Tag: nevin manimala

Acc Chem Res. 2023 Jun 5. doi: 10.1021/acs.accounts.3c00168. Online ahead of print.

ABSTRACT

ConspectusUnderstanding the thermoelectric effects that convert energy between heat and electricity on a molecular scale is of great interest to the nanoscience community. As electronic devices continue to be miniaturized to nanometer scales, thermoregulation on such devices becomes increasingly critical. In addition, the study of molecular thermoelectricity provides information that cannot be accessed through conventional electrical conductance measurements. The field of molecular thermoelectrics aims to explore thermoelectric effects in electrode-molecule-electrode tunnel junctions and draw inferences on how the (supra)molecular structure of active molecules is associated with their thermopower. In this Account, we introduce a convenient and useful junction technique that enables thermovoltage measurements of one molecule thick films, self-assembled monolayers (SAMs), with reliability, and discuss the atomic-detailed structure-thermopower relations established by the technique. The technique relies on a microelectrode composed of non-Newtonian liquid metal, eutectic gallium-indium (EGaIn) covered with a native gallium oxide layer. The EGaIn electrode makes it possible to form thermoelectric contacts with the delicate structure of SAMs in a noninvasive fashion. A defined interface between SAM and the EGaIn electrode allows time-effective collection of large amounts of thermovoltage data, with great reproducibility, efficiency, and reliable interpretation and statistical analysis of the data. We also highlight recent efforts to utilize the EGaIn technique for probing molecular thermoelectricity and structure-thermopower relations. Using the technique, it was possible to unravel quantum-chemical mechanisms of thermoelectric functions, based on the Mott formula, in SAM-based large-area junctions, which in turn led us to set various hypotheses to boost the Seebeck coefficient. By validating the hypotheses again with the EGaIn technique, we revealed that the thermopower of junction increases through the reduction of the energy offset between accessible molecular orbital energy level and Fermi level or the tuning of broadening of the orbital energy level. Such alterations in the shape of energy topography of junction could be achieved through structural modifications in anchoring group and molecular backbone of SAM, and the bottom electrode. Molecular thermoelectrics offers a unique opportunity to build a well-defined nanoscale system and isolate an effect of interest from others, advancing fundamental understanding of charge transport across individual molecules and molecule-electrode interfaces. In the Account, we showed our recent work involving carefully designed molecular system that are relevant to answering the question of how thermopower differs between the tunneling and thermal-hopping regimes. The field of molecular thermoelectrics needs to address practical application-related issues, particularly molecular degradation in thermal environments. In this regard, we summarized the results highlighting the thermal instability of SAM-based junctions based on a traditional thiol anchor group and how to circumvent this problem. We also discussed the power factor (PF)─a practical parameter representing the efficiency for converting heat into electricity─of SAMs, evaluated using the EGaIn technique. In the Conclusion section of this Account, we present future challenges and perspectives.

PMID:37276526 | DOI:10.1021/acs.accounts.3c00168

Heliyon. 2023 May 19;9(6):e16317. doi: 10.1016/j.heliyon.2023.e16317. eCollection 2023 Jun.

ABSTRACT

Inappropriate variety use in different agroecology is one of the primary issues which significantly affect garlic phenotype, growth, yield, and nutritional quality. For this reason, a trial was done during the 2022 main season at the demonstration site of Bule Hora University, to see the impact of genotypes on phenotype, growth, yield-related attributes, and nutritional quality of garlic. The experiment was composed of four varieties namely Kuriftu, Holleta, Chafe, Tsedey 92, and one local cultivar. The trial was set up in a randomized complete block design replicated four times. The output showed that garlic varieties statistically (p < 0.05) affected all phenotype, growth, yield-related attributes, and nutritional qualities. Using a variety of Holleta and kuriftu minimize days of emergence by 9.82 and 10.33 days after planting and 75% physiological maturity by 23.6 and 25.90 days after planting, respectively, beyond variety Tsedey 92. The highest marketable bulb yield (8.21 t/ha, and 8.18 t/ha) was observed from Kuriftu and Holleta, respectively. While the lowest (4.39 t/ha) was from Tsedey 92. The highest Ash, energy, and carbohydrate were recorded from Kuriftu and Holleta, while the least from the Local cultivar. However, the highest moisture content, protein, and fat were observed from local cultivars, while the least from Kuriftu, and Holleta. In general, garlic varieties significantly affected all the phenotype, growth, bulb yield-related, and Nutritional quality. Therefore, it can be concluded that using the variety Kuriftu, and Holleta at Bule Hora agroecology is suggested to boost early germination, better performance, marketable bulb yield, and nutritional quality of garlic.

