Tag: nevin manimala

Cancer Med. 2026 Feb;15(2):e71595. doi: 10.1002/cam4.71595.

ABSTRACT

INTRODUCTION: Advances in mesothelioma management have translated into longer patient survival and different treatment-related side effects including nephrotoxicity. The risk of developing adverse renal outcomes in patients with mesothelioma and associated risk factors remains undefined.

METHODS: We analysed territory-wide data from electronic health records of patients with mesothelioma followed at public hospitals in Hong Kong between 1st January 2000 to 31st December 2022. Prevalence of acute kidney injury (AKI), renal progression (> 30 mL/min drop in eGFR), and upstaging of chronic kidney disease (CKD) and associated risk factors were evaluated.

RESULTS: 222 patients were included. 18 (5.1%) patients developed acute kidney injury (AKI), and risk factors included diabetes mellitus (DM), use of bevacizumab and the presence of third space fluid (pleural effusion, pericardial effusion, ascites). 47 (21.2%) patients had upstage of CKD, and 31 (14.0%) patients showed renal progression. 18, 9, and 4 patients developed renal progression within 12 months from diagnosis, 12-24 months from diagnosis, and more than 24 months from diagnosis. Risk factors for upstage of CKD included the presence of third space fluid, platinum-based chemotherapy, use of immune check-point inhibitors, AKI during follow-up, more lines of cytotoxic chemotherapy received, and cycles of pemetrexed used. Predictors for renal progression included the presence of ascites and use of bevacizumab.

CONCLUSION: Short- and long-term adverse kidney outcomes are prevalent in patients with mesothelioma and show strong associations with treatments received. Careful patient selection and close monitoring of renal function may help avoid untoward acute and chronic nephrotoxicity.

PMID:41614227 | DOI:10.1002/cam4.71595

Front Digit Health. 2026 Jan 14;7:1698551. doi: 10.3389/fdgth.2025.1698551. eCollection 2025.

ABSTRACT

INTRODUCTION: Dementia is a progressive condition that impacts cognitive and motor functions, with early symptoms often subtle and difficult to detect. Early detection is crucial for effective intervention and improved care. Recent advances in sensor technology enable continuous monitoring of human motion, providing valuable indicators of dementia and cognitive decline.

METHODS: This systematic review is the first to focus exclusively on motion-based dementia detection, excluding other neurological conditions. The study aimed to address gaps in the literature by analysing evidence for motion assessment as a tool for dementia detection and by identifying and comparing sensor types, sensor placements, motion assessment tasks, extracted motion features, and analytical methods. Electronic databases (PubMed, Web of Science, IEEE Xplore and Scopus) were searched for articles published between January 2015 to May 2025.

RESULTS: A total of 23 published articles were included. Sensors used across studies included inertial measurement units, pressure mats, cameras, and passive infrared sensors, with placements on body parts, wall-mounted, or floor-based. Motion assessment tasks were grouped into three categories: gait, activities of daily living, and standing postural control. Regarding analytical approaches, 11 studies employed machine learning techniques, while 12 studies utilised statistical analysis. The findings indicate that motion-based assessments demonstrate strong potential for dementia detection, as motion-related features extracted from specific tasks can serve as sensitive indicators of dementia-related cognitive decline.

DISCUSSION: Compared with traditional dementia diagnostic pathways that often involve lengthy assessment cycles, this review’s findings provide guidance on refining motion-based sensor selection, task design, and analytical methods to improve standardisation and reproducibility. Future research should prioritise: (1) large-scale, longitudinal data collection with confirmed dementia diagnoses to support machine learning model development; (2) standardisation of sensor types, placements, and motion metrics to enhance comparability; and (3) integration of multimodal data, including motion and brain signals, using explainable machine learning techniques to improve detection accuracy and clinical interpretability.

PMID:41614144 | PMC:PMC12850517 | DOI:10.3389/fdgth.2025.1698551

BMC Public Health. 2026 Jan 29. doi: 10.1186/s12889-026-26359-8. Online ahead of print.

ABSTRACT

BACKGROUND: Unsafe child feces disposal is a recognized public health concern linked to adverse child health outcomes. While previous studies have examined its impact, the spatial heterogeneity and determinants of unsafe child feces disposal in India remain underexplored. This study addresses this research gap by investigating the spatial distribution and key factors influencing unsafe disposal practices across Indian districts.

