Tag: nevin manimala

Quintessence Int. 2025 Jul 1;0(0):1-33. doi: 10.3290/j.qi.b6335983. Online ahead of print.

ABSTRACT

BACKGROUND: Various salivary cytokines are overexpressed in the saliva of Sjögren’s syndrome (SjS) patients. In addition, the levels of salivary cytokines can differ according to local and systemic conditions, besides SjS itself.

OBJECTIVES: This study aimed to analyze the associations and correlations of caries experience, sialometry, and systemic co-morbidities with levels of the following salivary cytokines: Interleukin (IL): IL-1β, IL-6, IL-8, IL-10, TNF-α and IL-17A among SjS patients.

METHODS: Upon ethical approval and signed informed consent, 20 women with SjS were recruited. Clinical examinations included Decayed, Missing, and Filled Teeth (DMFT) index measurements, sialometry, and saliva sampling. Levels of salivary cytokines: IL-1β, IL-6, IL-8, IL-10, TNF-α, and IL-17A were measured by Enzyme- Linked Immunosorbent Assay (ELISA). Statistical analysis was performed using the Independent-Samples Mann-Whitney U Test for the associations between the categorial parameters, and Spearman’s correlation test to analyze the correlations between continuous variables.

RESULTS: We report that Salivary cytokines are inter-correlated in a statistically significant manner (p<0.05). Age is correlated with IL-17A levels (p<0.05), and decayed teeth were cor-related with IL-6, IL-8, and IL-10 (p<0.05). The liquid fraction in the unstimulated salivary flow rate significantly correlates with all salivary cytokines that were measured. Cardiac disease is correlated with IL-10 levels, and Rheumatoid Arthritis is correlated with IL-1β levels (p<0.05).

CONCLUSIONS: These results suggest that local factors such as caries experience and salivary flow rates as well as systemic factors such as co-morbidities should be taken into consideration when testing the levels of salivary cytokines in SjS.

PMID:40590144 | DOI:10.3290/j.qi.b6335983

Quintessence Int. 2025 Jul 1;0(0):0. doi: 10.3290/j.qi.b6336017. Online ahead of print.

ABSTRACT

OBJECTIVES: This retrospective study assesses the long-term effects of implants on alveolar and basal bone to determine if a patient’s sex affects dimensional changes in the jaw and evaluate whether dental implants halt the atrophy of bone when compared to no post-extraction intervention.

METHODS AND MATERIALS: IRB approval was obtained for this study. Of the 125 patients (432 sites) in the study, 53% were female. All had two CBCTs taken, an average of 4.7 years apart. The scans were divided into three groups. In the control group, the extraction site (first CBCT or T1) was not replaced when the second scan was taken (T2). Group 2 had no implant at T1 and an implant at T2. Group 3 had an implant at T1 and T2. Measurements were made from landmarks at predetermined levels (superior cortex of the IAN or the most inferior point in the nasal floor (NF) in the direction of the crest of bone height (Group C, 2, and 3). To avoid osseous changes due to placement, measurements were made from the inferior alveolar nerve for mandibular implants or the nasal floor for maxillary implants. Recognizing gender-based disparities in jaw size, we monitored percentage changes in bone.

RESULTS: Loss of alveolar bone width across all groups was common. When bivariate analysis was performed after Bonferroni correction (p<0.025), changes in alveolar bone width were significantly greater in females (p = 0.004). Although the loss in the basal bone was present, it was not significant between the sexes nor as great as alveolar bone resorption (p=0.880). When comparing groups using bivariate analysis, differences were not statistically significant between treatment groups and the control group (p=0.050) for basal bone and for alveolar bone (p=0.052). In the regression analysis for sex or groups, neither was statistically significant for either basal or alveolar bone (p >0.05).

CONCLUSION: Dental implants do not arrest post-extraction atrophy in either alveolar or basal bone. Females exhibited a statistically greater rate of alveolar bone loss. Stable long-term implant success necessitates precise placement.

