Tag: nevin manimala

J Med Imaging (Bellingham). 2023 Sep;10(5):051807. doi: 10.1117/1.JMI.10.5.051807. Epub 2023 Apr 18.

ABSTRACT

PURPOSE: Population-based screening programs for the early detection of breast cancer have significantly reduced mortality in women, but they are resource intensive in terms of time, cost, and workload and still have limitations mainly due to the use of 2D imaging techniques, which may cause overlapping of tissues, and interobserver variability. Artificial intelligence (AI) systems may be a valuable tool to assist radiologist when reading and classifying mammograms based on the malignancy of the detected lesions. However, there are several factors that can influence the outcome of a mammogram and thus also the detection capability of an AI system. The aim of our work is to analyze the robustness of the diagnostic ability of an AI system designed for breast cancer detection.

APPROACH: Mammograms from a population-based screening program were scored with the AI system. The sensitivity and specificity by means of the area under the receiver operating characteristic (ROC) curve were obtained as a function of the mammography unit manufacturer, demographic characteristics, and several factors that may affect the image quality (age, breast thickness and density, compression applied, beam quality, and delivered dose).

RESULTS: The area under the curve (AUC) from the scoring ROC curve was 0.92 (95% confidence interval = 0.89 – 0.95). It showed no dependence with any of the parameters considered, as the differences in the AUC for different interval values were not statistically significant.

CONCLUSION: The results suggest that the AI system analyzed in our work has a robust diagnostic capability, and that its accuracy is independent of the studied parameters.

PMID:37082509 | PMC:PMC10111789 | DOI:10.1117/1.JMI.10.5.051807

Zhonghua Kou Qiang Yi Xue Za Zhi. 2023 May 9;58(5):422-426. doi: 10.3760/cma.j.cn112144-20230209-00038. Online ahead of print.

ABSTRACT

Objective: To measure and analyze the shoulder circumferences of adults’ permanent teeth crown preparations based on data collected through the intraoral scanning, so as to provide dental anatomy data for clinical diagnosis and analysis. Methods: Intraoral scanning data of 840 complete crown preparations were collected, and were entrusted to the World Dental Laboratory Co., Ltd. in Fuzhou between March 2021 and June 2022. Except the data of the third molar, the rest data were categorized in terms of 14 tooth positions in the upper and lower jaw (each category involved 30 samples from male group and 30 samples from female group). Image measurement software was used to measure the shoulder circumferences of permanent teeth crown preparations. And analysis was conducted to reveal the difference of shoulder circumference diameters between male and female groups. And then they were grouped according to the mean value at each tooth position, on the premise that the difference between the maximum and minimum values and the mean value of the entire group was≤±1.00 mm. Analysis were further conducted to determine the differences of shoulder circumference diameters between each dental position and the differences between male and female in the same groups. Results: Bivariate analysis of variance showed that gender had no effect on the shoulder circumference of full crown preparations (F=0.55, P=1.457), while tooth position had a significant impact on the shoulder circumference of full crown preparations (F=273.15, P<0.001). The samples were classified into 5 groups according to the mean values of shoulder circumference diameters relating to each tooth position. Statistical analysis showed that Group 1, covering maxillary lateral incisor, mandibular central incisor and mandibular lateral incisor, had shoulder circumference with diameters of (16.62±2.21) mm; Group 2, consisting of maxillary central incisor, maxillary cusp, mandibular cusp, mandibular first premolar and mandibular second premolar, had diameters of (20.78±2.48) mm; Group 3, consisting of maxillary first premolar and maxillary second premolar, had diamerters of (22.09±2.72) mm; Group 4, covering maxillary first molar, maxillary second molar and mandibular first molar, had diamerters of (30.21±2.67) mm; while group 5, with mandibular second molar alone its member, had diamerters of (31.34±3.18) mm. The difference among the 5 groups was statistically significant (P<0.05). Conclusions: Significant differences of shoulder circumference diameters could be found between different tooth positions, while at the same tooth position, the differences between male and female are not significant. The 14 tooth positions could be grouped into 5 groups according to their shoulder circumference diameters. Future research could take the grouping as reference.

