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Nevin Manimala Statistics

Feature generation and contribution comparison for electronic fraud detection

Sci Rep. 2022 Oct 27;12(1):18042. doi: 10.1038/s41598-022-22130-2.

ABSTRACT

Modern money transfer services are convenient, attracting fraudulent actors to run scams in which victims are deceived into transferring funds to fraudulent accounts. Machine learning models are broadly applied due to the poor fraud detection performance of traditional rule-based approaches. Learning directly from raw transaction data is impractical due to its high-dimensional nature; most studies construct features instead by extracting patterns from raw transaction data. Past literature categorizes these features into recency, frequency, monetary, and anomaly detection features. We use various machine learning algorithms to examine the performance of features in these four categories with real transaction data; we compare them with the performance of our feature generation guideline based on the statistical perspectives and characteristics of (non)-fraudulent accounts. The results show that except for the monetary category, other feature categories used in the literature perform poorly regardless of which machine learning algorithm is used; anomaly detection features perform the worst. We find that even statistical features generated based on financial knowledge yield limited performance on a real transaction dataset. Our atypical detection characteristic of normal accounts improves the ability to distinguish them from fraudulent accounts and hence improves the overall detection results, outperforming other existent methods.

PMID:36302818 | DOI:10.1038/s41598-022-22130-2

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Nevin Manimala Statistics

Syndemics of intimate partner violence among women in HIV endemic South Africa: geospatial analysis of nationally representative data

Sci Rep. 2022 Oct 27;12(1):18083. doi: 10.1038/s41598-022-20230-7.

ABSTRACT

Despite some improvement in lowering HIV incidence, HIV-related challenges, such as intimate partner violence (IPV), remain unacceptably high among women in South Africa. For decades, researchers and activists have pointed to the complex and intertwined reality of the substance abuse, violence and AIDS (SAVA) syndemic that endangers women. However, more recent systematic review/meta-analysis evidence points to inconclusive association between IPV and alcohol use. Furthermore, much of the evidence is often non-population-based that focuses on the co-occurrence rather than synergistic SAVA interaction. In this study, using the latest data from the South Africa Demographic and Health Survey (SA-DHS), we identified geographic synergistic clustering of IPV associated with HIV and substance abuse in South Africa as a measure of population-level interactions among these factors. The SA-DHS is a nationally representative sample that includes wide-ranging data on health, social challenges and household geo-locations of 5,874 women who participated in the domestic violence module. First, geographical IPV, harmful alcohol use (as the substance abuse measure available in SA-DHS) and HIV clusters were identified using the Kulldorff spatial scan statistic in SaTScan. Second, synergistic interactions related to recent IPV (i.e. recent physical, sexual, emotional violence during the last 12 months) with harmful alcohol use and HIV challenge were measured using RERI [Relative excess risk due to interaction], AP [attributable proportion] and S [Synergy index]. In our results, we spatially identified geographical physical IPV syndemic interactions in parts of the Eastern Cape/Free State Provinces (RERI = 4.42 [95% CI: 2.34-6.51], AP = 0.56 [95% CI: 0.44-0.68], S = 2.77 [95% CI: 2.01-3.84], but not in other forms of IPV. Although IPV, based on decade old concept of SAVA syndemic, was less common/widespread than expected from the national scale population-based data, we identified population-level physical violence syndemic occurring in South Africa. Our study highlights the need to prioritize public health response targeting vulnerable populations residing in these high-risk areas of syndemic mechanisms linking these synergistic epidemics that women face in South Africa.

PMID:36302814 | DOI:10.1038/s41598-022-20230-7

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Nevin Manimala Statistics

Genetic causal inference between amblyopia and perinatal factors

Sci Rep. 2022 Oct 27;12(1):18050. doi: 10.1038/s41598-022-22121-3.

ABSTRACT

Amblyopia is a common visual disorder that causes significant vision problems globally. Most non-ocular risk factors for amblyopia are closely related to the intrauterine environment, and are strongly influenced by parent-origin effects. Parent-origin perinatal factors may have a direct causal inference on amblyopia development; therefore, we investigated the causal association between perinatal factors and amblyopia risk using a one-sample Mendelian Randomization (MR) with data from the UK Biobank Cohort Data (UKBB). Four distinct MR methods were employed to analyze the association between three perinatal factors (birth weight [BW], maternal smoking, and breastfeeding) and amblyopia risk, based on the summary statistics of genome-wide association studies in the European population. The inverse variance weighting method showed an inverse causal association between BW and amblyopia risk (odds ratio, 0.48 [95% CI, 0.29-0.80]; p = 0.004). Maternal smoking and breastfeeding were not causally associated with amblyopia risk. Our findings provided a possible evidence of a significant genetic causal association between low BW and increased amblyopia risk. This evidence may highlight the potential of BW as a predictive factor for visual maldevelopment and the need for careful management of amblyopia risk in patients with low BW.

PMID:36302817 | DOI:10.1038/s41598-022-22121-3

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Nevin Manimala Statistics

ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma

Sci Rep. 2022 Oct 27;12(1):18066. doi: 10.1038/s41598-022-22505-5.

