Tag: nevin manimala

Child Abuse Negl. 2021 Nov 10;123:105377. doi: 10.1016/j.chiabu.2021.105377. Online ahead of print.

ABSTRACT

BACKGROUND: Childhood sexual abuse (CSA) contributes to increased risk of substance use and mental health disorders in the general population.

OBJECTIVE: To assess the prevalence and associations of CSA and suicide attempts, substance use, and mental health disorders as a function of sex (female, male) and sexual orientation (lesbian, gay, bisexual, heterosexual-identified with same-sex attraction and/or behavior, heterosexual-identified without same-sex attraction and/or behavior, and unsure).

PARTICIPANTS AND SETTING: Data were collected using structured diagnostic face-to-face interviews in a nationally representative sample of 36,309 US adults.

METHODS: We used descriptive statistics and logistic regression modeling to analyze data from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III).

RESULTS: Childhood sexual abuse was most prevalent among sexual minorities, especially bisexual females. Nearly one-third of bisexual females (30.6%) reported experiencing two or more types of CSA, p < .001. Among all participants, exposure to one or more types of CSA was associated with greater odds of lifetime suicide attempts, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) alcohol, tobacco or other drug use disorder, and mental health disorders, after adjusting for other childhood adversity/maltreatment and general life stressors.

CONCLUSIONS: Sexual minority females and males in the US are more likely than their heterosexual counterparts to report CSA. Higher risk of suicide attempts and DSM-5 alcohol, tobacco, other drug use, and mental health disorders in adulthood was directly associated with CSA, particularly among bisexual females. Health professionals working with individuals who have experienced CSA should assess these risks and intervene as needed.

PMID:34773839 | DOI:10.1016/j.chiabu.2021.105377

Forensic Sci Int. 2021 Nov 4;329:111093. doi: 10.1016/j.forsciint.2021.111093. Online ahead of print.

ABSTRACT

Over the last few years there has been a dramatic increase in the amount of “Fantasy” type drugs seized in New Zealand, with gamma-butyrolactone (GBL) being by far the most prevalent. In 2018, N-methyl-2-pyrrolidone (NMP) was detected in a liquid, along with GBL, for the first time in New Zealand. Since this seizure, the number of seizures containing mixtures of GBL and NMP that have been submitted for analysis by New Zealand authorities have significantly increased, with 82% of submitted samples containing GBL also containing NMP. Analysis of these liquids showed that the majority had GBL and NMP purities of approximately 60-70% and 30-40%, respectively. Subsequent investigations by New Zealand authorities revealed a potential source of these liquids being a diverted legitimate industrial product. The health and psychoactive effects of NMP, along with GBL and NMP mixtures, are unknown. Health statistics in New Zealand have indicated increased harm from GBL use over the last few years.

PMID:34773817 | DOI:10.1016/j.forsciint.2021.111093

Forensic Sci Int. 2021 Nov 4;329:111094. doi: 10.1016/j.forsciint.2021.111094. Online ahead of print.

ABSTRACT

INTRODUCTION: In the field of forensic toxicology, many unexpected deaths are investigated as to whether toxicological substances may have caused or contributed to someone’s death. One of the factors that makes interpretation of the results of quantitative analysis in postmortem toxicology challenging, is that measured postmortem drugs levels may vary according to the sampling site and the interval between death and specimen collection. These site- and time-dependent variations are caused by ‘postmortem redistribution’ (PMR). Literature shows that there are several factors that determine the degree of PMR, such as cell and tissue changes after death, decomposition and the physicochemical characteristics of drugs. Blood from peripheral sites seems to be less affected by PMR than cardiac blood. Therefore, the ratio of cardiac blood concentration/peripheral blood concentration (C/P) of a drug is often used as a marker of the extent of postmortem redistribution. In this study, we investigated the relationship between different potentially important variables and the C/P ratio of morphine in humans in order to provide new insights that might assist in the interpretation of quantitative results in forensic casework.

METHOD: Toxicological results of all morphine positive postmortem cases investigated by the Netherlands Forensic Institute between January 1, 2010 and July 31, 2020 were reviewed. Morphine was quantified in both femoral and cardiac blood in a total of 103 cases. The C/P ratios were determined for all selected cases. To collect data for this study, all corresponding files were reviewed. C/P ratios were compared between subgroups by performing either a Mann-Whitney U test or a Kruskal-Wallis test, followed by a post-hoc Mann-Whitney U test. Bonferroni correction was performed to correct for the likelihood of a significant result by chance due to multiple testing. After Bonferroni correction, a p-value< 0.004 was considered statistically significant.