PMID:37274705 | PMC:PMC10238683 | DOI:10.1016/j.heliyon.2023.e16317

Heliyon. 2023 May 23;9(6):e16362. doi: 10.1016/j.heliyon.2023.e16362. eCollection 2023 Jun.

ABSTRACT

Based on the implementation of the third stage of “Three-year Action Plan for Preschool Education”, this research took preschool education resources of 31 provinces (cities), autonomous regions (excluding Hong Kong, Macao and Taiwan) and municipalities in China from 2003 to 2019 as research samples. At the same time, according to the data of Educational Statistics Yearbook of China (2003-2019) and China Educational Finance Statistics Yearbook (2004-2020), this research collected the data of preschool education human resources, material resources, and financial resources. As for the data analysis, this research was based on the methodology of entropy method, repeated indicators method, and the Theil index and so on, and evaluated the state of preschool education resources allocation in China from 2003 to 2019. Simultaneously, according to the state of preschool education resources allocation, this research analyzed the spatio-temporal differences of preschool education resources allocation between various provinces and various areas, then analyzed the causes of spatio-temporal differences. After that, suggestions were put forward according to the analysis. The results show that, since the implementation of the third stage of “Three-year Action Plan for Preschool Education“, the condition of preschool education resources allocation has been generally improved. However the preschool education resources allocation still presents a low-level and uneven development trend. Preschool education resources have formed a “preschool education resource advantage belt” in Beijing, Tianjin and the Yangtze River Delta; Comparing with material resources, the development of human resources in preschool education lags behind in China; In terms of each regions in China, eastern China has the most significant difference in the preschool education resources allocation, which is followed by western China, and inner China has the least significant difference; The main factor affecting the regional preschool education resources allocation difference is the inter-provincial differences in eastern China, inner China, and western China; And the main factors affecting the differences in preschool education resources in eastern, inner, and western China are respectively financial resources, human resources, and financial resources. At the same time, financial resources in eastern China and human resources in inner China tend to expand. Based on this, this study proposes methods to narrow the regional differences in preschool education resources allocation, so as to provide references for realizing preschool education equity and preschool education sustainable development.

PMID:37274700 | PMC:PMC10238904 | DOI:10.1016/j.heliyon.2023.e16362

Heliyon. 2023 May 23;9(6):e16441. doi: 10.1016/j.heliyon.2023.e16441. eCollection 2023 Jun.

ABSTRACT

Offshore operations are generally challenging and hazardous, and the workers are exposed to conditions that may lead to fatigue. A cross-sectional study evaluated physical and psychological job demands and their associations with fatigue among offshore workers. The offshore workers (n = 251) completed a questionnaire including demographic/job details, Multidimensional Fatigue Inventory (MFI‒20), and Job Content Questionnaire (JCQ). Data were analysed using linear regression modelling. Results indicated that the physical (particularly performing repetitive motions and applying pressure with hands and wrists) and psychological (e.g., intense task concentration and fast working) job demands were relatively high. The total mean (SD) fatigue score (MFI‒20) was 56.3 (13.9). Individual factors (Body Mass Index ‒ BMI), physical job demands (awkward working postures, frequent moving/lifting heavy objects and doing lots of physical efforts) and psychological job demands (task interruptions by other people and doing an excessive amount of work) were the main variables associated with different dimensions of fatigue in the multivariate models. While physical fatigue was only associated with the physical job demands, both physical and psychological job demands were significantly associated with mental fatigue in the multivariate context. The findings have possible implications for job design and implementation of intervention programmes to promote health and performance of the employees.

PMID:37274697 | PMC:PMC10238685 | DOI:10.1016/j.heliyon.2023.e16441

Heliyon. 2023 May 23;9(6):e16213. doi: 10.1016/j.heliyon.2023.e16213. eCollection 2023 Jun.

ABSTRACT

OBJECTIVE: The purpose of this study was to evaluate the efficacy and safety of Zishen Yutai Pill combined with western medicine for the treatment of women with threatened miscarriage during the first trimester of pregnancy.

