Tag: nevin manimala

Environ Sci Process Impacts. 2023 Mar 8. doi: 10.1039/d2em00444e. Online ahead of print.

ABSTRACT

Plug-in fragrance diffusers are one of myriad volatile organic compound-containing consumer products that are commonly found in homes. The perturbing effects of using a commercial diffuser indoors were evaluated using a study group of 60 homes in Ashford, UK. Air samples were taken over 3 day periods with the diffuser switched on and in a parallel set of control homes where it was off. At least four measurements were taken in each home using vacuum-release into 6 L silica-coated canisters and with >40 VOCs quantified using gas chromatography with FID and MS (GC-FID-QMS). Occupants self-reported their use of other VOC-containing products. The variability between homes was very high with the 72 hour sum of all measured VOCs ranging between 30 and >5000 μg m^-3, dominated by n/i-butane, propane, and ethanol. For those homes in the lowest quartile of air exchange rate (identified using CO₂ and TVOC sensors as proxies) the use of a diffuser led to a statistically significant increase (p-value < 0.02) in the summed concentration of detectable fragrance VOCs and some individual species, e.g. alpha pinene rising from a median of 9 μg m^-3 to 15 μg m^-3 (p-value < 0.02). The observed increments were broadly in line with model-calculated estimates based on fragrance weight loss, room sizes and air exchange rates.

PMID:36883522 | DOI:10.1039/d2em00444e

Wiad Lek. 2023;76(1):145-154. doi: 10.36740/WLek202301120.

ABSTRACT

OBJECTIVE: The aim: To find the risk factors of microalbuminuria and estimated Glomerular Filtration Rate (eGFR) in patients with type 1 diabetes mellitus.

PATIENTS AND METHODS: Materials and methods: One hundred ten patients of type 1 diabetes mellitus in this cross-sectional study at diabetic and endocrinology center in Al-Najaf during the period from September 2021 to March 2022. All patients were asked about sociodemographic characteristics (age, gender, smoking, duration of DM type1, family history of DM type1), measured (body mass index BMI, blood pressure) and laboratory investigations done to all patients (G.U.E, s. creatinine, lipid profile, HBA1C, calculated estimated Glomerular Filtration Rate (eGFR) and Spot Urine Albumin-Creatinine Ratio (ACR).

RESULTS: Results: Out of 110 patients, 62 male and 48 female, the mean age was (22±12). The patients with microalbuminuria (ACR ≥ 30 mg/g) show statistically significant with increase HBA1C, duration of DM type 1, total cholesterol (T.C), low density lipoprotein (LDL), triglycerides (TG) and family history of DM type 1, while there were not statistically significant with age, gender, smoking, BMI, eGFR, high density lipoprotein (HDL) and hypertension. Patients with eGFR<90mL/min/1.73m2 show statistically significant with increase HBA1C, duration of DM type1, LDL, TG, T.C, while significantly decrease in HDL and there were not statistically significant with age, gender, smoking, family history of DM type 1, BMI and hypertension.

CONCLUSION: Conclusions: The degree of glycemic control, duration of type1 (DM) and dyslipidemia were associated with increased microalbuminuria and reduced eGFR (nephropathy). Family history of DM type1 was risk factor for microalbuminuria.

PMID:36883503 | DOI:10.36740/WLek202301120

Wiad Lek. 2023;76(1):136-144. doi: 10.36740/WLek202301119.

ABSTRACT

OBJECTIVE: The aim: To evaluate the effectiveness of the use of the Deprilium® complex for the relief of subclinical symptoms of depression in patients with NCD.

PATIENTS AND METHODS: Materials and methods: There were 140 patients involved in the study. To assess the subclinical symptoms, the Hamilton Depression Rating Scale (HAM-D) was used. In order to obtain additional information about the patient’s condition, the Somatic Symptom Scale SSS-8 and the Quality of Life Scale (QOLS) were used. Patients were randomized by block randomization to an intervention group, which took Deprilium® complex, and a control group, which took placebo.

