Tag: nevin manimala

Eur Urol Focus. 2025 Jun 21:S2405-4569(25)00147-6. doi: 10.1016/j.euf.2025.05.015. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVE: Patients undergoing orchiectomy for testicular cancer (TC) may have body image concerns, with a testicular prosthesis (TP) as a potential solution. Data on regret regarding synchronous TP placement are limited. We investigated postoperative patient-reported satisfaction and decision regret after unilateral orchiectomy for TC with or without synchronous TP placement.

METHODS: A retrospective analysis was conducted on 142 cN0M0 TC patients who underwent orchiectomy at two tertiary-referral academic centers between 2014 and 2023. A synchronous TP was proposed in all cases. In October 2024, patients completed a decision regret scale and questions on TP placement and satisfaction. Descriptive statistics and logistic regression were used for the analysis.

KEY FINDINGS AND LIMITATIONS: Sixty-one (43%) patients had synchronous TP placement. Patients with a TP more frequently reported that their decision was correct (p < 0.01), they had less regret (p = 0.01), and they would have repeated the same choice (p = 0.02). Patients without a TP more frequently reported that they were still missing the removed testicle and they felt ashamed about their body image (all p < 0.01). Partner’s complaints about patient’s body image were more common in men without a TP (p = 0.01). A multivariable analysis showed that TP placement (odds ratio 0.4, p = 0.03) was associated with less regret. This study may have selection biases, and larger, multicentric studies are needed.

CONCLUSIONS AND CLINICAL IMPLICATIONS: Patients with synchronous TP placement reported higher satisfaction, less negative body image, lower partner disappointment, and less regret than those without a TP. Preoperative counseling should emphasize long-term satisfaction with a TP.

PMID:40545427 | DOI:10.1016/j.euf.2025.05.015

J Health Popul Nutr. 2025 Jun 21;44(1):216. doi: 10.1186/s41043-025-00923-1.

ABSTRACT

BACKGROUND: Achieving the sustainable development goal target 3.4 requires an all-hand-on-deck approach. Healthcare professionals are expected to provide health advice on lifestyle changes that will reduce the risk of developing non-communicable diseases, or improve the quality of life of those who already have the condition. The study examined the prevalence and correlates of receiving health advice among adults in Cape Verde.

METHODS: We analyzed the data 1,098 adults aged 18-69 years who participated in the 2020 WHO STEPS survey. All estimates were weighted. Bivariable and multivariable logistic regression were performed to assess correlates of receiving at least one health advice. Statistical significance was set at p < 0.05, with 95% confidence intervals reported.

RESULTS: Overall, 60.4% (95%CI: 55.3, 62.3) of adults in Cape Verde had received at least one health advice. Compared to younger adults (< 30 years), individuals aged 30-59 years having 1.55 times higher odds (AOR = 1.55, 95%CI: 1.11-2.15) and those aged 60 years and older having nearly three times the odds (AOR = 2.93, 95%CI: 1.71-5.02) of receiving advice. Previously married (AOR = 1.69, 95%CI: 1.09-2.61) and cohabiting individuals had higher odds (AOR = 1.56, 95%CI: 1.12-2.18) of receiving advice compared to those who were never married. Alcohol consumption was inversely associated with receiving advice, as drinkers had 40% lower odds of receiving advice compared to non-drinkers (AOR = 0.60, 95%CI: 0.45-0.81). Individuals consuming fewer than four servings of fruit per day had significantly lower odds of receiving advice (AOR = 0.58, 95%CI: 0.37-0.90), while those consuming fewer than four servings of vegetables per day had 1.41 times higher odds (AOR = 1.41, 95%CI: 1.06-1.88). The likelihood of receiving health advice was high among those living with hypertension (AOR = 1.94, 95%CI: 1.41-2.65).

CONCLUSION: Evidence from this study suggests that there is a moderately high prevalence of receiving health advice in Cape Verde. The key correlates are hypertension status, increasing age, marital status, alcohol consumption and dietary habits. The findings underscore the need for targeted health education and counseling strategies that address the unique needs of different population subgroups, particularly younger adults, non-drinkers, and those with suboptimal dietary habits, to ensure equitable access to health advice.

