Tag: nevin manimala

Can J Public Health. 2022 Jul 11. doi: 10.17269/s41997-022-00661-5. Online ahead of print.

ABSTRACT

OBJECTIVE: To examine proportions and predictors of change in alcohol intake and binge drinking during the first 2 waves of the COVID-19 pandemic among middle-aged and older participants in the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Questionnaire Study.

METHODS: A total of 28,559 (67.2% of the potential sample) CLSA participants consented to the study with 24,114 completing the exit survey (fall 2020). Descriptive statistics and logistic regressions to examine predictors of change (increase or decrease) in alcohol intake and binge drinking were performed.

RESULTS: Among alcohol users, 26.3% reported a change in alcohol consumption during the first 10 months of the pandemic. Similar percentages increased (13.0%) or decreased (13.3%) consumption. In our mutually adjusted logistic regression model, odds of change in alcohol intake were greater for younger age, higher income, current cannabis smoker, positive screen for depression, anxiety, and loneliness. The magnitude of all associations for decreased intake was less than that of increased intake, and the directions were opposite for male sex and age. Predictors of current binge drinking (27.9% of alcohol users) included male sex, younger age, higher education and income, cannabis use, depression, and anxiety.

CONCLUSION: Factors predictive of potentially worrisome alcohol use (i.e. increased intake, binge drinking) included younger age, sex, greater education and income, living alone, cannabis use, and worse mental health. Some of these factors were also associated with decreased intake, but the magnitudes of associations were smaller. This information may help direct screening efforts and interventions towards individuals at risk for problematic alcohol intake during the pandemic.

PMID:35818014 | DOI:10.17269/s41997-022-00661-5

Nat Genet. 2022 Jul 11. doi: 10.1038/s41588-022-01103-1. Online ahead of print.

ABSTRACT

The quantitative geneticist W. G. (‘Bill’) Hill, awardee of the 2018 Darwin Medal of the Royal Society and the 2019 Mendel Medal of the Genetics Society (United Kingdom), died on 17 December 2021 at the age of 81 years. Here, we pay tribute to his multiple key scientific contributions, which span population and evolutionary genetics, animal and plant breeding and human genetics. We discuss his theoretical research on the role of linkage disequilibrium (LD) and mutational variance in the response to selection, the origin of the widely used LD metric r² in genomic association studies, the genetic architecture of complex traits, the quantification of the variation in realized relationships given a pedigree relationship and much more. We demonstrate that basic theoretical research in quantitative and statistical genetics has led to profound insights into the genetics and evolution of complex traits and made predictions that were subsequently empirically validated, often decades later.

PMID:35817969 | DOI:10.1038/s41588-022-01103-1

Nat Microbiol. 2022 Jul 11. doi: 10.1038/s41564-022-01162-4. Online ahead of print.

ABSTRACT

Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous pandemic V. cholerae strains. Using a co-occurrence analysis of VSP genes in >200,000 bacterial genomes we built gene networks to infer biological functions encoded in these islands. This revealed that dncV, a component of the cyclic-oligonucleotide-based anti-phage signalling system (CBASS) anti-phage defence system, co-occurs with an uncharacterized gene vc0175 that we rename avcD for anti-viral cytodine deaminase. We show that AvcD is a deoxycytidylate deaminase and that its activity is post-translationally inhibited by a non-coding RNA named AvcI. AvcID and bacterial homologues protect bacterial populations against phage invasion by depleting free deoxycytidine nucleotides during infection, thereby decreasing phage replication. Homologues of avcD exist in all three domains of life, and bacterial AvcID defends against phage infection by combining traits of two eukaryotic innate viral immunity proteins, APOBEC and SAMHD1.

PMID:35817890 | DOI:10.1038/s41564-022-01162-4

Int J Obes (Lond). 2022 Jul 11. doi: 10.1038/s41366-022-01178-0. Online ahead of print.

ABSTRACT

BACKGROUND: Despite compelling links between excess body weight and cancer, body mass index (BMI) cut-points, or thresholds above which cancer incidence increased, have not been identified. The objective of this study was to determine if BMI cut-points exist for 14 obesity-related cancers.

SUBJECTS/METHODS: In this retrospective cohort study, patients 18-75 years old were included if they had ≥2 clinical encounters with BMI measurements in the electronic health record (EHR) at a single academic medical center from 2008 to 2018. Patients who were pregnant, had a history of cancer, or had undergone bariatric surgery were excluded. Adjusted logistic regression was performed to identify cancers that were associated with increasing BMI. For those cancers, BMI cut-points were calculated using adjusted quantile regression for cancer incidence at 80% sensitivity. Logistic and quantile regression models were adjusted for age, sex, race/ethnicity, and smoking status.

