Int J Comput Assist Radiol Surg. 2025 Jun 4. doi: 10.1007/s11548-025-03409-x. Online ahead of print.
NO ABSTRACT
PMID:40465168 | DOI:10.1007/s11548-025-03409-x
Tag: nevin manimala
Trop Anim Health Prod. 2025 Jun 4;57(5):242. doi: 10.1007/s11250-025-04486-5.
ABSTRACT
Dromedary camels thrive in arid regions and play a crucial role in meat, milk, and labor production. The transition period around parturition impacts maternal and neonatal health by altering antioxidant capacity and increasing oxidative stress. This study investigated the relationship between the transition period and antioxidant capacity in dromedary camels to enhance management practices and welfare. Ten multiparous pregnant camels were monitored from 60 days AP to 60 days PP under ethical guidelines with proper feeding and management. Blood samples and liver biopsies were collected to assess antioxidant enzymes (CAT, SOD, GPx), oxidized product (MDA), and hepatic gene expression via ELISA and qPCR. Statistical analyses in SAS determined time effects, with significance set at P < 0.05. Parturition significantly affected CAT, MDA, and GPx concentrations (P < 0.01). CAT peaked three days AP before declining PP, while MDA spiked at parturition. SOD decreased AP but returned to baseline PP, whereas GPx dropped significantly by seven days PP. Antioxidant-related gene expression increased significantly around parturition, while TNF-α and IL-6 remained stable. PP, some genes returned to AP levels, while others exhibited delayed recovery. This study highlights the liver’s key role in regulating oxidative stress during the transition period and provides insights into improving camel health and productivity in harsh environments. These findings pave the way for future research on nutritional and management strategies to strengthen antioxidant defenses in livestock.
PMID:40465156 | DOI:10.1007/s11250-025-04486-5
Eur Geriatr Med. 2025 Jun 4. doi: 10.1007/s41999-025-01249-1. Online ahead of print.
NO ABSTRACT
PMID:40465142 | DOI:10.1007/s41999-025-01249-1
Phys Eng Sci Med. 2025 Jun 4. doi: 10.1007/s13246-025-01573-7. Online ahead of print.
NO ABSTRACT
PMID:40465136 | DOI:10.1007/s13246-025-01573-7
Eur Arch Paediatr Dent. 2025 Jun 4. doi: 10.1007/s40368-025-01054-1. Online ahead of print.
ABSTRACT
PURPOSE: This cross-sectional epidemiological study aimed to provide population-based data on hypersensitivity associated with molar-incisor hypomineralisation (MIH) in 8- to 10-year-olds from Bavaria, Germany. It was hypothesized that hypersensitivity would be equally distributed among MIH teeth.
METHODS: A total of 5418 schoolchildren (8-10 years) were examined using the MIH criteria of the European Academy of Paediatric Dentistry (EAPD) and the MIH Treatment Need Index (MIH-TNI). MIH-TNI 1 was linked with mild MIH; MIH-TNI 2-4 corresponded to severe MIH. Hypersensitivity was recorded dichotomously (yes/no) after a two-second, 2.8-bar air blast (Schiff test). Descriptive statistics and a mixed-effects logistic regression model-adjusted for age, sex, region, tooth type, and caries status-explored hypersensitivity in MIH-affected teeth.
RESULTS: The MIH prevalence was 17.5% (n = 945). In this group, 9.8% of the children showed hypersensitivity in at least one tooth; 5.6% of all MIH-affected teeth were hypersensitive. Nearly half of the MIH-affected children (49.7%) presented severe MIH-TNI findings; MIH-TNI 2 was the most frequent finding (39.9%). Regression analyses indicated that demarcated opacities were significantly less likely to be associated with hypersensitivity (aOR = 0.054, p < 0.001). However, enamel breakdown did not show a significant association with hypersensitivity (aOR = 0.853, p = 0.693).
CONCLUSION: Although MIH was relatively common, overall hypersensitivity rates were low. Demarcated opacities were significantly less prone to hypersensitivity, yet enamel breakdown did not significantly differ from healthy teeth. Further standardised epidemiological research is needed to clarify variations in hypersensitivity rates and explore additional risk factors, e.g., breakdown depth or defect extension.
PMID:40465132 | DOI:10.1007/s40368-025-01054-1
J Fluoresc. 2025 Jun 4. doi: 10.1007/s10895-025-04380-1. Online ahead of print.
