Tag: nevin manimala

Annu Rev Vis Sci. 2023 Mar 31. doi: 10.1146/annurev-vision-120522-031739. Online ahead of print.

ABSTRACT

Deep neural networks (DNNs) are machine learning algorithms that have revolutionized computer vision due to their remarkable successes in tasks like object classification and segmentation. The success of DNNs as computer vision algorithms has led to the suggestion that DNNs may also be good models of human visual perception. In this article, we review evidence regarding current DNNs as adequate behavioral models of human core object recognition. To this end, we argue that it is important to distinguish between statistical tools and computational models and to understand model quality as a multidimensional concept in which clarity about modeling goals is key. Reviewing a large number of psychophysical and computational explorations of core object recognition performance in humans and DNNs, we argue that DNNs are highly valuable scientific tools but that, as of today, DNNs should only be regarded as promising-but not yet adequate-computational models of human core object recognition behavior. On the way, we dispel several myths surrounding DNNs in vision science. Expected final online publication date for the Annual Review of Vision Science, Volume 9 is September 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

PMID:37001509 | DOI:10.1146/annurev-vision-120522-031739

Cell. 2023 Mar 30;186(7):1493-1511.e40. doi: 10.1016/j.cell.2023.02.018.

ABSTRACT

Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of 1,635 open-access datasets from four donors (∼30 tissues × ∼15 assays). The datasets are mapped to matched, diploid genomes with long-read phasing and structural variants, instantiating a catalog of >1 million allele-specific loci. These loci exhibit coordinated activity along haplotypes and are less conserved than corresponding, non-allele-specific ones. Surprisingly, a deep-learning transformer model can predict the allele-specific activity based only on local nucleotide-sequence context, highlighting the importance of transcription-factor-binding motifs particularly sensitive to variants. Furthermore, combining EN-TEx with existing genome annotations reveals strong associations between allele-specific and GWAS loci. It also enables models for transferring known eQTLs to difficult-to-profile tissues (e.g., from skin to heart). Overall, EN-TEx provides rich data and generalizable models for more accurate personal functional genomics.

PMID:37001506 | DOI:10.1016/j.cell.2023.02.018

Psychiatry Res. 2023 Mar 15;323:115170. doi: 10.1016/j.psychres.2023.115170. Online ahead of print.

ABSTRACT

Some evidence puts health professionals at increased risk of suicide, especially females, whereas other research suggests a lower risk in high-skilled occupations. This study investigated the suicide risk of four health professions (physicians, dentists, veterinarians, pharmacists) and three other high-skilled occupations (notaries, lawyers, tax advisors/public accountants) in Austria compared to the general population, and analyzed suicide methods across occupations. Data was collected from professional associations and Austrian cause-of-death statistics to determine suicide cases. Gender-specific standardized mortality ratios (SMRs), crude and age-adjusted suicide rates and frequencies for suicide methods were calculated for each profession (maximum time span 1986-2020). Among males, only veterinarians had a significantly elevated suicide risk compared to the general population. Physicians and tax advisors/public accountants had a significantly lower suicide risk. Among females, the veterinarians, physicians, and pharmacists had a significantly elevated suicide risk; for dentists, it was also elevated, though non-significantly. Age-adjusted suicide rates showed a smaller gap between men and women in all professions compared to the general population. Poisoning was the predominant suicide method among health professions, except dentists. These findings are consistent with some of the prior literature and call for specific suicide prevention efforts in health professions, focusing on women.

PMID:37001488 | DOI:10.1016/j.psychres.2023.115170

Pediatr Neurol. 2023 Feb 12;143:59-63. doi: 10.1016/j.pediatrneurol.2023.02.003. Online ahead of print.

