Tag: nevin manimala

Medicine (Baltimore). 2022 Jul 1;101(26):e29765. doi: 10.1097/MD.0000000000029765.

ABSTRACT

BACKGROUND: In recent years, the role of metformin in girls with precocious puberty (PP) has been increasingly frequently studied. The objective of this present study is to assess the effect of metformin on low birth weight girls with precocious puberty (LBW-PP girls).

METHODS: We search the confirmed studies about circulating metformin and PP from the databases of EMBASE, PubMed, and Web of Science. Data were reported as weighted mean difference (WMD) and associated 95% confidence intervals (CIs). Analysis was performed by Review Manager 5.3 and Stata version 12.0.

RESULTS: A total of 205 cases (metformin group n = 102, untreated group n = 103) were included in this study. The meta-analysis of randomized controlled trials (RCTs) suggested that metformin had statistically significant effects on testosterone (P = .001), androstenedione (P = .022), bone mineral density (BMD; P = .151), triglycerides (P ≤ .001), body mass index Z score (BMI Z score; P ≤ .001), dehydroepiandrosterone-sulfate (DHEAS; P = .053), sex hormone-binding globulin (SHBG; P = .049), high-density lipoprotein (HDL) cholesterol (P ≤ .001), low-density lipoprotein (LDL) cholesterol (P = .021), fat mass (P ≤ .001), lean mass (P = .025), and fasting insulin (P = .002).

CONCLUSION: This meta-analysis provided evidence of the efficacy of metformin in girls with LBW-PP girls, which proved that metformin could improve metabolism and reduce weight. Metformin had a positive effect on preventing LBW-PP girls from developing into obesity and polycystic ovarian syndrome. In addition, this meta-analysis provided important reference opinions and directions for the treatment of LBW-PP girls.

PMID:35776991 | DOI:10.1097/MD.0000000000029765

Medicine (Baltimore). 2022 Jul 1;101(26):e29766. doi: 10.1097/MD.0000000000029766.

ABSTRACT

Apathy and impulsiveness are 2 common non-motor symptoms in Parkinson disease that could occur in different periods or simultaneously. Apathy and impulsiveness could be interpreted as opposite extremes of a spectrum of motivated behavior dependent on dopaminergic dysfunction, in which, impulsivity, is a result of a hyperdopaminergic state, whereas apathy is viewed as a hypodopaminergic. The study aimed to investigate the presence of impulsiveness and other neuropsychiatric symptoms in Parkinson disease patients with apathy symptoms. Eighty-one patients with Parkinson disease were enrolled in this retrospective study. All subjects were evaluated by the Italian version of the Dimensional Apathy Scale and the Barratt Impulsiveness Scale-version 11, to assess, respectively, apathy and impulsiveness; they were divided into 2 groups (apathy and no apathy). All patients were administered also with questionnaires assessing depressive and anxious symptoms. Statistical analyses showed relevant results. In no-apathy group, education was a significant predictor on impulsiveness (attentional and motor) and apathy (executive and emotional); depression was a significant predictor on planning impulsivity and apathy. This study aimed to consider the importance of apathy and impulsivity in Parkinson disease. Although these are considered as opposite extremes of a spectrum of motivated behavior dependent on dopaminergic dysfunction, these can also occur separately. Moreover, several variables could represent important predictors of apathy and impulsiveness, such as depression. Future investigations should deepen the role of other demographics and psychological variables.

PMID:35776985 | DOI:10.1097/MD.0000000000029766

Medicine (Baltimore). 2022 Jul 1;101(26):e29757. doi: 10.1097/MD.0000000000029757.

ABSTRACT

BACKGROUND: Clinically relevant postoperative pancreatic fistula (CR-POPF) is a common and troublesome complication after pancreatoduodenectomy (PD). We conducted a systematic review and meta-analysis to identify the risk factors of CR-POPF after PD.

METHODS: We searched PubMed, EMBASE, and Cochrane Library databases for studies related to risk factors of CR-POPF after PD. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were extracted from the included studies, then a meta-analysis was conducted. If necessary, sensitivity analysis would be performed by changing the effect model or excluding 1 study at a time. Publication bias was assessed by funnel plot and Begg test and Egger test.

