Tag: nevin manimala

J Hypertens. 2022 Jun 1;40(Suppl 1):e23. doi: 10.1097/01.hjh.0000835488.45395.d3.

ABSTRACT

OBJECTIVE: Functional characteristics of the vascular system underly changes associated with aging, such as increasing arterial stiffness. Research suggests that these age-associated changes may be accelerated in the presence of cardiovascular risk factors. So far, normative data on arterial stiffness in unselected adolescents and young adults have been scarce. Recently, measurements of carotid stiffness (cS) parameters have been included in a national health examination survey.

DESIGN AND METHOD: The population-based KiGGS cohort 11-year-follow-up included high-resolution B-mode sonography with semi-automated edge-detection and automatic electrocardiogram-gated real-time quality control. In 4,305 participants aged 14-28 years, distensibility coefficient (DC), stiffness index ß, Young’s (YEM) and Peterson’s elastic modulus (Ep) were assessed. Centiles were modelled by sex, age and height simultaneously, using generalized additive models for location, scale and shape. Log- binomial regression models were used to investigate associations of blood pressure with cS > = 90th centile (P90) as outcomes. Hypertensive blood pressure was defined according to German guidelines (> = P95 systolic or diastolic for age, height and sex according to KiGGS centiles until age 17 and > = 140/90 mmHg from age 18).

RESULTS: Multivariable models show that hypertensive blood pressure in childhood is associated with an increased risk of elevated cS (> = P90 for age, height and sex) eleven years later for all parameters of cS, with the exception of stiffness indexß (no association). Effect estimates for DC, YEM and Ep range from 1.77 [CI 1.28-2.44] for DC to 1.41 [CI 0.99-2.01] for YEM. Cross-sectional associations of blood pressure with cS parameters show even stronger associations (relative risks between 1.3 and 3.3).

CONCLUSIONS: Using state-of-the-art sonography and centiles computed with novel statistical methods, this study confirms that, at the population level, hypertensive blood pressure in childhood is linked to increased carotid stiffness in young adulthood. The results emphasize that healthy lifestyles and healthy living environments in childhood and adolescence represent an early investment in cardiovascular health.

PMID:36027534 | DOI:10.1097/01.hjh.0000835488.45395.d3

J Hypertens. 2022 Jun 1;40(Suppl 1):e14-e15. doi: 10.1097/01.hjh.0000835416.29059.27.

ABSTRACT

OBJECTIVE: Atrial fibrillation (AF) is the most common sustained arrhythmia which often is asymptomatic and undiagnosed. An automated blood pressure (BP) monitor with an algorithm which detects atrial fibrillation with high diagnostic accuracy during routine measurement was used for AF screening in the elderly general population Greece.

DESIGN AND METHOD: EMENO health survey (2013 to 2016) applied a multi-stage stratified random sampling method to select a random sample of the general adult (> = 18 years) population of Greece. For participants aged > = 65 years screening for AF was performed with triplicate automated BP measurements using a validated automated upper-arm cuff oscillometric device with embedded algorithm for detecting AF (Microlife BPA100 Plus AFIB).

RESULTS: A total of 1,838 individuals aged > = 65 years were recruited and 975 with AF data on at least 1 BP measurement were analysed (mean [SD] age 75.3 (6.6)) years, men 45.1%, BMI 30.3 (5.2) kg/m2, hypertensives 80.7%). Of them, 65 (7.1%) had AF detected in all their 3 BP readings (AF group), 661 (69.5%) have no AF in all 3 readings (no AF group), and 249 (23.4%) had AF in 1 or 2 readings (uncertain AF group). Participants with AF were older than non-AF (by 3.4 years on average, p < 0.001), had lower systolic BP (by 4.6 mmHg, p < 0.05), and more frequent cardiovascular disease (29% vs 14%, p < 0.01). Among AF patients, 43% reported a previous AF diagnosis compared to 8.8% and 11.9% in no AF and uncertain AF group respectively (p < 0.001). Hypertension tended to be more common in the AF than the non-AF group (88% vs. 80%, p = NS). Of the 65 AF group, 57% were undiagnosed and all required anticoagulant therapy (men with CHA2DS2-VASc > = 1 or women > = 2).

CONCLUSIONS: Almost 7% of people aged > = 65 years in Greece had AF detected during routine automated BP measurement. 57% of them were undiagnosed and all required anticoagulant treatment for stroke prevention. Screening for AF using routing automated BP measurement in the elderly appears to be a useful method for early detection and management of asymptomatic AF.

