Tag: nevin manimala

JAMA Otolaryngol Head Neck Surg. 2023 Jun 1. doi: 10.1001/jamaoto.2023.1089. Online ahead of print.

ABSTRACT

IMPORTANCE: Mandibular osteoradionecrosis (ORN) is a progressive disease that can be difficult to treat. Conservative measures often fail, while conventional definitive management requires a morbid segmental resection with osteocutaneous reconstruction. Evidence of the anterolateral thigh fascia lata (ALTFL) rescue flap technique’s safety, effectiveness, and long-term outcomes is needed.

OBJECTIVE: To determine the long-term outcomes of the ALTFL rescue flap procedure for treating patients with mandibular ORN.

DESIGN, SETTINGS, AND PARTICIPANTS: This was a retrospective medical record review performed at a single tertiary-level academic health care institution with patients who were appropriate candidates for the ALTFL procedure to treat mandibular ORN from March 3, 2011, to December 31, 2022. Data analyses were performed from January 1 to March 26, 2023.

MAIN OUTCOMES AND MEASURES: Patient characteristics, preoperative radiographic Notani staging, intraoperative defect size, length of stay, complication rates, and clinical and radiographic findings of progression-free intervals.

RESULTS: The study population of 43 patients (mean [SD] age, 66.1 [47-80] years; 24 [55.8%] male individuals) included 52 cases of mandibular ORN. The preoperative Notani staging of the study population was known for 46 of the 52 total cases: 11 cases (23.9%) were stage I; 21 (45.7%), stage II; and 14 (30.4%), stage III. The mean defect area was 20.9 cm2. Successful arrest of ORN disease progression was noted in the clinical and radiographic findings of 50 of the 52 (96.2%) cases, with only 2 (3.8%) cases subsequently requiring fibular free flap reconstruction. The major complication rate was 1.9% (1 case). Clinical and radiographic progression-free intervals were assessed, and no statistically significant differences were noted between Notani staging groups (log-rank P = .43 and P = .43, respectively); ie, patients with stage III disease had no significant difference in risk of clinical (HR, 0.866; 95% CI, 0.054-13.853) or radiographic (HR, 0.959; 95% CI, 0.059-15.474) progression vs those with stage I disease. Weibull profiling revealed 96.9%, 94.6%, and 93.1% successful mandibular ORN arrest at 1, 3, and 5 years, respectively. The major complication rate was 1.9%. Mean (SD) length of stay was 2.7 (0.0-7.0) days. Mean (SD) radiographic follow-up was 29.3 (30.7) months.

CONCLUSIONS AND RELEVANCE: The findings of this large retrospective patient case series support the continued success of the ALTFL rescue flap technique, a safe and highly effective long-term treatment for mandibular ORN in carefully selected patients.

PMID:37261824 | DOI:10.1001/jamaoto.2023.1089

Ann Am Thorac Soc. 2023 Jun;20(6):794-796. doi: 10.1513/AnnalsATS.202302-169ED.

NO ABSTRACT

PMID:37261790 | DOI:10.1513/AnnalsATS.202302-169ED

Nord J Psychiatry. 2023 Jun 1:1-7. doi: 10.1080/08039488.2023.2218349. Online ahead of print.

ABSTRACT

OBJECTIVE: Associations between debt and suicidal behaviour have been identified, but the research is sparse. Thus, more research is needed to understand the association between economic vulnerability and suicide. The study aimed to generate further knowledge about over-indebted individuals who have attempted suicide at least once.

METHOD: Participants were a Swedish sample comprising 641 over-indebted individuals. The inclusion criteria were that the participants should be indebted and have been subjected to debt collection measures and/or seizure orders by the Swedish Enforcement Authority. Participants answered questionnaires regarding socio-demographic variables, debt size, history of suicide attempt, critical life events, and social contacts, and filled the Hospital Anxiety and Depression Scale (HADS). In the statistical analyses, Chi² test for independence and t-test was used, and binary logistic regression to adjust for the confounding effects of the variables on each other.

RESULTS: The analysis revealed that nearly one in five (19.3%, N = 123) had attempted suicide at least once. A larger part of the respondents who had a history of suicide attempts reported that they were living alone (OR 2.30 (95% CI 1.34-3.89, p = .002). Many of those living alone were women (χ² (1, n = 121) = 4.88, p = 0.03, ɸ = 0.22).

CONCLUSIONS: The results of the current study point to the fact that economic vulnerability is an important psychosocial aspect to take into serious consideration concerning mental health and suicide prevention. Longitudinal research is needed to explain, predict and prevent suicide due to over-indebtedness.

PMID:37261778 | DOI:10.1080/08039488.2023.2218349

J Exp Psychol Hum Percept Perform. 2023 May;49(5):709-724. doi: 10.1037/xhp0001120.