RESULTS: The data suggests a relationship between grade of decomposition at autopsy, position of the corpse at discovery, route of administration, attempted resuscitation and the C/P ratio of morphine with p-values of 0.010, 0.026, 0.035 and 0.046, respectively.

CONCLUSION: Grade of decomposition at autopsy, position of the corpse at discovery, route of administration and attempted resuscitation seem to be influencing the C/P ratio of morphine. Of these four variables, the route of administration seems to have the greatest impact.

PMID:34773819 | DOI:10.1016/j.forsciint.2021.111094

J Environ Manage. 2021 Nov 10;302(Pt B):114062. doi: 10.1016/j.jenvman.2021.114062. Online ahead of print.

ABSTRACT

Environmental impact associated with production and consumption of pulses in the United States was evaluated using life cycle assessment (LCA). The system boundary was set to cradle-to-grave with a functional unit of 60 g (dry basis) of pulses consumed in a US household. Varieties of pulses modeled in the study included field pea (Pisum sativum), lentil (Lens culinaris), chickpea (Cicer arietinum), and dry bean. Three methods of cooking pulses at the consumer stage tested in the study were cooking in open vessel on electric cooking range (OVC), cooking in stovetop pressure cooker on electric cooking range (SPC), and cooking in electric pressure cooker (EPC). OVC formed the base scenario against which all other scenarios were compared. The environmental impact of pulses varied with type of pulse crop, cooking method, and the batch size. Consumption of approximately 60 g of dry pulses resulted in the greatest environmental impact for OVC. The consumer stage contributed at least 83, 81, 76, 75, and 87 percent for global warming potential (GWP), fossil resource scarcity (FRS), water consumption (WC), freshwater eutrophication (FE), and marine eutrophication (ME), respectively for this scenario. EPC resulted in the greatest decrease in the environmental impact, compared to OVC, for GWP, FRS, FE, and ME for all pulse varieties, which was validated in the uncertainty analysis. SPC, on the other hand, decreased the impact across these categories only for chickpea and dry bean. The uncertainty analysis suggested that the differences associated with cooking methods in the mean land use and water consumption scores of pulses were statistically non-significant. The impact categories were also highly sensitive to the mass of pulses cooked in a batch. Increasing the reference flow in OVC to 1 kg decreased the environmental impact of pulses by 49-87 percent for all impact categories, excluding land use. Overall, the study identified the consumer stage as the hotspot for environmental impact in the supply chain of pulses in the United States. The large contribution of the consumer stage to the overall environmental impact of pulses was attributed to electricity consumption for cooking and associated upstream emissions.

PMID:34773783 | DOI:10.1016/j.jenvman.2021.114062

Epilepsy Res. 2021 Oct 26;178:106794. doi: 10.1016/j.eplepsyres.2021.106794. Online ahead of print.

ABSTRACT

INTRODUCTION: Epilepsy affects almost 1% of people and is characterized by sudden seizures. To date, no reliable biomarker has been found to diagnose or predict the outcomes of epilepsy. Brain-derived neurotrophic factor (BDNF) levels have recently been shown to differ between patients with certain neurologic disorders and normal population, and it is unknown whether this is the case for epilepsy. In this study, we mainly aim to answer this question.

METHODS: We searched three databases for studies comparing BDNF levels between patients with epilepsy and controls. Quality assessment of included studies was performed using the Newcastle-Ottawa scale and statistical analyses were carried out in STATA software version 16.

RESULTS: Final analyses included 10 studies involving 403 patients with epilepsy. BDNF levels were statistically similar between patients and controls (standardized mean difference (SMD) = – 0.30, 95% CI = – 1.32 to 0.71, p = 0.56). When categorized by epilepsy subtype, patients with partial epilepsy showed lower BDNF measures than controls (95% CI = – 1.42 to – 0.32, p < 0.01), while the difference was not significant in patients with generalized epilepsy (95% CI = – 2.81 to 1.65, p = 0.61). Subgroup analyses indicated that BDNF was lower in patients than controls when age or sex matching was not present. Patient samples acquired in the morning also showed significantly lower BDNF levels than controls, unlike afternoon samples. Meta-regression identified no predictor for the difference in BDNF levels.

CONCLUSION: Generally, patients with epilepsy had BDNF levels similar to general population, although patients with partial epilepsy showed lower BDNF levels. Taking into account the sub-group analyses, further studies with higher qualities are required to evaluate the role and utility of BDNF in epilepsy.