PMID:40544311 | DOI:10.1186/s41043-025-00923-1

Trials. 2025 Jun 21;26(1):216. doi: 10.1186/s13063-025-08901-y.

ABSTRACT

BACKGROUND: Sepsis is a life-threatening condition with high mortality rates of up to 40% due to multiple organ dysfunction. Systemic inflammatory response plays a key role in the pathophysiology and progression of this disease. Therefore, anti-inflammatory drugs can be considered as augmentation therapy for the management of the early phase of inflammation in septic patients, along with appropriate antimicrobial therapy and source control. Experimental studies suggest the beneficial effects of colchicine in animal septic models. However, the clinical effects of colchicine in the setting of sepsis have not been investigated yet.

METHODS: This prospective, double-blinded, placebo-controlled, randomized trial will be conducted at Imam Reza Hospital, the largest northwest referral hospital, in Tabriz, Iran. A total of 44 patients aged 18 to 80 years with sepsis diagnosis will be randomized 1:1 to receive colchicine 1 mg daily or placebo for 10 days. The primary outcome is interleukin-6 (IL-6) changes from the baseline through day 4. Sequential organ failure assessment (SOFA) and qSOFA scores will be evaluated at baseline, day 4, and day 10. Patients will be assessed regarding the need for supplemental oxygen, mechanical ventilation, and vasopressor from the randomization through day 4 and day 10.

DISCUSSION: The Colchicine IN Sepsis (COLINS) trial will be the first to investigate colchicine’s efficacy versus placebo in sepsis patients. The results of this trial will be a step forward in treating patients with sepsis.

TRIAL REGISTRATION: Clinical trial ID: IRCTID: IRCT20231017059748N1. Registration date: 21 October 2023. https://irct.behdasht.gov.ir/trial/73232 .

PMID:40544304 | DOI:10.1186/s13063-025-08901-y

BMC Oral Health. 2025 Jun 21;25(1):956. doi: 10.1186/s12903-025-06360-0.

ABSTRACT

BACKGROUND: Implant placement in the posterior maxilla is challenging, so modifications of the surgical techniques were introduced to overcome these challenges. The undersized drilling technique uses a final drill smaller than the diameter of the implant. The single drilling technique is a simplified method where the osteotomy is made using a single drill without sequential widening. This study was directed to evaluate the peri-implant bone behavior of the undersized drilling technique versus the single drilling technique of immediately loaded dental implants inserted in the posterior maxilla.

PATIENTS AND METHODS: 32 patients were selected for prosthetic replacement of a missing maxillary posterior single tooth by an immediately loaded dental implant and divided randomly into two equal groups. In Group I: 16 patients received 16 implants using the undersized drilling technique, while in Group II: 16 patients received 16 implants using the single drilling technique. Insertion torque, implant stability, modified sulcus bleeding index (mBI), peri-implant probing depth, bone density, and marginal bone height were evaluated for both groups. Statistical analysis was made for clinical and radiographic data.

RESULTS: 32 implants were inserted in the posterior maxilla. During a 12-month follow-up, every dental implant was successful with no complications. Both techniques showed high insertion torque (≥ 35 Ncm) and primary stability (> 70 ISQ) with no significant difference between the two groups (P > 0.05). Also, there were no significant differences between the study groups regarding peri-implant soft tissue health, bone density, and marginal bone loss (P > 0.05).

CONCLUSION: Both techniques revealed comparable, promising clinical and radiographic outcomes over a 12-month post-loading follow-up period when the immediate loading protocol was used in the posterior maxilla, where bone density is poor, but preparing the implant bed using the single drilling technique offers several merits for both the patient and clinician. In addition to avoiding excessive heat generation, mechanical damage, and high frictional forces during drilling procedures, surgical operations, and surgical site exposure take less time.

TRIAL REGISTRATION: Clinical-Trials.gov PRS ( https://register.

CLINICALTRIALS: gov ) had this study registered under the identifier number. NCT06770231 on 01/01/2025.

PMID:40544298 | DOI:10.1186/s12903-025-06360-0

BMC Oral Health. 2025 Jun 21;25(1):957. doi: 10.1186/s12903-025-06372-w.

