Tag: nevin manimala

Technol Cancer Res Treat. 2025 Jan-Dec;24:15330338251394573. doi: 10.1177/15330338251394573. Epub 2025 Nov 14.

ABSTRACT

IntroductionBody mass index (BMI) is a common clinical parameter associated with cancer prognosis, but its association with survival outcomes in lung cancer patients receiving immune checkpoint inhibitors (ICIs) remains unclear. This study aimed to clarify the prognostic value of BMI in ICI-treated lung cancer patients.MethodsA systematic review and meta-analysis were conducted based on online databases including PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov up to December 1, 2024. Eligible studies included lung cancer patients treated with ICIs and reported hazard ratios (HRs) for overall survival (OS) and/or progression-free survival (PFS) stratified by BMI. Random-effects models were used to determine HRs with 95% confidence intervals (CIs).ResultsA total of 30 studies involving 5987 patients were included. High BMI was significantly associated with better OS (HR = 0.69, 95%CI = 0.60-0.80) and PFS (HR = 0.82, 95%CI = 0.72-0.93). The subgroup analysis showed improved survival outcomes particularly in patients with BMI ≥ 30 kg/m² as compared with others. However, this association was not statistically significant in small-cell lung cancer.ConclusionHigh BMI was associated with a better prognosis than low BMI in ICI-treated patients with lung cancer. Due to study limitations, the prognostic impact of BMI still requires further clarification with additional evidence.

PMID:41236792 | DOI:10.1177/15330338251394573

Hum Vaccin Immunother. 2025 Dec;21(1):2583804. doi: 10.1080/21645515.2025.2583804. Epub 2025 Nov 14.

ABSTRACT

While international and domestic recommendations advocating for influenza vaccination during pregnancy, the vaccination rate among this demographic in China remains low, mainly due to concerns about fetal safety. This retrospective cohort enrolled mothers who registered and delivered between August 2020 and July 2023. The relationship between maternal influenza vaccination and adverse neonatal outcomes was assessed using Poisson regression models and logistic regression analyses. The adverse neonatal outcomes under evaluation included small for gestational age (SGA), large for gestational age (LGA), preterm birth (PTB), low birth weight (LBW), low Apgar score, congenital anomalies, neonatal intensive care unit (NICU) admission or referral, as well as stillbirth or neonatal death. Of the 2,517 women, 203 (8.1%) had received influenza vaccination during their pregnancies. The incidence rate of gestational complications in the vaccinated group being significantly higher than that in the unvaccinated group. In comparison with no vaccination, there was no statistically connection between vaccination and an increased risk of any adverse neonatal outcomes. The adjusted risk ratios (95% CIs) were: SGA 1.354 (0.842-2.177), LGA 1.504 (0.808-2.798), PTB 0.639 (0.257-1.590), LBW 0.294 (0.072-1.211), low Apgar score 0.918 (0.213-3.958), congenital anomaly 0.676 (0.087-5.247), and NICU admission or referral 0.151 (0.021-1.089). In this study, there was only 1 stillbirth and 1 neonatal death in the unvaccinated group, resulting in a cumulative incidence of 0.1%. No stillbirths or neonatal deaths occurred in the vaccinated group. These findings endorse public health initiatives aimed at enhancing vaccination rates among pregnant women.

PMID:41236786 | DOI:10.1080/21645515.2025.2583804

J Manag Care Spec Pharm. 2025 Nov 14:1-10. doi: 10.18553/jmcp.2025.25148. Online ahead of print.

ABSTRACT

BACKGROUND: In the United States, rIX-FP, rFIXFc, and rFIX are approved as treatment options for people with hemophilia B (PwHB). Although clinical trials have demonstrated the efficacy and safety of each product, real-world data can help to understand their use and treatment outcomes in the absence of direct head-to-head trials.

OBJECTIVE: To assess real-world factor IX (FIX) consumption and bleeding outcomes for PwHB receiving rIX-FP, rFIXFc, or rFIX prophylaxis.

METHODS: Retrospective, deidentified medical record information for PwHB with moderate or severe hemophilia B (FIX activity ≤5%) treated with rIX-FP, rFIXFc, or rFIX prophylaxis for at least 12 months was obtained from Hemophilia Treatment Centers in the United States between 2020 and 2023. FIX consumption was calculated using the most recently prescribed dosing frequency and dosage. Annualized bleeding rate (ABR), annualized spontaneous bleeding rate, and annualized joint bleeding rate were calculated based on the number of bleeding events over the observation period. Generalized linear models adjusting for covariates were used to test the statistical significance of the differences of consumption and ABR among the products.