RESULTS: Results: After 60 days a statistically significant difference was observed in all clinical indicators between the intervention group and the control group. The median value of the HAM-D scale differed between the groups by 6 points, significantly (p <0.000) lower results were observed in the intervention group, which participants were taking the Deprilium® complex. When comparing the indicators of the intervention group on the 1st and on the 60th day of the study, statistically significant changes (p <0.000) were observed in all three indicators.

CONCLUSION: Conclusions: The received results confirm the available evidence for the properties of SAMe in depression and complement them with evidence of the ef-fectiveness of the Deprilium® complex that contains SAMe and L-methylfolate with methylcobalamin, which together produce pharmacological and clinical synergy to reduce the severity of subclinical depressive manifestations in patients with NCD. Further studies of the effectiveness of the use of the Deprilium® complex in patients with NCD are required.

PMID:36883502 | DOI:10.36740/WLek202301119

Wiad Lek. 2023;76(1):131-135. doi: 10.36740/WLek202301118.

ABSTRACT

OBJECTIVE: The aim: To analyze the current state of the problem and develop a modern methodology for the correction and prevention of stress disorders in female veterans.

PATIENTS AND METHODS: Materials and methods: The following methods were used during the research: theoretical and interdisciplinary analysis, complex, сlinical and psychopatho¬logical examination and methods of mathematical and statistical data processing.

RESULTS: Results: In the course of our work, it was developed an algorithm for medical and psychological support for women who suffered from results of the fighting includes the following components: monitoring of the psychological and mental state of veteran women; increased psychological care; psychological support for veteran women; psychotherapy; psychoeducation; creation of a re-adaptation atmosphere; formation of a health-centred living style and strengthening of psychosocial resources.

CONCLUSION: Conclusions: The complex system of treatment and prevention of stress-social disorders in women veterans should be aimed at decreasing the level of anxiety-depressive symptoms and the excessive nervous and psychological tension; infective re-evaluation of the traumatic experience; building a positive attitude towards the future and creating a new cognitive model of life.

PMID:36883501 | DOI:10.36740/WLek202301118

Wiad Lek. 2023;76(1):97-107. doi: 10.36740/WLek202301114.

ABSTRACT

OBJECTIVE: The aim: To correlate variable clincopathological parameters with molecular subtypes of the breast carcinoma, which affect the prognosis and management of breast malignancy.

PATIENTS AND METHODS: Materials and methods: In this study a total of 511 female patients with breast carcinoma were included, ranging from 32 to 85 years of age, with 35.8% premenopausal and 64.1% being post-menopausal. The sample slides were stained immunohistochemically for estrogen receptors (ER), progesterone receptors (PR), ki67 and HER2, the tumors were graded histologically using the Nottingham criteria system.

RESULTS: Results: Most tumors (72.8%) ranged between 2 and 5 cm in size; the most common histological type of breast carcinoma (49.7%) was invasive ductal carcinoma of no special type, with grade 2 presented in 51.8% cases; most frequent stage at time of presentation was stage 3A, found in 39.9%; the most frequent molecular subtype was ER and/or PR+, Her2- with low proliferation rate ki67<14% subtype in 48.5%, and those group were more likely (statistically significant) to be older, have stage 3 breast cancer, present with tumor size between 2 and 5 cm and tend to be well differentiated histological grade (grade1), mostly with lymph node positive, and most likely have tumor type of invasive ductal carcinoma of no special type.

CONCLUSION: Conclusions: the most common histological type of breast carcinoma in Iraq south was invasive ductal carcinoma of no special type and most cases showed (ER and/or PR+, HER 2-, low ki67) as the most common molecular subtype.

PMID:36883497 | DOI:10.36740/WLek202301114

Wiad Lek. 2023;76(1):90-96. doi: 10.36740/WLek202301113.