RESULTS: A total of 27 studies with 24,740 patients were included, and CR-POPF occurred in 3843 patients (incidence = 17%, 95% CI: 16%-19%). Male (OR = 1.56, 95% CI: 1.42-1.70), body mass index >25 kg/m2 (OR = 1.98, 95% CI: 1.23-3.18), pancreatic duct diameter <3 mm (OR = 1.87, 95% CI: 1.66-2.12), soft pancreatic texture (OR = 3.49, 95% CI: 2.61-4.67), and blood transfusion (OR = 3.10, 95% CI: 2.01-4.77) can significantly increase the risk of CR-POPF. Pancreatic adenocarcinoma (OR = 0.54, 95% CI: 0.47-0.61), vascular resection (OR = 0.57, 95% CI: 0.39-0.83), and preoperative chemoradiotherapy (OR = 0.68, 95% CI: 0.57-0.81) can significantly decrease the factor of CR-POPF. Diabetes mellitus was not statistically associated with CR-POPF (OR = 0.66, 95% CI: 0.40-1.08). However, the analysis of body mass index, pancreatic texture, and diabetes mellitus had a high heterogeneity, then sensitivity analysis was performed, and the result after sensitivity analysis showed diabetes mellitus can significantly decrease the risk of CR-POPF. There was no significant publication bias in this meta-analysis.

CONCLUSIONS: The current review assessed the effects of different factors on CR-POPF. This can provide a basis for the prevention and management of CR-POPF. Effective interventions targeting the above risk factors should be investigated in future studies for decreasing the occurrence of CR-POPF.

PMID:35776984 | DOI:10.1097/MD.0000000000029757

Oper Dent. 2022 May 1;47(3):346-356. doi: 10.2341/21-015-L.

ABSTRACT

OBJECTIVES: The purpose of this study was to compare the mechanical properties and push-out bond strength of self-adhesive resin cements (SACs) and a conventional resin cement (CRC).

METHODS AND MATERIALS: Eighty bovine incisors were divided into four groups for cementation of a fiberglass post (Whitepost – FGM Dental Group, Coral Springs, FL) with different resin cements: three SACs (Maxcem Elite, MAX – Kerr; Calibra Universal, CAL – Dentsply; and RelyX Unicem 2, RUN – 3M Oral Care) and one CRC (RelyX Ultimate, RXU – 3M Oral Care). The groups were subdivided into two groups each (n=10) for evaluation of the push-out bond strength test (POBS) after 24 hours of water storage or after thermal aging (5000 cycles), following 24 hours of storage. The failure modes were evaluated using a stereomicroscope. Flexural strength (FS) and modulus of elasticity (EM) were determined using a three-point bending. Also, pH of the cements was measured over 48 hours and filler morphology was observed by scanning electron microscopy. Appropriate statistical analyses were performed by SPSS 21.0 (SPSS Inc., Chicago, IL, USA), with a significance level set at 5%. Results: RXU presented the highest POBS at both evaluation times. Among the SACs, RUN and CAL presented significantly lower POBS than MAX in cervical and middle-thirds at the 24-hour evaluation, and in all root regions after thermocycling. Adhesive failure between the cement and dentin were the most prevalent fractures at both times evaluated. MAX presented the lowest FS and RUN showed the highest EM. The pH reached the minimal point at the 30-minute evaluation for RXU and MAX. For RUN and CAL, the minimal pH was observed at the 60-minute evaluation. RXU and RUN presented spherical and regular filler particles, while MAX and CAL presented irregularly shaped and sized filler particles.

CONCLUSIONS: The mechanical behavior of SACs is not superior to CRC; however, among all the SACs evaluated, MAX presented the highest POBS and stability after thermocycling evaluation. MAX also reached the closest neutral pH after 48 hours. Therefore, SACs with low initial pH and strong neutralization reactions are recommended, because these characteristics may lead to better mechanical properties and stability.

PMID:35776956 | DOI:10.2341/21-015-L

JMIR Hum Factors. 2022 Jul 1;9(3):e38469. doi: 10.2196/38469.

