ characteristics associated with anxiety/depression were demographic and clinical, while caregivers’ characteristics associated with patients’ anxiety/depression were their self-reports and demographic characteristics. Knowledge of factors that influence anxiety and depression can enable health care professionals to offer appropriate interventions tailored to their needs.

PMID:41384283 | PMC:PMC12694892 | DOI:10.19102/icrm.2025.16114

Front Health Serv. 2025 Nov 26;5:1466958. doi: 10.3389/frhs.2025.1466958. eCollection 2025.

ABSTRACT

INTRODUCTION: The Affordable Care Act (ACA) represents the most comprehensive U.S. health reform since Medicare and Medicaid. However, evidence on its impact on population health in the general U.S. population, particularly mental health, remains limited.

METHODS: We analyzed a nationally representative sample of non-elderly adults aged 18-64 from the Medical Expenditure Panel Survey (2007-2019). Outcomes included two health-related quality of life (HRQOL) measures derived from the SF-12 v2: physical component summary (PCS) and mental component summary (MCS) scores. Using conditional-mean and quantile-regression difference-in-differences models, we examined the effect of the ACA by comparing pre-post changes in PCS and MCS scores among non-elderly adults relative to counterfactuals from TRICARE beneficiaries not subject to ACA provisions.

RESULTS: Our conditional-mean DID estimates indicate that the ACA was associated with a 2.7% increase in PCS scores among non-elderly adults during 2011-2013. Although statistically insignificant, MCS scores exhibited increases of growing magnitude following the implementation of the major ACA major provisions in 2014. Notably, simultaneous-quantile DID estimates suggest that the increases in PCS and MCS scores attributable to the ACA were concentrated among individuals with relatively lower health levels, particularly those around the 30th to 60th percentiles of the score distributions.

DISCUSSION: Findings indicate that the ACA led to measurable gains in physical and mental health, particularly among relatively lower-middle levels of physical and mental health. Policymakers assessing the value of the ACA, or more generally debating the value of expanding access to health insurance in the population, should consider these positive gains in population health.

PMID:41384265 | PMC:PMC12689885 | DOI:10.3389/frhs.2025.1466958

Dent Res J (Isfahan). 2025 Nov 25;22:46. doi: 10.4103/drj.drj_428_24. eCollection 2025.

ABSTRACT

BACKGROUND: This study aimed to synthesize mesoporous zinc oxide nanoparticles (ZnO NPs) and evaluate their effect as dentin pretreatments on the microshear bond strength (μSBS) of a universal adhesive.

MATERIALS AND METHODS: This in vitro experimental study used 100 extracted human molars sectioned to expose mid-coronal dentin. Samples were divided into five groups (n = 20) based on pretreatment: no treatment, chlorhexidine (CHX), calcined mesoporous ZnO NPs, noncalcined mesoporous ZnO NPs, and ZnO NPs. Each group was subdivided into two subgroups (n = 10) based on the universal adhesive application mode: etch-and-rinse (E and R) or self-etch (SE). Pretreatments were applied for 1 min. Composite resin was bonded using a universal adhesive. After 24 h of storage in distilled water at 37°C, μSBS testing was performed. Statistical analysis included the Shapiro-Wilk test for normality, two-way analysis of variance with Tukey’s post hoc test, and t-tests, with significance set at P < 0.05.

RESULTS: The noncalcined mesoporous ZnO NP group showed the highest μSBS, followed by the ZnO NP group, with significant differences compared to other groups (P < 0.05). Lower μSBS values were observed in the calcined mesoporous ZnO NP, CHX, and untreated groups. The adhesive application mode had a significant effect only in the untreated and calcined mesoporous ZnO NP groups (P < 0.05), with SE yielding higher μSBS than E and R.

CONCLUSION: Noncalcined mesoporous ZnO NPs enhanced dentin bond strength more effectively than other pretreatments, including CHX, indicating their potential as a promising alternative in adhesive dentistry.

PMID:41384264 | PMC:PMC12694918 | DOI:10.4103/drj.drj_428_24

Dent Res J (Isfahan). 2025 Nov 25;22:43. doi: 10.4103/drj.drj_319_24. eCollection 2025.

ABSTRACT

BACKGROUND: Bone remodeling is essential for orthodontic tooth movement. Techniques such as micro-osteoperforation (MOP) and vibration have been introduced to accelerate treatment by stimulating biological responses.

MATERIALS AND METHODS: Randomized clinical trial study adult orthodontic patients who required bilateral extraction of maxillary first premolars were randomly assigned to two groups (n = 10) of intervention and control. Both groups received MOP at the onset of canine retraction. The intervention group also used a VPro5 vibrator for 28 days after the onset of canine retraction in addition to MOP. GCF samples were collected before the onset of orthodontic treatment (T0), right before canine retraction (T1), and after 24 h (T2), 7 days (T3), and 28 days (T4) by a paper point, and the GCF levels interleukin (IL)-1 B, receptor activator of nuclear factor kappa-B ligand (RANKL), C-C motif chemokine ligand (CCL) 2, and tumor necrosis factor-alpha (TNF)-α were measured. Data were analyzed using SPSS v25. Repeatedmeasures Analysis of Variance was employed to compare quantitative outcomes between groups and over time, with statistical significance set at P < 0.05.