PMID:40590143 | DOI:10.3290/j.qi.b6336017

Quintessence Int. 2025 Jul 1;0(0):0. doi: 10.3290/j.qi.b6335908. Online ahead of print.

ABSTRACT

BACKGROUND: Silver diamine fluoride (SDF) is increasingly recognized as a minimally invasive and effective treatment for early childhood caries (ECC). However, the dark discoloration from its application significantly limits its acceptability among parents, especially for anterior teeth. Zinc, with known antimicrobial and biofilm-modulating properties, has recently been proposed as a potential adjunct to reduce SDF-induced staining.

AIM: This study aimed to evaluate the effectiveness of zinc pretreatment in reducing SDF-induced discoloration on primary tooth carious lesions that involved dentin. This study also aimed to examine surface morphology and elemental composition changes associated with Zinc adjunct SDF treatments.

METHODS: Extracted human primary teeth were allocated into three groups: untreated control, positive control (38% SDF alone), and experimental group (20M zinc pretreatment followed by 38% SDF). Tooth color changes were assessed using grayscale intensity analysis via standardized photography at baseline, immediately post-treatment, and up to 14 days. Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS) were employed to investigate morphological and compositional changes in both sound and naturally carious dentin areas. Statistical analyses included two-sample t-tests, linear regression, and likelihood ratio tests.

RESULTS: Teeth pretreated with zinc demonstrated less discoloration compared to the SDF-only group. Although this difference was not statistically significant (p = 0.125), it may have potential clinical relevance. SEM images revealed modified silver deposition patterns characterized by dispersed and less densely packed silver aggregates in zinc-pretreated groups. EDS analysis confirmed the presence of zinc, suggesting its interaction with silver deposition processes.

CONCLUSION: Zinc pretreatment effectively reduces SDF-induced discoloration in primary dentition, potentially improving aesthetic outcomes and parental acceptance. This approach represents a promising advancement in minimally invasive pediatric dental care and warrants further clinical exploration.

PMID:40590141 | DOI:10.3290/j.qi.b6335908

Hypertension. 2025 Jul 1. doi: 10.1161/HYPERTENSIONAHA.124.24640. Online ahead of print.

ABSTRACT

BACKGROUND: Automated blood pressure (BP) devices may be less accurate in women than men, but this requires further investigation. This study aimed to determine sex differences in automated BP, measured with a single brand and model of device, compared with manual BP, with a focus on cuff sizes and associations with measures of adiposity.

METHODS: Automated (Omron HEM-907XL) and manual BP were taken sequentially in a random order among a subsample of participants attending the US National Health and Nutrition Examination Survey, 2017 to 2018. Anthropometry and dual-energy x-ray absorptiometry were used to record body size and composition. Analyses, including multivariable regression to determine sex differences in BP, by cuff size, followed complex survey statistical principles.

RESULTS: A total of 3735 participants (49.0% women [95% CI, 46.4-51.6], 45 years [43-46]) were included. In women, automated systolic BP (SBP) incrementally underestimated manual SBP across larger cuffs up to extra-large (-6.4 mm Hg [-8.0 to -4.9]). In men, automated SBP underestimated manual SBP only with extra-large cuffs (-2.4 mm Hg [95% CI-3.9 to -0.9]). Underestimation by automated SBP with extra-large cuffs was independently associated with all measures of body size indicative of increased adiposity in both women and men. Hypertension classification from automated and manual SBP had moderate agreement for adult/large cuffs (weighted kappa range 0.66-0.79) but weak agreement for extra-large cuffs (0.55-0.58) for women and men.

CONCLUSIONS: The automated device used in this study underestimated manual SBP at larger cuff sizes, which was associated with indices of adiposity. Poorer accuracy of automated BP in larger cuff sizes could contribute to inequitable BP-related health care for women and men and requires further investigation.