ABSTRACT

We aimed to characterize the existing knowledge of cerebral palsy (CP) prevalence globally and identify any existing publication disparities that may impact our understanding of the global burden of CP. To identify existing publications on CP prevalence, PubMed and Web of Science were searched in May 2021 with the following strategy: “cerebral palsy”[title] AND (rate OR prevalence OR epidemiology). This search yielded 2720 results on PubMed and 2314 on Web of Science. Studies published in English, Spanish, or Japanese and which were available in full text were included. Studies that did not report a CP prevalence statistic were excluded. We identified 94 studies meeting inclusion and exclusion criteria. Of 94 studies, 69 (73.4%) studies came from Europe, North America, and Australia with the remaining 25 (26.6%) from Asia, the Middle East, and Africa. No studies from Latin America were identified. CP prevalence estimates ranged from 0.8 to 4.4 per 1000 live births. Studies from Europe are cited more than studies from other regions, ranging from 7.61 citations/year since publication for European studies to 2.1 citations/year for Middle Eastern studies. Studies from Western countries are written almost exclusively by Western authors (99.69%-100%), while studies from Africa consist of a lower proportion of African authors (31.06%). Our results highlight geographical disparities in our knowledge of CP epidemiology. Existing literature from Latin America, Asia, Africa, and the Middle East are relatively undercited by the field. To better grasp the true impact of CP globally, we must support institutions and researchers in underrepresented regions of the world.

PMID:37001463 | DOI:10.1016/j.pediatrneurol.2023.02.003

Lung Cancer. 2023 Mar 23;179:107182. doi: 10.1016/j.lungcan.2023.107182. Online ahead of print.

ABSTRACT

OBJECTIVE: This study investigated the association between occupational asbestos exposure (OAE) and survival in patients with histologically confirmed lung cancer (LC).

METHODS: This monocentric study was conducted in the Comprehensive Cancer Centre Léon Bérard, Lyon, France. A systematic screening has been in place since 2014 for occupational exposure to carcinogens using a self-assessment questionnaire sent to all patients newly diagnosed with histologically confirmed LC identified through the multidisciplinary LC board from 2014 to 2019. When the physician suspected a work-related exposure from the questionnaire including job history, an occupational cancer consultation was carried out to detail carcinogen exposures and assess if the LC was work-related. Demographics, clinical characteristics and survival data were extracted from medical records. The association between asbestos exposure and overall survival (hazard ratio and 95% confidence intervals) was estimated by Cox proportional hazards regression.

RESULTS: Overall, 702 patients were eligible to the present study, including 180 patients with OAE. In the crude analysis, LCs assessed as moderately or highly attributable to OAE were associated with decreased overall survival (HR = 1.32, 95 %CI 1.04-1.67) compared to LC without OAE or with a low degree of imputability to OAE (median follow-up 28.8 months). After adjustment for confounding (age at diagnosis, smoking status, stage, brain metastasis at diagnosis, and histology), the association of OAE with overall survival was no longer statistically significant (HR = 1.21, 95 %CI 0.94-1.56).

CONCLUSION: Overall survival in occupationally asbestos exposed LC patients may be decreased in comparison with non-exposed LC patients, warranting further investigations in larger studies.

PMID:37001440 | DOI:10.1016/j.lungcan.2023.107182

Gen Hosp Psychiatry. 2023 Feb 22;82:86-94. doi: 10.1016/j.genhosppsych.2023.02.004. Online ahead of print.

ABSTRACT

OBJECTIVE: To examine the effectiveness of a 12-month MHBC intervention in the prevention of onset depression in primary health care (PHC).

METHODS: Twenty-two PHC centres took part in the cluster-randomized controlled trial. Patients were randomized to receive either usual care or an MHBC intervention. The endpoints were onset of major depression and reduction of depressive symptoms in participants without baseline depression at a 12-month follow-up.

RESULTS: 2531 patients agreed and were eligible to participate. At baseline, around 43% were smokers, 82% were non-adherent to the Mediterranean diet and 55% did not perform enough physical activity. The intervention group exhibited a greater positive change in two or more behaviours (OR 1.75 [95%CI: 1.17 to 2.62]; p = 0.006); any behaviour (OR 1.58 [95%CI: 1.13 to 2.20]; p = 0.007); and adherence to the Mediterranean diet (OR 1.94 [95%CI: 1.29 to 2.94]; p = 0.002), while this increase was not statistically significant for smoking and physical activity. The intervention was not effective in preventing major depression (OR 1.17; [95% CI 0.53 to 2.59)]; p = 0.690) or reducing depressive symptoms (Mean difference: 0.30; [95% CI -0.77 to 1.36]; p = 0.726) during follow-up.

