Tag: nevin manimala

J Nephrol. 2022 Nov 18. doi: 10.1007/s40620-022-01478-8. Online ahead of print.

ABSTRACT

BACKGROUND: Tubulointerstitial nephritis and uveitis syndrome (TINU) is a rare condition characterised by bilateral uveitis and interstitial nephritis. There is no nationally, or internationally agreed upon treatment regimen. A systematic review was undertaken to report the renal outcomes in TINU, and treatments used.

METHODS: Medline (1969-2021) and EMBASE (1988-2021) databases were searched for primary studies, clinical practice guidelines and case reports of adult and paediatric TINU cases, as defined by Mandeville criteria. Two reviewers identified articles meeting inclusion criteria (registered with PROSPERO). Data were extracted into a synthesis table and meta-analysis performed. Quality of case series was also assessed.

RESULTS: One hundred twenty-two articles were identified, totalling 257 cases included in the meta-analysis. Females were more commonly affected than males (2:1), and median age was 19 years. GFR at follow-up correlated with nadir GFR, and the proportion with GFR <90 ml/min/1.73 m² was statistically different between adult and paediatric groups. Of the entire cohort, 40% had GFR <90 ml/min/1.73 m² at follow-up. Glucocorticoid monotherapy was the most common treatment (70%); other strategies included no treatment (9%) and immunosuppressant drugs (e.g. azathioprine), mostly in steroid-resistant cases, or as ‘steroid-sparing’ alternatives.

CONCLUSIONS: The majority of literature regarding TINU is limited to case reports and case series. There are no prospective trials assessing the effects of different treatments on renal outcomes, and currently employed treatment strategies are physician-specific without a reliable evidence-base. Prospective data collection as part of multicentre trials should be a research focus to improve the evidence-base.

PMID:36396848 | DOI:10.1007/s40620-022-01478-8

Sci Rep. 2022 Nov 17;12(1):19736. doi: 10.1038/s41598-022-21242-z.

ABSTRACT

Rapid industrialization and urbanization have resulted in environmental pollution and unsustainable development of cities. The concentration of 12 potentially toxic metal(loid)s in windowsill dust samples (n = 50) were investigated from different functional areas of Qom city with the highest level of urbanization in Iran. Spatial analyses (ArcGIS 10.3) and multivariate statistics including Principal Component Analysis and Spearman correlation (using STATISTICA-V.12) were adopted to scrutinize the possible sources of pollution. The windowsill dust was very highly enriched with Sb (50 mg/kg) and Pb (1686 mg/kg). Modified degree of contamination (mC_d) and the pollution load indices (PLI_zone) indicate that windowsill dust in all functional areas was polluted in the order of industrial > commercial > residential > green space. Arsenic, Cd, Mo, Pb, Sb, Cu, and Zn were sourced from a mixture of traffic and industrial activities, while Mn in the dust mainly stemmed from mining activities. Non-carcinogenic health risk (HI) showed chronic exposure of Pb for children in the industrial zone (HI = 1.73). The estimations suggest the possible carcinogenic risk of As, Pb, and Cr in the dust. The findings of this study reveal poor environmental management of the city. Emergency plans should be developed to minimize the health risks of dust to residents.

PMID:36396803 | DOI:10.1038/s41598-022-21242-z

Biol Cybern. 2022 Nov 18. doi: 10.1007/s00422-022-00951-8. Online ahead of print.

ABSTRACT

Motor systems show an overall robustness, but because they are highly nonlinear, understanding how they achieve robustness is difficult. In many rhythmic systems, robustness against perturbations involves response of both the shape and the timing of the trajectory. This makes the study of robustness even more challenging. To understand how a motor system produces robust behaviors in a variable environment, we consider a neuromechanical model of motor patterns in the feeding apparatus of the marine mollusk Aplysia californica (Shaw et al. in J Comput Neurosci 38(1):25-51, 2015; Lyttle et al. in Biol Cybern 111(1):25-47, 2017). We established in (Wang et al. in SIAM J Appl Dyn Syst 20(2):701-744, 2021. https://doi.org/10.1137/20M1344974 ) the tools for studying combined shape and timing responses of limit cycle systems under sustained perturbations and here apply them to study robustness of the neuromechanical model against increased mechanical load during swallowing. Interestingly, we discover that nonlinear biomechanical properties confer resilience by immediately increasing resistance to applied loads. In contrast, the effect of changed sensory feedback signal is significantly delayed by the firing rates’ hard boundary properties. Our analysis suggests that sensory feedback contributes to robustness in swallowing primarily by shifting the timing of neural activation involved in the power stroke of the motor cycle (retraction). This effect enables the system to generate stronger retractor muscle forces to compensate for the increased load, and hence achieve strong robustness. The approaches that we are applying to understanding a neuromechanical model in Aplysia, and the results that we have obtained, are likely to provide insights into the function of other motor systems that encounter changing mechanical loads and hard boundaries, both due to mechanical and neuronal firing properties.