PMID:37082845 | DOI:10.3760/cma.j.cn112144-20230209-00038

Zhonghua Kou Qiang Yi Xue Za Zhi. 2023 May 9;58(5):414-421. doi: 10.3760/cma.j.cn112144-20230115-00021. Online ahead of print.

ABSTRACT

Objective: To provide a new solution for the digital design of nasal prostheses, this study explores the three-dimensional (3D) facial morphology completion method for external nasal defects based on the non-rigid registration process of 3D face template. Methods: A total of 20 male patients with tooth defect and dentition defect who visited the Department of Prosthodontics, Peking University School and Hospital of Stomatology from June to December 2022 were selected, age 18-45 years old. The original 3D facial data of patients were collected, and the 3D facial data of the external nose defect was constructed in Geomagic Wrap 2021 software. Using the structured 3D face template data constructed in the previous research of the research group, the 3D face template was deformed and registered to the 3D facial data of external nose defect (based on the morphology of non-defective area) by non-rigid registration algorithm (MeshMonk program), and the personalized deformed data of the 3D face template was obtained, as the complemented facial 3D data. Based on the defect boundary of the 3D facial data of the external nose defect, the complemented external nose 3D data can be cut out from the complemented facial 3D data. Then the nasofacial angle and nasolabial angle of the complemented facial 3D data and the original 3D facial data was compared and analyzed, the ratio between the nose length and mid-face height, nose width and medial canthal distance of the complemented facial 3D data was measured, the edge fit between the edge curve of the complemented external nose 3D data and the defect edge curve of the 3D facial data of external nose defect was evaluated, and the morphological difference of the nose between the complemented external nose 3D data and the original 3D facial data was analyzed. Results: There was no significant statistically difference (t=-0.23, P=0.823; Z=-1.72, P=0.086) in the nasofacial angle (28.2°±2.9°, 28.4°±3.5° respectively) and nasolabial angle [95.4°(19.2°), 99.9°(9.5°) respectively] between the 20 original 3D facial data and the complemented facial 3D data. The value of the ratio of nose length to mid-face height in the complemented facial 3D data was 0.63±0.03, and the value of the ratio of nose width to medial canthal distance was 1.07±0.08. The curve deviation (root mean square value) between the edge curve of the complemented external nose 3D data and the defect edge curve of the 3D facial data of external nose defect was (0.37±0.09) mm, the maximum deviation was (1.14±0.32) mm, and the proportion of the curve deviation value within±1 mm was (97±3)%. The distance of corresponding nose landmarks between the complemented facial 3D data and the original 3D facial data were respectively, Nasion: [1.52(1.92)] mm; Pronasale: (3.27±1.21) mm; Subnasale: (1.99±1.09) mm; Right Alare: (2.64±1.34) mm; Left Alare: (2.42± 1.38) mm. Conclusions: The method of 3D facial morphology completion of external nose defect proposed in this study has good feasibility. The constructed complemented external nose 3D data has good facial coordination and edge fit, and the morphology is close to the nose morphology of the original 3D facial data.

PMID:37082844 | DOI:10.3760/cma.j.cn112144-20230115-00021

Stat Appl Genet Mol Biol. 2023 Apr 24;22(1). doi: 10.1515/sagmb-2022-0025. eCollection 2023 Jan 1.

ABSTRACT

It is often of research interest to identify genes that satisfy a particular expression pattern across different conditions such as tissues, genotypes, etc. One common practice is to perform differential expression analysis for each condition separately and then take the intersection of differentially expressed (DE) genes or non-DE genes under each condition to obtain genes that satisfy a particular pattern. Such a method can lead to many false positives, especially when the desired gene expression pattern involves equivalent expression under one condition. In this paper, we apply a Bayesian partition model to identify genes of all desired patterns while simultaneously controlling their false discovery rates (FDRs). Our simulation studies show that the common practice fails to control group specific FDRs for patterns involving equivalent expression while the proposed Bayesian method simultaneously controls group specific FDRs at all settings studied. In addition, the proposed method is more powerful when the FDR of the common practice is under control for identifying patterns only involving DE genes. Our simulation studies also show that it is an inherently more challenging problem to identify patterns involving equivalent expression than patterns only involving differential expression. Therefore, larger sample sizes are required to obtain the same target power to identify the former types of patterns than the latter types of patterns.

