Tag: nevin manimala

Med Confl Surviv. 2023 Jun 16:1-23. doi: 10.1080/13623699.2023.2222360. Online ahead of print.

ABSTRACT

Armed conflict exposure is associated with multiple mental health problems. However, more needs to be known about the differential effects of particular modalities of armed conflict violence and war methods on mental health. This study a) examined the modalities of violence employed in the Colombian armed conflict and b) assessed their association with mental health problems in armed conflict survivors. Using armed conflict data from the Colombian Armed Conflict Events Information System, we identified three violence modalities: armed confrontations, indiscriminate attacks, and selective violence. Descriptive statistics showed that selective violence generated most (86%) of the 333,219 victims of the Colombian armed conflict between 1996 and 2016. A subsample of armed conflict survivors (n = 551) from the 2015 Colombian Mental Health Survey was used to assess the association of each modality of violence with depression and anxiety, Post Traumatic Stress Disorder (PTSD), and substance abuse. Adjusted Odds Ratios (aOR) (p < .05, 95% CI) showed that survivors of selective violence crimes such as forced disappearance of loved ones, kidnapping, sexual violence, and massacres were at increased risk of experiencing Common Mental Health Disorders, PTSD symptoms, and hazardous drinking. Identifying those at elevated risk for developing mental health problems and substance misuse among survivors of armed conflict may help to use limited resources more effectively.

PMID:37325901 | DOI:10.1080/13623699.2023.2222360

Cancer Med. 2023 Jun 16. doi: 10.1002/cam4.6221. Online ahead of print.

ABSTRACT

OBJECTIVE: The objective of this research was to analyze the prognostic significance of the minimum count of lymphocytes (LY) and the corresponding ratio of neutrophil-to-lymphocyte (NLR) in cervical cancer (CC) patients receiving radiotherapy.

METHODS: We retrospectively collected data from 202 CC patients who received concurrent chemoradiotherapy or radiotherapy alone at our hospital. Statistical methods including the Kaplan-Meier method, log-rank test and the Cox proportional hazards model were included to examine survival differences and identify independent factors that may affect overall survival (OS) and progression-free survival (PFS).

RESULTS: The research enrolled a total of 202 patients. Patients with higher LY levels and lower NLR values during radiotherapy had significantly better survival prognosis than those with lower LY levels and higher NLR values. Multivariate COX regression analysis revealed that FIGO stage I, pathological types of SqCC, absence of lymph node metastasis, concurrent chemoradiotherapy, higher LY levels during radiotherapy, and lower NLR values before radiotherapy were independently associated with poorer PFS. Similarly, FIGO stage I, absence of lymph node metastasis and lower NLR values during and before radiotherapy were independently linked with poorer OS.

CONCLUSION: Minimum LY value and its corresponding NLR during radiotherapy serve as prognostic factors for CC.

PMID:37325889 | DOI:10.1002/cam4.6221

Brain Behav. 2023 Jun 16:e3116. doi: 10.1002/brb3.3116. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to analyze the impact of regular prevention and control of COVID-19 on the physical activity level (PAL) of adolescents and the relationship between PAL and mental health.

METHODS: Using the convenience sampling method, two stages of the on-site cross-sectional investigation were conducted in 11 middle schools in Guiyang City in China. There were 1132 participants who completed the Physical Activity Questionnaire for old children (PAQ-C) in October 2020, and 1503 participants who completed the PAQ-C and Mental Health Inventory of Middle-school students (MMHI-60) in October 2021. All participants reported their demographic data. Descriptive, quantitative statistics were used for data analysis. One-way ANOVA was used to explore associations between PAL and mental health.

RESULTS: The results of statistical analysis showed a gradual yearly increase in the PAL of teenagers, and the PAL of male junior middle school students has a significant increase (p < .05); while that of adolescents in Grade 10 significantly decreased (p < .001). There is a statistically significant correlation between adolescents’ mental health (except for anxiety) and PAL (p < .05). The overall abnormal rate of mental health was 27.9%; The PAL and the total mean score of mental health had a negative correlation (p < .001). There was a significant difference between mental health scores and corresponding PAL (p < .001). Furthermore, there are statistically significant differences in scores of mental health factors corresponding to varying PAL among junior high school students and male students (p < .05).

CONCLUSIONS: The regular epidemic prevention and control measures had significant adverse effects on the PAL of girls and high school adolescents, especially Grade 10 adolescents. Improving adolescents’ PAL can promote their mental health. Interventions based on PAL slightly lower than the level recommended in the physical activity guidelines can bring significant mental health effects.