ABSTRACT
In this study, Schiff base was synthesized under condensation reaction and thoroughly characterized using 1H and 13C NMR, FT-IR, UV-Vis, and fluorescence spectroscopy. Structural analysis revealed that these compounds predominantly exist in the E-conformation, stabilized by an intramolecular six-membered-ring hydrogen bond. Notably, chloro-functionalized Schiff bases exhibit an additional weak intramolecular C-H···Cl hydrogen bond. Photophysical studies indicate that compounds 2AM24Cl and SA2AM exclusively exhibit long-wavelength emission. Furthermore, the geometric structures, FMOs, and absorption spectrum were elucidated using DFT and TD-DFT calculations. The FMO study calculated energy gaps are 3.54 eV and 3.65 eV for 2AM24CL and SA2AM, respectively. The compounds 2AM24Cl and SA2AM show a good emission (fluorescence) spectrum, it good matched in theoretical fluorescence spectrum. Electron density distribution was visualized through color-mapped representations. Molecular docking studies demonstrated significant interactions between these Schiff base derivatives and amino acid residues, reinforcing their potential biological relevance. The 2AM24CL compound’s lowest binding energy is -5.45 kcal/mol and the SA2AM compound’s lowest binding energy is -5.66 kcal/mol, with an inhibition constant is 101.54 μm for 2AM24Cl and 71.33 μm for SA2AM, respectively.
PMID:40465120 | DOI:10.1007/s10895-025-04380-1
Mol Biol Rep. 2025 Jun 4;52(1):548. doi: 10.1007/s11033-025-10631-y.
ABSTRACT
BACKGROUND: Recurrent pregnancy loss (RPL) is a multifactorial disorder, with unexplained causes in 50% of cases, and immune system involvement is suspected. The decidua, a maternal-fetal interface, requires immune cells such as B cells, NK cells, and dendritic cells for a healthy pregnancy. OX40L, expressed in these cells, plays a crucial immune regulatory role. Variations in OX40L (rs1234314 and rs844648) have not yet been studied in RPL patients.
OBJECTIVE: This study aims to investigate the association of these polymorphisms (rs1234314 and rs844648) with RPL in a Turkish population sample and is the first to do so in this regard.
METHODS: A genetic case-control study was conducted with 195 women who had a history of two or more miscarriages. Allele and genotype frequencies were compared between the RPL group and 135 control women.
RESULTS: No statistically significant differences were observed in allele frequencies for rs1234314 and rs844648 between the RPL and control populations. However, AA carriers of the rs844648 polymorphism were associated with a reduced risk of recurrent pregnancy loss in the recessive model (OR = 2.07, 95% CI = 1.11-3.89, p = 0.02).
CONCLUSION: This study is the first to examine the genetic association of rs1234314 and rs844648 SNPs of OX40L with RPL in a Turkish population. The significant association of the rs844648 AA genotype with a decreased risk of RPL suggests that this variant may play an important role as a protective factor against RPL, potentially through mechanisms related to immune regulation.
PMID:40465113 | DOI:10.1007/s11033-025-10631-y
Health Care Manag Sci. 2025 Jun 4. doi: 10.1007/s10729-025-09712-y. Online ahead of print.
ABSTRACT
Cardiovascular diseases (CVDs) are one of the primary reasons for death worldwide. These diseases often occur due to the occlusion of coronary arteries, thereby leading to insufficient blood and oxygen supply that damages cardiac muscle cells. Electrocardiogram (ECG) signals which reflect heart electrical activity are being used for diagnosing various cardiac diseases. Typically, a standard ECG consists of 12 channels referred to as leads which enable practitioners to monitor heartbeats through different channels where each heartbeat lasts approximately 600 ms. The majority of studies focus on the classification and early diagnosis of arrhythmias. Although the current studies on change-point methods have acquired massive accuracy in detecting potential shifts during a multi-channel process, they lack flexibility in manually assigning more weights to the channels, which are of more importance for experts. This could be addressed by implementing the weighted multivariate functional principal component analysis (WMFPCA). The objective of this study is to develop a novel change-point detection method to monitor long-term cardiovascular treatment. A third-order tensor structure was employed to represent the 12-lead ECG data in three dimensions (beats × samples × leads). Exploiting intra-beat, inter-beat, and inter-lead correlations along with channel significance in the third-order tensor, the WMFPCA is incorporated into Hotelling’s T 2 statistic to construct monitoring schemes. Simulation results show that the proposed approach outperforms the existing methods in monitoring multi-channel processes. Finally, applying the suggested model on a real-world dataset containing Myocardial Infarction (MI) subjects verifies the model.
