Tag: nevin manimala

BMC Oral Health. 2023 Apr 22;23(1):236. doi: 10.1186/s12903-023-02942-y.

ABSTRACT

BACKGROUND: Dentists started to follow the era of using single-shade resin composite restorations to avoid color shade selection. Our study was done to evaluate and compare the color stability of two single-shade resin composite materials.

METHODS: Sixty samples were randomly allocated into two main groups (n = 30) according to the composite resin used: Group O: (Omnichroma) samples and Group V: (Venus Peral) samples. Each group was then divided into two subgroups (n = 15): group O1 and V1: samples immersed in coffee. Group O2 and V2: samples immersed in distilled water. Color changes (ΔE) and roughness values (Ra) were evaluated at baseline, first, and 14^th days of immersion. The color change was assessed using Vita Easyshade V, while surface roughness was assessed using a profilometer and Atomic Force Microscope (AFM). Data were collected and statistically analyzed using two-way variance analysis (ANOVA) and Tukey’s post-hoc test (p < 0.05).

RESULTS: Group O1 and V1 recorded the highest ΔE₀₀ (P = 0.002, 0.0001, respectively) and Ra values (P < 0.001) with no significant difference between both materials at 14 days.

CONCLUSION: Single shade resin composite with innovative chromatic material technology has dramatic color change and surface roughness that sacrifice esthetic success.

PMID:37087507 | DOI:10.1186/s12903-023-02942-y

Int J Cardiol. 2023 Apr 20:S0167-5273(23)00587-9. doi: 10.1016/j.ijcard.2023.04.033. Online ahead of print.

NO ABSTRACT

PMID:37087054 | DOI:10.1016/j.ijcard.2023.04.033

J Theor Biol. 2023 Apr 20:111497. doi: 10.1016/j.jtbi.2023.111497. Online ahead of print.

ABSTRACT

Recent evidence suggests that nongenetic (epigenetic) mechanisms play an important role at all stages of cancer evolution. In many cancers, these mechanisms have been observed to induce dynamic switching between two or more cell states, which commonly show differential responses to drug treatments. To understand how these cancers evolve over time, and how they respond to treatment, we need to understand the state-dependent rates of cell proliferation and phenotypic switching. In this work, we propose a rigorous statistical framework for estimating these parameters, using data from commonly performed cell line experiments, where phenotypes are sorted and expanded in culture. The framework explicitly models the stochastic dynamics of cell division, cell death and phenotypic switching, and it provides likelihood-based confidence intervals for the model parameters. The input data can be either the fraction of cells or the number of cells in each state at one or more time points. Through a combination of theoretical analysis and numerical simulations, we show that when cell fraction data is used, the rates of switching may be the only parameters that can be estimated accurately. On the other hand, using cell number data enables accurate estimation of the net division rate for each phenotype, and it can even enable estimation of the state-dependent rates of cell division and cell death. We conclude by applying our framework to a publicly available dataset.

PMID:37087049 | DOI:10.1016/j.jtbi.2023.111497

World Neurosurg. 2023 Apr 20:S1878-8750(23)00546-6. doi: 10.1016/j.wneu.2023.04.062. Online ahead of print.

ABSTRACT

BACKGROUND: The aim of this study was to investigate the effect of burr hole width on postoperative chronic subdural hematoma thickness and midline shift radiologically.

METHODS: The files of 92 patients who were operated after diagnosis of Chronic Subdural Hematoma between April 1, 2015 and July 1, 2021 were reviewed retrospectively. Preoperative and postoperative computerized tomography (CT) scans were scrutinized and the thickness of hematoma and midline shift and the diameters of two burr holes opened were measured and recorded. The correlation between burr hole diameter width and chronic subdural hematoma thickness in postoperative CT and improvement in midline shift was investigated statistically.

RESULTS: When the CT scans performed on the postoperative 1^st day and postoperative 1^st month were examined, it was determined that the preoperative hematoma thickness and midline shift were significantly reduced (p<0.001). A positive significant correlation was found between the improvement of the midline shift, the posterior burr hole diameter and the anterior-posterior burr hole arithmetic mean (p<0.001; p=0.029, respectively).

CONCLUSION: Having examined the current surgical treatment techniques in the treatment of chronic subdural hematoma, we found that an increase in the width of burr hole craniotomies (BHC), especially the posterior BHC, contributed to the improvement in midline shift.

PMID:37087033 | DOI:10.1016/j.wneu.2023.04.062

Mol Phylogenet Evol. 2023 Apr 20:107797. doi: 10.1016/j.ympev.2023.107797. Online ahead of print.