RESULTS: Overall, 213 PwHB (53% with severe disease) aged 12 years and older were included for main analysis, with a mean age (range) of 32.7 (12-84) years. PwHB treated with rIX-FP prophylaxis had significantly lower mean FIX consumption compared with those receiving rFIXFc (45.8 vs 65.4 IU/kg/week; P = 0.0003) and rFIX (95.7 IU/kg/week; P < 0.0001). The mean dosing interval was 10.2, 7.3, and 5.2 days for rIX-FP, rFIXFc, and rFIX, respectively. Mean ABR was significantly lower in PwHB receiving rIX-FP compared with the other 2 products (rIX-FP vs rFIXFc: 1.2 vs 2.1; P = 0.0119; rIX-FP vs rFIX: 1.2 vs 2.3; P = 0.004). Mean annualized spontaneous bleeding rate was 0.4, 1.0, and 0.7 for rIX-FP, rFIXFc, and rFIX, respectively. Mean annualized joint bleeding rate was 0.7, 1.1, and 1.2 for rIX-FP, rFIXFc, and rFIX, respectively. The pattern of results for PwHB of all ages (including those aged <12 years, N = 50) were similar to those reported for PwHB aged 12 years and older. In a subgroup of 16 PwHB who switched to rIX-FP from a previous FIX product, mean FIX consumption was significantly reduced after switching to rIX-FP (49.0 vs 94.2 IU/kg/week; P = 0.0004). Mean ABR was also significantly reduced after switching to rIX-FP (3.2 vs 1.7; P = 0.0009).

CONCLUSIONS: In this retrospective study, rIX-FP prophylaxis was associated with lower FIX consumption and potentially improved protection against bleeds compared with prophylactic treatment with rFIXFc and rFIX.

PMID:41236778 | DOI:10.18553/jmcp.2025.25148

J Asthma. 2025 Nov 14:1-11. doi: 10.1080/02770903.2025.2589785. Online ahead of print.

ABSTRACT

OBJECTIVES: This study aimed to examine the effectiveness of motivational interviewing (MI) in enhancing asthma self-efficacy among adults in a primary care setting in Northern Jordan.

METHODS: A quality improvement project employing a quasi-experimental pre-post design was conducted using a convenience sample of adults diagnosed with asthma. The Asthma Self-Efficacy Scale (ASES) was administered at baseline and again eight weeks after implementation of the MI intervention. The sessions were guided by Bandura’s self-efficacy framework, focusing on mastery experiences, social persuasion, and emotional regulation. Data were analyzed using paired t-tests at a significance level of 0.05.

RESULTS: Participants demonstrated a significant improvement in asthma self-efficacy scores and symptom control following the intervention. The paired t-test indicated a statistically significant increase in self-efficacy (p < 0.001), confirming the intervention’s effectiveness. Additionally, participants reported lower perceived stress and a 56% reduction in asthma symptom flare-ups.

CONCLUSIONS: Motivational interviewing proved effective in strengthening asthma self-management by enhancing patients’ confidence and promoting behavioral change. The integration of MI into routine primary care is recommended to foster patient empowerment and improve clinical outcomes.

PMID:41236776 | DOI:10.1080/02770903.2025.2589785

JAMA Health Forum. 2025 Nov 7;6(11):e254235. doi: 10.1001/jamahealthforum.2025.4235.

ABSTRACT

IMPORTANCE: Evidence is limited regarding whether end-of-life care for individuals with dementia varies by race and ethnicity, and whether observed variations can be explained by differences in the physicians providing their care.

OBJECTIVE: To evaluate end-of-life care among individuals with dementia across racial and ethnic groups, and to investigate whether care variations are explained by differences in treating physicians.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study used national, population-based claims data from a 20% random sample of Medicare fee-for-service beneficiaries aged 66 years or older with a diagnosis of dementia who died between 2016 and 2019. Data were analyzed from January 2024 to June 2025.

MAIN OUTCOMES AND MEASURES: Emergency department, hospital, and intensive care unit use, mechanical ventilation or cardiopulmonary resuscitation, and feeding tube placement in last 30 days of life; death in acute care hospital; hospice use and palliative care counseling in last 180 days of life; and any billed advance care planning before death.

