Tag: nevin manimala

Cancer Epidemiol. 2021 Nov 10;75:102054. doi: 10.1016/j.canep.2021.102054. Online ahead of print.

ABSTRACT

Comorbidities and advanced stage diagnosis (ASD) are both associated with poorer cancer outcomes, but the association between comorbidities and ASD is poorly understood. We summarized epidemiological evidence on the association between comorbidities and ASD of selected cancers in a systematic review and meta-analysis. We searched PubMed and Web of Science databases up to June 3rd, 2021 for studies assessing the association between comorbidities and ASD of lung, breast, colorectal, or prostate cancer. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random-effects models. Also, potential variations in the associations between comorbidities and ASD by cancer type were investigated using random-effects meta-regression. Thirty-seven studies were included in this review, including 8,069,397 lung, breast, colorectal, and prostate cancer patients overall. The Charlson comorbidity index score was positively associated with ASD (stages III-IV) of breast cancer but was inversely associated with ASD of lung cancer (p_interaction = 0.004). Regarding specific comorbidities, diabetes was positively associated with ASD (OR = 1.17, 95%CI = 1.09-1.26), whereas myocardial infarction was inversely associated with ASD (OR = 0.84, 95%CI = 0.75-0.95). The association between renal disease and ASD differed by cancer type (p_interaction < 0.001). A positive association was found with prostate cancer (OR = 2.02, 95%CI = 1.58-2.59) and an inverse association with colorectal cancer (OR = 0.84, 95%CI = 0.70-1.00). In summary, certain comorbidities (e.g., diabetes) may be positively associated with ASD of several cancer types. It needs to be clarified whether closer monitoring for early cancer signs or screening in these patients is reasonable, considering the problem of over-diagnosis particularly relevant in patients with short remaining life expectancy such as those with comorbidities. Also, evaluation of the cost-benefit relationship of cancer screening according to the type and severity of comorbidity (rather than summary scores) may be beneficial for personalized cancer screening in populations with chronic diseases.

PMID:34773768 | DOI:10.1016/j.canep.2021.102054

Respir Med. 2021 Nov 2;190:106676. doi: 10.1016/j.rmed.2021.106676. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: The main target of inspiratory muscle training (IMT) is to improve diaphragm function in patients with COPD who have inspiratory muscle weakness. Ventilatory demand is already increased during quiet breathing in patients with COPD, and whether threshold load imposed by IMT would active more accessory muscle remained to be determined. The purpose of this study was to examine diaphragm and sternocleidomastoid (SCM) activation during IMT with intensities of 30% and 50% maximal inspiratory pressure (P_Imax).

METHODS: Patients with COPD and a P_Imax lower than 60 cmH₂O were recruited for the study. Surface electromyography (EMG) was used to measure diaphragm and SCM activation, and group-based trajectory modeling (GBTM) was used to identify activation patterns during IMT. The generalized estimating equation (GEE) was then used to detect differences of variables between various breathing tasks. Statistical significance was established at p < 0.05.

RESULTS: A total of 30 patients with COPD participated in this study. All patients demonstrated significant increases in diaphragm and SCM activation during 30% and 50% P_Imax of IMT than during quiet breathing (all p < 0.001). Diaphragm demonstrated two distinct patterns in response to IMT: low activation (n = 8) and high activation (n = 22) group using GBTM analysis.

CONCLUSION: Diaphragm and SCM were substantially activated during IMT in patients with COPD who had inspiratory muscle weakness. Regardless of whether diaphragm activation was high or low, SCM was activated to a greater extent in response to IMT.

PMID:34773734 | DOI:10.1016/j.rmed.2021.106676

Int Immunopharmacol. 2021 Nov 10;101(Pt A):108333. doi: 10.1016/j.intimp.2021.108333. Online ahead of print.