ABSTRACT

OBJECTIVE: To evaluate the effectiveness of fully guided botulinum toxin (BTX) injection in lateral pterygoid muscle (LPM) using muscle segmentation technique and compare it with electromyography (EMG) for management of symptomatic disc displacement with reduction (DDWR).

MATERIALS AND METHODS: This prospective randomized controlled trial (RCT) included 20 patients suffering from DDWR. Patients were randomly allocated to two groups receiving BTX injection in LPM using fully guided technique of muscle segmentation for LPM in group I (study) while using EMG in group II (control). Evaluation was done for disc position after 3 months and for maximum interincisal opening (MIO), temporomandibular joint (TMJ) and LPM tenderness, and clicking after 1,3 and 6 months.

RESULTS: Maximum interincisal opening showed reduction at 1-month follow-up, followed by significant improvement in both groups. Significant disappearance of clicking, reduction in LPM and TMJ tenderness and disc position reduction were detected in both groups. However, the difference between both groups was not statistically significant except in LPM tenderness, there was a statistically significant difference in favor of group I at 3-and 6- month follow-up.

CONCLUSION: The findings suggest that the fully guided technique using muscle segmentation is a viable, cost-effective and reproducible alternative to EMG for BTX injection in LPM.

CLINICAL RELEVANCE: The fully guided technique by muscle segmentation in LPM is as effective as EMG, providing 3D virtual augmented environment of the muscle with its surrounding skeletal and dental structures.

TRIAL REGISTRATION: This prospective RCT has been retrospectively registered at Clinical Trials.gov with identification number: NCT06633445, 2024-10-01.

PMID:40544291 | DOI:10.1186/s12903-025-06372-w

Anim Microbiome. 2025 Jun 21;7(1):70. doi: 10.1186/s42523-025-00436-6.

ABSTRACT

BACKGROUND: Animals coexist with complex microbiota, including bacteria, viruses, and eukaryotes (e.g., fungi, protists, and helminths). While high-throughput sequencing is commonly used to characterize bacterial communities in animal microbiota, these methods are less often applied to gut eukaryotic composition. Here we used shotgun metagenomic sequencing to characterize eukaryotic diversity in the microbiomes of wild baboons and tested the degree to which eukaryotic community composition was predicted by host social group membership, sex, age, sequencing depth, and season of sample collection.

RESULTS: We analyzed a total of 75 fecal samples collected in 2012 and 2014 from 73 wild baboons in the Amboseli ecosystem in Kenya. DNA from these samples was subjected to shotgun metagenomic sequencing, revealing members of the kingdoms Protista, Chromista, and Fungi in 90.7%, 46.7%, and 20.3% of all samples, respectively (percentages indicate the percent of samples in which each kingdom was observed). Social group membership explained 11.2% of the global diversity in gut eukaryotic species composition, but we did not detect statistically significant effects of season, host age, or host sex. Across samples, the most prevalent protists were Entamoeba coli (74.66% of samples), Enteromonas hominis (53.33% of samples), and Blastocystis subtype 3 (38.66% of samples), while the most prevalent fungi included Pichia manshurica (14.66% of samples), and Ogataea naganishii (6.66% of samples).

CONCLUSIONS: Protista, Chromista, and Fungi are common members of the gut microbiome of wild baboons. More work on eukaryotic members of primate gut microbiota is important for primate health monitoring and management strategies.

PMID:40544290 | DOI:10.1186/s42523-025-00436-6

Cancer Imaging. 2025 Jun 21;25(1):78. doi: 10.1186/s40644-025-00901-0.

ABSTRACT

BACKGROUND: Percutaneous computed tomography (CT)-guided biopsy and cryoablation are commonly used techniques for diagnosing and treating pulmonary malignant tumors. Performing these procedures simultaneously allows for tissue diagnosis while potentially offering therapeutic benefits. This study aimed to evaluate whether the efficacy and safety of simultaneous percutaneous CT-guided biopsy and cryoablation in managing pulmonary tumors suspected of malignancy are comparable to those of sequential procedures.