PMID:36027516 | DOI:10.1097/01.hjh.0000835416.29059.27

J Hypertens. 2022 Jun 1;40(Suppl 1):e7. doi: 10.1097/01.hjh.0000835352.04456.88.

ABSTRACT

OBJECTIVE: According to some guidelines white-coat hypertension (WCH) carries little or no increase of cardiovascular (CV) risk in absence of organ damage (OD) but no data are available on this issue.

DESIGN AND METHOD: Using the population data from Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA), we evaluated CV and total mortality over a median follow-up of 29 years in WCH (elevated office and normal 24-hour or home blood pressure, BP) and normotensive controls (N, normal in- and out-of-office BP) with no echocardiographic left ventricular hypertrophy and no reduction of estimated glomerular filtration rate. Analysis was extended to sustained hypertension (SH, in- and out-of-office BP elevation) and to N, WCH and SH with cardiac and renal OD.

RESULTS: During the 29 years follow-up there were in the 1423 subjects nalysed 165 CV and 526 all cause deaths. OD was detected in 10.6%, 30.5% and 43.8% of N, WCH and SH, respectively. After adjustment for confounders no-ODWCH exhibited a risk of fatal CV events lower than that of no-ODSH but greater than that of no-ODN (HR 2.0, 95% CI: 1.1-3.6, P = 0.02), this being the case also for all cause mortality. Compared with no-ODN, no-ODWCH also exhibited a greater 10 year adjusted risk to develop new SH or OD. Similar findings were obtained in N, WCH and SH with OD. The present study provides the first evidence that WCH with no cardiac and renal OD is accompanied by an increased long-term risk of mortality, new hypertension and new OD, thereby not representing a clinically innocent condition.

CONCLUSIONS: The present study provides the first evidence that WCH with no cardiac and renal OD is accompanied by an increased long-term risk of mortality, new hypertension and new OD, thereby not representing a clinically innocent condition.

PMID:36027500 | DOI:10.1097/01.hjh.0000835352.04456.88

J Hypertens. 2022 Jun 1;40(Suppl 1):e7. doi: 10.1097/01.hjh.0000835344.28675.93.

ABSTRACT

OBJECTIVE: It has been hypothesized that unattended blood pressure (BP) measurement may provide complementary clinical information to conventionally attended BP measurement. The role of sympathetic nervous system activation during attended and unattended BP measurements is largely undetermined.

DESIGN AND METHOD: We studied 161 untreated hypertensive patients undergoing attended and unattended office BP measurements. Patients were divided into two groups – group A, unattended systolic BP greater than the attended systolic BP (n = 79), and group B, unattended systolic BP equal or lower than the attended (n = 82). All participants underwent muscle sympathetic nerve activity (MSNA) estimation by microneurography. Unattended and attended BP measurements were performed with the same device in a random order for each patient on the day of MSNA recording. MSNA levels were compared between the two groups.

RESULTS: We examined 161 hypertensive patients [54% men, mean age 56 ± 12 years, BMI 29 ± 5 kg/m2, mean attended BP 140 ± 17 / 87 ± 13 mmHg, mean unattended BP 141 ± 20 / 85 ± 12 mmHg]. Group A and group B had statistically significant differences between attended systolic BP (136.7 ± 17.8 vs 143.7 ± 15.7 mmHg respectively, p = 0.009), attended diastolic BP (85.5 ± 14.7 vs 89.7 ± 11.4 mmHg respectively, p = 0.04), unattended systolic BP (145.5 ± 19 vs 135.7 ± 19.9 mmHg respectively, p = 0.002) and unattended diastolic BP (86.9 ± 13 vs 83.2 ± 11.2 mmHg respectively, p = 0.05). However, the two groups did not differ as regards MSNA levels (41.6 ± 8.9 vs. 42.1 ± 8.1 bursts per minute respectively, p = 0.7). MSNA levels did not correlate to attended and unattended systolic/diastolic BP in both groups.

CONCLUSIONS: sympathetic nervous system activity may not contribute significantly to the differential BP levels during attended or unattended BP measurements.

PMID:36027498 | DOI:10.1097/01.hjh.0000835344.28675.93

J Hypertens. 2022 Jun 1;40(Suppl 1):e4. doi: 10.1097/01.hjh.0000835316.96189.00.