METHODS: Randomized controlled trials published before the end of Apr 1, 2023 on Zishen Yutai Pill and threatened miscarriage were systematically retrieved from China National Knowledge Infrastructure, Wanfang, Sinomed, VIP, PubMed, EMBASE, Web of Science and the Cochrane Library. The international clinical trial registration platform and the Chinese clinical trial registration platform of clinical trials was searched from their inception until Apr 1, 2023. Meta analysis of random effect model was used to combine the research data. Chi-squared test and I² statistics were used for heterogeneity test.

RESULTS: Twenty-three trials (enrolling 2411 participants) were included in the review. Zishen Yutai pill combined with western medicine therapy showed significant improvement on human chorionic gonadotropin [MD 19.33 IU/ml, 95% CI (15.84, 22.81)], the total effective rate [RR 1.19, 95% CI (1.15-1.23)], progesterone [MD 7.14 ng/ml, 95% CI (6.14, 8.13)], estradiol [MD 33.69 pg/ml, 95% CI (27.42, 39.96)], duration of abdominal pain [MD -2.36 d, 95% CI (- 3.54, – 1.18)], duration of vaginal bleeding [MD -1.94 d, 95% CI (- 2.93, – 0.94)], and fibrinogen [MD -0.34 g/L, 95% CI (- 0.57, – 0.11)]. There was no significant difference in hematocrit [MD 0.68%, 95% CI (- 0.08, 1.44)] between the experimental and the control group. Zishen Yutai Pill may improve the clinical symptoms in women with threatened miscarriage, such as human chorionic gonadotropin the total effective rate, progesterone, estradiol, duration of abdominal pain, duration of vaginal bleeding, and fibrinogen. Especially for progesterone, the effect of treatment ≦2 weeks is significantly better than treatment of >2 weeks. For estradiol, the effect of treatment >2 weeks is significantly better than treatment of ≦ 2 weeks.

CONCLUSION: Zishen Yutai Pill, as a complementary therapy, significantly improved human chorionic gonadotropin, the total effective rate, progesterone, estradiol, abdominal pain, vaginal bleeding, and fibrinogen in patients with threatened miscarriage in first-trimester pregnancy. However, the systematic review has some limitations, such as degraded information quality, no blinding of patients or doctors, etc. Due to the small sample size and low quality of research, it needs to be further confirmed by large sample and high-quality randomized controlled trials, such as blinding of patients, doctors and outcome assessment should be complemented, clinical follow-up, live birth rate, fetal growth should be supplemented.

SYSTEMATIC REVIEW REGISTRATION: INPLASY202320039.

PMID:37274687 | PMC:PMC10238576 | DOI:10.1016/j.heliyon.2023.e16213

Heliyon. 2023 May 25;9(6):e16530. doi: 10.1016/j.heliyon.2023.e16530. eCollection 2023 Jun.

ABSTRACT

OBJECTIVE: To explore the roles of Enoxaparin Sodium-Polymethyl methacrylate bone cement on inflammatory factors Interleukin-6 and Tumour Necrosis Factor-α in a rabbit knee replacement model. As well as the mechanisms underlying its potential effects on lipopolysaccharide-induced endothelial cell injury.

METHODS: A knee replacement model was established using New Zealand rabbits. Forty rabbits were randomly divided into four groups: PMMA, ES-PMMA, sham-operated, and blank control groups (n = 10 in each group). Local tissues around the incision were taken at the 30th, 60th, and 90th minute after the surgical implantation of the corresponding bone cement. Immunohistochemistry in the surgical field was used to measure the expression of local inflammatory factors IL-6 and TNF-α. In the in vitro experiments, 1 cm³ of bone cement was immersed in 3 mL of the medium for 24 h. The bone cement was discarded and diluted to 25% with normal medium. Pre-experiments were screened for the best LPS-inducing concentration of 100 mg/mL, and the most compatible LPS concentration was used for subsequent experiments simulating the primary cultures of rats’ Inferior Vena Cava Endothelial Cells. The experiments were divided into four groups: blank control group, LPS induction group, PMMA + LPS group, and ES-PMMA + LPS group. The apoptosis rate was detected by flow cytometry, and the expression levels of TNF-α and IL-6 in the cells and supernatant were measured by ELISA, western blotting, and immunofluorescence.

