Tag: nevin manimala

Oper Dent. 2023 May 23. doi: 10.2341/21-132-C. Online ahead of print.

ABSTRACT

OBJECTIVES: To compare the clinical performance of mildly acidic universal adhesives Scotchbond Universal (SU, 3M Oral Care, St Paul, MN, USA) and Prime & Bond Elect (PBE, Dentsply Sirona, Charlotte, NC, USA) in the restoration of noncarious cervical lesions (NCCLs).

METHODS AND MATERIALS: A total of 63 patients in need of 203 NCCL restorations participated in this randomized controlled clinical trial. Notch-shaped lesions were restored with Kalore (GC Corporation, Tokyo, Japan) after application of either SU or PBE, following the etch-and-rinse (ER) or self-etch (SE) techniques. Subjects were followed up for 60 months. The focus of the statistical analyses was on the change of outcome over time as assessed by the Modified USPHS rating system (ie, Alfa vs Bravo + Charlie outcomes). Logistic regression was performed for each outcome separately with compound symmetric variance-covariance structure assumed to consider a correlation of restorations within subjects. All analyses were conducted using SAS 9.4 (SAS, Cary, NC, USA).

RESULTS: One-hundred twenty-nine teeth in 35 subjects were assessed at the 60-month follow-up. In addition, three restorations that failed prior to the 60-month evaluation, two of which were in subjects who did not present for the 60-month follow-up, were included in the statistical analysis. In total, two restorations in the SU_ER group and three restorations in the PBE_SE group failed the retention category. Statistically significant differences were obtained for the comparison of restorations in the PBE_SE and PBE_ER groups, where the former was 58% less likely to maintain a score of Alfa for marginal discoloration than the latter.

CONCLUSIONS: SU and PBE demonstrated acceptable clinical performance at 60 months with regard to restoration retention. Phosphoric-acid etching of the NCCLs prior to adhesive application significantly improved the performance of PBE in regard to marginal discoloration.

PMID:37226698 | DOI:10.2341/21-132-C

J Adv Nurs. 2023 May 24. doi: 10.1111/jan.15719. Online ahead of print.

ABSTRACT

AIM: The purpose of this study was to explore the relationship between nurses’ well-being and their ethical leadership, and the mediating role of workplace mindfulness in this relationship.

DESIGN: This was a quantitative cross-sectional study.

METHODS: This cross-sectional study was conducted in three tertiary hospitals in central China from May 2022 to July 2022, and the Nurses’ Workplace Mindfulness, Ethical Leadership and Well-Being Scale were distributed and collected via the Internet. A total of 1579 nurses volunteered to participate in this study. SPSS 26.0 statistical software was used to analyse the data by Z-test and Spearman’s rank correlation; the internal mechanism of workplace mindfulness and ethical leadership on nurses’ well-being was completed by AMOS 23.0 statistical software.

RESULTS: The scores of nurses’ well-being, workplace mindfulness and ethical leadership were 93.00 (81.00, 108.00), 96.00 (80.00, 112.00) and 73.00 (67.00, 81.00) respectively. The professional title, age and department atmosphere affect their well-being. Spearman’s analysis showed that nurses’ well-being was positively correlated with ethical leadership (r = .507, p < .01) and workplace mindfulness (r = .600, p < .01); workplace mindfulness partially mediated the relationship between ethical leadership and nurses’ well-being accounting for 38.5% of the total effect ratio [p < .001, 95% CI = (0.215, 0.316)].

CONCLUSION: Nurses’ well-being was at a medium level, and had a higher score in ethical leadership and workplace mindfulness, and workplace mindfulness played a partial mediating role between ethical leadership and nurses’ well-being.

IMPACT: This suggests that nursing managers need to pay attention to clinical nurses’ well-being experience, actively focus on the relationship among ethical leadership, workplace mindfulness and well-being and integrate core values such as positivity and morality into nurses’ daily routines, so as to improve the work enthusiasm and well-being experience of clinical nurses, enhancing the nursing quality and stabilizing the nursing team.

PMID:37226654 | DOI:10.1111/jan.15719

J Oral Rehabil. 2023 May 24. doi: 10.1111/joor.13517. Online ahead of print.