ABSTRACT

Alternaria sensitization is correlated with persistent asthma. Type 2 (T2)-asthma endotypes are characterized by the release of eosinophils. However, the prevalence and sensitization patterns in patients with Alternaria asthma between T2-high and T2-low endotypes are unknown. We retrospectively reviewed 582 patients with Alternaria asthma and divided them into T2-high (n = 376) and T2-low (n = 206) groups with a threshold of 300 cells/µL in blood eosinophil counts. Data for basic information, skin test or IgE detection results, and blood eosinophil counts were collected. The age of patients in the T2-high group (13.66 ± 13.23) was lower than that of the T2-low group (18.02 ± 15.03). Patients with T2-high asthma had relatively higher rates of taking inhaled corticosteroids (ICS) and positive family history than the T2-low group. Pet keepers and allergen immunotherapy (AIT) patients were comparable between these groups, In the T2-high group, patients had higher levels of total serum IgE (T-IgE) and showed a significant positive correlation with eosinophil counts (r = 0.166, P = 0.001), followed by higher Alternaria-specific IgE (sIgE) levels (median, 13.7; range, 4.86-25.3). Compared to the T2-low group, the frequency of poly-sensitized patients and the rate of each allergen among the nine common allergens were all higher in the T2-high group; the statistical differences mainly focused on pollens such as birch (P = 0.005), firmiana (P = 0.004), and mugwort (P = 0.005). Young, male patients had a high prevalence of T2-high Alternaria asthma, along with higher rates of T-IgE, sIgE levels, and poly-sensitized patterns.

PMID:34773759 | DOI:10.1016/j.intimp.2021.108333

J Periodontol. 2021 Nov 13. doi: 10.1002/JPER.21-0428. Online ahead of print.

ABSTRACT

BACKGROUND: Three- dimensional (3D) technology has been suggested to overcome these limitations in guided bone regeneration (GBR) procedures because 3D-printed scaffolds can be easily molded to patient-specific bone defect site. This study aimed to investigate the effect of 3-D printed polylactic acid (PLA) scaffolds with or without hyaluronic acid (HA) in a rabbit calvaria model.

METHODS: A calvaria defect with a diameter of 15 mm was created in 30 New Zealand white rabbits. The rabbits were randomly allocated into 3 groups including no graft group (control, n = 10) , 3D printed PLA graft group (3D-PLA, n = 10) , and 3D printed PLA with hyaluronic acid graft group (3D-PLA/HA, n = 10) . Five animals in each group were sacrificed at 4 and 12 weeks after surgery. Microcomputed tomography and histologic and histomorphometric analyses were performed.

RESULTS: Over the whole examination period, no significant adverse reactions were observed. There were no statistically significant differences in bone volume (BV) /tissue volume (TV) among the three groups at 4 weeks. However, the highest BV/TV was observed in the 3D-PLA/HA group at 12 weeks. The new bone area for control, 3D-PLA, and 3D-PLA/HA showed no statistical differences at 4 weeks. However, the value was significantly higher in the 3D-PLA and 3D-PLA/HA groups compared to the control group at 12 weeks.

CONCLUSION: The 3D printed PLA scaffolds was biocompatible and integrated well with bone defect margin. They were also provided the proper space for new bone formation. Therefore, 3D printed PLA/HA might be a potential tool to enhance bone augmentation. This article is protected by copyright. All rights reserved.

PMID:34773704 | DOI:10.1002/JPER.21-0428

Clin Chem Lab Med. 2021 Nov 15. doi: 10.1515/cclm-2021-0904. Online ahead of print.

ABSTRACT

OBJECTIVES: Testing for thyroid disease constitutes a high proportion of the workloads of clinical laboratories worldwide. The setting of analytical performance specifications (APS) for testing methods and aiding clinical interpretation of test results requires biological variation (BV) data. A critical review of published BV studies of thyroid disease related measurands has therefore been undertaken and meta-analysis applied to deliver robust BV estimates.

METHODS: A systematic literature search was conducted for BV studies of thyroid related analytes. BV data from studies compliant with the Biological Variation Data Critical Appraisal Checklist (BIVAC) were subjected to meta-analysis. Global estimates of within subject variation (CV_I) enabled determination of APS (imprecision and bias), indices of individuality, and indicative estimates of reference change values.

RESULTS: The systematic review identified 17 relevant BV studies. Only one study (EuBIVAS) achieved a BIVAC grade of A. Methodological and statistical issues were the reason for B and C scores. The meta-analysis derived CV_I generally delivered lower APS for imprecision than the mean CV_A of the studies included in this systematic review.