ABSTRACT

Pleione is an orchid endemically distributed in high mountain areas across the Hengduan Mountains (HDM), Himalayas, Southeast Asia and South of China. The unique flower shapes, rich colors and immense medicinal importance of Pleione are valuable ornamental and economic resources. However, the phylogenetic relationships and evolutionary history of the genus have not yet been comprehensively resolved. Here, the evolutionary history of Pleione was investigated using single-copy gene single nucleotide polymorphisms and chloroplast genome datasets. The data revealed that Pleione could be divided into five clades. Discordance in topology between the two phylogenetic trees and network and D-statistic analyses indicated the occurrence of reticulate evolution in the genus. The evolution could be attributed to introgression and incomplete lineage sorting. Ancestral area reconstruction suggested that Pleione was originated from the HDM. Uplifting of the HDM drove rapid diversification by creating conditions favoring rapid speciation. This coincided with two periods of consolidation of the Asian monsoon climate, which caused the first rapid diversification of Pleione from 8.87 to 7.83 Mya, and a second rapid diversification started at around 4.05 Mya to Pleistocene. The interaction between Pleione and climate changes, especially the monsoons, led to the current distribution pattern and shaped the dormancy characteristic of the different clades. In addition to revealing the evolutionary relationship of Pleione with orogeny and climate changes, the findings of this study provide insights into the speciation and diversification mechanisms of plants in the East Asian flora.

PMID:37086913 | DOI:10.1016/j.ympev.2023.107797

J Stomatol Oral Maxillofac Surg. 2023 Apr 20:101476. doi: 10.1016/j.jormas.2023.101476. Online ahead of print.

ABSTRACT

BACKGROUND: The aim of this study is to compare wound healing and vestibular depth gain in individuals undergoing vestibule deepening surgery using diode laser and conventional technique and to further investigate the possible wound healing effect of low-level laser therapy (LLLT).

MATERIAL AND METHODS: 52 systemically healthy individuals with insufficient vestibular depth in the region of teeth 33-43 in the lower jaw were included. Following nonsurgical periodontal treatment, patients were divided into four groups as follows: a) diode laser (L); b) diode laser + LLLT; c) conventional surgery and d) conventional surgery + LLLT. Vestibular depth and horizontal wound size measurements of the individuals were recorded using digital calipers. Reepithelization was evaluated via an image analysis program.

RESULTS: Vestibular depth measurements were found to be higher in the conventional surgery groups compared to that of diode laser groups after the operation, while the results were not statistically different between groups (p >0.05). Reepithelization area did not differ between groups in the evaluated time periods (p >0,05). On the other hand, horizontal wound shrinkage was significantly higher in the conventional surgery group than that of diode laser.

CONCLUSIONS: Within the limits of this study, both methods yielded in vestibule depth gain. On the other hand, LLLT did not have an additional positive effect on mucosal wound healing. As a clinical relevance, the results are valuable for clinicians in terms of showing that suturing of the mucosal flap formed following vestibule deepening should not be necessary in laser assisted surgery for attaining more vestibule depth.

PMID:37086896 | DOI:10.1016/j.jormas.2023.101476

Neuroimage. 2023 Apr 20:120089. doi: 10.1016/j.neuroimage.2023.120089. Online ahead of print.

ABSTRACT

To embrace big-data neuroimaging, harmonizing the site effect in resting-state functional magnetic resonance imaging (R-fMRI) data fusion is a fundamental challenge. A comprehensive evaluation of potentially effective harmonization strategies, particularly with specifically collected data, has been scarce, especially for R-fMRI metrics. Here, we comprehensively assess harmonization strategies from multiple perspectives, including tests on residual site effect, individual identification, test-retest reliability, and replicability of group-level statistical results, on widely used R-fMRI metrics across various datasets, including data obtained from participants with repetitive measures at different scanners. For individual identifiability (i.e., whether the same subject could be identified across R-fMRI data scanned across different sites), we found that, while most methods decreased site effects, the Subsampling Maximum-mean-distance based distribution shift correction Algorithm (SMA) and parametric unadjusted CovBat outperformed linear regression models, linear mixed models, ComBat series and invariant conditional variational auto-encoder in clustering accuracy. Test-retest reliability was better for SMA and parametric adjusted CovBat than unadjusted ComBat series and parametric unadjusted CovBat in the number of overlapped voxels. At the same time, SMA was superior to the latter in replicability in terms of the Dice coefficient and the scale of brain areas showing sex differences reproducibly observed across datasets. Furthermore, SMA better detected reproducible sex differences of ALFF under the site-sex confounded situation. Moreover, we designed experiments to identify the best target site features to optimize SMA identifiability, test-retest reliability, and stability. We noted both sample size and distribution of the target site matter and introduced a heuristic formula for selecting the target site. In addition to providing practical guidelines, this work can inform continuing improvements and innovations in harmonizing methodologies for big R-fMRI data.

PMID:37086875 | DOI:10.1016/j.neuroimage.2023.120089

Int J Infect Dis. 2023 Apr 20:S1201-9712(23)00531-3. doi: 10.1016/j.ijid.2023.04.400. Online ahead of print.