ABSTRACT

BACKGROUND: Disc displacement with reduction (DDwR) therapy should be performed only when pain or discomfort is presented. Data on treatment options for painful DDwR are very limited.

OBJECTIVE: The aim was to investigate whether an isometric training of the lateral pterygoid muscle (LPM) is equivalent to stabilization appliance therapy with regard to treatment of painful DDwR. The training program is based on the science of Janda.

METHODS: This was a prospective, randomized study with a comparative treatment group. Sixty patients (≥18 years) with DDwR and pain were randomly assigned to two groups: (1) muscle training, (2) stabilization appliance. The following variables were recorded at baseline examination and after 2, 4 and 6 months: changes in orofacial pain, clicking sounds of the temporomandibular joint (TMJ), force degrees for the lateral movement of the mandible and interincisal opening distance. P values of < 0.05 were considered statistically significant but 95% confidence intervals were also presented.

RESULTS: A decrease in orofacial pain intensity was seen in both groups (P < 0.0001). Registered TMJ clicking disappeared after 6 months of treatment in 37% (n=11) of the patients in the training group and in 27% (n=8) of the appliance group (P = 0.0009 and P = 0.0047). Muscle training showed 27 improvements in Janda force degrees at the end of the study (P < 0.0001).

CONCLUSION: Muscle training and appliance therapy improved mouth opening and reduced pain intensity in both patient groups. Muscle training might be a promising option in treatment of patients suffering from painful DDwR.

PMID:37226632 | DOI:10.1111/joor.13517

Wiad Lek. 2023;76(4):831-837. doi: 10.36740/WLek202304120.

ABSTRACT

OBJECTIVE: The aim: Нygienic assessment of labour conditions and risks for the Ukrainian agricultural personnel treating berries and melon crops with fungicides, herbicides and insecticides for justification of their safe use regulations.

PATIENTS AND METHODS: Materials and methods: Natural studies of labour conditions and risk correspond to the acting laws of Ukraine. The results were statistically treated using IBM SPSS StatisticsBase v.22.

RESULTS: Results: The natural studies of fungicides, insecticides, used for treatment of berries and melon crops, show that labour air environment corresponds to hygienic standards. The authors have established that the hazard index of complex fungicides effect on spray fueling attendants and tractor drivers is 0.110}0.046 and 0.155}0.071, that of herbicides – 0.34}0.025 and 0.380}0.257, that of insecticides – 0.221}0.111 and 0.222}0.110, respectively; hazard index of combined effect of several acting substances makes up- 0.239}0.088 and 0.336}0.140 for spray fueling attendants and tractor drivers, respectively. The statistical analysis shows that the hazard coefficients of inhalation and percutaneous penetration do not differ statistically between spray fueling attendants and tractor drivers (р>0.05). The percutaneous risk (%) of various pesticide groups for spray fueling attendants ranges 65.74-97.58 %, for tractor drivers – 50.72-95.23 %.

CONCLUSION: Conclusions: The analysis has shown that the professional risk of fungicides, herbicides, insecticides, during agricultural treatment of the berries and melon crops does not exceed standards.

PMID:37226623 | DOI:10.36740/WLek202304120

Wiad Lek. 2023;76(4):799-804. doi: 10.36740/WLek202304115.

ABSTRACT

OBJECTIVE: The aim: To investigate the dynamics of the volumes and outcomes of medical care for patients with skin cancer in Ukraine during 2010-2020.

PATIENTS AND METHODS: Materials and methods: Official statistical data from the reports of the Center for Medical Statistics of the Center for public health of the Ministry of Health of Ukraine and the National Cancer Registry for 2010-2020. Statistical and bibliosemantic methods were used in the work.

RESULTS: Results: A decrease in the capacity to provide medical care to patients with skin cancer was identified, as evidenced by a decrease in the number of oncological dispensaries, oncological and examination rooms in outpatient clinics, oncological and radiological beds, with a relatively unchanged level of staffing. An analysis of the main indicators of the organization and activities of medical care for patients with cancer skin revealed problems with early detection of tumors, in particular during preventive examinations, and incomplete coverage of patients with stages I-II of the disease with special treatment. The positive dynamics of melanoma treatment outcome indicators were revealed (increase in accumulation index, 5-year patient survival rate, decrease in lethality and mortality).