PMID:36396795 | DOI:10.1007/s00422-022-00951-8

Eur Radiol. 2022 Nov 18. doi: 10.1007/s00330-022-09216-1. Online ahead of print.

ABSTRACT

OBJECTIVES: To develop a U-Net-based deep learning model for automated segmentation of craniopharyngioma.

METHODS: A total number of 264 patients diagnosed with craniopharyngiomas were included in this research. Pre-treatment MRIs were collected, annotated, and used as ground truth to learn and evaluate the deep learning model. Thirty-eight patients from another institution were used for independently external testing. The proposed segmentation model was constructed based on a U-Net architecture. Dice similarity coefficients (DSCs), Hausdorff distance of 95% percentile (95HD), Jaccard value, true positive rate (TPR), and false positive rate (FPR) of each case were calculated. One-way ANOVA analysis was used to investigate if the model performance was associated with the radiological characteristics of tumors.

RESULTS: The proposed model showed a good performance in segmentation with average DSCs of 0.840, Jaccard of 0.734, TPR of 0.820, FPR of 0.000, and 95HD of 3.669 mm. It performed feasibly in the independent external test set, with average DSCs of 0.816, Jaccard of 0.704, TPR of 0.765, FPR of 0.000, and 95HD of 4.201 mm. Also, one-way ANOVA suggested the performance was not statistically associated with radiological characteristics, including predominantly composition (p = 0.370), lobulated shape (p = 0.353), compressed or enclosed ICA (p = 0.809), and cavernous sinus invasion (p = 0.283).

CONCLUSIONS: The proposed deep learning model shows promising results for the automated segmentation of craniopharyngioma.

KEY POINTS: • The segmentation model based on U-Net showed good performance in segmentation of craniopharyngioma. • The proposed model showed good performance regardless of the radiological characteristics of craniopharyngioma. • The model achieved feasibility in the independent external dataset obtained from another center.

PMID:36396792 | DOI:10.1007/s00330-022-09216-1

Neuropsychopharmacology. 2022 Nov 18. doi: 10.1038/s41386-022-01497-w. Online ahead of print.

ABSTRACT

Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover new therapies for PTSD/AUD. Here, we employed a rat model of comorbid PTSD/AUD to evaluate compounds that inhibit FK506-binding protein 51 (FKBP5), a co-chaperone modulator of glucocorticoid receptors implicated in stress-related disorders. Male and female rats received a familiar avoidance-based shock stress followed by voluntary alcohol drinking. We then assessed trauma-related behaviors through sleep bout cycles, hyperarousal, fear overgeneralization, and irritability. To evaluate the role of stress and alcohol history on the sensitivity to FKBP5 inhibitors, in two separate studies, we administered two FKBP5 inhibitors, benztropine (Study 1) or SAFit2 (Study 2). FKBP5 inhibitors were administered on the last alcohol drinking session and prior to each trauma-related behavioral assessment. We also measured plasma corticosterone to assess the actions of FKBP5 inhibitors after familiar shock stress and alcohol drinking. Benztropine reduced alcohol preference in stressed males and females, while aggressive bouts were reduced in benztropine-treated stressed females. During hyperarousal, benztropine reduced several startle response outcomes across stressed males and females. Corticosterone was reduced in benztropine-treated stressed males. The selective FKBP5 inhibitor, SAFit2, reduced alcohol drinking in stressed males but not females, with no differences in irritability. Importantly, SAFit2 decreased fear overgeneralization in stressed males and females. SAFit2 also reduced corticosterone across stressed males and females. Neither FKBP5 inhibitor changed sleep bout structure. These findings indicate that FKBP5 inhibitors modulate stress-related alcohol drinking and partially modulate trauma-related behaviors. This work supports the hypothesis that targeting FKBP5 may alleviate PTSD/AUD comorbidity.