RESULTS: A total of 7079 cancer patients (mean age 58.5 years, mean BMI 30.5 kg/m²) and 270,441 non-cancer patients (mean age 43.8 years, mean BMI 28.8 kg/m²) were included in the study. In adjusted logistic regression analyses, statistically significant associations were identified between increasing BMI and the incidence of kidney, thyroid, and uterine cancer. BMI cut-points were identified for kidney (26.3 kg/m²) and uterine (26.9 kg/m²) cancer.

CONCLUSIONS: BMI cut-points that accurately predicted development kidney and uterine cancer occurred in the overweight category. Analysis of multi-institutional EHR data may help determine if these relationships are generalizable to other health care settings. If they are, incorporation of BMI into the screening algorithms for these cancers may be warranted.

PMID:35817851 | DOI:10.1038/s41366-022-01178-0

Sci Rep. 2022 Jul 11;12(1):11762. doi: 10.1038/s41598-022-15344-x.

ABSTRACT

This study investigates the contribution of external trunk morphology and posture to running performance in an evolutionary framework. It has been proposed that the evolution from primitive to derived features of torso shape involved changes from a mediolaterally wider into a narrower, and antero-posteriorly deeper into a shallower, more lightly built external trunk configuration, possibly in relation to habitat-related changes in locomotor and running behaviour. In this context we produced experimental data to address the hypothesis that medio-laterally narrow and antero-posteriorly shallow torso morphologies favour endurance running capacities. We used 3D geometric morphometrics to relate external 3D trunk shape of trained, young male volunteers (N = 27) to variation in running velocities during different workloads determined at 45-50%, 70% and 85% of heart rate reserve (HRR) and maximum velocity. Below 85% HRR no relationship existed between torso shape and running velocity. However, at 85% HRR and, more clearly, at maximum velocity, we found highly statistically significant relations between external torso shape and running performance. Among all trained subjects those with a relatively narrow, flat torso, a small thoracic kyphosis and a more pronounced lumbar lordosis achieved significantly higher running velocities. These results support the hypothesis that external trunk morphology relates to running performance. Low thoracic kyphosis with a flatter ribcage may affect positively respiratory biomechanics, while increased lordosis affects trunk posture and may be beneficial for lower limb biomechanics related to leg return. Assuming that running workload at 45-50% HRR occurs within aerobic metabolism, our results may imply that external torso shape is unrelated to the evolution of endurance running performance.

PMID:35817835 | DOI:10.1038/s41598-022-15344-x

Sci Rep. 2022 Jul 11;12(1):11747. doi: 10.1038/s41598-022-15174-x.

ABSTRACT

Grinding stones and ground stone implements are important technological innovations in later human evolution, allowing the exploitation and use of new plant foods, novel tools (e.g., bone points and edge ground axes) and ground pigments. Excavations at the site of Madjedbebe recovered Australia’s (if not one of the world’s) largest and longest records of Pleistocene grinding stones, which span the past 65 thousand years (ka). Microscopic and chemical analyses show that the Madjedbebe grinding stone assemblage displays the earliest known evidence for seed grinding and intensive plant use, the earliest known production and use of edge-ground stone hatchets (aka axes), and the earliest intensive use of ground ochre pigments in Sahul (the Pleistocene landmass of Australia and New Guinea). The Madjedbebe grinding stone assemblage reveals economic, technological and symbolic innovations exemplary of the phenotypic plasticity of Homo sapiens dispersing out of Africa and into Sahul.

PMID:35817808 | DOI:10.1038/s41598-022-15174-x

Sci Rep. 2022 Jul 11;12(1):11761. doi: 10.1038/s41598-022-15894-0.