METHODS: This retrospective study involved 124 patients with 131 highly suspicious malignant pulmonary nodules. Patients either underwent synchronous percutaneous core-needle biopsy and cryoablation (Group A) or separately underwent these procedures (Group B) from December 2020 to May 2024. All procedures were performed under CT guidance using a percutaneous approach. We analyzed technical success rates, complications, diagnostic yield, and local tumor control.

RESULTS: Technical success rates were 100% in both groups. The rate of pneumothorax was 42.1% (16/38) in Group A and 34.9% (30/86) in Group B. In Group A, hemoptysis and pleural effusion rates were 18.4% (7/38) and 23.7% (9/38), respectively, while in Group B, these rates were 16.3% (14/86) and 12.8% (11/86). These differences were not statistically significant. The diagnostic positive rate in Group A was 87.5%. The mean follow-up duration was 11.8 months (95% confidence interval [CI], 10.2-13.4), with local tumor control rates of 97% for Group A and 88% for Group B. The effectiveness rates of synchronous and separate procedures were similar.

CONCLUSION: Synchronous biopsy-ablation is an effective method for obtaining tumor pathology and local treatment of lung tumors simultaneously. It is a viable option for select patients where expedited diagnosis-therapy is clinically justified, particularly when molecular profiling is not immediately indicated.

PMID:40544289 | DOI:10.1186/s40644-025-00901-0

Pilot Feasibility Stud. 2025 Jun 21;11(1):87. doi: 10.1186/s40814-025-01668-8.

ABSTRACT

BACKGROUND: Currently, there is insufficient evidence supporting geriatric home rehabilitation after hospital discharge. Some studies demonstrate a positive effect, but meta-analytic evidence demonstrates uncertainty on the magnitude of the expected effect. Yet, evidence from other populations indicates that home rehabilitation could also be an effective strategy for older persons. Therefore, we aim to evaluate the effectiveness of geriatric home rehabilitation in older persons discharged from the hospital with disability. Given the potential challenges in recruiting participants delivering the intervention, and executing other study procedures in a multi-centre study, we will first carry out a pilot study.

METHODS: The pilot study will commence with an initial start-up phase at two centres: UZ Leuven and CHU UCL Namur, Belgium. Up to three participants per centre will be included to test the procedures and assessments, excluding randomisation and intervention delivery. The study then progresses to the full pilot phase to evaluate and confirm the feasibility of the proposed trial. This pilot study will take place at the same two centres. The pilot study aligns with the design of the envisioned full trial, i.e. a pragmatic, multicentre, individually randomised superiority trial. A 1 to 1 allocation ratio will be used for the pilot. A total of 24 participants from the two centres will be recruited to investigate the pilot study objectives. The pilot endpoints will be used to determine the feasibility of recruitment and study procedures including data collection, assessments and delivery of the intervention (a 6-week program consisting of exercise sessions 3 times per week, 45 min each). The results from the pilot study will be discussed within the pilot study steering group. Progression criteria will be reviewed to determine if the study progresses to a full trial, and which adaptations are needed.

DISCUSSION: In case of a successful pilot, the study will progress to a full trial. The ambition of the full trial is to recruit 333 participants across 8 centres in Belgium, and to investigate the effectiveness of home rehabilitation for older persons discharged from the hospital with disability.

TRIAL REGISTRATION: Clinicaltrials.gov, NCT06404138 on 08 May 2024.

PMID:40544287 | DOI:10.1186/s40814-025-01668-8

Infect Agent Cancer. 2025 Jun 21;20(1):41. doi: 10.1186/s13027-025-00665-z.

ABSTRACT

OBJECTIVE: Bladder cancer (BCa) has become a growing concern worldwide, highlighting the importance of early detection and new treatment methods. Recent studies have shown that viruses from the HERV family play a significant role in the development of various cancers and can act as early diagnostic biomarkers. Although hypomethylation of HERV-K has been proven in bladder cancer, no studies have yet explored the role of HERV-K oncogenes such as env, gag, np9, and rec. In this study, for the first time, we investigate the expression of these genes and their relationship with each other, aiming to shed light on their potential role in bladder cancer progression and diagnosis.