ABSTRACT

OBJECTIVE: The nycterohemeral rhythm of blood pressure (BP) and heart rate has been associated with cardiovascular outcomes. However, long-term prognostic significance of BP at different levels of heart rates has rarely been studied. We therefore conducted the present analysis to investigate the prognostic values for cardiovascular outcome by the ambulatory BP parameters during different time windows.

DESIGN AND METHOD: We enrolled 5 large cohorts from whole world, including CARDIA, IDACO, JHS, SPRINT to find out independent prognostic factors for cardiovascular disease mortality, feature engineering and feature transformation were used. Several statistical and machine learning methods including the stepwise procedure, lasso penalty, and random survival forest with bootstrap technique were used to screen important candidates of risk factors. Models building are based on systolic BP replacement into the established Framingham risk score. Directly one to one replacement and indirectly two stage replacement methods are considered with variable diversity. C-statistics, NRI are used for model performance evaluation.

RESULTS: In model building procedure, nighttime BP combined with pulse pressure, morning-evening difference of SBP and weighted SBP consistently had a higher C-statistics than had office systolic BP. In validation datasets, equations incorporating mean BP and pulse pressure had best performance in C-index (0.754). In contrast, the C-index (higher is better), of the usual Framingham risk score with office systolic BP are 0.744. Furthermore, the best model had acceptable predicted accuracy based on model calibration statistics (p > 0.05).

CONCLUSIONS: Our study demonstrated that mean BP at night combined with pulse pressure, morning-evening difference of SBP and weighted SBP, throughout 24 hours had the largest predictive power of 20-year cardiovascular death in population with ABPM recordings. The transportability of the proposed cardiovascular risk function should be evaluated in future studies.

PMID:36027491 | DOI:10.1097/01.hjh.0000835316.96189.00

J Hypertens. 2022 Jun 1;40(Suppl 1):e317. doi: 10.1097/01.hjh.0000838844.45851.de.

ABSTRACT

OBJECTIVE: To compare the effects of intensive vs standard blood pressure (BP) targets on the mortality of hypertensive patients with chronic renal disease.

DESIGN AND METHOD: A bibliographic search of all relevant databases was carried out without restriction by language, year of publication or publication status.We considered randomized controlled clinical trials on patients older than 18 years, diagnosed with hypertension and chronic renal disease who were allocated to either “intensive” BP target (less than or equal to 130/80 mmHg) or “standard” BP target (less than or equal to 140-160/90-100 mmHg). Additionally, trials should include more than 50 participants per group followed during at least one year. Trials were not limited by any concomitant disease or baseline cardiovascular risk.We contacted trials’ authors to obtain Individual Patient Data and, if necessary, extracted information from chronic renal patients.COVIDENCE software was used for screening, the Cochrane Review Manager (RevMan web) for data synthesis and analysis, and the Cochrane Risk of Bias Tool (ROB2) to assess the risk of bias for each trial.

RESULTS: A total of 2298 records were identified by the bibliographic search. We obtained the full text of 29 publications from the pre-selected studies. Of these, six studies met the inclusion criteria and we obtained Individual Patient Data for all of them (AASK, SPRINT, HOT, ACCORD BP, MDRD, SPS3).There was no statistically significant difference in total mortality between the intensive and standard blood pressure target groups (RR 0.92, 95%CI 0.75-1.13, p = 0.42, 6 studies, 7,348 participants). In absolute terms, there were 5 additional deaths per 1000 participants in the standard target group (95% CI: 6 fewer to 16 more deaths per 1000 participants). Overall deaths were 227/3352 (6.8%) in the intensive target group vs 285/3996 (7.9%) in the standard target group (Figure).The quality of evidence was moderate according to the GRADE assessment.

CONCLUSIONS: Intensive blood pressure lowering targets in patients with arterial hypertension and chronic renal disease do not result in lower mortality compared to standard blood pressure lowering.

PMID:36027480 | DOI:10.1097/01.hjh.0000838844.45851.de

J Hypertens. 2022 Jun 1;40(Suppl 1):e315-e316. doi: 10.1097/01.hjh.0000838824.44837.1f.

ABSTRACT

OBJECTIVE: Metabolic syndrome (MetS) is a collection of disorders including diabetes, hypertension, obesity, and dyslipidemia that increase the risk of cardiovascular diseases and mortality. Several studies have discovered that, in addition to its angiotensin receptor blocker activity, telmisartan is a partial agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma), which is a nuclear receptor involved in the regulation of metabolic homeostasis. Evidence also exists that activators of PPAR exert anti-inflammatory, anti-oxidative, and anti proliferative effects on vascular walls. Therefore through PPAR gamma modulating activity, telmisartan can be a valuable agent for treating MetS.