CONCLUSION: Conclusions: the organization of medical care for patients with skin tumors, especially non-melanoma ones, needs further improvement in the context of preventive interventions, ensuring the coverage of patients with special treatment.

PMID:37226618 | DOI:10.36740/WLek202304115

Wiad Lek. 2023;76(4):772-777. doi: 10.36740/WLek202304111.

ABSTRACT

OBJECTIVE: The aim: To present a comparative analysis of the educational technologies effectiveness that were used in the process of professional training of masters of dentistry during quarantine restrictions and martial law.

PATIENTS AND METHODS: Materials and methods: To perform the set tasks, the following the empirical methods of scientific research were used: quantitative data were collected based on analyzing the results of students’ educational achievements, as well as implementing special questionnaire that was sent to the students of the Faculty of Dentistry of NMU; qualitative data were collected with the help of several focus groups formed from students and teachers of the faculty. Analysis was undertaken using statistical methods (Pearson’s test), and qualitative data were analyzed descriptively.

RESULTS: Results: This paper analyzes the effectiveness of educational technologies used during quarantine restrictions and martial law, the role of phantom classes in providing professional training of dentistry specialists, summarizes the results of a comprehensive analysis of scientific literature, teaching experience at the dental faculty and the results of sociological research (student surveys, discussion in focus groups).

CONCLUSION: Conclusions: The outbreak of the COVID-19 pandemic and the full-scale war unleashed by the russian federation in Ukraine forced to quickly find and implement mixed forms of teaching future masters of dentistry, which, in combination with digital technologies, enables implementing high-quality and effective training.

PMID:37226614 | DOI:10.36740/WLek202304111

Wiad Lek. 2023;76(4):758-764. doi: 10.36740/WLek202304109.

ABSTRACT

OBJECTIVE: The aim: To study the dynamics of gadget use by higher education students of the Bogomolets National Medical University and to assess technological impact on the physical health of students.

PATIENTS AND METHODS: Materials and methods: To accomplish the tasks set using theoretical and experimental methods of scientific research: systematic analysis, comparison and generalization of the bibliosemantic method, questionnaires, and interviews with students. Quantitative data collected during the survey of students studying in the «Dentistry», «Pediatrics», «Medicine», «Pharmacy, Industrial Pharmacy», «Physical Therapy, Occupational Therapy», and «Medical Psychology» specialties were processed using the MedCalc statistical software, and there was carried out comparative analysis afterwards.

RESULTS: Results: During the quarantine and martial law, medical university students were forced to study distantly or in a mixed format using various gadgets and computers. It is obvious that the physical condition of a person is affected by the duration of their use of various devices. In this paper, therefore, the risks and the researched dynamics of gadget use by higher education students of the Bogomolets National Medical University were identified. Thus, the technological impact on the physical health of students was also defined. Moreover, the data based on the results of height and weigh calculation of higher education students, which used to diagnose types of obesity by anthropometric indicators, were also collected.

CONCLUSION: Conclusions: According to the results of the research, it was established that the students of the Bogomolets National Medical University spent a significant part of their study time sitting in the classroom or at the computer (40 hours weekly average). We found that in the process of distance learning, prolonged sitting at a PC or other gadget (as well as general sedentary lifestyle) has affected the female higher education students majoring in 222 «Medicine» course their body mass index. The time spent using gadgets both in the educational and non-formal education (self-education) processes has increased significantly. We attribute this fact to the emergence of a significant number of online educational resources in the public domain, the growing number of webinars, trainings, and master classes conducted by both domestic and foreign experts online.

PMID:37226612 | DOI:10.36740/WLek202304109

J Food Drug Anal. 2023 Mar 15;31(1):137-151. doi: 10.38212/2224-6614.3447.