PMID:40590130 | DOI:10.1161/HYPERTENSIONAHA.124.24640

Clin Otolaryngol. 2025 Jul 1. doi: 10.1111/coa.70005. Online ahead of print.

ABSTRACT

OBJECTIVE: The effect of noise on the postural control process is of ongoing interest. This exploratory study aims to determine the effect of personal listening devices (PLD) on postural stability among adolescents and young adults.

METHODS: Participants aged between 13 and 25 with a history of PLD usage were included. The study was carried out in two parts. The first part involved determining the PLD listening level and the preferred sound level. In the second part, postural stability was assessed using the modified Clinical Test for Sensory Interaction in Balance (mCTSIB) and dynamic postural stability.

RESULTS: 64 participants were recruited with a mean age of 18.78 (SD: 3.11). The majority were female (62.5%) and of Chinese ethnicity (38.1%). The reported mean PLD listening level and preferred volume levels were 57.50 dB (SD: 6.15) and 46.48% (SD: 15.98), respectively. Male PLD users had higher listening levels and preferred volume levels. Adolescents were found to have a higher listening level than young adults. Female PLD users revealed a higher sway and postural stability index than male PLD users. Young adults were found to have a higher sway and postural stability index. Statistical significance is demonstrated between the age of PLD users and mCTSIB sway index (coef: 0.367; p = 0.003).

CONCLUSION: The current study suggests that the younger generation is susceptible to postural instability following PLD exposure. Yet, the provided data is inadequate to draw a conclusion, and future randomised controlled studies with large sample sizes are warranted.

PMID:40590127 | DOI:10.1111/coa.70005

J Agric Food Chem. 2025 Jul 1. doi: 10.1021/acs.jafc.5c02463. Online ahead of print.

ABSTRACT

Thiophenols were recently identified in wine as undesirable compounds contributing to the ashy aftertaste associated with smoke taint. These potential odorants enhanced the unpleasant sensory properties associated with smoke taint at ultratrace (ng/L) levels when present in wine with volatile phenols, but accurate quantification of volatile sulfur compounds at this concentration remains challenging. A simple, stable isotope dilution assay (SIDA) method employing ultrahigh-pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) was developed and validated for accurate quantification of six thiophenols (benzenethiol, 2-methylbenzenethiol, 3-methylbenzenethiol, 4-methylbenzenethiol, 2-methoxybenzenethiol, and methylsulfanylbenzene) using N-ethylmaleimide (NEM) as a derivatizing agent and a chemically matched deuterated analogue (d₅-benzenethiol) as the internal standard. It was shown that NEM reacted quickly with thiophenols to form stable derivatives in an unmodified wine matrix. The preparation of samples and the analytical method were optimized to achieve limits of quantification at nanogram-per-liter levels and validated in different wine matrices. The developed method was then applied to wines produced from grapes exposed to smoke (pre-veraison) during the 2019 Australian wildfires. The concentration of thiophenols ranged from below the limit of detection (LOD, <0.5 ng/L) to 445 ng/L; statistical relationships with smoke aroma and flavor were investigated.

PMID:40590110 | DOI:10.1021/acs.jafc.5c02463

Microsc Res Tech. 2025 Jul 1. doi: 10.1002/jemt.70030. Online ahead of print.