PMID:37082815 | DOI:10.1515/sagmb-2022-0025

Diabet Med. 2023 Apr 21:e15120. doi: 10.1111/dme.15120. Online ahead of print.

ABSTRACT

AIM: Managing type 1 diabetes in young children can cause significant stress for parents. Continuous glucose monitoring (CGM) may reduce parental burden. The Strategies to Enhance CGM Use in Early Childhood (SENCE) trial randomized parents of children (ages 2 to <8 years) with type 1 diabetes to CGM with family behavioral intervention (CGM+FBI), CGM alone (Standard-CGM), or blood glucose monitoring for 26 weeks before receiving CGM+FBI (BGM-Crossover). This report assesses changes in psychosocial outcomes for all groups over 52 weeks.

METHODS: CGM+FBI (n=45), Standard-CGM (n=42), and BGM-Crossover (n=44) participants completed psychosocial assessments at baseline, 26 weeks, and 52 weeks. Repeated measures linear regression models evaluated change within and between treatment groups.

RESULTS: The BGM-Crossover group reported improved diabetes burden (Δ -6.9, 95% CI [-11.3, -2.6], p=0.003), fear of hypoglycemia (Δ -6.4, CI [-10.1, -2.6], p=0.002), and technology satisfaction (Δ 7.3, CI [2.4, 12.2], p=0.005) from 26 to 52 weeks, similar to published findings in the CGM+FBI group over the first 26 weeks. The Standard-CGM group reported increased technology satisfaction (Δ 7.3, CI [0.6, 14.0], p=0.027) from baseline to 52 weeks. The CGM+FBI group reported less diabetes burden and fear of hypoglycemia from baseline to 52 weeks, but changes were not statistically significant. Scores from 26 to 52 weeks did not deteriorate.

CONCLUSIONS: Parents demonstrated psychosocial benefits following FBI that appeared to maintain without additional intervention. CGM-focused education with behavioral support likely helps parents of young children with type 1 diabetes reduce burden and worry in the short- and long-term.

PMID:37083018 | DOI:10.1111/dme.15120

Eur Heart J Cardiovasc Imaging. 2023 Apr 21:jead063. doi: 10.1093/ehjci/jead063. Online ahead of print.

ABSTRACT

AIMS: Icosapent ethyl (IPE) significantly reduced ischaemic events in statin-treated patients with atherosclerosis or diabetes and elevated triglycerides in REDUCE-IT, including large reductions in myocardial infarction and elective, urgent, and emergent coronary revascularization. However, the mechanisms driving this clinical benefit are not fully known. The EVAPORATE trial demonstrated that IPE significantly reduced plaque burden. No study to date has assessed the impact of IPE on coronary physiology. Fractional flow reserve (FFR) derived from coronary computed tomography angiography (CTA) data sets (FFRCT) applies computational fluid dynamics to calculate FFR values in epicardial coronary arteries. Our objective was to assess the impact of IPE on coronary physiology assessed by FFRCT using imaging data from EVAPORATE.

METHODS AND RESULTS: A total of 47 patients and of 507 coronary lesions at baseline, 9 months, and 18 months with coronary CTA and FFRCT were studied in a blinded core lab. The pre-specified primary endpoint was the FFRCT value in the distal coronary segment from baseline to follow-up in the most diseased vessel per patient using IPE compared with placebo. The pre-specified secondary endpoint was the change in translesional FFRCT (ΔFFRCT) across the most severe (minimum 30% diameter stenosis) coronary lesion per vessel. Baseline FFRCT was similar for IPE compared with placebo (0.83 ± 0.08 vs. 0.84 ± 0.08, P = 0.55). There was significant improvement in the primary endpoint, as IPE improved mean distal segment FFRCT at 9- and 18-month follow-up compared with placebo (0.01 ± 0.05 vs. -0.05 ± 0.09, P = 0.02, and -0.01 ± 0.09 vs. -0.09 ± 0.12, P = 0.03, respectively). ΔFFRCT in 140 coronary lesions was improved, although not statistically significant, with IPE compared with placebo (-0.06 ± 0.08 vs. -0.09 ± 0.1, P = 0.054).