ABSTRACT

Static statistical regularities in the placement of targets and salient distractors within the search display can be learned and used to optimize attentional guidance. Whether statistical learning also extends to dynamic regularities governing the placement of targets and distractors on successive trials remains controversial. Here, we applied the same dynamic cross-trial regularity-one-step shift of the critical item in clockwise/counterclockwise direction-to either the target or a distractor. In two experiments, we found and replicated robust learning of the predicted target location: processing of the target at this location was facilitated, compared to random target placement. But we found little evidence of proactive suppression of the predictable distractor location-even in a close replication of Wang et al. (2021), who had reported a dynamic distractor suppression effect. Facilitation of the predictable target location was associated with explicit awareness of the dynamic regularity, whereas participants showed no awareness of the distractor regularity. We propose that this asymmetry arises because, owing to the target’s central role in the task set, its location is explicitly encoded in working memory, enabling the learning of dynamic regularities. In contrast, the distractor is not explicitly encoded; so, statistical learning of dynamic distractor locations is more precarious. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37261775 | DOI:10.1037/xhp0001120

J Exp Psychol Hum Percept Perform. 2023 May;49(5):672-686. doi: 10.1037/xhp0001104.

ABSTRACT

Previous studies have posited that spatial location plays a special role in object recognition. Notably, the “spatial congruency bias (SCB)” is a tendency to report objects as the same identity if they are presented at the same location, compared to different locations. Here we found that even when statistical regularities were manipulated in the opposite direction (objects in the same location were three times more likely to be different identities), subjects still exhibited a robust SCB (more likely to report them as the same identity). We replicated this finding across two preregistered experiments. Only in a third experiment where we explicitly informed subjects of the manipulation did the SCB disappear, though the lack of a significantly reversed bias suggests the ingrained congruency bias was not completely overcome. The inclusion of catch trials where the second object was completely masked further bolsters previous evidence that the congruency bias is perceptual, not simply a guessing strategy. These results reinforce the dominant role of spatial information during object recognition and present the SCB as a strong perceptual phenomenon that is incredibly hard to overcome even in the face of opposing regularities and explicit instruction. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37261773 | DOI:10.1037/xhp0001104

J Exp Psychol Hum Percept Perform. 2023 May;49(5):623-634. doi: 10.1037/xhp0001108.

ABSTRACT

We investigated the perception of higher-order interpersonal affordances for kicking that emerged from lower-order personal and interpersonal affordances in the context of soccer. Youth soccer players reported the minimum gap width between two confederates through which they could kick a ball. In Experiment 1, we independently manipulated the egocentric distance of gaps from participants, and the nominal role of the confederates, either as teammates or opponents. In Experiment 2, we additionally varied the direction in which the confederates were facing, either together (i.e., into the gap) or away (i.e., away from the gap). Perceived minimum kickable gap width was larger for farther egocentric distances, when confederates were identified as opponents rather than as teammates, and (in Experiment 2) when confederates faced toward, rather than away from the gap. In both experiments, these main effects were subsumed in statistically significant interactions. We argue that these interactions reveal perception of higher-order interpersonal affordances for kicking that emerged from the simultaneous influence of lower-order affordances. The results are compatible with the hypothesis that these higher-order affordances were perceived, as such, and were not additively combined from independent perception of underlying, lower-order affordances. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37261770 | DOI:10.1037/xhp0001108

Psychol Trauma. 2023 Jun 1. doi: 10.1037/tra0001528. Online ahead of print.

ABSTRACT

OBJECTIVE: This study examined the relationships between race-based traumatic stress symptoms (RBTSS), posttraumatic stress disorder (PTSD) symptoms, and negative affect (NA) in the past year.

METHOD: Participants were 185 community-based respondents who completed a paper and pencil survey of the race-based traumatic stress symptoms scale (RBTSSS), diagnostic and statistical manual (DSM)-related PTSD symptoms, and negative emotions.

RESULTS: Two canonical correlation analyses were conducted for two participant groups: those with no race-based traumatic stress (RBTS) elevations and those with one or more RBTS elevations. Results showed a significant relationship between RBTS symptoms and PTSD symptoms for the no elevation group, and a significant relationship between RBTS symptoms and NA for the race-based stress/traumatic stress group. Notably, RBTS inclusion was not significantly correlated with NA.

CONCLUSIONS: Those with average-level RBTS symptoms appear to endorse more PTSD criteria, while those with elevated RBTS scores do not. The study, therefore, highlights the need for further investigation of how diagnostic measures of trauma may differentiate from trauma symptoms related to race-based experiences. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37261756 | DOI:10.1037/tra0001528

Environ Sci Pollut Res Int. 2023 Jun 1. doi: 10.1007/s11356-023-28004-y. Online ahead of print.