ABSTRACT

Autophagy plays a critical role in tumor pathogenesis. However, autophagy-related signature in Hepatocellular carcinoma (HCC) has not been revealed yet. We quantified the levels of various cancer hallmarks and identified ATG101 as the major risk factor for overall survival in HCC. A robust ATG101-related gene signature (ATS) for prognosis was constructed using a combination of bioinformatic and statistical approaches. Additionally, genetic and immunological properties were measured between ATS-high and ATS-low groups. The ATS signature was associated with shortened overall survival in HCC patients independently of clinicopathological characteristics. ATS status defines an inflamed yet exhausted tumor microenvironment, in which the activities of the exhausted CD8+ or CD4+ T cells were strongly associated with ATS. The ATS signature predicts the drug resistance to the immunotherapy, thus a combination of targeted therapy and immunotherapy might be suitable for ATS-high patients. This work shed light on the function of ATG101-related genes in HCC and revealed that the ATS signature may be a useful prognostic biomarker for differentiating molecular and immunological features and predicting probable response to the therapy.

PMID:36302799 | DOI:10.1038/s41598-022-22505-5

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Nevin Manimala Statistics

Galerkin finite element analysis for magnetized radiative-reactive Walters-B nanofluid with motile microorganisms on a Riga plate

Sci Rep. 2022 Oct 27;12(1):18096. doi: 10.1038/s41598-022-21805-0.

ABSTRACT

In order to understand the characteristics of bio-convection and moving microorganisms in flows of magnetized Walters-B nano-liquid, we developed a model employing Riga plate with stretchy sheet. The Buongiorno phenomenon is likewise employed to describe nano-liquid motion in the Walters-B fluid. Expending correspondence transformations, the partial differential equation (PDE) control system has been transformed into an ordinary differential equation (ODE) control system. The COMSOL program is used to generate mathematical answers for non-linear equations by employing the Galerkin finite element strategy (G-FEM). Utilizing logical and graphical metrics, temperature, velocity, and microbe analysis are all studied. Various estimates of well-known physical features are taken into account while calculating nanoparticle concentrations. It is demonstrated that this model’s computations directly relate the temperature field to the current Biot number and parameter of the Walters-B fluid. The temperature field is increased to increase the approximations of the current Biot number and parameter of the Walters-B fluid.

PMID:36302798 | DOI:10.1038/s41598-022-21805-0

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Nevin Manimala Statistics

Mathematical modeling suggests U.S. counties are still unprepared for COVID spikes

America was unprepared for the magnitude of the pandemic, which overwhelmed many counties and filled some hospitals to capacity. A new study suggests there may have been a mathematical method, of sorts, to the madness of those early COVID days.
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Nevin Manimala Statistics

Examination of Complementary and Supportive Practices and Self-efficacy Against Foot Ulcers in Diabetic Patients

Altern Ther Health Med. 2022 Oct 28:AT7548. Online ahead of print.

ABSTRACT

CONTEXT: Medical treatment is critical in the healing of diabetic foot ulcers. Diabetic patients in many countries have recently started using complementary and supportive practices.

OBJECTIVES: The study intended to examine the complementary and supportive medical practices and their self-efficacy against foot ulcers that can develop in diabetic patients.

DESIGN: The research team conducted a cross-sectional and descriptive study.

SETTING: The study took place at internal-medicine outpatient clinics at a hospital in Turkey.

PARTICIPANTS: Participants were 656 diabetes patients who came the clinics between March and May 2021.

OUTCOME MEASURES: The research team collected data with a structured questionnaire and the Diabetic Foot Care Self-efficacy Scale (DFCSES).

RESULTS: Significant differences existed in gender, educational status, and average income level as well as between the (CAM) users and non-CAM A statistically significant difference existed between users and non-users of CAM. Users diabetes treatment type, go to regular doctor check-up, had other chronic disease, had a foot problem, regularly did leg and foot gymnastics, regularly did foot examination and often did foot examination.

CONCLUSIONS: The most popular products among CAM users were herbal products: Nigella sativa, Nigella sativa oil, cinnamon, and cinnamon oil. The mean scores for non-users of CAM were lower on the DFCSES.

PMID:36302232

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Nevin Manimala Statistics

Reliable Cognitive Decline in Late-Life Major Depression

Arch Clin Neuropsychol. 2022 Oct 27:acac083. doi: 10.1093/arclin/acac083. Online ahead of print.

ABSTRACT

OBJECTIVE: Major depression in older adults increases the statistical likelihood of dementia. It is challenging to translate statistical evidence of cognitive decline at the group level into knowledge of individual cognitive outcomes. The objective of the current study is to investigate 2-year reliable cognitive change in late-life depression (LLD), which will enhance understanding of cognitive changes in LLD and provide a means to assess individual change.

METHODS: In a sample of non-depressed cognitively normal older adults or NDCN (n = 113), we used linear regression to predict tests of global cognition, processing speed-executive functioning, and memory administered 1 and 2 years later. Stepwise regression was used to select covariates among demographics and raw test scores (either baseline or year 1) and we cross-validated the final models using the predicted residual error sum of squares (PRESS). We then derived a z-change score from the difference between actual and predicted follow-up scores and investigated the proportion of LLD patients (n = 199) and NDCN adults who experienced reliable “decline” (a z-score < -1.645), “stability” (z-scores between + – 1.645), and “improvement” (z scores > +1.645).

