Tag: nevin manimala

Alzheimers Dement. 2025 Sep;21(9):e70650. doi: 10.1002/alz.70650.

ABSTRACT

INTRODUCTION: We investigated the associations between diabetes (type 2), hypertension and hypercholesterolemia with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) diagnoses by race-ethnicity and sex.

METHODS: Data (n = 22,950) were derived via the National Alzheimer’s Coordinating Center. Logistic regression was used to assess the relationship between each comorbid condition and MCI and AD.

RESULTS: For non-Hispanic White (NHW) and non-Hispanic Black (NHB) males, diabetes and hypertension had a significant positive association with MCI. For NHW females, diabetes, hypertension, and hypercholesterolemia were significantly associated with increased MCI. Diabetes was significantly associated with AD in Asian and Pacific Islander (API) males and NHW females.

DISCUSSION: Targeted interventions aimed at curbing diabetes and hypertension onset for NHW and NHB males, and potentially reducing all comorbid conditions for NHW females may reduce MCI outcomes. Heterogeneity in the Hispanic and API diasporas should be considered when delineating comorbid conditions with MCI and/or AD.

HIGHLIGHTS: For non-Hispanic White (NHW) and non-Hispanic Black (NHB) males, diabetes and hypertension were associated with MCI. Diabetes, hypertension, and hypercholesterolemia were associated with mild cognitive impairment (MCI) for NHW females. Only hypertension was associated with MCI in NHB females. Diabetes was associated with Alzheimer’s disease (AD) in NHW females and Asian and Pacific Islander (API) males.

PMID:40916002 | DOI:10.1002/alz.70650

Biol Trace Elem Res. 2025 Sep 8. doi: 10.1007/s12011-025-04808-6. Online ahead of print.

ABSTRACT

The uncharted effects of cadmium and cesium on circadian syndrome (CircS), an emerging circadian rhythm disorder drawing considerable attention, and underlying mechanisms warrant exigent elaboration. Data of 11141 subjects from National Health and Nutrition Examination Survey 2005-2018 were incorporated to investigate separate-, joint-/interaction-, and mixture-effects of urinary cadmium and cesium on prevalent CircS risk exploiting survey weight regression and quantile g-computation. The underlying mechanisms were probed by network toxicological analysis. Separately, elevated cadmium or cesium was related to elevated (odds ratio = 1.32; 95% confidence interval: 1.15 ~ 1.52) or decreased (0.74; 0.58 ~ 0.94) CircS risk. Jointly, the effect of elevated cadmium on CircS was interactively (P_interaction = 0.002) exacerbated by decreased cesium with participants with high-cadmium and low-cesium manifested the highest CircS risk (1.71; 1.27 ~ 2.34), and mixture of cadmium and cesium was related to elevated CircS risk (1.30; 1.21 ~ 1.40). Hypoxia-inducible factor-1 (HIF-1), phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt), and mitogen-activated protein kinases (MAPK) signaling pathways were enriched and common (tumor necrosis factor [TNF], interleukin-6 [IL-6], tumor protein-53 [TP53]) and unique (HIF1A for cadmium, albumin [ALB] for cesium) targets were identified in linking cadmium and cesium with CircS. Separate exposure to cadmium or cesium was associated with increased or decreased CircS risk, while joint exposure to mixture of cadmium and cesium was interactively related to elevated CircS risk. Cadmium and cesium might affect CircS through mechanisms of modulating HIF-1, MAPK, and PI3K-Akt signaling pathways and shared (TNF, IL-6, and TP53) and unique (HIF1A for cadmium while ALB for cesium) targets.

PMID:40915987 | DOI:10.1007/s12011-025-04808-6

EJNMMI Rep. 2025 Sep 8;9(1):32. doi: 10.1186/s41824-025-00265-5.

ABSTRACT

BACKGROUND: Because the myocardium thickness and blood flow of the right ventricular (RV) are lower than those of the left ventricle, it is challenging to perceive the RV myocardium in normal individuals. This study aimed to measure the myocardial perfusion in the RV (myocardial blood flow [MBF]_RV, myocardial flow reserve [MFR]_RV) from 13N-ammonia PET images and investigate the associations between the MBF_RV and MFR_RV in patients with and without coronary artery disease (CAD) in the right coronary artery (RCA) region. A total 121 MBF_RV and MFR_RV were retrospectively measured from PET images by referring to the radioactivity and clinical blood flow values of the left ventricle. Adenosine-stressed and resting MBF_RV and MFR_RV were statistically compared among patients with RCA-MFR < 2.0 (group 1 [n = 61]), without RCA-MFR < 2.0 but with reduced MBF (group 2 [n = 16]), and without MFR < 2.0 (group 3 [n = 44]) using one-way analysis of variance with Tukey or Dunn post hoc analyses.