PMID:37325875 | DOI:10.1002/brb3.3116

Biometrics. 2023 Jun 16. doi: 10.1111/biom.13886. Online ahead of print.

ABSTRACT

Causal inference practitioners have increasingly adopted machine learning techniques with the aim of producing principled uncertainty quantification for causal effects while minimizing the risk of model misspecification. Bayesian nonparametric approaches have attracted attention as well, both for their flexibility and their promise of providing natural uncertainty quantification. Priors on high-dimensional or nonparametric spaces, however, can often unintentionally encode prior information that is at odds with substantive knowledge in causal inference-specifically, the regularization required for high-dimensional Bayesian models to work can indirectly imply that the magnitude of the confounding is negligible. In this paper, we explain this problem and provide tools for (i) verifying that the prior distribution does not encode an inductive bias away from confounded models and (ii) verifying that the posterior distribution contains sufficient information to overcome this issue if it exists. We provide a proof-of-concept on simulated data from a high-dimensional probit-ridge regression model, and illustrate on a Bayesian nonparametric decision tree ensemble applied to a large medical expenditure survey.

PMID:37325868 | DOI:10.1111/biom.13886

J Bioinform Comput Biol. 2023 Jun 15:2350011. doi: 10.1142/S0219720023500117. Online ahead of print.

ABSTRACT

The P53 protein levels exhibit a series of pulses in response to DNA double-stranded breaks (DSBs). However, the mechanism regarding how damage strength regulates physical parameters of p53 pulses remains to be elucidated. This paper established two mathematical models translating the mechanism of p53 dynamics in response to DSBs; the two models can reproduce many results observed in the experiments. Based on the models, numerical analysis suggested that the interval between pulses increases as the damage strength decreases, and we proposed that the p53 dynamical system in response to DSBs is modulated by frequency. Next, we found that the ATM positive self-feedback can realize the system characteristic that the pulse amplitude is independent of the damage strength. In addition, the pulse interval is negatively correlated with apoptosis; the greater the damage strength, the smaller the pulse interval, the faster the p53 accumulation rate, and the cells are more susceptible to apoptosis. These findings advance our understanding of the mechanism of p53 dynamical response and give new insights for experiments to probe the dynamics of p53 signaling.

PMID:37325863 | DOI:10.1142/S0219720023500117

Anthropol Anz. 2023 Jun 16. doi: 10.1127/anthranz/2023/1679. Online ahead of print.

ABSTRACT

Changes in the environment in which a particular population develops, including socio-economic factors, can influence craniofacial dimensions over time. The study aimed to investigate intergenerational changes in selected cranial measurements of adolescents (16-18 years of age) from Kraków, Poland. The analysis was based on the anthropometric measurements of four cohorts (years 1938, 1950, 2007 and 2020) of adolescents aged 16-18. Analysed characteristics included head breadth, length and head breadth-to-length ratio. The normality of each characteristic’s distribution was assessed using Shapiro-Wilk’s test, and the statistical significance of the differences between the cohorts was calculated using the two-way ANOVA or Kruskal-Wallis test. The pace of the secular changes of the analysed characteristics was also calculated. There was a secular increase in the head length from 1938 to 2020. The breadth of the head decreased between 1938 and 2007, but an increase was noted from 2007 to 2020. Changes analogous to head breadth were noted for the breadth-to-length ratio. The secular changes occurred the fastest between 2007 and 2020 for the length (18-year-olds), breadth (16-year old boys and 18-year-old girls) and the cephalic index (16-year old boys and 17-year-old girls). In conclusion, there was a tendency toward debrachycephalisation in the more contemporary cohorts. Observed changes may be associated with more favourable overall developmental conditions as well as possible changes in the growth tempo of the Polish population.

PMID:37325854 | DOI:10.1127/anthranz/2023/1679

Anthropol Anz. 2023 May 17. doi: 10.1127/anthranz/2023/1704. Online ahead of print.