PMID:36396784 | DOI:10.1038/s41386-022-01497-w

Breast Cancer Res Treat. 2022 Nov 17. doi: 10.1007/s10549-022-06802-1. Online ahead of print.

ABSTRACT

PURPOSE: We estimated the cost-effectiveness of 4 radiotherapy modalities to treat early breast cancer in the UK. In a subgroup of patients eligible for all modalities, we compared whole-breast (WB) and partial breast (PB) radiotherapy delivered in either 15 (WB15F, PB15F) or 5 fractions (WB5F, PB5F). In a subgroup ineligible for PB radiotherapy, we compared WB15F to WB5F.

METHODS: We developed a Markov cohort model to simulate lifetime healthcare costs and quality-adjusted life years (QALYs) for each modality. This was informed by the clinical analysis of two non-inferiority trials (FAST Forward and IMPORT LOW) and supplemented with external literature. The primary analysis assumed that radiotherapy modality influences health only through its impact on locoregional recurrence and radiotherapy-related adverse events.

RESULTS: In the primary analysis, PB5F had the least cost and greatest expected QALYs. WB5F had the least cost and the greatest expected QALYs in those only eligible for WB radiotherapy. Applying a cost-effectiveness threshold of £15,000/QALY, there was a 62% chance that PB5F was the cost-effective alternative in the PB eligible group, and there was a 100% chance that WB5F was cost-effective in the subgroup ineligible for PB radiotherapy.

CONCLUSIONS: Hypofractionation to 5 fractions and partial breast radiotherapy modalities offer potentially important benefits to the UK health system.

PMID:36396774 | DOI:10.1007/s10549-022-06802-1

Sci Rep. 2022 Nov 17;12(1):19800. doi: 10.1038/s41598-022-24361-9.

ABSTRACT

Random walks are common in nature and are at the basis of many different phenomena that span from neutrons and light scattering to the behaviour of animals. Despite the evident differences among all these phenomena, theory predicts that they all share a common fascinating feature known as Invariance Property (IP). In a nutshell, IP means that the mean length of the total path of a random walker inside a closed domain is fixed by the geometry and size of the medium. Such a property has been demonstrated to hold not only in optics, but recently also in the field of biology, by studying the movement of bacteria. However, the range of validity of such a universal property, strictly linked to the fulfilment of equilibrium conditions and to the statistical distributions of the steps of the random walkers, is not trivial and needs to be studied in different contexts, such as in the case of biological entities occupied in random foraging in an open environment. Hence, in this paper the IP in a virtual medium inside an open environment has been studied by using actual movements of animals recorded in nature. In particular, we analysed the behaviour of a grazer mollusc, the chiton Acanthopleura granulata. The results depart from those predicted by the IP when the dimension of the medium increases. Such findings are framed in both the condition of nonequilibrium of the walkers, which is typical of animals in nature, and the characteristics of actual animal movements.

PMID:36396773 | DOI:10.1038/s41598-022-24361-9

Environ Sci Pollut Res Int. 2022 Nov 18. doi: 10.1007/s11356-022-24018-0. Online ahead of print.

ABSTRACT

In recent times, reduced graphene oxide has gained more attention in various fields. In our study, a direct synthesis of reduced graphene oxide using a novel carbon-rich agro-waste from Pennisetum glaucum was used. Ferrocene acted as an oxidizing agent during thermal degradation at 300 °C for 15 and 20 min to promote graphene oxide and reduced graphene oxide formation. The X-ray diffraction peak at 2θ indicating a shift from 16.86 to 24.28°, presence of functional groups like -OH stretching, -C = C-, C = O, C-O, and C-OH by Fourier transmission infrared spectroscopy, prominent D and G bands at 1308 cm^-1 and 1578 cm^-1 by Raman spectra and UV-visible spectroscopy peak shift from 235 to 245 nm (π-π*, C = C bonds) confirmed the reduction of graphene oxide to reduced graphene oxide. The average particle size values 233.3 nm for graphene oxide and 63.57 nm for reduced graphene oxide illustrate the nanoscale range of our synthesized material. The negative zeta potential values in the range – 45.5 mV and – 29.5 mV for graphene oxide and its reduced forms infer the dispersion stability along with surface oxygen group presence. We have also highlighted the formation of graphene oxide quantum dots by magnetic stirring and confirmed by UV transilluminator and photoluminescence spectra. The photodegradation efficiency was optimized using central composite design for dosage, dye concentration, pH, and time for both malachite green and reactive blue dye. The kinetic studies report pseudo-first-order kinetic model for catalytic degradation and statistical Analysis of variance proved the significance of the process for p value < 0.05. Thus, the synthesized graphene materials could be used as a potential candidate for environmental applications.