RESULTS: A greater proportion LLD compared with NDCN experienced cognitive decline in processing speed/executive functioning and global cognition over 2 years. When compared to NDCN, a greater proportion of LLD also significantly improved on one test of processing speed over 2 years.

CONCLUSIONS: Older adults with LLD are at risk of meaningful cognitive decline over a relatively short period, particularly in the domain of executive functioning and processing speed. This study provides a series of reliable change equations for common neuropsychological tests that can be applied clinically.

PMID:36302229 | DOI:10.1093/arclin/acac083

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Nevin Manimala Statistics

Angiographic and clinical outcomes in patients with versus without diabetes mellitus after revascularization with BioMime sirolimus-eluting stent

Coron Artery Dis. 2022 Dec 1;33(8):643-647. doi: 10.1097/MCA.0000000000001188. Epub 2022 Oct 14.

ABSTRACT

INTRODUCTION: Drug-eluting stents (DES) significantly improved angiographic and clinical outcomes compared with bare-metal stents in patients with diabetes. The clinical effects of BioMime sirolimus-eluting stent (SES) in patients with diabetes have not been evaluated. Therefore, we compared the efficacy of BioMime DES in coronary artery disease (CAD) patients with versus without diabetes.

METHODS: This prospective analytical study compared angiographic in-segment late loss and clinical effectiveness of BioMime SES stents in treating patients with (patients: 77 and lesions: 83) versus without (patients: 154 and lesions: 162) diabetes. The purpose of this study was the comparison of angiographic in-segment late loss at 12 months. Major adverse cardiac events (MACEs) were also monitored as secondary outcomes 24 months after the index procedure.

RESULTS: Of 231 patients enrolled in the study, the mean age was 63.3 years and 153 patients were male. Angiographic follow-up rate was 84.8% (patients: 196) and intravascular ultrasound (IVUS) follow-up rate was 67.9% (patients: 157) at 12 months. Diabetic patients were comparable to nondiabetic patients for 12-month in-segment late loss (0.01 ± 0.31 mm for the nondiabetes group versus 0.04 ± 0.11 mm for the diabetes group; P = 0.158; P < 0.05). At 24 months, MACEs, including death, myocardial infarction and ischemic-driven target lesion revascularization were not statistically different between the two treatment groups.

CONCLUSIONS: BioMime SES stents in treating patients with diabetes were comparable in reducing angiographic restenosis at 12 months and MACEs at 24 months compared to nondiabetic patients with CAD.

PMID:36302183 | DOI:10.1097/MCA.0000000000001188

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Nevin Manimala Statistics

Graft survival after kidney transplantation with standard versus prolonged kidney procurement time

Can J Surg. 2022 Sep 1;65(5):E573-E579. doi: 10.1503/cjs.005721. Print 2022 Sep-Oct.

ABSTRACT

BACKGROUND: During kidney procurement, after ice removal, kidneys located in the retroperitoneum are at risk for rewarming owing to the time taken to retrieve other abdominal and thoracic organs, which may lead to poorer outcomes. The purpose of this study was to evaluate the impact of prolonged kidney procurement time (PKP) on outcomes of kidney transplantation performed at the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.

METHODS: We retrospectively reviewed the cases of all adult (age ≥ 18 yr) patients who underwent kidney transplantation at the Queen Elizabeth II Health Sciences Centre between Jan. 1, 2010, and Dec. 31, 2015. We included all patients who received kidney transplants from deceased donors with a minimum follow-up period of 3 years. We defined PKP as more than 65 minutes from aortic cross-clamp to final organ extraction, and standard procurement time (SP) as 65 minutes or less.

RESULTS: Among the 455 transplantation procedures performed during the study period, we reviewed the cases of 145 patients who received kidneys from Nova Scotian donors and were followed in Nova Scotia. No statistically significant differences were seen in outcomes between kidney-only (n = 46) and multiorgan (n = 99) procurement, although more organs from kidney-only donors than multiorgan donors had a Kidney Donor Profile Index score greater than 50% (32 [69.6%] v. 48 [48.5%], p < 0.01). Compared to the SP group (n = 115), the PKP group (n = 30) had a higher rate of 30-day graft loss (6.7% v. 0.0%, p < 0.01), a higher incidence of de novo formation of donor-specific antibodies (3 [10.0%] v. 1 [0.9%], p < 0.01) and a lower 5-year graft survival rate (90.0% v. 97.4%, p = 0.03). Left kidneys remained 11 minutes longer on the donor than right kidneys when multiorgan procurement was performed (p < 0.01), and their 5-year survival rate was significantly lower than that of right kidneys (p = 0.03).

CONCLUSION: Procurement times longer than 65 minutes may be associated with poorer outcomes after kidney transplantation. Measures to reduce kidney exposure to rewarming during procurement may improve long-term outcomes.

PMID:36302131 | DOI:10.1503/cjs.005721