RESULTS: Stress MBF_RV was lower in Group 1 than in Group 3, whereas resting MBF_RV was higher in Group 1 than in Group 3. MFR_RV gradually decreased from Group 3 to Group 1.

CONCLUSIONS: This study demonstrated the potential clinical applications of RV myocardial perfusion imaging using PET data. Our results highlight the importance of evaluating the MBF_RV, particularly in patients with CAD. In CAD cases, the MFR_RV was significantly reduced, with a more pronounced decrease, reflecting the severity of the disease. Additionally, increased resting MBF_RV in patients with CAD may indicate compensatory mechanisms or microcirculatory disorders. These findings provide a foundation for further exploration of MBF_RV and support the development of robust automated processing techniques to enhance clinical applicability.

PMID:40915986 | DOI:10.1186/s41824-025-00265-5

J Clin Periodontol. 2025 Sep 7. doi: 10.1111/jcpe.70019. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVE: Traditional and planimetric plaque indices rely on plaque-disclosing agents and cannot quantify three-dimensional (3D) structures of dental biofilms. We introduce a novel computer-assisted method for evaluating and visualising plaque volume using intraoral scans (IOSs).

MATERIALS AND METHODS: This was a 4-day, non-brushing, plaque-regrowth study (n = 15). All plaque was removed at baseline (T0). IOSs at T0 and after 4 days (T4) were used for volumetric plaque assessment in six steps: model acquisition, model superimposition, computer-aided determination of tooth-surface margins, tooth-surface superimposition, visualisation and volumetric evaluation of biofilms. Plaque formation at T4 was additionally assessed with the Turesky Modification of the Quigley-Hein Plaque Index (TMQHPlI). We used Pearson’s correlation coefficients and multilevel models to investigate the relationships between TMQHPlI, volumetric plaque index (VPI) and the adjusted volumetric plaque index (AVPI, plaque volume/area).

RESULTS: VPI and AVPI positively correlated with the TMQHPlI, showing higher variability at lower TMQHPlI scores. VPI had a lower threshold for plaque detection and higher sensitivity than the TMQHPlI. VPI and TMQHPlI were highest on vestibular, maxillary and molar surfaces.

CONCLUSION: VPI quantifies biofilm deposits, is a more precise measure for plaque detection than the TMQHPlI and can be visualised using colour-coded maps displaying areas of equal plaque thickness.

PMID:40915977 | DOI:10.1111/jcpe.70019

J Clin Periodontol. 2025 Sep 7. doi: 10.1111/jcpe.70029. Online ahead of print.

ABSTRACT

AIM: To characterise periodontal and faecal microbiomes of individuals with periodontal health (PH) and diseases, and evaluate associations with periodontal, sociodemographic, anthropometric, nutritional and lifestyle factors.

MATERIALS AND METHODS: Dental biofilm and faecal samples from individuals (n = 24/group) with PH, gingivitis (GG) and periodontitis (PE) were sequenced (16S rRNA). Anthropometric data and questionnaires on demographics, lifestyle, diet and intestinal habits were collected. Data were statistically analysed (p < 0.05).

RESULTS: GG and PE groups showed higher age, BMI, waist/abdominal circumferences and trans-fat intake and lower selenium and vitamin E intake compared to PH. Individuals with PE had higher hip circumference and lower income, education and intake of iron as well as vitamins A and B9. PE microbiomes (oral and faecal) showed distinct compositions, with the highest number of unique oral species. Faecal richness was lower in PE and GG compared to PH. Specific microbial taxa correlated with periodontal status and host factors.

CONCLUSION: Periodontal and faecal microbiomes vary across periodontal conditions. Discriminant analysis classified 77% of individuals by periodontal status, with key markers for PE including older age, poor dietary quality and distinct microbial oral and faecal signatures. These findings highlight the role of clinical, dietary and microbial factors in periodontal disease profiling.