PMID:36396762 | DOI:10.1007/s11356-022-24018-0

Environ Sci Pollut Res Int. 2022 Nov 17. doi: 10.1007/s11356-022-24168-1. Online ahead of print.

ABSTRACT

Bottom sediments deposited in retention tanks (RTs) located on two urban streams (Oliwski and Strzyza) in the central part of Gdansk (Poland) were analysed for polycyclic aromatic hydrocarbons’ (PAHs) content. PAHs were extracted from samples with methylene chloride, then the extracts were subjected to clean-up applying the solid phase extraction (SPE) method. Quantitative and qualitative determination of 16 PAHs was performed with the use of gas chromatography/mass spectrometry technique. A multi-dimensional approach was applied to analyse PAHs’ spatial distribution, source, and contamination status. Potential sources of PAHs were verified using isomer ratios supported by a statistical approach. The Σ16PAHs (in mg/kg d.w.) ranged from 1.95 ± 0.64 to 20.4 ± 6.8 for RTs located on the Oliwski Stream and from 0.50 ± 0.17 to 8.6 ± 2.9 for RTs located on the Strzyza Stream. PAHs detected in bottom sediments were mainly composed of 4- and 5-ring compounds. PAH isomer ratios such as Phen/Anth, Flth/Pyr, B(a)A/B(a)A + Chry, Inpy/Inpy + B(ghi)P, Flth/Flth + Pyr, Anth/Anth + Phen, and Flth/Flth + Pyr suggested delivery pathways for biomass, coal, and petroleum combustion. Petrogenic PAHs related to fuel leaks from cars were not detected. Statistical analyses confirmed traffic and heating system sources, while factor analysis (FA) pointed out the abrasion of wasting parts of vehicles. Based on threshold levels presented in sediment quality guidelines (SQGs), in most cases, PAHs were at low levels with occasional negative biological effects on organisms. Only sediments deposited in two RTs located on the Oliwski Stream presented harmful features for sediment-dwelling organisms. The risk assessment performed accordingly to the Σ16PAHs presented a moderate and high risk for biota. This study not only reflects the direct threat related to PAH content in bottom sediments, but also highlights the overall pollution of an area, considered to be a recreational part of the city (Oliwski Stream catchment). The findings of this study highlight the need to launch preventative methods to protect the area against pollution from heating system emission and traffic.

PMID:36396761 | DOI:10.1007/s11356-022-24168-1

Sci Rep. 2022 Nov 17;12(1):19790. doi: 10.1038/s41598-022-23920-4.

ABSTRACT

The production and leaf quality of Telfairia occidentalis in Cameroon are gravely threatened by leaf spot disease. A field study was conducted in July 2019 and 2020 to determine the influence of tillage systems and sowing dates on the incidence of Telfairia occidentalis leaf spot caused by Phoma sorghina. A randomized block design with three replications and four planting dates was used. The soil physicochemical properties were also determined. Data for disease incidence were registered once every two weeks and submitted to generalized linear model for statistical analysis. The means were separated by Duncan’s multiple range test at a 95% confidence interval. Calculations for disease incidence and statistical analysis were conducted using the Microsoft Excel program and SPSS version 23, respectively. Statistical analysis revealed that the zero tilled field generally registered a lower leaf spot disease incidence than the tilled field, which was highly significant (p ≤ 0.05). In addition, the second sowing date in the zero tilled field proved to be better in terms of low disease incidence than other sowing dates employed in the study. Therefore, to minimize the devastating effects of leaf spot disease, zero tillage coupled with the second sowing date could be exploited.

PMID:36396737 | DOI:10.1038/s41598-022-23920-4