RESULTS: The GCF level of the four inflammatory factors was not significantly different between the two groups at any time point (P > 0.05). The trend of change in GCF level of the four inflammatory factors was also the same in the two groups over time, such that the lowest level of all four markers was recorded at T0. The highest level of TNF-α was recorded at T2, and the highest level of RANKL, IL1-B, and CCL2 was recorded at T2 and T3.

CONCLUSION: It does not seem that combined MOP with vibration can increase the level of inflammatory factors in GCF.

PMID:41384263 | PMC:PMC12694923 | DOI:10.4103/drj.drj_319_24

Dent Res J (Isfahan). 2025 Nov 25;22:45. doi: 10.4103/drj.drj_225_25. eCollection 2025.

ABSTRACT

BACKGROUND: This study assessed the linear accuracy of three-dimensionally (3D)-printed mandibular models from cone-beam computed tomography (CBCT) scans with two voxel sizes.

MATERIALS AND METHODS: In this in vitro study, five dry human mandibles underwent CBCT with 0.2- and 0.3-mm voxel sizes. The images were converted to STL format, and the distances between (I) mental foramen (MF) and alveolar ridge crest, (II) MF and inferior border of the mandible (IBM), and (III) alveolar crest and IBM at the midline, as well as the (IV) left central incisor socket depth, (V) left second premolar buccolingual socket width, and (VI) right third molar buccolingual socket width were measured on the CBCT scans, 3D-printed models, and dry mandibles. Two observers recorded the measurements twice, 1 week apart. We analyzed the data using the intraclass correlation coefficient and Pearson’s correlation test. Statistical significance was set at P < 0.05.

RESULTS: Since the interobserver agreement was high, the mean data was used for the comparisons. The linear accuracy was high for MF-IBM, MF-alveolar crest, and alveolar crest-IBM distances, and second premolar and third molar buccolingual socket width. CBCT scans demonstrated reliable accuracy for left central incisor socket depth measurement, but a lack of significant correlation was found between the 3D-printing and gold-standard measurements of this variable.

CONCLUSION: The linear accuracy of CBCT scans taken with 0.3- and 0.2-mm voxel sizes was comparable, and they may be used for the fabrication of linearly accurate 3D-printed models of mandible. 3D-printed models demonstrated high precision in all measured parameters except socket depth.

PMID:41384259 | PMC:PMC12694914 | DOI:10.4103/drj.drj_225_25

Front Physiol. 2025 Nov 26;16:1661258. doi: 10.3389/fphys.2025.1661258. eCollection 2025.

ABSTRACT

INTRODUCTION: Snoring is a common symptom of Obstructive Sleep Apnea (OSA) and has also been associated with an elevated risk of cerebrovascular disease. However, existing snoring detection studies predominantly focus on individuals with Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS), with limited attention given to the specific acoustic characteristics of patients with concomitant cerebrovascular diseases. To address this gap, this paper proposes a snoring classification method integrating dynamic convolution and attention mechanisms, and explores the acoustic feature differences between patients with cerebrovascular stenosis and those without stenosis.

METHODS: First, we collected nocturnal snoring sounds from 31 patients diagnosed with OSAHS, including 16 patients with cerebrovascular stenosis, and extracted four types of acoustic features: Mel spectrogram, Mel-frequency cepstral coefficients (MFCCs), Constant Q Transform (CQT) spectrogram, and Chroma Energy Normalized Statistics (CENS). Then, based on the ConvNeXt backbone, we enhanced the network by incorporating the Alterable Kernel Convolution (AKConv) module, the Convolutional Block Attention Module (CBAM), and the Conv2Former module. We conducted experiments on snoring versus non-snoring classification and stenotic versus non-stenotic snoring classification, and validated the role of each module through ablation studies. Finally, the Mann-Whitney U test was applied to compare intergroup differences in low-frequency energy ratio, snoring frequency, and snoring event duration.

RESULTS: This method achieves the best performance on the Mel spectrogram, with a snoring classification accuracy of 90.24%, compared to 88.16% for the ConvNeXt baseline model. It also maintains superiority in classifying stenotic versus non-stenotic snoring. Ablation analysis indicates that all three modules contribute to performance improvements. Moreover, the Mann-Whitney U test revealed significant differences $\left(p<0.05\right)$ between the stenotic and non-stenotic groups in terms of low-frequency energy ratio and nocturnal snoring frequency, whereas snoring event duration showed no significant difference.