ABSTRACT

OBJECTIVE: The aim: To determine the effectiveness of application of special therapeutic physical exercises to improve the indicators of body weight, anthropometric parameters and quality of life of obese women in the conditions of quarantine restrictions.

PATIENTS AND METHODS: Materials and methods: We examined 10 women aged 37 ± 5 years with obesity of various degrees, which was determined by the body mass index (BMI, kg/m2). All women for two months were involved in specially designed therapeutic exercises in the remote mode. Evaluation of the effectiveness of therapeu¬tic exercises use was performed using the survey method to determine the quality of life of obese women according to a short version of the questionnaire “The world health organization quality of life (WHOQOL-BREF)”; anthropometric measurements of body parts sizes; bioimpedance analysis of body weight composition; statistical methods of data processing.

RESULTS: Results: The effect of therapeutic gymnastics according to the proposed programme on the component composition of body weight of obese women was proved, which indicates a decrease in total body weight, reduction of body fat, increase in total body water and muscle component of body weight. It is shown that under the influence of corrective physical exercises the proportions of the body of women changed, as evidenced by the dynamics of the circumferences of all measured parts of the body of obese women. The improvement of women’s quality of life in all indicators was identified.

CONCLUSION: Conclusions: The use of special complexes of physical exercises, aimed at correction of the body weight of obese women,showed its significant effectiveness and led to the expected result.

PMID:36883496 | DOI:10.36740/WLek202301113

Wiad Lek. 2023;76(1):84-89. doi: 10.36740/WLek202301112.

ABSTRACT

OBJECTIVE: The aim: To evaluate and compare the prevalence of gingivitis according to the PMA index in children aged 5 to 6 years in preschool with ASD and without disorders (Kyiv, Ukraine).

PATIENTS AND METHODS: Materials and methods: Oral assessment was conduct on 69 children with ASD and 23 children without ASD aged 5 to 6 years. To determine the periodontal status it was used the papillary-marginal-alveolar index – PMA (according to Schour, Massler, in the modification of Parma).

RESULTS: Results: Children with ASD (18.84%) were 3.7 times less likely to have a clinically healthy periodontium than children without disorders (69.57%). The average PMA index among the main group was 6.8 times higher (15.31 ± 1.49%) than in the control group (2.25. ± 0.73%), but this difference was not statistically confirmed (p> 0.05). The most common pathology of periodontal tissues was chronic catarrhal gingivitis. 49.28% of children in main group with ASD had mild catarrhal gingivitis, while just 30.47% of children in control group without ASD had this pathology. Catarrhal moderate gingivitis was diagnosed in 31.88% of children from main group, symptoms of moderate gingivitis were not detected in the control group without disorders.

CONCLUSION: Conclusions: ASD children 5-6 years old may have major risk of developing such periodontal lesions as mild and moderate gingivitis. Further investigations need to be done to clarify prevalence of other oral pathologies in ASD individuals to understand the effect of the disorder on oral health.

PMID:36883495 | DOI:10.36740/WLek202301112

Wiad Lek. 2023;76(1):71-76. doi: 10.36740/WLek202301110.

ABSTRACT

OBJECTIVE: The aim: To detect the main problems regarding available high-quality stomatological service in Ukraine and define their main solutions.

PATIENTS AND METHODS: Materials and methods: The authors used general scientific methods of synthesis, generalization, scientific data interpreting, systemic approach method, medical statistic method, and analysis of the activity of state and private institutions dealing with stomatological service in Ukraine. The paper is based on the materials of a representative selective study of Ukrainian households, held by the State Committee of Statistics of Ukraine to study people’s self-estimation of their health and the availability of certain medical services.