ABSTRACT

New psychoactive substances (NPS) have been rapidly emerged as legal alternatives to controlled drugs, which raised severe public health issue. The detection and monitoring of its intake by complete metabolic profiling is an urgent and vital task. Untargeted metabolomics approach has been applied for several NPS metabolites studies. Although the number of such works is relatively limited but with a rapidly growing need. The present study aimed to propose a procedure that includes liquid chromatography high-resolution mass spectrometry (LC-HRMS) analysis and a signal selection software, MetaboFinder, programed as a web tool. The comprehensive metabolites profile of one kind of NPS, 4-methoxy-α-pyrrolidinovalerophenone (4-MeO-α-PVP), was studied by using this workflow. In this study, two different concentrations of 4-MeO-α-PVP along with as blank sample were incubated with human liver S9 fraction for the conversion to their metabolites and followed by LC-MS analysis. After retention time alignment and feature identification, 4640 features were obtained and submitted to statistical analysis for signal selection by using MetaboFinder. A total of 50 features were considered as 4-MeO-α-PVP metabolite candidates showing significant changes (p < 0.00001 and fold change >2) between the two investigated groups. Targeted LC-MS/MS analysis was conducted focusing on these significantly expressed features. Assisted by chemical formula determination according to high mass accuracy and in silico MS² fragmentation prediction, 19 chemical structure identifications were achieved. Among which, 8 metabolites have been reported derived from 4-MeO-α-PVP in a previous literature while 11 novel 4-MeO-α-PVP metabolites were identified by using our strategy. Further in vivo animal experiment confirmed that 18 compounds were 4-MeO-α-PVP metabolites, which demonstrated the feasibility of our strategy for screening the 4-MeO-α-PVP metabolites. We anticipate that this procedure may support and facilitate traditional metabolism studies and potentially being applied for routine NPS metabolites screening.

PMID:37224557 | DOI:10.38212/2224-6614.3447

Nucleic Acids Res. 2023 May 24:gkad373. doi: 10.1093/nar/gkad373. Online ahead of print.

ABSTRACT

Polygenic risk scores (PRSs) are expected to play a critical role in precision medicine. Currently, PRS predictors are generally based on linear models using summary statistics, and more recently individual-level data. However, these predictors mainly capture additive relationships and are limited in data modalities they can use. We developed a deep learning framework (EIR) for PRS prediction which includes a model, genome-local-net (GLN), specifically designed for large-scale genomics data. The framework supports multi-task learning, automatic integration of other clinical and biochemical data, and model explainability. When applied to individual-level data from the UK Biobank, the GLN model demonstrated a competitive performance compared to established neural network architectures, particularly for certain traits, showcasing its potential in modeling complex genetic relationships. Furthermore, the GLN model outperformed linear PRS methods for Type 1 Diabetes, likely due to modeling non-additive genetic effects and epistasis. This was supported by our identification of widespread non-additive genetic effects and epistasis in the context of T1D. Finally, we constructed PRS models that integrated genotype, blood, urine, and anthropometric data and found that this improved performance for 93% of the 290 diseases and disorders considered. EIR is available at https://github.com/arnor-sigurdsson/EIR.

PMID:37224538 | DOI:10.1093/nar/gkad373

Nucleic Acids Res. 2023 May 24:gkad445. doi: 10.1093/nar/gkad445. Online ahead of print.

ABSTRACT

We present GePI, a novel Web server for large-scale text mining of molecular interactions from the scientific biomedical literature. GePI leverages natural language processing techniques to identify genes and related entities, interactions between those entities and biomolecular events involving them. GePI supports rapid retrieval of interactions based on powerful search options to contextualize queries targeting (lists of) genes of interest. Contextualization is enabled by full-text filters constraining the search for interactions to either sentences or paragraphs, with or without pre-defined gene lists. Our knowledge graph is updated several times a week ensuring the most recent information to be available at all times. The result page provides an overview of the outcome of a search, with accompanying interaction statistics and visualizations. A table (downloadable in Excel format) gives direct access to the retrieved interaction pairs, together with information about the molecular entities, the factual certainty of the interactions (as verbatim expressed by the authors), and a text snippet from the original document that verbalizes each interaction. In summary, our Web application offers free, easy-to-use, and up-to-date monitoring of gene and protein interaction information, in company with flexible query formulation and filtering options. GePI is available at https://gepi.coling.uni-jena.de/.

PMID:37224532 | DOI:10.1093/nar/gkad445