DISCUSSION: The proposed method demonstrates excellent performance in snoring classification and provides preliminary evidence for exploring acoustic features associated with cerebrovascular stenosis.

PMID:41384251 | PMC:PMC12689313 | DOI:10.3389/fphys.2025.1661258

Front Physiol. 2025 Nov 26;16:1708619. doi: 10.3389/fphys.2025.1708619. eCollection 2025.

ABSTRACT

BACKGROUND: Badminton is a high-intensity sport that demands explosive strength, dynamic balance, and agility. Plyometric training (PT) is crucial for enhancing these abilities, yet there is limited research comparing sand-based PT to hard-surface PT in badminton players.

OBJECTIVE: This study compared the effects of sand-based PT and hard-surface PT on lower-extremity explosive strength, dynamic balance, and agility in male badminton players.

METHODS: Twenty-eight male collegiate badminton players were randomly assigned to a sand-based PT group (n = 14) or a hard-surface PT group (n = 14). Both groups performed plyometric programs twice weekly for 8 weeks. Outcomes measurement before and after training included countermovement jump (CMJ) height, squat jump (SJ) height, drop jump (DJ) height, standing long jump (SLJ) distance, Y-balance test (YBT), hexagon jump test, and badminton-specific agility test (lateral agility test and four-corner agility test). We used two-way repeated measures analysis of variance (ANOVA) (time × group) with Bonferroni post hoc tests, and effect sizes were reported as partial eta squared ( ${\eta }_p^2$ ) or Cohen’s d (p < 0.05).

RESULTS: Statistical analysis revealed significant time main effects across multiple metrics: CMJ height (F = 81.26, p < 0.01, ${\eta }_p^2$ = 0.75), SJ height (F = 82.86, p < 0.01, ${\eta }_p^2$ = 0.76), DJ height (F = 54.58, p < 0.01, ${\eta }_p^2$ = 0.68, large effect), SLJ distance (F = 49.86, p < 0.01, ${\eta }_p^2$ = 0.66), dynamic balance ability (p < 0.01), and agility (p < 0.01), no significant between-group differences were found for any of the variables (p > 0.05). Additionally, a significant interaction effect between time and group was observed in the left leg to right (F = 4.76, p = 0.04).

CONCLUSION: This study indicates that both sand-based PT and hard-surface PT over 8 weeks significantly enhance explosive power, dynamic balance, and agility performance, with no significant differences between groups.

PMID:41384248 | PMC:PMC12689396 | DOI:10.3389/fphys.2025.1708619

Ther Adv Neurol Disord. 2025 Dec 9;18:17562864251396529. doi: 10.1177/17562864251396529. eCollection 2025.

ABSTRACT

BACKGROUND: Although migraine is the second most prevalent form of headache, its preventive treatment has some contraindications and complications. It has been postulated that lacosamide reacts with collapsin response mediator protein 2 and prevents its phosphorylation, inhibiting calcitonin gene-related peptide release in the trigeminal system, which might have a role in migraine management.

OBJECTIVE: Our study aimed mainly to evaluate the efficacy and safety of lacosamide as an alternative medication to topiramate for the prevention of migraine, especially in patients who had contraindications to topiramate and other approved antiseizure medications used for migraine prevention.

DESIGN: Our study included two parallel groups: the lacosamide and the topiramate groups.

METHODS: We recruited episodic migraine patients between the ages of 18 and 65; the lacosamide group received lacosamide 50 mg once daily for 1 week, then twice daily from the 8th day till the 90th day); while the topiramate group received topiramate 50 mg once daily for 1 week, then 50 mg twice daily from the 8th day till the 90th day.

RESULTS: There was not a statistically significant difference between the lacosamide and topiramate in the absolute change in monthly migraine days (MMD) at 90 days with p-value 0.34, there was no significant difference between lacosamide and topiramate groups regarding the percentage of patients with ⩾50% reduction in the baseline migraine days frequency in the last 4 weeks of the treatment period with a p-value 0.11. In total, 14.0 (4.7%) patients in the lacosamide group and 24.0 (8.0%) in the topiramate group stopped treatment prematurely due to intolerance to drug-related adverse effects, hazard ratio 2.83, 95% confidence interval (1.34-4.72), p-value 0.03.

CONCLUSION: In episodic migraine patients, the regular use of lacosamide 50 mg Bid for 3 months yielded reductions in the MMD, migraine days that required acute medications, and Headache Impact Test-6 score comparable to those achieved using topiramate 50 mg Bid. Lacosamide was more tolerable than topiramate in episodic migraine patients.

TRIAL REGISTRATION: Prospectively registered on clinicaltrials.gov, NCT06243692-January 29, 2024; https://clinicaltrials.gov/study/NCT06243692.

PMID:41384236 | PMC:PMC12690048 | DOI:10.1177/17562864251396529