ABSTRACT

Femoral head-neck defects are commonly reported in the anatomical and anthropological literature. The best-known types are Poirier’s facet and Allen’s fossa; however, their aetiology and definition are still debated. The aim of this study was to analyse the frequency of Poirier’s facet in the skeletal population from Radom (Poland, 14^th-19^th century). Additionally, a comparison of Poirier’s facet prevalence in two chronological periods (the populations from Radom during the 14^th-17^th century and the 18^th-19^th century) was done. The femora of 367 adult individuals (184 males, 140 females, 43 unknown sex) from the osteological collections from Radom (14^th-19^th century) (Poland) were analysed according to the frequency of Poirier’s facet. In the Late Medieval population from Radom (14^th-17^th century), Poirier’s facet was noted in 33% of individuals, while in Radom individuals from 18th-19th century, Poirier’s facet was observed in 34%. In the analysed skeletal group, Poirier’s facet was usually observed on both femoral bones. Males from 18th-19th century had more occasions of Poirier’s facet observed compared to the 14^th-17^th century males, while in females, Poirier’s facet was slightly more frequently observed in 14th-17th century Radom individuals. There were not statistically significant differences in the Poirier’s facet frequencies between males and females in Radom from the 14^th-17^th century (38% in males, 29% in females). In the Medieval and Modern skeletal series from Radom (18^th-19^th), males had significantly higher frequencies (44%) of this skeletal trait compared to females (18%). It could be hypothesised that 18^th-19^th century Radom males engaged in more demanding physical activity than females. Poor knowledge about Poirier’s facet aetiology, insufficient archaeological and historical knowledge about the Radom individuals’ lifestyle, and a small sample size from the 14^th-17^th Radom sample do not allow for drawing such unambiguous conclusions, and further analyses are needed.

PMID:37325851 | DOI:10.1127/anthranz/2023/1704

J Mark Access Health Policy. 2023 Jun 13;11(1):2218633. doi: 10.1080/20016689.2023.2218633. eCollection 2023.

ABSTRACT

BACKGROUND AND OBJECTIVES: Multiple reforms aimed at improving the Chinese population’s health have been introduced in recent years, including several designed to improve access to innovative drugs. We sought to review current factors affecting access to innovative drugs in China and to anticipate future trends.

METHODS: Targeted reviews of published literature and statistics on the Chinese healthcare system, medical insurance and reimbursement processes were conducted, as well as interviews with five Chinese experts involved in the reimbursement of innovative drugs.

RESULTS: Drug reimbursement in China is becoming increasingly centralized due to the removal of provincial pathways, the establishment of the National Healthcare Security Administration and the implementation of the National Reimbursement Drug List (NRDL), which is now the main route for drug reimbursement in China. There is also an increasing number of other channels via which patients may access innovative treatments, including various types of commercial insurance and special access. Health technology assessment (HTA) and health economic evidence are becoming pivotal elements of the NRDL decision-making process. Alongside the optimization of HTA decision making, innovative risk-sharing agreements are anticipated to be increasingly leveraged in the future to optimize access to highly specialized technologies and encourage innovation while safeguarding limited healthcare funds.

CONCLUSIONS: Drug public reimbursement in China continues to align more closely with approaches widely used in Europe in terms of HTA, health economics and pricing. Centralization of decision-making processes for public reimbursement of innovative drugs allows consistency in assessment and access, which optimizes the improvement of the Chinese population’s health.

PMID:37325810 | PMC:PMC10266112 | DOI:10.1080/20016689.2023.2218633

Front Sociol. 2023 Jun 1;8:1114095. doi: 10.3389/fsoc.2023.1114095. eCollection 2023.

ABSTRACT

In 2004 the African Union adopted an innovative gender index, the Afriacn Gender and Development Index (AGDI). It is composed of the quantitative Gender Status Index (GSI) and the qualitative African Women’s Progress Scorecard (AWPS). The tool is built on the use of national data collected by a national team of specialists. Since the beginning three cycles of implementation have occurred. After the last cycle the AGDI was revised. In this article the authors assess the implementation of the AGDI, against the background of other gender indices, and discuss the latest revisions.

PMID:37325791 | PMC:PMC10267327 | DOI:10.3389/fsoc.2023.1114095

bioRxiv. 2023 May 18:2023.05.16.540882. doi: 10.1101/2023.05.16.540882. Preprint.

ABSTRACT

MOTIVATION: The Jaccard similarity on $k$-mer sets has shown to be a convenient proxy for sequence identity. By avoiding expensive base-level alignments and comparing reduced sequence representations, tools such as MashMap can scale to massive numbers of pairwise comparisons while still providing useful similarity estimates. However, due to their reliance on minimizer winnowing, previous versions of MashMap were shown to be biased and inconsistent estimators of Jaccard similarity. This directly impacts downstream tools that rely on the accuracy of these estimates.

RESULTS: To address this, we propose the minmer winnowing scheme, which generalizes the minimizer scheme by use of a rolling minhash with multiple sampled $k$-mers per window. We show both theoretically and empirically that minmers yield an unbiased estimator of local Jaccard similarity, and we implement this scheme in an updated version of MashMap. The minmer-based implementation is over 10 times faster than the minimizer-based version under the default ANI threshold, making it well-suited for large-scale comparative genomics applications.

PMID:37325780 | PMC:PMC10268037 | DOI:10.1101/2023.05.16.540882