RESULTS: Among 259 945 decedents with dementia (mean [SD] age, 85.8 [8.0] years; 60.4% female), 8.3% were non-Hispanic Black, 4.4% were Hispanic, and 87.3% were non-Hispanic White. Compared with non-Hispanic White decedents, non-Hispanic Black decedents were more likely to receive emergency department (difference, 5.7 percentage points [pp]; 95% CI, 5.0-6.4 pp), hospital (difference, 4.0 pp; 95% CI, 3.3-4.7 pp), intensive care unit (difference, 4.3 pp; 95% CI, 3.7-4.9 pp), mechanical ventilation or cardiopulmonary resuscitation (difference, 3.8 pp; 95% CI, 3.3-4.3 pp), and feeding tube placement (difference, 1.8 pp; 95% CI, 1.5-2.1 pp) care, as well as die in a hospital (difference, 3.5 pp; 95% CI, 2.9-4.1 pp). Non-Hispanic Black decedents were less likely to use hospice (difference, -6.1 pp; 95% CI, -6.8 to -5.4 pp) and more likely to receive palliative care counseling (difference, 3.2 pp; 95% CI, 2.6-3.9 pp) and billed advance care planning (difference, 1.8 pp; 95% CI, 1.2-2.3 pp) than non-Hispanic White decedents. Similar patterns were observed among Hispanic decedents. Variations in end-of-life care remained qualitatively unchanged when comparing decedents treated by the same physician.

CONCLUSIONS AND RELEVANCE: Findings from this cohort study suggest that non-Hispanic Black and Hispanic decedents with dementia received more intensive end-of-life care despite higher rates of billed advance care planning and palliative care counseling than non-Hispanic White decedents. Observed racial and ethnic variations were not explained by differences in the physicians treating them.

PMID:41236764 | DOI:10.1001/jamahealthforum.2025.4235

Hum Vaccin Immunother. 2025 Dec;21(1):2583577. doi: 10.1080/21645515.2025.2583577. Epub 2025 Nov 14.

ABSTRACT

Human Papillomavirus (HPV) vaccination has been implemented for more than 15 years to prevent HPV infection and associated precancerous lesions. However, limited data are available regarding the long-term impacts of HPV vaccination, particularly concerning cross-protection and type replacement. Using data from the 2007-2016 National Health and Nutrition Examination Survey (NHANES), we employed the survey-weighted Student’s t-tests, chi-square tests, and logistic regression models to examine the association between vaccine effectiveness and timing of vaccination. Among 9040 females aged 18 years and over, vaccination showed great effectiveness against both vaccine-targeted and non-vaccine-targeted high-risk HPV (hrHPV) among those vaccinated before sexual debut. After full adjustment, participants vaccinated after sex had a 48% increased risk of hrHPV infection (OR (95% CI) = 1.48 (1.16, 1.88)) compared to unvaccinated participants, and their sexual behaviors were more active as well. The most prevalent HPV subtypes were HPV 16/51/52/66, and the prevalence of subtypes 18/35/52/66/68 differed significantly across racial groups. Despite the prevalence of most hrHPV subtypes declined continuously or fluctuated over time, it is noteworthy that the infection rate of HPV 66 increased by 59% compared to the unvaccinated (95% CI: 0.18-0.92). Continuous surveillance is warranted for hrHPV types antigenically distant from vaccine strains, as early type replacement may be emerging. Given the notable difference in effectiveness based on vaccination timing, public-health education should emphasize both the benefits and limitations of HPV vaccination in the context of sexual health.

PMID:41236750 | DOI:10.1080/21645515.2025.2583577

JAMA Netw Open. 2025 Nov 3;8(11):e2543385. doi: 10.1001/jamanetworkopen.2025.43385.

ABSTRACT

IMPORTANCE: Obstructive sleep apnea (OSA) is common among patients with ischemic stroke and transient ischemic attack (TIA) and is associated with poor outcomes. Guidelines favor considering sleep testing among patients with cerebrovascular events.

OBJECTIVE: To evaluate the effectiveness of a quality improvement intervention to increase OSA diagnostic testing after stroke or TIA.

DESIGN, SETTING, AND PARTICIPANTS: This stepped-wedge cluster randomized trial of patients with ischemic stroke or TIA admitted to Department of Veterans Affairs facilities assessed outcomes during 8 data periods of 7-month duration (May 15, 2019, to January 24, 2024).