RESULTS: According to immunohistochemical results, IL-6-positive cells were concentrated in the tissue interstitial space. In the PMMA and sham-operated groups, the number of IL-6-positive cells gradually increased over time. At all time points, IL-6 expression in the ES-PMMA group was much lower than in the PMMA and sham-operated groups. At 30 min, TNF-α positive cells in the ES-PMMA group expressed less than those in the PMMA and sham-operated groups, with no discernible difference between the PMMA and ES-PMMA groups at 60 or 90 min. Using ELISA and flow cytometry, the expression levels of IL-6 and TNF-α were improved and the apoptosis rate was magnified in the LPS-induced group (***P < 0.001) in contrast with the blank control group. Additionally, the expression levels of IL-6 and TNF-α were reduced in the ES-PMMA + LPS group compared with the LPS-induced group (*P < 0.05) and the apoptosis rate was reduced (***P < 0.001), with statistically significant variations. Western blotting and immunofluorescence analysis confirmed that IL-6 and TNF-α protein expression in cells was upregulated in the LPS-induced group compared to the blank control group (***P < 0.001), and the mean fluorescence intensity was enlarged (***P < 0.001). Meanwhile, IL-6 and TNF-α expression in the ES-PMMA + LPS group were down-regulated (**P < 0.01 or *P < 0.05) compared with the LPS-induced group and PMMA + LPS crew protein expression, and the average fluorescence intensity of IL-6 and TNF-α was lowered in the ES-PMMA + LPS group compared to the LPS-induced group (***P < 0.001).

CONCLUSIONS: ES-PMMA bone cement reduced the expression levels of local inflammatory factors IL-6 and TNF-α in a rabbit knee model. ES-PMMA bone cement reduced the rate of LPS-induced endothelial cell apoptosis and diminished local inflammatory damage by regulating the secretion of inflammatory factors TNF-α and IL-6.

PMID:37274684 | PMC:PMC10238720 | DOI:10.1016/j.heliyon.2023.e16530

Heliyon. 2023 May 24;9(6):e16294. doi: 10.1016/j.heliyon.2023.e16294. eCollection 2023 Jun.

ABSTRACT

Antenatal Care utilizations have become an essential phenomenon to all pregnant women as a means of disease preclusion during pregnancy and safe live birth. To lessen maternal death and disease, proper (minimum eight) antenatal care (ANC) contacts are necessary according to World Health Organization (WHO) new guideline. The aim of this study is to assess the factors affecting proper antenatal care utilization of pregnant Bangladeshi women. The study used data from the most recent Bangladesh Demographic and Health Survey 2017-18 for conducting a two-level binary logistic regression model. A weighted sample of 4866 women and 675 clusters were considered as individual and community level respectively. The results exhibited only 11.6% women took proper antenatal care during pregnancy. The study found 23.9% variability in utilizations of Antenatal care belongs to community-level factors. At individual-level, mother’s occupation, body mass index, birth-order, pregnancy intention, education, delivery place, and media access and at community-level, rural communities (AOR = 0.70, 95% C.I = 0.542-0.920), and communities having media access (AOR = 1.38, 95% C.I = 0.979-1.96) had significant relationship with proper antenatal care utilizations of pregnant women. After testing random slopes of individual-level variables, only education of women covariate was found to be varied from community to community. This study suggests that uptake of proper antenatal care depend on both individual and community level covariates and there lies extensive variation among them. Future studies on wider aspect are therefore suggested to determine obstacles in making proper Antenatal care utilizations.

PMID:37274676 | PMC:PMC10238893 | DOI:10.1016/j.heliyon.2023.e16294

Heliyon. 2023 May 23;9(6):e16424. doi: 10.1016/j.heliyon.2023.e16424. eCollection 2023 Jun.

ABSTRACT

A seasonal study was conducted to assess the levels, sources, and potential ecological risks of heavy metals (HM) in coastal sediments along the Giresun Coast, located on the southeast coast of the Black Sea. The mean concentrations of HMs as mg/kg were ranked as Fe (27646.37) > Al (27348.55) > Mn (571.87) > Zn (94.16) > Cr (60.64) > Cu (45.66) > Pb (41.37) > Ni (27.29) > Co (14.47) > As (7.36) > Cd (0.20), respectively. At all stations through the year, Al, Cr, Mn, Fe, Co, and Ni were in “the minimum enrichment” class as evaluated by the enrichment factor (EF). As assessed by the contamination factor (CF), all HM levels except Pb, Fe and Cu were “low” or “moderately polluted” at all stations and seasons. With the exception of Cd levels, all HMs in all seasons and stations pointed out “low ecological risk” according to the ecological risk index (E_rⁱ). According to the sediment quality guidelines, Ni, Cu and Pb were observed to pose a high ecological risk to habitat. The combined risk assessment indices pointed out low to moderate ecological risk. The study concluded that the region is subject to minimum anthropogenic disturbances in the aquatic environment.