PMID:40915974 | DOI:10.1111/jcpe.70029

Clin Breast Cancer. 2025 Aug 5:S1526-8209(25)00221-6. doi: 10.1016/j.clbc.2025.07.024. Online ahead of print.

ABSTRACT

BACKGROUND: Emerging evidence suggests that the gut microbiota (GM) may influence the progression of breast cancer by modulating immune responses. Given the vast diversity of GM and immune cell phenotypes, this study aimed to utilize the most advanced and comprehensive data to explore the causal relationships among the GM, immune cell phenotypes, and survival rates in hormone receptor-positive (HR+) breast cancer patients under different treatment regimens.

METHODS: We investigated the causal relationships between the GM, immune cell phenotypes, and survival rates in HR+ breast cancer patients treated with 11 distinct therapeutic strategies using Mendelian randomization. Inverse variance weighted analysis served as the primary statistical method. Additionally, we explored whether immune cell phenotypes act as mediators in the pathway from the GM to HR+ breast cancer survival rates.

RESULTS: In this comprehensive study, we identified 116 distinct GM species that established causal links with survival rates across 11 different subgroups of HR+ breast cancer patients. Furthermore, we discovered 13 potential pathways through which the GM might influence immune cell phenotypes, thereby affecting patient survival rates.

CONCLUSION: The GM is causally associated with survival rates in HR+ breast cancer patients treated with 11 different therapeutic strategies, and immune cell phenotypes serve as mediators in the pathway from the GM to HR+ breast cancer survival rates.

PMID:40915962 | DOI:10.1016/j.clbc.2025.07.024

Encephale. 2025 Sep 6:S0013-7006(25)00139-3. doi: 10.1016/j.encep.2025.06.004. Online ahead of print.

ABSTRACT

INTRODUCTION: Body Dysmorphic Disorder (BDD) is a condition characterized by a distorted perception of one’s own body image. Individuals with BDD exhibit excessive concern about their appearance, often fixating on perceived flaws that are either imaginary or minor. The prevalence of body image-related eating disorders has been increasing among university students, particularly in health-related fields, where students frequently experience pressure to maintain an ideal body shape and weight.

METHODS: This cross-sectional qualitative study was conducted with Nutrition students at a community university in Caçador, Santa Catarina, Brazil. Body image perception was assessed using the Silhouette Matching Task (SMT) by means of an online questionnaire via Google Forms. Data analysis was performed using Student’s t-test and Pearson’s correlation, with statistical significance set at P<0.05.

RESULTS: A total of 46 students participated, of whom 76.08% (n=35) were female. The mean BMI was 23.33kg/m², with a predominance of eutrophic individuals (74.28%). In contrast, the mean BMI for males was 28.42kg/m², with overweight being the predominant nutritional status. Regarding body image perception, 77.14% of females and 63.64% of males reported dissatisfaction with excess weight. The study found that males had a significantly higher weight (P=0.00003; r=0.578). Additionally, body dissatisfaction was more prevalent among females (P=0.00531; r=0.357) and increased with BMI (P=0.0015; r=0.455).

CONCLUSION: The findings indicate a high prevalence of body dissatisfaction among students, even among those with a nutritionally adequate status, particularly females. These results highlight the strong sociocultural pressure surrounding body image which significantly impacts this population.

PMID:40915951 | DOI:10.1016/j.encep.2025.06.004

J Matern Fetal Neonatal Med. 2025 Dec;38(1):2522998. doi: 10.1080/14767058.2025.2522998. Epub 2025 Sep 7.

ABSTRACT

OBJECTIVE: To evaluate the association between low-volume chorionic villus sampling (CVS) and delay in patient care.

METHODS: This is a retrospective cohort study of patients who underwent CVS from 8/19/2019 to 12/31/2022 in a single center. The exposure was low-volume CVS, defined as less than 15 mg of sample. The primary outcome of delay in patient care, was a composite of need for repeat procedure, delay in karyotype results ≥14 days, and ≥14 days to time of pregnancy termination. Secondary outcomes included change in lab protocol and canceled fluorescence in situ hybridization (FISH) tests.

RESULTS: There were 305 patients included with 113 (37%) with low-volume CVS. The primary outcome of delay in patient care occurred more often in the low-volume group compared to the high-volume group (23.9% vs 10.4% OR 2.70 95% CI 1.43-5.09). This association persisted in the adjusted models after adjusting for significant covariates. However, the individual outcome of delay to pregnancy termination was not different between the groups, even with controlling for covariates (14.2% vs 8.9% OR 1.70 95% CI 0.82-3.51).