METHOD: This study utilized data from the National Family Health Survey-5 (2019-2021) to conduct a comprehensive spatial analysis. Univariate and Bivariate Local Indicators of Spatial Association (LISA) clustering were employed to identify spatial patterns of unsafe child feces disposal. To examine the determinants, a Spatial Error Model (SEM) was applied, while Fairlie decomposition was used to quantify the contribution of various factors to regional disparities.

RESULTS: The Univariate LISA analysis identified 170 hotspot districts characterized by high levels of unsafe child feces disposal, primarily located in Odisha, Jharkhand, Bihar, Assam, and Tamil Nadu. The SEM analysis revealed that maternal education, household wealth, sanitation access, and religious affiliation are significant determinants. Hotspot districts demonstrated a 22% higher likelihood of unsafe disposal compared to cold spots. Decomposition results indicated that household wealth accounted for 65.3% of the observed disparity, followed by sanitation (17.1%), religion (7.4%), media exposure (4.5%), and education (3.2%).

CONCLUSION: This study underscores the pronounced spatial disparities in unsafe child feces disposal across Indian districts. Addressing these disparities requires targeted interventions focusing on improving sanitation, enhancing maternal education, and leveraging media outreach to promote safe disposal practices.

PMID:41612356 | DOI:10.1186/s12889-026-26359-8

J Orthop Surg Res. 2026 Jan 30. doi: 10.1186/s13018-026-06671-0. Online ahead of print.

ABSTRACT

BACKGROUND: Achilles tendon rupture (ATR) often limits early rehabilitation following conventional repair. The ligament augmentation reconstruction system (LARS) offers immediate mechanical stability and enables early mobilization. However, few studies have directly compared LARS with conventional suture techniques in ATR.

PURPOSE: To compare the efficacy and safety of the LARS versus the conventional Kessler suture technique for managing acute closed ATR.

STUDY DESIGN: Retrospective Cohort Study.

METHODS: A retrospective analysis was conducted on 91 patients who underwent surgical repair for ATR. The cohort was divided into two groups: 59 patients were treated with the LARS and 32 with the conventional Kessler suture technique. Functional outcomes were assessed using the Achilles tendon Total Rupture Score (ATRS) and American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score at 3, 6, and 12 months postoperatively. Complications and re-rupture rates were systematically documented and compared between the groups.

RESULTS: At the 3-month follow-up, the LARS group demonstrated significantly superior functional outcomes, with markedly higher ATRS (78.00 ± 15.01 vs. 55.00 ± 16.30, P < 0.001) and AOFAS scores (87.03 ± 5.44 vs. 82.03 ± 3.92, P < 0.001) compared to the conventional repair group. This superiority was maintained at the 6-month assessment for both the ATRS (88.00 ± 12.18 vs. 76.00 ± 13.23; P < 0.001) and AOFAS scores (94.78 ± 4.90 vs. 89.06 ± 4.54; P < 0.001). However, by 12 months postoperatively, the differences in both ATRS and AOFAS scores between the two groups were no longer statistically significant (P > 0.05). The LARS group reported one case of gastrocnemius weakness, while the conventional group experienced two cases of delayed wound healing and one superficial infection.

CONCLUSION: LARS repair enables a faster functional recovery in the short term compared to conventional Kessler repair, without increasing complication rates. While both techniques yield comparable excellent results by one year, the accelerated recovery pathway provided by LARS establishes it as a safe and effective treatment option, especially valuable for patients requiring an early return to activity.

PMID:41612352 | DOI:10.1186/s13018-026-06671-0

BMC Health Serv Res. 2026 Jan 29. doi: 10.1186/s12913-025-13990-1. Online ahead of print.

ABSTRACT

BACKGROUND: The prevalence of obesity worldwide has reached pandemic levels and is anticipated to escalate swiftly in developing nations. Given the substantial surge in obesity rates observed over the last three decades, assessing obesity-related costs is imperative for informing policy decisions.

OBJECTIVES: This study aimed to estimate direct medical and non-medical costs, along with indirect costs associated with laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en-Y bypass (LRYGB), and pharmacotherapy for obesity in adult populations in Iran.

METHODS: An economic analysis was conducted to evaluate the costs of pharmacological and surgical obesity treatments over a one-year period in 2023 from a societal perspective. This analysis incorporated direct medical costs (e.g., medications, counseling, hospitalization), direct non-medical costs (e.g., transportation), and indirect costs (e.g., lost productivity). Cost components and resource use were identified through literature reviews and expert validation. Medical tariffs and hospital bills informed medical cost estimations, while patient self-report questionnaires were utilized for non-medical and indirect cost calculations. The analysis followed established reporting guidelines and employed a micro-costing approach to ensure a comprehensive evaluation.