CONCLUSIONS: As compared to usual care, the MHBC intervention provided a non-significant reduction in the incidence of major depression.

TRIAL REGISTRATION: ClinicalTrials.gov, NCT03136211.

PMID:37001428 | DOI:10.1016/j.genhosppsych.2023.02.004

J Geriatr Oncol. 2023 Mar 29;14(4):101479. doi: 10.1016/j.jgo.2023.101479. Online ahead of print.

ABSTRACT

INTRODUCTION: Limited data are available to explore the association between preoperative frailty and cognitive impairment with postoperative delirium among older adults with cancer. We explored this association in a single Comprehensive Cancer Center where postoperative delirium and frailty are assessed in routine care using the Confusion Assessment Method (CAM) and Memorial Sloan Kettering Frailty Index (MSK-FI), respectively.

MATERIALS AND METHODS: Retrospective study on patients with cancer, aged 65+, who underwent surgery from April 2018 to March 2019 with hospital stay ≥1 day. We used logistic regression with postoperative delirium as the outcome, primary predictor MSK-FI, adjusted for age, operative time, and preoperative albumin. As the MSK-FI includes a component related to cognitive impairment, we additionally evaluated the impact of this component, separately from the rest of the score, on the association between frailty and postoperative delirium.

RESULTS: Among 1,257 patients with available MSK-FI and CAM measures, 47 patients (3.7%) had postoperative delirium. Increased frailty was associated with increased risk of postoperative delirium (odds ratio [OR] 1.51; 95% confidence interval [CI] 1.26, 1.81; p < 0.001). However, this was largely related to the effect of cognitive impairment (OR 15.29; 95% CI 7.18; 32.56; p < 0.001). In patients with cognitive impairment, the association between frailty and postoperative delirium was not significant (OR 0.97; 95% CI 0.65, 1.44; p-value = 0.9), as having cognitive impairment put patients at high risk for postoperative delirium even without taking into account the other components of the MSK-FI. While the association between frailty and postoperative delirium in patients with intact cognitive function was statistically significant (OR 1.58; 95% CI 1.27, 1.96; p < 0.001), it was not clinically meaningful, particularly considering the low risk of delirium among patients with intact cognitive function (e.g., 1.3% vs 3.2% for MSK-FI 1 vs 3).

DISCUSSION: Cognitive function should be a greater focus than frailty, as measured by the MSK-FI, in preoperative assessment for the prediction of postoperative delirium.

PMID:37001348 | DOI:10.1016/j.jgo.2023.101479

Foot (Edinb). 2023 Mar 25;56:102026. doi: 10.1016/j.foot.2023.102026. Online ahead of print.

ABSTRACT

PURPOSE: Syndesmotic injuries are associated with long recovery times and high morbidity. Systematic reviews show a trend toward better outcomes of suture buttons compared to screw fixation. The anteroinferior tibiofibular ligament (AITFL) confers the most significant component of translational and rotatory stability. Techniques have developed which reinforce the AITFL. This study aimed to assess results of syndesmotic stabilisation with dynamic stabilisation and reinforcement of the AITFL, with an early mobilisation program.

MATERIALS AND METHODS: Retrospective case series of 30 patients (mean age 31 years). Syndesmotic instability was confirmed with clinical examination, MRI and weightbearing-CT. Dynamic syndesmotic stabilisation with a single suture button was performed followed by the placement of an Internal Brace over the AITFL. A standardised postoperative rehabilitation protocol was established. Foot and Ankle Ability Measure (FAAM) scores were collected postoperatively.