RESULTS: Results: Most citizens of Ukraine (60-80%) are treated in the state/public healthcare sector. Though, during the last century, a decrease in dental visits per citizen in the state and public institutions has been noted, as well as a decrease of all medical service types’ volume, offered in the mentioned institutions. In Ukraine the observed trends are represented as the decrease in the network institutions number, insufficient budgeting of state/public medical institutions, prevailing commercial characteristics of stomatological service and people’s low income, which leads to decreased affordability, and quality of medical service, thus negatively affecting people’s health.

CONCLUSION: Conclusions: The fundamental studies of the quality assessment show that the medical service requires strong structure, process quality, and result quality. The quality of medical service organization is extremely important and it should be maintained high on all levels of management and treatment processes, regarding the conditions of medical process and resources of medical organizations. Medical service should be patient-centered. To solve the problem, the entire state system of quality management is required in Ukraine.

PMID:36883493 | DOI:10.36740/WLek202301110

Wiad Lek. 2023;76(1):52-57. doi: 10.36740/WLek202301107.

ABSTRACT

OBJECTIVE: The aim: To determine the opinion of 6th year students and interns in the specialty “General Practice – Family Medicine” on vaccination against COVID-19.

PATIENTS AND METHODS: Materials and methods: We conducted an anonymous online survey of 268 sixth-year students, interns of the first and second year of study in the specialty GP/FM. Research design: 1.Creating a pilot version of the questionnaire based on a literary search. 2.Approbation and discussion of the questionnaire in the focus group. 3.Online surveys of respondents and statistical processing of the data.

RESULTS: Results: The questionnaire was completed by 188 students, 48 interns in 1 year of study and 32 interns in 2 years of study. Among interns in 1st and 2nd year of study, the vaccination rate was 95.8% and 93.8%, respectively, among students – 71.3%, which is twice as much as among the general population. 30% did not receive the vaccine they considered most effective, but were vaccinated with the one that was available.

CONCLUSION: Conclusions: The level of vaccination against COVID-19 in future doctors was 78.3%. The most significant reasons for refusing COVID-19 vaccination were past illness (COVID-19) – 24%, fear of vaccination – 24%, uncertainty about the effectiveness of immunoprophylaxis – 17.2%. Reasons that stimulated vaccination: the desire to protect against severe COVID-19 – 62.8%, the need to work in the medical field – 49.5%, the desire to protect others from the risks of COVID-19 infection – 38%.

PMID:36883490 | DOI:10.36740/WLek202301107

Wiad Lek. 2023;76(1):35-40. doi: 10.36740/WLek202301104.

ABSTRACT

OBJECTIVE: The aim: To determine the features of daily shifts in blood pressure (BP), the influence of the presence of rheumatoid arthritis (RA) on BP control and identify factors that affect BP among patients with RA in combination with resistant hypertension (RH).

PATIENTS AND METHODS: Materials and methods: All material for writing this scientific work were the results of a comprehensive survey of 201 people with RH and RA, hypertension (H) and RA, RA without H, H without RA and relatively healthy individuals. A laboratory study was performed: rheumatoid factor, C-reactive protein (CRP), K+ serum, and creatinine levels. All patients underwent office BP measurement and ambulatory BP monitoring for 24 hours. Statistical processing of the study results was carried out using “IBM SPSS Statistics 22”.

RESULTS: Results: Among patients with RA in combination with RH non-dippers (38.7%) are the most common type of BP profile. Patients with RH in combination with RA are characterized by an increase in BP more at night (p <0.003), which corresponds to the high frequency of night-peackers (17.7%). The presence of RA determines worse control of diastolic BP (p <0.01) and more vascular overload on organs and systems during the night (p <0.05).

CONCLUSION: Conclusions: An increase in BP in patients with RA in combination with RH is more significant at night, characterized by poorer BP control and greater vascular load at night indicating the need for tighter control of BP during sleep. Non-dippers are most often detected among patients with RA in combination with RH, which is prognostically unfavorable for the development of nocturnal “vascular accidents”.

PMID:36883487 | DOI:10.36740/WLek202301104