INTERVENTION: The quality improvement intervention was implemented with a virtual kickoff; site teams reviewed their facility’s baseline data, identified improvement opportunities, considered barriers and potential solutions to diagnosing OSA among patients with cerebrovascular disease, and developed a site-specific action plan. Team members attended monthly collaborative conferences. A web-based platform provided quality data, action plans, and a resource library. The research team provided external facilitation.

MAIN OUTCOMES AND MEASURES: The primary outcome was 30-day OSA diagnostic testing rate. Secondary outcomes were 30-day positive airway pressure treatment rate, 90-day recurrent vascular event rate, and 90-day readmission rate. Implementation effects were assessed using generalized linear mixed-effects models with binomial distributions and log link fit to patient-level data with site-level random effects.

RESULTS: The study included 1747 patients at 6 intervention sites (mean [SD] age, 68.7 [11.1] years; 1634 [93.5%] male) and 7454 patients at 30 usual care sites (mean [SD] age, 71.8 [10.8] years; 7114 [95.4%] male). The index event was stroke (vs TIA) in 1429 (81.8%) at the intervention sites and 5931 (79.6%) at the usual care sites. The 30-day diagnostic testing rate increased from 2.1% (20 of 952) during baseline to 29.1% (189 of 650) during implementation (odds ratio [OR], 16.13; 95% CI, 8.25-31.53); the 30-day diagnostic testing rate varied from 0.7% to 2.2% among usual care sites across data periods. Thirty-day positive airway pressure treatment increased from 0.3% (3 of 952) during baseline to 2.8% (18 of 650) during implementation (OR, 14.22; 95% CI, 2.40-84.40) at the intervention sites, while varying from 0.0% (0 of 876) to 0.4% (4 of 1158) at the usual care sites. No statistically significant changes were observed in 90-day readmission or recurrent vascular event rates.

CONCLUSIONS AND RELEVANCE: In this cluster randomized trial of patients with acute cerebrovascular events, quality improvement approaches increased OSA testing. These results suggest that health care systems can improve the delivery of guideline-concordant care for patients with acute ischemic stroke and TIA by delivering inpatient sleep medicine services.

TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04322162.

PMID:41236739 | DOI:10.1001/jamanetworkopen.2025.43385

JAMA Netw Open. 2025 Nov 3;8(11):e2543637. doi: 10.1001/jamanetworkopen.2025.43637.

ABSTRACT

IMPORTANCE: The long-term impacts of the COVID-19 pandemic on after-school activity patterns among youths remain poorly understood, hindering the development of policies to promote beneficial engagement.

OBJECTIVE: To examine longitudinal changes in after-school activity participation before (2019), during (2020 to 2021), and after (2022) the COVID-19 pandemic and assess whether these changes differed by sex.

DESIGN, SETTING, AND PARTICIPANTS: This longitudinal cohort study used linked yearly census survey data from the Well-Being and Engagement Collection (WEC) survey in South Australia. Participants were youths starting year 6 of school on January 29, 2019, who progressed to starting year 9 by January 31, 2022. Data analyzed were collected in weeks 2 to 5 of term 2 (May 2019 to May 2022).

EXPOSURE: COVID-19 pandemic.

MAIN OUTCOMES AND MEASURES: Weekly frequency of engagement in 11 after-school activities was measured in the WEC survey. Ordinal logistic regression models examined the trajectory of after-school activity participation. The results were visualized as estimated proportions over time.

RESULTS: A total of 14 350 participants (mean [SD] age in 2019, 11.7 [0.5] years; 7232 [50.4%] male) contributing 36 572 observations were included in the analysis. Participation in music, art, reading for fun, hanging out with friends, tutoring, and sports declined during and after the pandemic. Among these participants, youths who never participated in art (2019, 25.7% [95% CI, 24.5%-27.0%]; 2022, 70.4% [95% CI, 68.8%-72.0%]) and reading for fun (2019, 10.8% [95% CI, 10.1%-11.6%]; 2022, 52.6% [95% CI, 50.5%-54.8%]) showed the largest changes. Conversely, time spent watching television, doing chores, and playing electronic games showed meaningful increases but returned to prepandemic levels in 2022. Social media was the only activity that showed consistent increases during the 4 years, demonstrating the greatest growth. Everyday use increased from 26.0% (95% CI, 24.6%-27.3%) in 2019 to 85.4% (95% CI, 84.1%-86.7%) in 2022. Females spent more time on social media than males, while males experienced a more pronounced decline in reading.