CONCLUSION: Icosapent ethyl demonstrated significant benefits in coronary physiology compared with placebo. This early and sustained improvement in FFRCT at 9- and 18-month follow-up provides mechanistic insight into the clinical benefit observed in the REDUCE-IT trial. Furthermore, this is the first assessment of FFRCT to determine drug effect.

PMID:37082990 | DOI:10.1093/ehjci/jead063

Q J Exp Psychol (Hove). 2023 Apr 21:17470218231172908. doi: 10.1177/17470218231172908. Online ahead of print.

ABSTRACT

Syntactic adaptation has been shown to occur for various temporarily ambiguous structures wherein an initially unexpected resolution becomes easier to process after repeated exposure. More controversial and less replicated is the claim that this adaptation toward a locally frequent structure occurs due to a strategic shifting of expectations to match short-term statistical regularities such that readers adapt away from the a priori more frequent structure. Experiment 1 replicates the initial adaptation toward a coordination garden path structure and away from a compound NP structure using self-paced reading; however, this paradigm has been criticized for its low reliability for detecting such small effects. To this end, Experiments 2 and 3 use a combination of self-paced reading and sentence completion tasks to replicate initial adaptation toward both coordination and reduced relative garden path structures and show evidence for a preference for these structures over their a priori more frequent alternatives. Together, these data reveal that participants may be tracking local structural statistics in real-time; however, they may not be able to rapidly use that information to update processing behaviors.

PMID:37082989 | DOI:10.1177/17470218231172908

Hypertension. 2023 Apr 21. doi: 10.1161/HYPERTENSIONAHA.123.20900. Online ahead of print.

ABSTRACT

BACKGROUND: Data from the US National Health and Nutrition Examination Survey are freely available and can be analyzed to produce hypertension statistics for the noninstitutionalized US population. The analysis of these data requires statistical programming expertise and knowledge of National Health and Nutrition Examination Survey methodology.

METHODS: We developed a web-based application that provides hypertension statistics for US adults using 10 cycles of National Health and Nutrition Examination Survey data, 1999 to 2000 through 2017 to 2020. We validated the application by reproducing results from prior publications. The application’s interface allows users to estimate crude and age-adjusted means, quantiles, and proportions. Population counts can also be estimated. To demonstrate the application’s capabilities, we estimated hypertension statistics for noninstitutionalized US adults.

RESULTS: The estimated mean systolic blood pressure (BP) declined from 123 mm Hg in 1999 to 2000 to 120 mm Hg in 2009 to 2010 and increased to 123 mm Hg in 2017 to 2020. The age-adjusted prevalence of hypertension (ie, systolic BP≥130 mm Hg, diastolic BP≥80 mm Hg or self-reported antihypertensive medication use) was 47.9% in 1999 to 2000, 43.0% in 2009 to 2010, and 44.7% in 2017 to 2020. In 2017 to 2020, an estimated 115.3 million US adults had hypertension. The age-adjusted prevalence of controlled BP, defined by the 2017 American College of Cardiology/American Heart Association BP guideline, among nonpregnant US adults with hypertension was 9.7% in 1999 to 2000, 25.0% in 2013 to 2014, and 21.9% in 2017 to 2020. After age adjustment and among nonpregnant US adults who self-reported taking antihypertensive medication, 27.5%, 48.5%, and 43.0% had controlled BP in 1999 to 2000, 2013 to 2014, and 2017 to 2020, respectively.

CONCLUSIONS: The application developed in the current study is publicly available and produced valid, transparent, and reproducible results.

PMID:37082970 | DOI:10.1161/HYPERTENSIONAHA.123.20900

Brain. 2023 Apr 21:awad135. doi: 10.1093/brain/awad135. Online ahead of print.