ABSTRACT

BACKGROUND: Cardiovascular disease and type 2 diabetes mellitus are two of the most prevalent chronic conditions worldwide. An unhealthy lifestyle greatly contributes to someone’s risk of developing these conditions. Mobile health is an emerging technology that can help deliver health promotion interventions to the population, for example, in the form of health apps.

OBJECTIVE: The aim of this study was to test the feasibility of an app-based intervention for cardiovascular and diabetes risk awareness and prevention by measuring nonusage, dropout, adherence to app use, and usability of the app over 3 months.

METHODS: Participants were eligible if they were aged 45 years or older, resided in Australia, were free of cardiovascular disease and diabetes, were fluent in English, and owned a smartphone. In the beginning, participants received an email with instructions on how to install the app and a user guide. After 3 months, they received an email with an invitation to an end-of-study survey. The survey included questions about general smartphone use and the user version of the Mobile Application Rating Scale. We analyzed app-generated and survey data by using descriptive and inferential statistics as well as thematic analysis for open-text comments.

RESULTS: Recruitment took place between September and October 2021. Of the 46 participants who consented to the study, 20 (44%) never used the app and 15 (33%) dropped out. The median age of the app users at baseline was 62 (IQR 56-67) years. Adherence to app use, that is, using the app at least once a week over 3 months, was 17% (8/46) of the total sample and 31% (8/26) of all app users. The mean app quality rating on the user version of the Mobile Application Rating Scale was 3.5 (SD 0.6) of 5 points. The app scored the highest for the information section and the lowest for the engagement section of the scale.

CONCLUSIONS: Nonusage and dropouts were too high, and the adherence was too low to consider the intervention in its current form feasible. Potential barriers that we identified include the research team not actively engaging with participants early in the study to verify that all participants could install the app, the intervention did not involve direct contact with health care professionals, and the app did not have enough interactive features.

PMID:35776504 | DOI:10.2196/38469

Phys Rev Lett. 2022 Jun 17;128(24):240601. doi: 10.1103/PhysRevLett.128.240601.

ABSTRACT

We define an ensemble of random Clifford quantum circuits whose output state undergoes an entanglement phase transition between two volume-law phases as a function of measurement rate. Our setup maps exactly the output state to the ground space of a spin glass model. We identify the entanglement phases using an order parameter that is accessible on a quantum chip. We locate the transition point and evaluate a critical exponent, revealing spin glass criticality. Our Letter establishes an exact statistical mechanics theory of an entanglement phase transition.

PMID:35776455 | DOI:10.1103/PhysRevLett.128.240601

Phys Rev Lett. 2022 Jun 17;128(24):241801. doi: 10.1103/PhysRevLett.128.241801.

ABSTRACT

We present a measurement of ν_{e} interactions from the Fermilab Booster Neutrino Beam using the MicroBooNE liquid argon time projection chamber to address the nature of the excess of low energy interactions observed by the MiniBooNE Collaboration. Three independent ν_{e} searches are performed across multiple single electron final states, including an exclusive search for two-body scattering events with a single proton, a semi-inclusive search for pionless events, and a fully inclusive search for events containing all hadronic final states. With differing signal topologies, statistics, backgrounds, reconstruction algorithms, and analysis approaches, the results are found to be either consistent with or modestly lower than the nominal ν_{e} rate expectations from the Booster Neutrino Beam and no excess of ν_{e} events is observed.

PMID:35776450 | DOI:10.1103/PhysRevLett.128.241801

Front Med. 2022 Jul 1. doi: 10.1007/s11684-021-0902-1. Online ahead of print.