CONCLUSIONS AND RELEVANCE: This cohort study found associations between the COVID-19 pandemic and after-school activity participation patterns among youths, with rapid increases in social media use compared with all other activities. These associations largely persisted 3 years after the onset of the pandemic. These findings provide a timely benchmark for evaluating forthcoming policies aimed at restricting youth access to social media platforms. Interventions to support activities such as sports, art, and music are warranted.

PMID:41236738 | DOI:10.1001/jamanetworkopen.2025.43637

JAMA Netw Open. 2025 Nov 3;8(11):e2543701. doi: 10.1001/jamanetworkopen.2025.43701.

ABSTRACT

IMPORTANCE: Although hepatitis C virus (HCV) is an oncovirus, its association with the risk of pancreatic ductal adenocarcinoma (PDAC) is unclear. In addition, it is unknown whether there is differential risk for PDAC across HCV genotypes.

OBJECTIVE: To assess the association between chronic HCV and PDAC.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective, national, population-based cohort study was conducted across Veterans Health Administration (VA) sites. The study included veterans with HCV testing documented in the VA or VA-linked Medicare with at least 1 inpatient or outpatient visit between October 1, 2001, and September 30, 2020. Patients were followed-up for at least 18 months after this visit. Data were analyzed from October 2023 to September 2025.

EXPOSURE: HCV status was categorized as chronic HCV, exposure to HCV, or no chronic HCV infection.

MAIN OUTCOMES AND MEASURES: The association of HCV status with PDAC was evaluated using Cox proportional hazards regression, adjusting for demographic and clinical confounders. Analysis was substratified by HCV genotype.

RESULTS: Of 6 330 856 people tested for HCV (5 841 571 men [92.3%]; median [IQR] age, 61.6 years [49.9-70.1]), 246 218 (3.9%) had chronic HCV and 209 492 (3.3%) were exposed. Of the 33 451 individuals (0.5%) who developed PDAC, age at diagnosis was younger among those with vs those without HCV (median [IQR] age, 65.0 [59.9-69.6] years vs 72.4 [66.7-79.0] years). Compared with no HCV infection, chronic HCV infection (adjusted hazard ratio [aHR], 1.76; 95% CI, 1.67-1.86) and HCV exposure (aHR, 1.18; 95% CI; 1.11-1.25) were associated with increased risk of incident PDAC. Hazards for PDAC were greater for HCV genotype 3 (aHR, 2.02; 95% CI, 1.67-2.45) and genotype 1 (aHR, 1.75; 95% CI, 1.64-1.87) than for genotype 2 (aHR, 1.35; 95% CI, 1.14-1.60) compared with no HCV infection.

CONCLUSIONS AND RELEVANCE: In this cohort study of veterans, chronic HCV infection was associated with a 1.8-fold higher risk of PDAC diagnosis, and HCV genotypes 3 and 1 had greater PDAC risk than genotype 2. These findings prompt future research on the mechanisms underlying this association and the impact of HCV treatment on PDAC risk.

PMID:41236736 | DOI:10.1001/jamanetworkopen.2025.43701

Cancer Epidemiol Biomarkers Prev. 2025 Nov 14. doi: 10.1158/1055-9965.EPI-25-1230. Online ahead of print.

ABSTRACT

BACKGROUND: C-reactive protein (CRP) is a widely used inflammatory biomarker that has been related to colorectal cancer (CRC) risk. However, observational studies are prone to confounding and reverse causality.

METHODS: We conducted a two-sample Mendelian randomization using CRP GWAS data from 59,605 Korean individuals and CRC GWAS data from 23,572 cases and 48,700 controls from an East Asia population. The analysis had 80% power to detect an odds ratio (OR) of 1.12 for CRC risk per two-fold increase in CRP levels.

RESULTS: Genetically predicted serum CRP levels (per two-fold increase) were not significantly associated with CRC risk (inverse-variance weighted OR: 0.995, 95% confidence interval: 0.893-1.109, P-value: 0.929). Null findings remained consistent in sensitivity analyses excluding the horizontally pleiotropic effect.

CONCLUSIONS: Despite sufficient statistical power, little evidence supported a causal association between CRP and CRC risk in East Asians.

IMPACT: Our findings suggest that CRP is unlikely to be a key determinant of colorectal carcinogenesis, aligning with prior studies in European populations.

PMID:41236733 | DOI:10.1158/1055-9965.EPI-25-1230