DESIGN AND METHOD: The PubMed, EMBASE databases and Cochrane Central of Controlled Trials were searched through October 2021. We pooled data extracted from the included studies using the standardized mean difference (SMD). Study-specific estimates were combined using inverse variance-weighted averages of SMDs in both fixed- and random-effects models. Heterogeneity was evaluated using Cochran’s Q- and the I2-test. GRADE assess the study’s quality. All analyses were conducted using StatsDirect statistical software Version 2.8.0.

RESULTS: A total of 582 patients were enrolled in the 11 included randomized clinical trials (RCTs). The pooled analysis revealed significant reduction in the percent changes of homeostasis model assessment index (HOMA) (SMD = -0.24; 95% CI: -0.40 to -0.07; p = 0.0036), changes of fasting glucose (mg/dL) (SMD = -0.49; 95% CI: -0.94 to 0.05; p = 0.0283), insulin (mU/mL) (SMD = -0.21; 95% CI: -0.38 to -0.05; p = 0.0084), and a significant increase in percent changes of adiponectin (umg/mL) (SMD = 0.63; 95% CI: 0.34 to 0.92; p < 0.0001),among patients with metabolic syndrome randomized to telmisartan versus control therapy. There was minimal trial heterogeneity in the analyses for HOMA index (I2 = 21.1%), insulin (I2 = 0%) and adiponectin levels (I2 = 0.1%). However, there was considerable heterogeneity in the analysis for fasting glucose (I2 = 83.6%).

CONCLUSIONS: Our study suggests that the PPAR gamma modulating activity of telmisartan has the potential to be a valuable therapeutic agent for treating MetS.

PMID:36027475 | DOI:10.1097/01.hjh.0000838824.44837.1f

J Hypertens. 2022 Jun 1;40(Suppl 1):e315. doi: 10.1097/01.hjh.0000838820.36483.00.

ABSTRACT

OBJECTIVE: Metabolic syndrome (MetS) is a collection of disorders including diabetes, hypertension, obesity, and dyslipidemia that increase the risk of cardiovascular diseases and mortality. Several studies have discovered that, in addition to its angiotensin receptor blocker activity, telmisartan is a partial agonist of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which is a nuclear receptor involved in the regulation of metabolic homeostasis. Evidence also exists that activators of PPAR-gamma exert anti-inflammatory, anti-oxidative, and antiproliferative effects on vascular walls. Therefore through PPAR-gamma modulating activity, telmisartan can be a valuable therapeutic agent for treating MetS.

DESIGN AND METHOD: he PubMed, EMBASE databases and Cochrane Central of Controlled Trials were searched through October 2021. We pooled data extracted from the included studies using the standardized mean difference (SMD). Study-specific estimates were combined using inverse variance-weighted averages of SMDs in both fixed- and random-effects models. Heterogeneity was evaluated using Cochran’s Q- and the I2-test. GRADE tool was used to assess the study’s quality. All analyses were conducted using StatsDirect statistical software Version 2.8.0.

RESULTS: A total of 582 patients were enrolled in the 11 included randomized clinical trials (RCTs). The pooled analysis revealed significant reduction in the percent changes of homeostasis model assessment index (HOMA) (SMD = -0.24; 95% CI: -0.40 to -0.07; p = 0.0036), changes of fasting glucose (mg/dL) (SMD = -0.49; 95% CI: -0.94 to 0.05; p = 0.0283), insulin (mU/mL) (SMD = -0.21; 95% CI: -0.38 to -0.05; p = 0.0084), and a significant increase in percent changes of adiponectin (umg/mL) (SMD = 0.63; 95% CI: 0.34 to 0.92; p < 0.0001),among patients with metabolic syndrome randomized to telmisartan versus control therapy. There was minimal trial heterogeneity in the analyses for HOMA index (I2 = 21.1%), insulin (I2 = 0%) and adiponectin levels (I2 = 0.1%). However, there was considerable heterogeneity in the analysis for fasting glucose (I2 = 83.6%).

CONCLUSIONS: Our study suggests that PPAR-gamma modulating activity of telmisartan therapy has the potential to be a valuable therapeutic agent for treating MetS.