ABSTRACT

Amyloid-beta is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. However, there is evidence that, independently of amyloid-beta, age-related tau pathology might be present outside of the medial temporal lobe. We therefore aimed to study age-related amyloid-beta-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstream effects of this on cognition and structural measures. We included 545 cognitively unimpaired adults (40-92 years) from the BioFINDER-2 study (in vivo) and 639 (64-108 years) from the Rush Alzheimer’s Disease Center cohorts (ex vivo). [18F]RO948- and [18F]flutemetamol-PET standardized uptake value ratios were calculated for regional tau and global/regional Aβ in vivo. Immunohistochemistry was used to estimate amyloid-beta load and tangle density ex vivo. In vivo medial temporal lobe volumes (subiculum, cornu ammonis 1) and cortical thickness (entorhinal cortex, Brodmann area 35) were obtained using Automated Segmentation for Hippocampal Subfields packages. Thickness of early and late neocortical Alzheimer’s disease regions was determined using FreeSurfer. Global cognition and episodic memory were estimated to quantify cognitive functioning. In vivo age-related tau deposition was observed in the medial temporal lobe and in frontal and parietal cortical regions, which was statistically significant when adjusting for amyloid-beta. This was also observed in individuals with low amyloid-beta load. Tau deposition was negatively associated with cortical volumes and thickness in temporal and parietal regions independently of amyloid-beta. The associations between age and cortical volume or thickness were partially mediated via tau in regions with early Alzheimer’s disease pathology, i.e., early tau and/or amyloid-beta pathology (subiculum/Brodmann area 35/precuneus/posterior cingulate). Finally, the associations between age and cognition were partially mediated via tau in Brodmann area 35, even when including amyloid-beta-PET as covariate. Results were validated in the ex vivo cohort showing age-related and amyloid-beta-independent increases in tau aggregates in and outside the medial temporal lobe. Ex vivo age-cognition associations were mediated by medial and inferior temporal tau tangle density, while correcting for amyloid-beta density. Taken together, our study provides support for Primary Age-related Tauopathy even outside the medial temporal lobe in vivo and ex vivo, with downstream effects on structure and cognition. These results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of Alzheimer’s disease. Moreover, this study suggests the potential utility of tau-targeting treatments in Primary Age-related Tauopathy, likely already in preclinical stages in individuals with low amyloid-beta pathology.

PMID:37082959 | DOI:10.1093/brain/awad135

Tissue Eng Part C Methods. 2023 Apr 21. doi: 10.1089/ten.TEC.2023.0025. Online ahead of print.

ABSTRACT

The aim of this study was to test the suitability of calcium phosphate cement mixed with poly(lactic-co-glycolic acid microparticles (CPC-PLGA) into a ring-shaped polymeric space-maintaining device as bone graft material for lateral bone augmentation. Therefore, the bone chambers were installed on the lateral portion of the anterior region of the mandibular body of mini-pigs. Chambers were filled with either calcium phosphate cement mixed with poly(lactic-co-glycolic acid microparticles (CPC-PLGA) or BioOss® particles for comparison and left for 4 and 12 weeks. Histology and histomorphometry were used to obtain temporal insight in material degradation and bone formation. Results indicated that between 4 and 12 weeks of implantation, a significant degradation of the CPC-PLGA (from 75.1% to 23.1%) as well as BioOss® material occurred (from 40.6% to 14.4%). Degradation of both materials was associated with the presence of macrophage-like and osteoclast-like cells. Further, a significant increase in bone formation occurred between 4 and 12 weeks for the CPC-PLGA (from 0.1% to 7.2%) as well as BioOss® material (from 8.3% to 23.3%). Statistical analysis showed that bone formation had progressed significantly better using BioOss® compared to CPC-PLGA (p<0.05). In conclusion, this mini-pig study showed that CPC-PLGA does not stimulate lateral bone augmentation using a bone chamber device. Both treatments failed to achieve “clinically” meaningful alveolar ridge augmentation.

PMID:37082957 | DOI:10.1089/ten.TEC.2023.0025