ABSTRACT

Evaluation of the effects of various nanoparticles (NPs), titanium dioxide (TiO₂), cerium dioxide (CeO₂), and copper oxide (CuO), when incorporated into universal adhesive (UA), on the micro tensile bond strength (μTBS), degree of conversion (DC), adhesive interface, and resin tag assessment. Before incorporating nanoparticles (NPs) into UA, elemental analysis was conducted on all NP types using energy-dispersive spectroscopy (EDS). The study involved 48 intact human molars, divided into four groups based on UA modification with different NPs: Group 1 (Control), Group 2 (TiO₂NPs), Group 3 (CeO₂NPs), and Group 4 (CuONPs). Samples were restored with composite and light cured. All specimens underwent 10,000 cycles of thermocycling for aging, followed by μTBS testing and failure mode evaluation using a universal testing machine and stereomicroscope. Fourier transform infrared spectroscopy (FTIR) was employed to assess the DC. Scanning electron microscopy (SEM) was utilized to evaluate resin tag length and examine the adhesive interface. Statistical analysis involved one-way analysis of variance (ANOVA) with Tukey’s post hoc test for multiple comparisons of μTBS, DC, and resin tag (p < 0.05). Group 3 (2% CeO₂NPs-UA) presented the maximum resin tag length (111.21 ± 2.81 μm) and highest μTBS (15.47 ± 0.88 MPa). However, the lowest bond integrity score (12.64 ± 0.5 MPa) and (76.29 ± 1.69 μm) was presented by Group 1 (0% NPs-UA) (12.64 ± 0.5 MPa) samples. Group 3 (2% CeO₂NPs-UA) (68.54 ± 6.77) adhesive showed DC comparable to 2% CuONPs-UA (67.58 ± 9.65) and UA-unmodified (74.33 ± 8.59) (p > 0.05). The UA enhanced with CeO₂NPs and CuONPs can be viewed as a viable option, given its improved μTBS and resin tag length as observed through SEM. Furthermore, the modification of UA using CeO₂NPs and CuONPs exhibits a DC comparable to that of the unmodified adhesive control.

PMID:40590099 | DOI:10.1002/jemt.70030

Korean J Radiol. 2025 Jul;26(7):650-659. doi: 10.3348/kjr.2025.0049.

ABSTRACT

OBJECTIVE: To compare the efficacy of microwave ablation (MWA) and surgical resection (SR) for small (≤3 cm) hepatocellular carcinoma (HCC) in older patients.

MATERIALS AND METHODS: This retrospective study initially enrolled 319 patients who were aged ≥65 years, had a single HCC ≤3 cm, and had Child-Pugh class A or B. Of these, 108 received MWA and 211 received SR. Overall survival (OS), disease-free survival (DFS), local tumor progression (LTP), complications, and postoperative hospital stay were compared between the groups. Hazard ratios (HRs) were estimated using the SR group as reference. Propensity score matching (PSM) was used to minimize confounding biases.

RESULTS: After PSM, 80 patients each were included in the MWA and SR groups. There were no statistically significant differences in the 1-, 3-, and 5-year OS rates (MWA: 96.2%, 80.3%, and 55.4%, respectively; SR: 91.3%, 81.4%, and 64.8%, respectively; HR = 1.06; 95% confidence interval [CI], 0.61-1.85; P = 0.839) and DFS rates (MWA: 72.4%, 43.2%, and 26.4%, respectively; SR: 78.8%, 51.2%, and 38.0%, respectively; HR = 1.27; 95% CI, 0.84-1.90; P = 0.247) between the MWA and SR groups. MWA was associated with a higher LTP rate (HR = 2.96; 95% CI, 1.21-7.28; P = 0.028). Additionally, older patients in the MWA group had fewer complications (52.5% vs. 97.5%, P < 0.001) and shorter postoperative hospital stay (3 days vs. 6 days, P < 0.001) than those in the SR group.

CONCLUSION: In older patients with a single HCC ≤3 cm, MWA was superior to SR in terms of complications and postoperative hospital stay, and there was no significant difference in the 5-year OS and DFS outcomes. Therefore, MWA may be an alternative curative treatment for such patients.

PMID:40590077 | DOI:10.3348/kjr.2025.0049

Korean J Radiol. 2025 Jul;26(7):626-637. doi: 10.3348/kjr.2024.1261.

ABSTRACT

OBJECTIVE: This study aimed to evaluate changes in left ventricular and left atrial mechanics in relation to the severity of aortic stenosis (AS) by comparing computed tomography (CT)-derived strain values in patients with mild-to-severe AS.