ABSTRACT

The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitors (ICIs) in China has not been quantified. This cross-sectional study was conducted to estimate the number of Chinese cancer patients with eligibility and response to ICIs based on the 2015 Chinese cancer statistics and the immune checkpoint inhibitor clinical practice guideline of the Chinese Society of Clinical Oncology. A total of 11 ICIs were recommended for 17 cancer types. The estimated number of eligible patients annually was 1 290 156 (55.18%), which included 888 738 males (60.05%) and 400 468 females (46.67%). The estimated number of responders annually was 448 972 (19.20%), which included 309 023 males (20.88%) and 139 764 females (16.29%). Gastric cancer (n=291 000, 12.45%), non-small-cell lung cancer (n=289 629, 12.39%), and hepatocellular carcinoma (n=277 100, 11.85%) were the top three cancer types with the highest number of eligible patients. Non-small-cell lung cancer (n=180 022, 7.70%), hepatocellular carcinoma (n=75 648, 3.24%), and small-cell lung cancer (n=64 362, 2.75%) were the top three cancer types with the highest number of responders. In conclusion, ICIs provide considerable benefit in Chinese cancer patients under optimal estimation.

PMID:35776405 | DOI:10.1007/s11684-021-0902-1

Environ Monit Assess. 2022 Jul 1;194(8):549. doi: 10.1007/s10661-022-10137-1.

ABSTRACT

Savar Upazila in the Dhaka District is a rapidly expanding city with a diverse range of industries and agricultural activities. This expansion poses environmental challenges including the threat to groundwater contamination. Based on these considerations, the objective of this research is to carry out a shallow groundwater hydrogeochemical characterization and an assessment of the suitablity of the groundwater for drinking and irrigational purposes using a geochemical approach, multivariate statistical techniques, and some indices of groundwater quality. The hydrogeochemical analyses of 42 groundwater samples from shallow depths (18 – 76 m) showed that the order of concentrations of cations, anions, and metals was Ca²⁺ > Na⁺ > Mg²⁺ > K⁺, HCO₃^– > Cl^– > SO₄^2- > NO₃^–, and Cr > As > Pb > Mn > Fe, respectively. Weathering of silicates was found to be the most significant hydrogeochemical process governing the chemistry of groundwater. Cation exchange also plays a significant role in the evolution of the groundwater chemistry. Principal component analysis and hierarchical cluster analysis suggested that anthropogenic activities are influencing groundwater quality. A drinking water quality index map showed that about 91% of the groundwater samples were in the excellent category and suitable for human consumption, with only a few samples exceeding the standards of the WHO and Bangladesh for concentrations of Ca²⁺, Mg²⁺, HCO₃^–, Fe, Mn, and As. An analysis of irrigation quality parameters found that most of the groundwater samples were either excellent or good for agricultural uses, except for one sample in the Tetuljhora Union that was unsuitable based on residual sodium carbonate. This finding may be useful to local governments in understanding the current status of groundwater quality, tracking potential threats of contamination, and initiating appropriate measures for long-term groundwater resource management.

PMID:35776389 | DOI:10.1007/s10661-022-10137-1

Behav Res Methods. 2022 Jul 1. doi: 10.3758/s13428-022-01890-9. Online ahead of print.

ABSTRACT

In this article, we present the Chinese Children’s Lexicon of Written Words (CCLOWW), the first grade-level database that provides frequency statistics of simplified Chinese characters and words for children. The database computes from a corpus of 34,671,424 character tokens and 22,427,010 word tokens (including single- and multicharacter words), extracted from 2131 books. It contains 6746 different character types and 153,079 different word types. CCLOWW provides several frequency indices of simplified Chinese for three grade levels (grade 2 and below, grades 3-4, grades 5-6) to profile children’s experience with written Chinese in and outside of school. We describe in this article the distributions of frequency and contextual diversity of the characters and words, as well as word length and syntactic categories of the words in the corpus and the subcorpora. We also report results of correlation analyses with other written corpora and of several naming and lexicon decision experiments. The findings suggest that CCLOWW frequency measures correlate well with other corpora. Importantly, they could reliably predict children’s and adults’ naming and lexical decision performances. They could also explain variance in adults’ visual word recognition, in addition to frequency measures computed in an adult corpus, indicating that early print exposure might influence readers’ lexical processing later on beyond an age of acquisition effect. CCLOWW will help researchers in language processing and development as well as educators with selecting language materials appropriate for children’s developmental stages. The database is freely available online at https://www.learn2read.cn/database/ .

PMID:35776384 | DOI:10.3758/s13428-022-01890-9