ABSTRACT

In present study, geophysical and geostatistical variability of ground water and agricultural soil investigated in the Jaipur region of Rajasthan (Western India) by applying the geographic information system (GIS), vertical electrical sounding (VES) ,and statistical analysis. Ground water and soil samples collected from different sites from the selected study area and variation pattern of quality parameters were assessed. A contour map analysis of distribution of metals and other contaminants in the samples was conducted using GIS. Maximum concentration of metals recorded in the soil samples in order of Fe, 11.25 mg kg^-1 > Mn, 8.6 mg kg^-1 > Zn, 7.2 mg kg^-1 > Cu, 0.455 mg kg^-1; however, maximum concentration of metals in the ground water samples was found as Zn, 2.64 mg L^-1 > Cu, 0.86 mg L^-1 > Fe, 0.39 mg L^-1 > Mn, 0.18 mg L^-1 > Pb, 0.065 mg L^-1 > Ni, 0.016 mg L^-1. Observed data emphasis variability in groundwater and soil quality parameter by PCA technique indicated 84.60% and 66.98% of variance, respectively. Soil quality index (SQI) value was observed as 0.482 indicating that 46% of soil sampling sites deteriorated and shown poor quality. Similarly, water quality index (WQI) value indicates good water quality at the sampling sites TW1, TW8, TW10, and TW12; however, TW3, TW4, TW6, TW19, TW20, and TW22 sites showed very poor water quality. The present study concludes that overexploitation of groundwater and unregulated discharge of wastewater leads to depletion of water and soil quality. Further, applying geographical and geostatistical techniques in assessing water and soil quality could be more effective tools in environmental monitoring and management for environmental and health safety.

PMID:37261695 | DOI:10.1007/s11356-023-28004-y

Environ Sci Pollut Res Int. 2023 Jun 1. doi: 10.1007/s11356-023-27821-5. Online ahead of print.

ABSTRACT

This study examined the impact of climate change on climate extreme indices in the Kaduna River basin, Nigeria. Large-scale atmospheric variables derived from the Global Climate Model (GCM), Coupled Model Intercomparison Project Phase 5 (CMIP5) (CanESM2) were used to develop a high-resolution climate using a Statistical Down Scaling Model. The adapted Caussinus-Mestre algorithm for homogenizing networks of temperature series and multivariate bias correction based on an N-dimension probability function were used to homogenize and correct the climate data, respectively. Fifteen climate extreme indices were computed using RClimdex. The coefficient of variance, Kruskal-Wallis test, and the modified Mann-Kendall test were used to assess the variation and trends. Wavelet analysis was used to determine the periodicities of the indices (1980-2020). The findings revealed a significant warming trend with low variability of temperature indices. The moderate variability with an insignificant decreasing trend was found for rainfall indices. Similarly, the future climate indices indicate a continuing positive trend in the temperature extreme indices. The majority of climate indices have a periodicity of less than or equal to 10 years for high frequency, except for PRCPTOT, R10MM, R20MM, Rx5day, SDII, TN90p, and TX90p for temperature indices. The findings conclude that the periodicity pattern of climate extreme indices is related to atmospheric phenomena (such as quasi-biennial oscillation, QBO), which indicate the impact of climate change. As a result, this can serve as an early warning for possible extreme event occurrences in the basin. The CMIP6 should be used to compare with the results of this study to provide a detailed assessment of the current implication of climate change on the catchment.

PMID:37261694 | DOI:10.1007/s11356-023-27821-5

J Patient Rep Outcomes. 2023 Jun 1;7(1):51. doi: 10.1186/s41687-023-00593-9.

ABSTRACT

BACKGROUND: The Respiratory Infection Intensity and Impact Questionnaire (RiiQ™) is a patient-reported outcome measure designed to assess symptoms and impacts of respiratory syncytial virus (RSV) infection. This study evaluated the construct validity, reliability, and responsiveness of the RiiQ™ Respiratory and Systemic Symptoms Scale scores.

METHODS: Prospective data were analyzed from a total of 1795 participants, including from non-hospitalized patients with acute respiratory infection (ARI) and no coinfections enrolled in a Phase 2b RSV vaccine study (RSV-positive: n = 60; RSV-negative: n = 1615), and two observational studies of patients hospitalized with RSV (n = 20; n = 100). Descriptive statistics, confirmatory factor analysis (CFA), test-retest intraclass correlation coefficients (ICCs), construct validity correlations (between a clinician-assessed clinical questionnaire and the RiiQ™ symptoms scale), known-groups validity, and responsiveness (correlations of change scores) were evaluated.

RESULTS: Mean patient age ranged from 66.5 to 71.5 years and the majority of patients were female. Initial assessments in the vaccine trial (ARI Day 1) were suggestive of less severe illness than in the observational studies with hospitalized patients. CFA loadings (> 0.40) supported summary scores. ICCs exceeding the recommended threshold of 0.70 supported test-retest reliability for Respiratory and Systemic Symptoms, except in the small observational study. At the scale level, correlations were moderate to strong (|r| ≥ 0.3) and positive between the Respiratory Symptoms Scale and the related clinical questionnaire scores, reflecting measurement of similar symptoms in support of convergent validity. Correlations with change in Patient Global Impression of Severity > 0.30 supported responsiveness.

CONCLUSIONS: Psychometric tests applied to the RiiQ™ Symptoms scales provide evidence of its reliability, construct validity, discriminating ability, and responsiveness for use in clinical studies to assess the onset and severity of RSV symptoms.

PMID:37261682 | DOI:10.1186/s41687-023-00593-9