MATERIALS AND METHODS: This single-center retrospective study included 120 patients (median age, 76 years; 45.0% male), comprising 30, 30, and 60 patients with mild, moderate, and severe AS, respectively, all of whom underwent multiphase cardiac CT between 2015 and 2021. Patients were selected from 177 individuals who met the initial eligibility criteria, with matching for age, sex, and hypertension in a 1:1:2 ratio across the mild, moderate, and severe AS groups. Electrocardiography-gated cardiac CT images were analyzed to obtain various quantitative left ventricle (LV) and left atrium (LA) strain parameters. Statistical differences in cardiac CT-derived LV and LA strain parameters among mild, moderate, and severe AS were evaluated using the Kruskal-Wallis test, followed by post-hoc tests.

RESULTS: The median LV global longitudinal strain differed significantly across AS severity (GLS: -19.4%, -18.2%, and -16.2% for mild, moderate, and severe AS, respectively; P < 0.001), with the absolute value decreasing as AS severity increased. Additionally, the median values of LV global circumferential strain (GCS: -29.8%, -30.8%, and -27.4%, respectively; P = 0.045), LV global radial strain (GRS: 50.1%, 50.3%, and 39.3%, respectively; P = 0.004), and LA conduit strain (11.5%, 11.2%, and 9.0%, respectively; P = 0.031) differed significantly according to AS severity, with lower absolute values observed in patients with severe AS.

CONCLUSION: In patients with AS, CT-derived LV and LA strains revealed changes in myocardial deformation according to AS severity. Specifically, there was a gradual decrease in the absolute value of LV GLS with increasing AS severity and initial preservation until moderate AS, followed by an eventual decrease in the absolute values of LV GCS, LV GRS, and LA conduit strain in severe AS.

PMID:40590075 | DOI:10.3348/kjr.2024.1261

Intern Med J. 2025 Jul 1. doi: 10.1111/imj.70138. Online ahead of print.

ABSTRACT

BACKGROUND: Lung cancer remains a significant public health problem and a leading cause of cancer-related mortality worldwide. The delays in the diagnosis of lung cancer are more pronounced for rural and regional Australians compared to their urban counterparts. Implementing an online HealthPathway is one way to reduce delays in the diagnosis of lung cancer.

AIM: The Townsville Lung Cancer Referral Pathway (TLCRP) was implemented to guide local general practitioners (GPs) in the referral process of people with suspected lung cancer. The aim of the study was to compare the time interval from initial GP consultation of the person with suspected lung cancer to the first specialist referral and from the first specialist referral to the initial specialist appointment, before and after implementation of TLCRP. Other lung cancer service outcomes were also compared between the pre- and post-implementation groups.

METHODS: A retrospective cohort study of 316 participants was conducted, and descriptive statistical analysis of the data was used to discern any difference in timelines and other clinical outcomes in the pre-pathway implementation group compared to the post-pathway implementation group.

RESULTS: The time interval from initial GP presentation to initial referral to specialist appointment was significantly reduced in the post-pathway group (15 days) compared to the pre-pathway group (8 days, P = 0.03). However, the time interval from GP referral to initial appointment with a specialist increased in the post-pathway group (15 and 20 days, P = 0.03). Many of the Cancer Australia lung cancer optimal care pathway referral guidelines were not met. Only 40% of the pre-pathway group and 34% of the post-pathway group were seen in the specialist clinic within 2 weeks of GP referral. Significant proportions of patients in both groups did not have chest x-rays ordered by the GP, and the proportion of participants who were appropriately referred to the respiratory clinic did not improve after implementation of TLCRP (76% and 72%). Nearly 30% of participants in both groups were diagnosed after emergency presentation.

CONCLUSIONS: TLCRP improved the time interval from initial GP consultation to specialist referral, thus meeting its primary objective. However, better strategies are required to improve other timelines and meet Cancer Australia’s lung cancer optimal care pathway guidelines.

PMID:40590064 | DOI:10.1111/imj.70138