PMID:37274673 | PMC:PMC10238681 | DOI:10.1016/j.heliyon.2023.e16424

Heliyon. 2023 May 19;9(6):e16364. doi: 10.1016/j.heliyon.2023.e16364. eCollection 2023 Jun.

ABSTRACT

This study examined student-teachers’ diversity and attitudes toward classroom participation in a Tanzanian university. A mixed research approach was used to answer three research questions: student-teachers’ attitudes toward classroom participation, attitude differences based on their diversity, and the reasons for their attitudes toward classroom participation. The study involved 701 student-teachers in their second and third years of study. Data were collected through questionnaires and focus group discussions and were analysed using Statistical Package for Social Science and MAXQDA software. Results indicated that student-teachers cooperated with colleagues in groups rather than the whole classroom. The results also indicated diversity in classroom participation by gender, programme, and year of study. Further, it was revealed that student-teachers’ attitudes toward classroom participation were based on prior experiences, cultural aspects, linguistic barriers, lecturer pedagogical practices, and teaching context. It is concluded that the student-teachers’ attitudes toward classroom participation were variably associated with their diversity, and the reasons for the attitudes were mediated internally and externally. Therefore, it is recommended that lectures be conducted by employing apt techniques for fostering active participation to enrich the classroom with student-teachers and lecturers’ voices in knowledge construction and sharing. The techniques should be gender, programme, and year of study sensitive while integrating students-teachers’ internal and external mediating factors to create interactive classroom moments that encourage knowledge creation and sharing among the classroom members.

PMID:37274672 | PMC:PMC10238682 | DOI:10.1016/j.heliyon.2023.e16364

Heliyon. 2023 May 25;9(6):e16224. doi: 10.1016/j.heliyon.2023.e16224. eCollection 2023 Jun.

ABSTRACT

INTRODUCTION: Menstrual hygiene management practice is the requirements and necessities; such as the use of a sanitary pad or clean and mushy absorbents, sufficient washing of the genital area, proper disposal of the used absorbents, and other special needs for the women during menstruation.

OBJECTIVE: To assess menstrual hygiene management practice and associated factors among prisoners in south Nation Nationalities and Peoples Region, Ethiopia, 2022.

METHODS: An institution-based cross-sectional study was conducted from May 1 to July 30/2022. The total sample size was 605 and a simple random sampling technique was used to select prison institutions and women. The data were collected through face-to-face interviews. Data were entered using Epi data 4.6 version and analyzed by using SPSS version 26 software. Multicollinearity was checked and the goodness of fit test was done by using the Hosmer Lemeshow model of goodness fit test. Univariate analysis was done and variables with p value less than 0.25 were taken to bivariate logistic regression analysis. Adjusted odds ratio with the 95% confidence interval was considered and statistical significance was at a p-value less than 0.05 in bivariate logistic regression analysis.

RESULT: The prevalence of menstrual hygiene management practice was 50.6% (95% CI 47.3-54.4). Age 19-29 years old [AOR: 5.03, 95% CI 1.73-14.62], educational status; not formally educated [AOR: 0.05, 95% CI 0.02-0.13], educational status; primary level [AOR: 0.17, 95% CI 0.07-0.39], previous occupation; student [AOR: 2.56, 95% CI 1.06-6.21], previous occupation; a private employee [AOR: 4.11, 95% CI 1.48-11.42], previous occupation; government employee [AOR: 3.46, 95% CI 1.18-10.14], absence of support from family [AOR: 0.14, 95% CI 0.08-0.24] and absence of work engagement in prison [AOR: 0.44, 95% CI 0.25-0.78] were associated with MHMP.

CONCLUSION: In this study, about five from ten women in prison practice menstrual hygiene management. Age, educational status, previous occupation, support from family, and work engagement in prison were important risk factors for MHMP. Therefore, support from family and engaging the women to work in prison institutions may increase the MHMP in prison institutions.

PMID:37274653 | PMC:PMC10238586 | DOI:10.1016/j.heliyon.2023.e16224