PMID:40465102 | DOI:10.1007/s10729-025-09712-y
Clin Exp Nephrol. 2025 Jun 4. doi: 10.1007/s10157-025-02709-5. Online ahead of print.
ABSTRACT
BACKGROUND: Membranous lupus nephritis (MLN), a distinct subtype of lupus nephritis (LN), is generally associated with more favorable outcomes than proliferative LN (PLN). However, clinical data regarding pure MLN are limited. We investigated the prognosis of patients with pure MLN in Japan.
METHODS: We performed a sub-analysis of a previously reported nationwide retrospective cohort study of patients with LN in Japan. This study included patients who underwent renal biopsy between 2007 and 2012. Patients with pure MLN (Class V, n = 90) were compared to those with PLN (Class III/IV ± V, n = 362) over a median follow-up period of 5 years. The primary outcome was defined as a 50% increase in serum creatinine (S-Cr) levels.
RESULTS: The renal and patient outcomes of the pure MLN and PLN groups were as follows: A ≥ 50% increase in S-Cr occurred in 12.2 vs. 16.3% of patients. Doubling of S-Cr or progression to end-stage kidney disease (ESKD) occurred in 4.4 vs. 8.6%, ESKD alone in 2.2 vs. 3.0%, and all-cause mortality in 7.9 vs. 5.5%. After adjusting for age, sex, baseline renal function, proteinuria, and the use of mycophenolate mofetil or intravenous cyclophosphamide, no significant differences in renal outcomes were observed between groups (hazard ratio 0.564; 95% confidence interval 0.272-1.170; P = 0.124).
CONCLUSION: In this nationwide Japanese cohort, no statistically significant differences in renal outcomes were observed between pure MLN and PLN. Further research is needed to explore strategies to improve outcomes in pure MLN.
PMID:40465063 | DOI:10.1007/s10157-025-02709-5
J Neurol. 2025 Jun 4;272(6):445. doi: 10.1007/s00415-025-13189-8.
ABSTRACT
BACKGROUND: Disease-modifying therapies (DMTs) have significantly improved the management of multiple sclerosis (MS), but their potential nervous system adverse events (AEs) remain a critical concern. This study aims to evaluate the risk of nervous system AEs associated with 11 DMTs using the FDA Adverse Event Reporting System (FAERS) database, following the READUS-PV guidelines.
METHODS: We performed a disproportionality analysis on FAERS data from Q1 2004 to Q3 2024, focusing on nervous system AEs related to DMTs, such as Alemtuzumab (AL), Ofatumumab (OF), Ocrelizumab (OC), and Fingolimod (FI). Using disproportionality analysis and Bayesian methods, we identified signals of these AEs. We also conducted subgroup analyses across age, gender, weight, geographic regions, and outcomes to assess AE distribution. In addition, a sensitivity analysis was done to evaluate the consistency of the association between DMTs and nervous system AEs across severities. The time to onset and clinical characteristics of AEs were examined as well.
RESULTS: Among 245,469 nervous system AE reports, Siponimod (SI), Natalizumab (NA), FI, and Teriflunomide (TE) exhibited the highest signal values (ROR > 3.0), with SI showing the strongest association [ROR = 3.44, 95% CI (3.34-3.55)]. Females accounted for 76.0% of nervous system AEs, and severe AEs such as central nervous system lesions (mortality rate: 0.97%) and cognitive disorders (mortality rate: 0.94%) were detected. The median time to onset of AEs varied significantly across DMTs, ranging from 14 days for AL to 816 days for Interferon Beta-1a (IN). Subgroup analyses highlighted variations in AE reporting across different demographics and geographic regions. The sensitivity analysis further confirmed the robustness of our findings, indicating consistent associations between DMTs and severe nervous system AEs.
CONCLUSIONS: This study highlights significant differences in the nervous system AEs profiles of DMTs, with SI, NA, FI, and TE showing higher risks of nervous system AEs. These findings underscore the importance of vigilant monitoring and personalized treatment strategies to mitigate nervous system risks in MS patients. Further research is needed to confirm these associations and investigate the mechanisms that underlie them.
PMID:40465056 | DOI:10.1007/s00415-025-13189-8