RESULTS: The total costs were highest for LSG (2,294.98 USD), followed by LRYGB (2,266.85 USD), and pharmacotherapy (402.67 USD). Direct medical costs represented the largest proportion of total costs for all interventions, followed by direct non-medical costs and then indirect costs. Direct non-medical costs were notably higher for LSG and LRYGB compared to pharmacotherapy, with no statistically significant difference observed between LSG and LRYGB. Indirect costs were significantly greater for surgical interventions compared to pharmacotherapy, while no significant difference was noted between LSG and LRYGB.

CONCLUSION: Surgical interventions incurred higher total costs than pharmacotherapy, primarily due to substantial direct medical costs associated with LSG. Pharmacotherapy exhibited relatively higher direct non-medical costs, and indirect costs were a notable contributor across all interventions. These findings shed light on the economic burden of obesity and advocate for further exploration of costs related to lifestyle modifications and long-term assessments. The data supports future cost-effectiveness studies, aiding decision-making in obesity management.

PMID:41612331 | DOI:10.1186/s12913-025-13990-1

BMC Oral Health. 2026 Jan 29. doi: 10.1186/s12903-026-07765-1. Online ahead of print.

ABSTRACT

OBJECTIVE: To assess the diagnostic performance of photon-counting detector computed tomography (PCD-CT) and cone-beam computed tomography (CBCT) at dose-matched radiation levels (high, standard, and low) for detecting and evaluating simulated endodontic conditions, treatments, and associated complications.

METHODS: Sixteen extracted third molars with eight endodontic tasks were imaged using PCD-CT and CBCT. Qualitative (image quality, artifact susceptibility, diagnostic interpretability) and quantitative (endodontic working length) parameters were assessed by two observers using a five-point Likert scale. Descriptive statistics and weighted kappa (κ) were used for data analysis.

RESULTS: High- and standard-dose PCD-CT demonstrated superior image quality and anatomical visualization compared to CBCT (median 5, IQR 5-5; κ = 1.0; all p < 0.001). Low-dose PCD-CT remained diagnostically robust, outperforming CBCT, except in root canal visualization, where both performed similarly. Diagnostic accuracy of pathologies and complications was slightly higher with PCD-CT (80-88%) than with CBCT (75-88%). Endodontic working length measurements were consistently accurate across all protocols, with near-perfect inter-observer agreement (κ = 0.84-0.86, all p < 0.001).

CONCLUSIONS: PCD-CT demonstrated superior diagnostic performance over CBCT across multiple endodontic tasks, particularly at high and standard doses. Even at low doses, PCD-CT maintained robust accuracy and image quality, outperforming dose-matched CBCT in most parameters. Endodontic working length assessment was equally reliable across both modalities. Overall, PCD-CT offers diagnostic advantages over CBCT, particularly in challenging cases involving complex anatomy or high-density materials. Its effective performance at lower radiation levels emphasizes its clinical potential and supports broader implementation in dentomaxillofacial diagnostics.

PMID:41612315 | DOI:10.1186/s12903-026-07765-1

Biomed Eng Online. 2026 Jan 29. doi: 10.1186/s12938-026-01516-7. Online ahead of print.

ABSTRACT

Heart failure is a leading cause of morbidity and mortality, and fluid congestion complicates its management. Conventional home-monitoring methods, such as daily weight measurements, are insufficiently sensitive, while invasive techniques are impractical for routine use. This paper introduces a novel, non-invasive approach using textile-based dry electrodes for bio-impedance spectroscopy to detect subtle changes in thoracic fluid volume in a mouse model. Twenty-three mice underwent controlled fluid infusion into the thoracic cavity following a six-stage protocol. Bio-impedance data were collected over 256 frequencies ($3–1000$ kHz) and analyzed to extract $R_0$ and $R_{\infty }$, from which total ($V_T$), extra-cellular ($V_E$), and intra-cellular ($V_I$) fluid volumes were calculated and normalized to baseline. Statistical analyses included two-way ANOVA and multiple linear regression to correlate impedance measurements with animal length and weight. No statistically significant differences in normalized fluid volumes ($V_T$, $V_E$, $V_I$) were observed across infusion stages ($p>0.05$), though there was an anecdotal increase in $V_T$ ($\Delta V_T=1.16\pm 1.79$ mL) and $V_I$ ($\Delta V_I=1.80\pm 2.91$ mL) after fluid infusion. Multiple linear regression revealed moderate correlations between impedance measurements and weight ($r^2=0.33$, $p=0.035$, RMSE $=19.34$ g) as well as length ($r^2=0.34$, $p=0.0066$, RMSE $=1.00$ cm). Additionally, a strong correlation was found between length and weight ($r^2=0.81$, $p=5.65\times {10}^{–8}$). The results indicate that textile-based dry electrodes can non-invasively measure thoracic fluid volume in mice, although the sensor’s sensitivity to small changes is limited. Further refinement is needed to enhance sensitivity and determine sensitivity threshold. These findings support the continued development of textile-based bio-impedance sensors as a practical tool for non-invasive heart failure monitoring.