ABSTRACT

Carex buekii is a highly adaptive species showing a fairly wide ecological spectrum. It belongs to the group of river corridor plants which are vulnerable to any human activity directed at transformation of river valley habitats worldwide. This study was aimed at: determining the phenotypic variability of the species in the central part of its range, examining effects of soil conditions on the sedge’s morphological traits, and finding out whether the phenotypic plasticity observed may have taxonomic implications. A total of 487 specimens from 26 populations were collected in Hungary, Poland and Slovakia and tested by univariate, bivariate, and multivariate statistical methods. The analysis involved 16 morphological traits and 7 soil parameters (organic matter, pH, potassium, phosphorus, nitrogen, magnesium, calcium). Soil conditions were shown to affect the C. buekii morphology; particularly important was potassium, the only soil parameter that was indicated as a factor affecting intra-specific variability. Sites with lower contents of bioavailable potassium hosted C. buekii individuals which were generally smaller than those at sites showing higher soil potassium contents. The relationship held true also with respect to generative traits important in sedge taxonomy, i.e. utricle and beak lengths. Consideration of morphological differences only, without analysing relationships between morphology and soil conditions, could have resulted in distinguishing new entities at the level of species, subspecies or variety. Thus, knowledge on the range of phenotypic plasticity in field populations seems to be of a key importance in taxonomic studies.

PMID:35817804 | DOI:10.1038/s41598-022-15894-0

Sci Data. 2022 Jul 11;9(1):396. doi: 10.1038/s41597-022-01501-4.

ABSTRACT

Researchers typically rely on fossils from the Family Bovidae to generate African paleoenvironmental reconstructions due to their strict ecological tendencies. Bovids have dominated the southern African fauna for the past four million years and, therefore, dominate the fossil faunal assemblages, especially isolated teeth. Traditionally, researchers reference modern and fossil comparative collections to identify teeth. However, researchers are limited by the specific type and number of bovids at each institution. B.O.V.I.D. (Bovidae Occlusal Visual IDentification) is a repository of images of the occlusal surface of bovid teeth. The dataset currently includes extant bovids from 7 tribes and 20 species (~3900). B.O.V.I.D. contains two scaled images per specimen: a color and a black and white (binarized) image. The database is a useful reference for identifying bovid teeth. The large sample size also allows one to observe the natural variation that exists in each taxa. The binarized images can be used in statistical shape analyses, such as taxonomic classification. B.O.V.I.D. is a valuable supplement to other methods for taxonomically identifying bovid teeth.

PMID:35817763 | DOI:10.1038/s41597-022-01501-4

Am J Health Promot. 2022 Jul 11:8901171221113317. doi: 10.1177/08901171221113317. Online ahead of print.

ABSTRACT

PURPOSE: To elicit preliminary pediatrician and parent perspectives on physical activity (PA) counseling and identify opportunities for improvement.

DESIGN: Mixed methods, including a cross-sectional survey and semi-structured interviews.

SETTING AND PARTICIPANTS: Primary care pediatricians (N = 73; 40% response rate) within a single large healthcare system and parents of students (N = 20) participating in a local school-based PA program in eastern Massachusetts.

METHODS: Electronic survey of pediatricians assessing opinions of American Academy of Pediatrics (AAP) PA guidelines and potential PA promotion tools; semi-structured qualitative interviews with parents assessing overall discussion, education, and recommendations relating to PA.

ANALYSIS: We report descriptive statistics for survey items and bivariate analyses comparing responses by physician characteristics. We performed thematic analysis of qualitative interviews and present results through an implementation science framework.

RESULTS: In this preliminary study, pediatricians reported adoption, appropriateness, and lower perceived effectiveness of PA counseling. School-based programs and educational materials were most often chosen as PA promotion tools. Responses varied by pediatrician characteristics. While parents reported satisfaction, opportunities for improvement included connections with community resources and continued conversations with the child about PA.

CONCLUSIONS: Pediatricians and parents highlighted gaps in PA counseling in primary care. While results are preliminary given small sample size, this study provides actionable targets to support PA promotion as a preventive health priority in this setting.

PMID:35817761 | DOI:10.1177/08901171221113317

J Am Coll Health. 2022 Jul 11:1-8. doi: 10.1080/07448481.2022.2093116. Online ahead of print.

ABSTRACT

Objective: Campus recreational sport activities impact college student health and well-being in a variety of domains. This multi-institutional study examined the participation of students in campus recreation during the pandemic and explored the relationship between student participation and their demographic markers, COVID-19 experience, and perceptions of risk, health and safety. Methods: Results from a survey of 1,815 American college students indicated the presence of statistical differences in sport participation based on Gender, Race, State, Personal COVID-19 Experience, Campus Safety Efforts, and Risk Perception Score within various areas of analysis. Results: The impact and meaning of these cross-sectional results are discussed with reference to the ongoing pandemic and student health. Recommendations are presented within the context of this vital programming area both during and beyond the current crisis. Conclusion: These results are especially important given the health benefits associated with participation in recreational sport as tools to mitigate against the unprecedented consequences of the pandemic.

PMID:35816740 | DOI:10.1080/07448481.2022.2093116