RESULTS: The average follow-up was 13 months. The total FAAM score for ADL was 95 ± 4.9 % (range, 83 – 100 %) and for sport activities 87 ± 13.6 % (range, 50 – 100 %). The rating of mean postoperative function for ADL was 94 ± 5.5 % (range, 80 – 100 %) and 90 ± 13 % (range, 35 – 100 %) for sportv. The difference between acute and chronic injuries was statistically higher (p < 0.05) for daily activities and sport, but the rating of current level of sport activites as well as for daily activites did not show a significant difference (p = 0.9296 and p = 0.1615, respectively). Twenty-seven patients (90 %) rated their overall current level of function as normal or nearly normal.

CONCLUSION: This technique aims to directly stabilise the AITFL and the interosseous components of the syndesmosis, and allow early mobilisation and return to sport at 10 weeks. Early results show the procedure is safe, with comparable results to the literature. Acute injuries showed better results of the FAAM score than chronic injuries.

PMID:37001344 | DOI:10.1016/j.foot.2023.102026

Phys Ther Sport. 2023 Mar 20;61:102-107. doi: 10.1016/j.ptsp.2023.03.005. Online ahead of print.

ABSTRACT

OBJECTIVES: The effect of knee position on joint moments during squats has been studied; however, the effect of trunk angle has been less well investigated. This study evaluated the effect of both trunk and knee sagittal plane position on the distribution of moments between the hip and knee extensors during the bilateral squat.

DESIGN: Observational study.

SETTING: Biomechanics laboratory.

PARTICIPANTS: One hundred individuals performed bilateral squats.

MAIN OUTCOME MEASURES: Motion and force data were collected using motion capture and force plates. Trunk and shank angles and hip and knee moments were calculated. A linear regression was used to associate the ratio between the hip and knee moments (hip-to-knee moment ratio) with the sagittal plane trunk and shank angles, while accounting for six squat depths (between 60° and 110° of knee flexion) and side.

RESULTS: Trunk angle and shank angle each contributed to the hip-to-knee moment ratio (P < .001) with trunk accounting for a higher proportion of variance than the other variables. The hip-to-knee moment ratio increased with increasing trunk angle and with decreasing shank angle.

CONCLUSIONS: This large cohort study supports the use of trunk position to instruct squat technique with the goal of modifying hip and knee moments.

PMID:37001335 | DOI:10.1016/j.ptsp.2023.03.005

Knee. 2023 Mar 29;42:161-169. doi: 10.1016/j.knee.2023.03.002. Online ahead of print.

ABSTRACT

BACKGROUND: The aim of the study was to investigate the effect of platelet-rich plasma (PRP) on subchondral bone marrow edema (BME) and the level of biomarkers in synovial fluid of the knee osteoarthritis.

METHODS: Eighty-one patients with symptomatic knee osteoarthritis were randomly divided into two groups according to the number of inpatients. Forty-five cases were treated with intra-articular injection of PRP (PRP group), 36 cases were treated with sodium hyaluronate (SH group), and the clinical effects were evaluated using the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. The changes of subchondral BME were assessed by magnetic resonance imaging (MRI) before and after treatment. The levels of TNFα, IL-6, MCP-1, MMP-1, MMP-3, and MMP-9 in synovial fluid were also detected.

RESULTS: All the patients completed the corresponding treatment and were followed up for 12 months without serious complications. After the treatment, the VAS and WOMAC scores of the two groups were significantly decreased, and the difference was statistically significant at different time points (P < 0.05). The VAS and WOMAC scores of the PRP group were better than those of the SH group (P < 0.05). MRI showed that the subchondral bone edema of the two groups were reduced in varying degrees, and the reduction was more noticeable in the PRP group (P < 0.05). The levels of TNFα, IL-6, MCP-1, MMP-1, MMP-3, and MMP-9 in two groups were decreased, and the difference was statistically significant at different time points (P < 0.05). However, the levels of TNFα, IL-6, MCP-1, MMP-1, MMP-3, and MMP-9 in the PRP group were significantly lower than those in the SH group (P < 0.05).

CONCLUSIONS: Intra-articular injection of PRP can significantly reduce the subchondral BME and the level of biomarkers in synovial fluid of the symptomatic knee osteoarthritis.

PMID:37001332 | DOI:10.1016/j.knee.2023.03.002