PMID:41612308 | DOI:10.1186/s12938-026-01516-7

BMC Public Health. 2026 Jan 29. doi: 10.1186/s12889-026-26297-5. Online ahead of print.

NO ABSTRACT

PMID:41612281 | DOI:10.1186/s12889-026-26297-5

BMC Ophthalmol. 2026 Jan 29. doi: 10.1186/s12886-026-04641-y. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate whether sub-Tenon anesthesia used during cataract surgery has a potential effect on pupillary dynamics by assessing late-term pupillary responses, and to compare these outcomes with those under topical anesthesia to ensure the safety of sub-Tenon anesthesia.

METHODS: The medical records of 63 eyes of 63 patients aged 50-70 who underwent cataract surgery between January 2022 and December 2023 were retrospectively analyzed. Demographic data and medical histories were reviewed. Comprehensive eye examinations including visual acuity, biomicroscopic and detailed fundus examination, and pupillography measurements (photopic, mesopic, scotopic, and dynamic responses) were recorded preoperatively and at postoperative week 1 follow-up.

RESULTS: The mean ages of patients in the topical and sub-Tenon anesthesia groups were 67.25 ± 10.29 and 68.84 ± 9.31 years, respectively. A total of 21 patients were male and 42 were female. Topical anesthesia was applied to 31 eyes and sub-Tenon anesthesia to 32 eyes. Both groups showed significant changes in pre- and postoperative scotopic, mesopic, and dynamic 10-second pupillary responses (p < 0.05). However, there was no statistically significant difference in static and dynamic pupil diameters between the two groups (p > 0.05).

CONCLUSIONS: Sub-Tenon’s anesthesia does not cause clinically significant changes in pupillary dynamics one week postoperatively, suggesting it is a safe alternative to topical anesthesia in terms of autonomic pupillary response.

PMID:41612272 | DOI:10.1186/s12886-026-04641-y

BMC Pregnancy Childbirth. 2026 Jan 30. doi: 10.1186/s12884-026-08704-2. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: In India, like most countries, the COVID-19 pandemic in successive waves severely hampered the emergency medical services (EMS) and the government made prompt interventions, including substantial investments in both EMS and maternal health care immediately after the first wave. The study assessed variations in EMS efficiency and critical perinatal outcomes between the pre-pandemic era and the post pandemic-resilient phase in 2023 and 2024.

DATA AND METHODS: The study analysed the key EMS metrics based on the calls related to pregnancy, including call volume, response and transfer time, hospital handoff time and ambulance travel distance, and important maternal-newborn health outcomes such as maternal and neonatal mortalities, home deliveries, institutional childbirths, C-section deliveries, miscarriages and complicated vaginal births. The data relied upon encompasses the period from January 2017 to December 2024, including eight pandemic phases in 2020-22 and the resilient period of 2023 and 2024, obtained from the Tamil Nadu 108 Ambulance Control Room. A time series analysis method evaluated the EMS metrics in various pandemic phases; a statistical comparison was made with the pre-pandemic period for maternal-newborn outcomes. The appropriate effect size metric quantified the change in both analyses.

RESULTS: In the pandemic phases, despite an increase in pregnancy related call volume, the EMS metrics such as response times, transfer times and hospital handoff times witnessed notable improvement. The maternal and childbirth outcomes, especially in the post-pandemic and resilient phases during 2023-24, were markedly superior when compared with the corresponding period in the pre-pandemic era. In particular, the maternal mortality rate reduced by 19%, with 37 deaths per 100,000 live births. This is far lower than the national average of 97 deaths per 100,000 live births. Also, the rates of infant death, neonatal death, miscarriage, difficult vaginal births, and home births went down by 19.35%, 17.03%, 28.02%, 19.23%, and 36.05%, respectively.

CONCLUSIONS: Government investments during the pandemic, along with the sustained focus on maternal health programmes, appear to have provided substantial support to pregnant women and newborns. The reproductive health of women in Tamil Nadu does not seem to have been undermined by the pandemic.

PMID:41612252 | DOI:10.1186/s12884-026-08704-2