PMID:34773766 | DOI:10.1016/j.eplepsyres.2021.106794

Cancer Epidemiol. 2021 Nov 10;75:102054. doi: 10.1016/j.canep.2021.102054. Online ahead of print.

ABSTRACT

Comorbidities and advanced stage diagnosis (ASD) are both associated with poorer cancer outcomes, but the association between comorbidities and ASD is poorly understood. We summarized epidemiological evidence on the association between comorbidities and ASD of selected cancers in a systematic review and meta-analysis. We searched PubMed and Web of Science databases up to June 3rd, 2021 for studies assessing the association between comorbidities and ASD of lung, breast, colorectal, or prostate cancer. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random-effects models. Also, potential variations in the associations between comorbidities and ASD by cancer type were investigated using random-effects meta-regression. Thirty-seven studies were included in this review, including 8,069,397 lung, breast, colorectal, and prostate cancer patients overall. The Charlson comorbidity index score was positively associated with ASD (stages III-IV) of breast cancer but was inversely associated with ASD of lung cancer (p_interaction = 0.004). Regarding specific comorbidities, diabetes was positively associated with ASD (OR = 1.17, 95%CI = 1.09-1.26), whereas myocardial infarction was inversely associated with ASD (OR = 0.84, 95%CI = 0.75-0.95). The association between renal disease and ASD differed by cancer type (p_interaction < 0.001). A positive association was found with prostate cancer (OR = 2.02, 95%CI = 1.58-2.59) and an inverse association with colorectal cancer (OR = 0.84, 95%CI = 0.70-1.00). In summary, certain comorbidities (e.g., diabetes) may be positively associated with ASD of several cancer types. It needs to be clarified whether closer monitoring for early cancer signs or screening in these patients is reasonable, considering the problem of over-diagnosis particularly relevant in patients with short remaining life expectancy such as those with comorbidities. Also, evaluation of the cost-benefit relationship of cancer screening according to the type and severity of comorbidity (rather than summary scores) may be beneficial for personalized cancer screening in populations with chronic diseases.

PMID:34773768 | DOI:10.1016/j.canep.2021.102054

Respir Med. 2021 Nov 2;190:106676. doi: 10.1016/j.rmed.2021.106676. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: The main target of inspiratory muscle training (IMT) is to improve diaphragm function in patients with COPD who have inspiratory muscle weakness. Ventilatory demand is already increased during quiet breathing in patients with COPD, and whether threshold load imposed by IMT would active more accessory muscle remained to be determined. The purpose of this study was to examine diaphragm and sternocleidomastoid (SCM) activation during IMT with intensities of 30% and 50% maximal inspiratory pressure (P_Imax).

METHODS: Patients with COPD and a P_Imax lower than 60 cmH₂O were recruited for the study. Surface electromyography (EMG) was used to measure diaphragm and SCM activation, and group-based trajectory modeling (GBTM) was used to identify activation patterns during IMT. The generalized estimating equation (GEE) was then used to detect differences of variables between various breathing tasks. Statistical significance was established at p < 0.05.

RESULTS: A total of 30 patients with COPD participated in this study. All patients demonstrated significant increases in diaphragm and SCM activation during 30% and 50% P_Imax of IMT than during quiet breathing (all p < 0.001). Diaphragm demonstrated two distinct patterns in response to IMT: low activation (n = 8) and high activation (n = 22) group using GBTM analysis.

CONCLUSION: Diaphragm and SCM were substantially activated during IMT in patients with COPD who had inspiratory muscle weakness. Regardless of whether diaphragm activation was high or low, SCM was activated to a greater extent in response to IMT.

PMID:34773734 | DOI:10.1016/j.rmed.2021.106676

Int Immunopharmacol. 2021 Nov 10;101(Pt A):108333. doi: 10.1016/j.intimp.2021.108333. Online ahead of print.