CONCLUSIONS: Systematic review and meta-analysis of studies of BV of thyroid disease biomarkers have enabled delivery of well characterized estimates of BV for some, but not all measurands. The newly derived APS for imprecision for both free thyroxine and triiodothyronine may be considered challenging. The high degree of individuality identified for thyroid related measurands reinforces the importance of RCVs. Generation of BV data applicable to multiple scenarios may require definition using “big data” instead of the demanding experimental approach.

PMID:34773727 | DOI:10.1515/cclm-2021-0904

Turk J Med Sci. 2021 Nov 13. doi: 10.3906/sag-2105-168. Online ahead of print.

ABSTRACT

BACKGROUND/AIM: The aim of this study was to investigate the healing effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) on experimental testicular torsion in rats.

MATERIALS AND METHODS: Three groups consisting of 10 Wistar albino rats each were created. In Group I, the left testicle was explored and relocated in the scrotum without any attempt to modify it. In Group II, the left testicle underwent torsion for three hours and then was detorsed and relocated. In Group III, in addition to torsion and detorsion, BM-MSCs were administered intratesticularly. The rats were sacrificed on the seventh day, and the healing status of the testicles was investigated with histopathological and biochemical analyses. BM-MSC involvement was investigated by immunofluorescence microscopy. Statistical analysis was performed using SPSS 15.0. A p-value < 0.05 was considered statistically significant for all variables.

RESULTS: Immunofluorescence microscopy showed that BM-MSCs were located around the Leydig cells in Group III. Under light microscopy, the mean Johnsen Score of Group III was significantly higher than that of Group II (p = 0.035). The interleukin-10 (IL-10) level was significantly higher in Group III compared to Group II (p = 0.003). While the malondialdehyde (MDA) values in Group I (the control group) were lower than in the other groups (p = 0.037), the superoxide dismutase (SOD) values were similar (p = 0.158). Although there was no statistically significant difference between Group II and Group III in terms of MDA, it was lower in Group III. Although the tissue SOD levels were higher in Group III than in Group II, the difference was not statistically significant.

PMID:34773694 | DOI:10.3906/sag-2105-168

Nurs Forum. 2021 Nov 13. doi: 10.1111/nuf.12671. Online ahead of print.

ABSTRACT

BACKGROUND: Hospital ethical climate (HEC) has been associated with nurses’ interprofessional collaboration, moral decision-making and judgment, job satisfaction, and job burnout.

OBJECTIVES: This study aimed to examine the effect of hospitals’ ethical climate on nurses’ quality of working life.

METHODS: A cross-sectional study design was employed and 286 nurses from two hospitals in Athens participated in the study from January to February 2020. The data collected using a three-part self-administrated questionnaire were analyzed using the IBM Statistical Package for Social Sciences 25 (SPSS).

RESULTS: According to the results, the staff nurses working on rotating shifts reported poorer Work-Related Quality of Life (WrQoL). Positive correlations were observed between age, control at work, and home-work interface, between the period of time the nurses were working in a specific department with the dimensions of the ethical climate scale, and between almost all the HEC aspects with WRQoL subscales. Only the domain of stress at work had fewer and less significant correlations.

CONCLUSIONS: Health authorities and hospital managers should provide the necessary ground for the institutionalization of professional ethics by creating an appropriate ethical climate. A positive ethical climate may lead to a better working environment with less distress for health professionals and better quality of care for the patients.

PMID:34773637 | DOI:10.1111/nuf.12671

Rheumatol Ther. 2021 Nov 13. doi: 10.1007/s40744-021-00392-y. Online ahead of print.

ABSTRACT

OBJECTIVE: To compare the effectiveness of azathioprine (AZA) and cyclosporine (CsA) as initial treatments for patients with idiopathic inflammatory myopathies (IIM).

METHODS: A retrospective cohort study was conducted using information from the National Health Insurance Service database of Republic of Korea. Patients with IIM who had started AZA or CsA as initial treatment between January 2007 and December 2011 were selected for the study. They were followed from the day of treatment initiation to the occurrence of study outcomes or the end of the study until December 2016. Effectiveness outcomes, defined as switching the drug or adding immunosuppressants, and discontinuation of corticosteroids, were compared between the two groups. The Cox proportional-hazards model was used to calculate the adjusted relative risk (aRR) with 95% confidence interval (CI) between the AZA and CsA groups.