ABSTRACT

OBJECTIVE: The objective of this study was to determine whether an observed peri-papillary ischemia is a potential biomarker of tick-borne infection (TI).

METHODS: An experimental design analyzing the optic nerve to demonstrate peri-papillary ischemia and vessel density changes through ocular coherence tomography with angiography (OCT-A) in subjects with TI. Glaucoma was ruled out and the study engaged subjects in the age range between 8-40 years. All subjects in the experimental group experienced visual symptoms. Subjects in the control group were asymptomatic and not previously diagnosed with TI. The OCT-A scanned vessel density of peri-capillary plexus surrounding the optic nerves, the images were rated by percentage of vessel density. A two-tail t-test analysis was used to analyze the results.

RESULTS: The t-test for each measure comparing the difference-of-differences to a zero change at baseline returned statistically significant results demonstrating reduced vessel density for the subjects in the experimental group (p < .0001; 95% CI [32.37409-43.50091]).

CONCLUSION: The appearance of peri-papillary ischemia in persons below the age of 50 represents a potential screening biomarker of TI. Primary care physicians, ophthalmologists and optometrists who have patients presenting sudden onset of visual symptoms in addition to the appearance of peri-papillary ischemia should be tested to rule out a tick-borne infection.

PMID:37086868 | DOI:10.1016/j.ijid.2023.04.400

Transl Behav Med. 2023 Apr 22:ibad016. doi: 10.1093/tbm/ibad016. Online ahead of print.

ABSTRACT

Despite effective treatment options, people who experience mental health conditions often do not receive needed care. E-mental health, for instance the use of mobile apps, is emerging as a way to increase access to and extend care. However, little formal training is available to increase the digital literacy level among behavioral healthcare providers (BHPs), seeking to employ such technology. The purpose of this study was to explore the acceptability and usability of an adapted in-person Digital Navigation Training (DNT) curriculum into e-Learning modules focused on the integrated environment for BHPs. BHP confidence to serve as digital navigators was also explored. E-Learning modules were adapted from an existing in-person DNT. A purposeful sampling strategy was used to recruit BHPs (n = 8) to complete the modules. Acceptability, usability, and confidence were assessed via survey and semi-structured interviews. Descriptive statistics were calculated for survey data and qualitative data were analyzed using a directed content analysis approach. BHPs who completed the training (n = 8) felt the modules were usable, enjoyed the structure, and felt the amount of time to complete the modules was acceptable. All participants thought the structure of the training worked well and enjoyed learning new information. While participants’ confidence in their digital navigation skills increased, they desired more information and/or experience with screening apps prior to increasing their use of apps within their care. E-Learning modules were an acceptable method of educating BHPs with digital navigation skills. Future research is needed to explore incentives needed for training along with if participating in these modules can increase use of quality mobile apps to augment care within BHP treatment plans.

PMID:37086443 | DOI:10.1093/tbm/ibad016

Neurourol Urodyn. 2023 Apr 22. doi: 10.1002/nau.25191. Online ahead of print.

ABSTRACT

OBJECTIVES: To compare treatment response in women who did and did not develop a urinary tract infection (UTI) within 14 days after intravesical onabotulinumtoxinA injections for treatment of refractory urgency urinary incontinence (UUI).

METHODS: This is a secondary analysis of women who received Onabotulinumtoxin A in the Refractory Overactive Bladder: Sacral Neuromodulation vs Botulinum Toxin Assessment (ROSETTA) Trial. Participants were grouped by presence or absence of UTI within 14 days of injection. UTI was defined as symptomatic with positive urine culture per the primary ROSETTA protocol. Our primary outcome was change from baseline in mean number of UUI episodes based on monthly 3-day bladder diaries averaged over 6 months. We performed t tests and chi-square/Fisher’s exact for continuous and categorical variables. A p value of <0.05 was considered statistically significant.

RESULTS: Of 187 participants in the onabotulinumtoxinA arm, 10 (5.3%) experienced UTI within 14 days of injection, and 177 (94.7%) did not. At baseline, groups did not differ in demographics, mean UUI episodes per day (no UTI [5.37 ± 2.65] vs. UTI [6.40 ± 3.02], p = 0.24), or other diary parameters. For our primary outcome, groups did not differ in the change in mean daily UUI episodes at 1 month (no UTI [-4.29 ± 2.75] vs. UTI [-3.74 ± 2.01]; mean difference [95% confidence interval, CI] -0.55 [-2.39 to 1.28], p: 0.55) or 6 months (no UTI [-3.63 ± 2.89] vs. UTI [-2.15 ± 3.18]; mean difference [95% CI] -1.48 [-3.44 to 0.48], p: 0.14).

CONCLUSIONS: UTI within 14 days after intravesical injection of onabotulinumtoxinA for refractory UUI was not significantly associated with inferior treatment response at 1 or 6 months.

PMID:37086398 | DOI:10.1002/nau.25191