CONCLUSION: Low-volume CVS was associated with an increased of delay in genetic testing results but did not increase the time to pregnancy termination in patients who opted for this outcome.

PMID:40915916 | DOI:10.1080/14767058.2025.2522998

Nihon Koshu Eisei Zasshi. 2025 Sep 8. doi: 10.11236/jph.25-060. Online ahead of print.

ABSTRACT

Objectives The Basic Act on Suicide Prevention was enacted in 2006, and 2026 will mark the 20th anniversary of this act. To commemorate this milestone, a symposium titled “20th Anniversary of the Basic Act on Suicide Prevention: Understanding the Reality of Suicide” was held at the 83rd Annual Meeting of the Japanese Society of Public Health. The aim was to reflect on Japan’s suicide prevention efforts to date through collaboration with experts.Methods: To accelerate suicide prevention efforts in Japan, we identified and organized the key challenges involved in understanding the reality of suicide.Results Considering the history of suicide prevention, we carefully reviewed the issues surrounding the Basic Act on Suicide Prevention and the Act on the Promotion of Research and Studies on Suicide. We conclude that revisions are necessary where appropriate. It is also important to incorporate measures for cultivating specialized professionals across various fields into the Basic Act on Suicide Prevention that will be responsible for suicide prevention in the next generation, as well as mechanisms that enable suicide-bereaved families to participate in policymaking. In terms of statistical issues, there has been a significant “apparent change” in the suicide statistics between 2021 and 2022 due to the revision of original data, which requires careful attention. There is an upward trend in deaths from external causes, including suicide and deaths from unknown causes, and it is necessary to analyze these trends carefully. In addition, municipalities can use police statistics to understand the realities of regional suicides. However, when analyzing municipal-level data, it is important to consider the underlying processes that lead to self-harm and suicide attempts, using regional suicide profiles as a reference. In addition, conducting independent surveys and research at the municipal level, separate from national statistics, is crucial for suicide prevention.Conclusion Suicide-related behavior is a complex issue influenced by various factors. It is essential to coordinate national measures with local initiatives. The following proposals are suggested to enhance future suicide prevention efforts:1. A review of the legal frameworks and establishment of support systems involving diverse stakeholders.2. Training of specialized personnel, including bereaved families, in the policymaking process.3. Conducting a thorough analysis of the statistical changes.4. Encouraging independent research and studies at the municipal level.By continuously updating our knowledge and fostering interdisciplinary discussions, we aim to ensure that these efforts are effectively implemented.

PMID:40915900 | DOI:10.11236/jph.25-060

J Epidemiol. 2025 Sep 6. doi: 10.2188/jea.JE20240447. Online ahead of print.

ABSTRACT

BackgroundIn 2023, a collaborative UNICEF-WHO group introduced the concept of small vulnerable newborns (SVNs) to improve the identification of newborns at increased risk of adverse outcomes and to guide more effective preventive strategies. However, global data on the prevalence of SVNs remains scarce. This study aimed to examine secular trends in the prevalence of SVNs and their three subgroups, namely term small for gestational age (SGA), preterm SGA, and preterm non-SGA, in the Japanese population.MethodsWe analyzed data from vital statistics including livebirths and stillbirths between 1997 and 2021. Secular trends in the prevalence of SVNs and their subgroups were assessed. In addition, we conducted regional analyses to explore associations with the distribution of medical resources.ResultsA total of 26,172,760 newborns were included. The overall prevalence of SVNs was 7.8% in 1997, peaked at 8.7% in 2005, and declined to 7.7% by 2021. This decline was primarily attributed to a reduction in term SGA births. In contrast, the prevalence of preterm SGA and preterm non-SGA remained largely unchanged. In 2021, the prevalence of term SGA, preterm SGA, and preterm non-SGA was 2.0%, 0.44%, and 5.3%, respectively. No significant association was found between the regional variation in the prevalence of SVNs and the distribution of medical resources.ConclusionThe prevalence of SVNs in Japan has declined since 2005, mainly due to reduced term SGA births. Persistent rates of preterm subgroups highlight the ongoing burden of prematurity, underscoring the need for targeted strategies to improve neonatal outcomes.

PMID:40915894 | DOI:10.2188/jea.JE20240447