RESULTS: A total of 376 patients with incident IIM who used AZA (n = 288) or CsA (n = 88) were identified. The aRR of switching the drug or adding immunosuppressants (1.45 [95% CI 0.99-2.11]) was not significantly different between the CsA and AZA groups. Among patients who were treated with corticosteroids at baseline, the rate of discontinuation of corticosteroids was not different between the two groups (1.69 [95% CI 0.82-3.47]).

CONCLUSIONS: The effectiveness of AZA and CsA as initial treatments for the management of IIM was comparable.

PMID:34773610 | DOI:10.1007/s40744-021-00392-y

Int J Comput Assist Radiol Surg. 2021 Nov 13. doi: 10.1007/s11548-021-02527-6. Online ahead of print.

ABSTRACT

PURPOSE: The diseases and injuries of the knee joint are the most common orthopedic disorders. Personalized knee models can be helpful in the process of early intervention and lasting treatment techniques development. Fully automatic reconstruction of knee joint anatomical structures from medical images (CT, MRI, ultrasound) remains a challenge. For this reason, most of state-of-the-art knee joint models contain simplifications such as representation of muscles and ligaments as line segments connecting two points which replace attachment areas. The paper presents algorithms for automatic detection of such points on knee CT images.

METHODS: This paper presents three approaches to automatic detection of ligaments and tendons attachment sites on the patients CT images: qualitative anatomical descriptions, analysis of bones curvature, and quantitative anatomical descriptions. Combinations of these approaches result in new automatic detection algorithms. Each algorithm exploits anatomical peculiarities of each attachment site, e.g., bone curvature and number of other attachments in a neighborhood of the site.

RESULTS: The experimental dataset consisted of 26 anonymized CT sequences containing right and left knee joints in different resolutions. The proposed algorithms take into account bone surface curvatures and spatial differences in locations of medial and lateral parts of both knees. The algorithms for detection of quadriceps femoris, popliteus, biceps femoris tendons, and lateral collateral and medial collateral ligaments attachment sites are provided, as well as examples of their application. Two algorithms are validated by comparison with known statistics of ligaments lengths and also using ground truth annotations for anatomical landmarks approved by clinical experts.

CONCLUSIONS: The algorithms simplify generation of patient-specific knee joint models demanded in personalized biomechanical models. The algorithms in the current implementation have two important limitations. First, the correctness of the produced results depends on the bones segmentation quality. Second, the presented algorithms detect a point of the attachment site, which is not necessarily its center. Therefore, manual correction of the attachment site location may be required for attachments with relatively large area.

PMID:34773571 | DOI:10.1007/s11548-021-02527-6

Biol Trace Elem Res. 2021 Nov 13. doi: 10.1007/s12011-021-03025-1. Online ahead of print.

ABSTRACT

A cross-sectional survey of 425 male artisanal and small-scale goldminers (ASGM) was conducted to examine the relationship between the occupational activities of the miners and their blood mercury levels while controlling for relevant biosocial and socio-cultural factors. The data was subjected to descriptive and inferential statistics. Initial findings showed that 43.29% of the ASGM miners had blood mercury levels above the occupational exposure threshold. Among the occupational factors, ASGM miners who amalgamate gold, burn amalgam, and ASGM miners who smelt gold were 2.260, 1.881, and 2.094 times respectively more likely to have high blood mercury levels as compared to ASGM miners who did not carry out these activities. Also, ASGM miners who suck excess mercury with their mouth (OR = 0.197, p < 0.001) were less likely to have high blood mercury levels. For the biosocial and socio-cultural attributes, high blood mercury levels was less likely among older ASGM miners (OR = 0.507, p < 0.05). Inversely, high blood mercury levels was more likely among ASGM miners who are married (OR = 1.627, p < 0.05), ASGM miners with junior (OR = 2.240, p < 0.001) and senior (OR = 1.575, p < 0.05) high school education, and ASGM miners who have 6-10 years (OR = 3.802, p < 0.001) and above 10 years (OR = 2.591, p < 0.001) work experience. ASGM miners who amalgamate gold, burn amalgam, and smelt gold are exposed to mercury and are at risk of mercury poisoning. This could, however, be minimized with the right capturing devices and personal protective equipment. This notwithstanding, unsafe, and unsustainable occupational practices such as working in mercury contaminated water and sucking excess mercury with the mouth should be discouraged.

PMID:34773577 | DOI:10.1007/s12011-021-03025-1