ABSTRACT

Alternaria sensitization is correlated with persistent asthma. Type 2 (T2)-asthma endotypes are characterized by the release of eosinophils. However, the prevalence and sensitization patterns in patients with Alternaria asthma between T2-high and T2-low endotypes are unknown. We retrospectively reviewed 582 patients with Alternaria asthma and divided them into T2-high (n = 376) and T2-low (n = 206) groups with a threshold of 300 cells/µL in blood eosinophil counts. Data for basic information, skin test or IgE detection results, and blood eosinophil counts were collected. The age of patients in the T2-high group (13.66 ± 13.23) was lower than that of the T2-low group (18.02 ± 15.03). Patients with T2-high asthma had relatively higher rates of taking inhaled corticosteroids (ICS) and positive family history than the T2-low group. Pet keepers and allergen immunotherapy (AIT) patients were comparable between these groups, In the T2-high group, patients had higher levels of total serum IgE (T-IgE) and showed a significant positive correlation with eosinophil counts (r = 0.166, P = 0.001), followed by higher Alternaria-specific IgE (sIgE) levels (median, 13.7; range, 4.86-25.3). Compared to the T2-low group, the frequency of poly-sensitized patients and the rate of each allergen among the nine common allergens were all higher in the T2-high group; the statistical differences mainly focused on pollens such as birch (P = 0.005), firmiana (P = 0.004), and mugwort (P = 0.005). Young, male patients had a high prevalence of T2-high Alternaria asthma, along with higher rates of T-IgE, sIgE levels, and poly-sensitized patterns.

PMID:34773759 | DOI:10.1016/j.intimp.2021.108333

J Periodontol. 2021 Nov 13. doi: 10.1002/JPER.21-0428. Online ahead of print.

ABSTRACT

BACKGROUND: Three- dimensional (3D) technology has been suggested to overcome these limitations in guided bone regeneration (GBR) procedures because 3D-printed scaffolds can be easily molded to patient-specific bone defect site. This study aimed to investigate the effect of 3-D printed polylactic acid (PLA) scaffolds with or without hyaluronic acid (HA) in a rabbit calvaria model.

METHODS: A calvaria defect with a diameter of 15 mm was created in 30 New Zealand white rabbits. The rabbits were randomly allocated into 3 groups including no graft group (control, n = 10) , 3D printed PLA graft group (3D-PLA, n = 10) , and 3D printed PLA with hyaluronic acid graft group (3D-PLA/HA, n = 10) . Five animals in each group were sacrificed at 4 and 12 weeks after surgery. Microcomputed tomography and histologic and histomorphometric analyses were performed.

RESULTS: Over the whole examination period, no significant adverse reactions were observed. There were no statistically significant differences in bone volume (BV) /tissue volume (TV) among the three groups at 4 weeks. However, the highest BV/TV was observed in the 3D-PLA/HA group at 12 weeks. The new bone area for control, 3D-PLA, and 3D-PLA/HA showed no statistical differences at 4 weeks. However, the value was significantly higher in the 3D-PLA and 3D-PLA/HA groups compared to the control group at 12 weeks.

CONCLUSION: The 3D printed PLA scaffolds was biocompatible and integrated well with bone defect margin. They were also provided the proper space for new bone formation. Therefore, 3D printed PLA/HA might be a potential tool to enhance bone augmentation. This article is protected by copyright. All rights reserved.

PMID:34773704 | DOI:10.1002/JPER.21-0428

Clin Chem Lab Med. 2021 Nov 15. doi: 10.1515/cclm-2021-0904. Online ahead of print.

ABSTRACT

OBJECTIVES: Testing for thyroid disease constitutes a high proportion of the workloads of clinical laboratories worldwide. The setting of analytical performance specifications (APS) for testing methods and aiding clinical interpretation of test results requires biological variation (BV) data. A critical review of published BV studies of thyroid disease related measurands has therefore been undertaken and meta-analysis applied to deliver robust BV estimates.

METHODS: A systematic literature search was conducted for BV studies of thyroid related analytes. BV data from studies compliant with the Biological Variation Data Critical Appraisal Checklist (BIVAC) were subjected to meta-analysis. Global estimates of within subject variation (CV_I) enabled determination of APS (imprecision and bias), indices of individuality, and indicative estimates of reference change values.

RESULTS: The systematic review identified 17 relevant BV studies. Only one study (EuBIVAS) achieved a BIVAC grade of A. Methodological and statistical issues were the reason for B and C scores. The meta-analysis derived CV_I generally delivered lower APS for imprecision than the mean CV_A of the studies included in this systematic review.

CONCLUSIONS: Systematic review and meta-analysis of studies of BV of thyroid disease biomarkers have enabled delivery of well characterized estimates of BV for some, but not all measurands. The newly derived APS for imprecision for both free thyroxine and triiodothyronine may be considered challenging. The high degree of individuality identified for thyroid related measurands reinforces the importance of RCVs. Generation of BV data applicable to multiple scenarios may require definition using “big data” instead of the demanding experimental approach.

PMID:34773727 | DOI:10.1515/cclm-2021-0904