METHODS AND MATERIALS: We collected a total of 42 samples, comprising 21 bladder transitional cell carcinoma (TCC) samples and 21 adjacent normal tissue samples. Following RNA extraction, the expression levels of HERV-K (HML-2) genes (env, gag, np9, and rec) were evaluated using quantitative real-time PCR (qRT-PCR). For statistical analysis, GraphPad software was employed, utilizing the Kruskal-Wallis test, Mann-Whitney U test, and correlation tests to assess the data.

RESULTS: We found that env and np9 were significantly upregulated in BCa tissues compared to normal tissues (p < 0.0001 and p = 0.022, respectively). While env showed strong associations with tumor grade (low-grade: p = 0.0006; high-grade: p = 0.0011) and stage (early stage: p = 0.0002; invasive stage: p = 0.0047), np9 exhibited consistent associations across all grades (low-grade: p = 0.017; high-grade: p = 0.042) but was exclusively linked to invasive stages (p = 0.001). Although gag expression did not differ significantly overall, it was elevated in the invasive stages of tumors (p = 0.0021). Interestingly, while rec expression showed an increase in cancerous tissues compared to normal tissues, this change was not statistically significant. However, it exhibited significant correlations with other HERV-K genes in cancerous tissue (r = 0.63, p < 0.0001 with env; r = 0.80, p < 0.0001 with gag; and r = 0.39, p = 0.015 with np9). Age-stratified analysis revealed tumor-specific env (p = 0.0272) and rec (p = 0.0017) variations, whereas normal tissues showed only marginal rec age-dependence (p = 0.0494).

CONCLUSION: The results of our study highlight the potential role of HERV-K genes, particularly env and np9, in BCa progression and demonstrate their promising utility as diagnostic biomarkers.

PMID:40544283 | DOI:10.1186/s13027-025-00665-z

J Ovarian Res. 2025 Jun 21;18(1):136. doi: 10.1186/s13048-025-01723-1.

ABSTRACT

BACKGROUND: Studies have shown that vitrified-thawed blastocyst re-expansion capacity is a good predictor of implantation. However, whether assisted hatching (AH) influences re-expansion is currently unstudied. Also, whether AH improves subsequent implantation rate remains highly uncertain.

OBJECTIVES: To investigate the impact of AH on re-expansion and subsequent implantation in vitrified-thawed blastocysts transfer cycles.

METHOD: The absolute initial single vitrified-thawed blastocyst cycles of patients between August 2019 and April 2024 in our center were included in this retrospective cohort study, totaling 4637 cycles. Grouping was performed according to laser-AH or not. Stratified analyses according to different trophoblastic ectoderm (TE) grades were applied (TE were categorized into three different grades (A-C) according to their number and cohesiveness), with specific focus on blastocysts with TE grade of C. Subgroup analyses were then carried out based on blastocyst stage (Day5 or Day6), in which AH and Non-AH were compared separately. Multifactorial regression analyses were performed on the main outcomes to clarify the effect of laser-AH.

RESULTS: There were no differences in pregnancy outcomes between AH group and Non-AH group, though the blastocyst stage proportions differed. Subgroup analysis based on blastocyst stage still revealed no statistically significant differences in pregnancy outcomes regarding AH or not (both in Day5 and Day6 blastocysts); while AH group had a lower re-expansion rate than Non-AH group in Day6 blastocysts (78.9% vs. 84.0%, P = 0.006). Multifactorial regression showed that AH had no effect on biochemical pregnancy rate in all cycles (aOR: 1.064, 95% CI: 0.938-1.206, P = 0.337), but increased the probability of implantation in TE grade = C cycles (aOR: 1.340, 95% CI: 1.017-1.766, P = 0.038). In the binary regression analysis on re-expansion rate, AH presented a negative effect both in all cycles and in TE grade = C cycles (all cycles: aOR: 0.774, 95% CI: 0.646-0.827, P = 0.005; TE = C cycles: aOR: 0.688, 95% CI: 0.481-0.984, P = 0.040).

CONCLUSION: Laser-AH negatively affects the ability of vitrified-thawed blastocysts to re-expand. Laser-AH had no significant effect on implantation in all blastocysts. AH may only be beneficial for the implantation of blastocysts with TE grade C.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:40544282 | DOI:10.1186/s13048-025-01723-1