PMID:36027474 | DOI:10.1097/01.hjh.0000838820.36483.00

J Hypertens. 2022 Jun 1;40(Suppl 1):e314. doi: 10.1097/01.hjh.0000838808.45705.35.

ABSTRACT

OBJECTIVE: To evaluate the effects of Sacubitril-Valsartan on early renal function and vascular function in patients during perimenopause with hypertension.

DESIGN AND METHOD: This study was a prospective, randomized, positive control and open label test. The subjects were 427 perimenopausal women (30-65 years old) with mild or moderate hypertension who were treated in the Department of Cardiovascular Medicine of the Second Hospital of Lanzhou University. They were randomly assigned to Sacubitril-Valsartan group (n = 165) or valsartan group (n = 262) for 24 weeks. Renal function, urinary renal function and vascular function were evaluated at baseline and 24 weeks after treatment.

RESULTS: There was no significant difference in the clinical baseline data between patients with sacubitril-valsartan and patients with valsartan (P> 0.05). Comparison of the systolic blood pressure (oSBP) and diastolic blood pressure(oDBP)before and after treatment: the baseline vs. 24-week difference between the sacubitril-valsartan group and the valsartan group was statistically significant (p < 0.001). The carotid-femoral pulse wave velocity (cfPWV) in the vascular function indexes of the sacubitril-valsartan group was significantly improved (p < 0.001). The improvement of valsartan group was not obvious. Other vascular function parameters such as cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) were not significantly improved in the two groups. Urinary microalbumin (MAU)was significantly improved in both blood renal function and urine renal function. The improvement was observed in the sacubitril-valsartan group (p < 0.001) and valsartan group (p = 0.027), but the improvement was stronger in the sacubitril-valsartan group (p < 0.001).

CONCLUSIONS: Sacubictril-valsartan has a stronger antihypertensive effect than valsartan in patients during perimenopause with hypertension, and can improve MAU and cfPWV in patients.

PMID:36027471 | DOI:10.1097/01.hjh.0000838808.45705.35

J Hypertens. 2022 Jun 1;40(Suppl 1):e314. doi: 10.1097/01.hjh.0000838800.92823.fc.

ABSTRACT

OBJECTIVE: It has been shown a significant difference in clinical characteristics of HTN and treatment response to antihypertensive therapy between males and females. The purpose of our article was to examine gender differences in the regulation of blood pressure (BP) by using ambulatory blood pressure monitoring (ABPM).

DESIGN AND METHOD: Two hundred seventy-five consecutive hypertensive patients were included in the study (146 females, mean age 64.11 ± 10.47 and 129 males, mean age 61.69 ± 13.59). All patients were on antihypertensive treatment for more than one year (average duration of HTN was 11.07 ± 8.24 years for women, and 10.31 ± 7.5 years for men). In all pts, AMBP was performed. The values obtained by AMBP were compared between the two groups.

RESULTS: There were no significant differences in the presence of coronary artery disease, obesity, diabetes mellitus, or heredity between the groups. There were more smokers among male patients (p = 0.007), while dyslipidemia was more present in female pts (p = 0.005). Male pts had higher values of systolic (124.05 ± 13.89 vs. 119.5 ± 16.58, p = 0.015) and diastolic BP (72.77 ± 8.42 vs. 69.24 ± 8.23, p = 0.001) and larger burden of high BP during the night (56.54 ± 35.52 vs. 33.11 ± 35.27, p = 0.000) compared to female pts. There were no significant differences in pulse pressure (PP) values between the male and female groups (51.17 ± 11.33 vs. 50.72 ± 10.38, p = 0.730). However, pathological values of PP (<40 mmHg or > 60 mmHg) were found in almost 1/3 of pts (34.92% in men and 28.57% in women). Also, there was no significant difference in dipping pattern but only 40 (31.01%) male and 50 (34.25%) female patients had dipper status. There was no statistically significant difference in antihypertensive therapy between the groups. The most commonly used drugs were the angiotensin-converting enzyme inhibitors (82.21% of all pts) and beta blockers (78.78%), while the angiotensin receptor blockers were the least used (15.98%).

CONCLUSIONS: Results indicate that women have better BP control than men. However, a high frequency of pathological PP values and disturbed dipping status detected by ABPM, in women as well as men, should highlight the importance of better BP management in both genders.

PMID:36027469 | DOI:10.1097/01.hjh.0000838800.92823.fc