Tag: nevin manimala

Cancer Med. 2022 Feb 23. doi: 10.1002/cam4.4609. Online ahead of print.

ABSTRACT

BACKGROUND: Surgical site infection (SSI) in thoracic surgery remains a significant cause of morbidity and prolonged hospitalization. Minimally invasive surgery (MIS) has significantly reduced the risk of SSI. We intended to compare whether there was difference between video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery (RATS) in SSI and highlight possible factors influencing SSI in lobectomy.

METHODS: This retrospective study analyzed patients who underwent minimally invasive lobectomy from January 2018 to December 2019. All patients’ clinical characteristics and surgery-related information which may be related to the likelihood of SSI were recorded.

RESULTS: A total of 1231 patients’ records were reviewed with 806 VATS and 425 RATS. SSI was classified as deep or superficial SSI. Eighty-six (7.0%) patients were found to develop an SSI with 62 patients having deep infections and 24 had superficial infection. No statistical difference in the incidence rate and category of SSI was observed between patients undergoing VATS and RATS.

CONCLUSIONS: There was no difference in the incidence of SSI between VATS and RATS lobectomy. Male gender, heavy smoking, uncontrolled diabetes mellitus, body mass index (BMI) > 27.9, more blood loss, and the higher National Healthcare Safety Network (NHSN) risk index score (1 or 2) were the independent risk factors of SSI following minimally invasive lobectomy, while male gender, uncontrolled diabetes mellitus, BMI > 27.9, more blood loss and the higher NHSN risk index score (1 or 2) were the main predictors of deep SSI.

PMID:35194968 | DOI:10.1002/cam4.4609

Clin Otolaryngol. 2022 Feb 23. doi: 10.1111/coa.13921. Online ahead of print.

ABSTRACT

NOE is a rare but life-threatening condition. Treatment is long-term intravenous antibiotics. However, there is no evidence on the complications of antibiotic treatment in this complex cohort of patients In our study, patients on average are treated with two different antibiotic regimes 63% of these changes in regimen are due to direct adverse effects from treatment including drug intolerance and lack of significant clinical response leading to deterioration and morbid complications Patients requiring multiple antibiotic regimes have a statistically longer duration of treatment. These adverse effects appear to occur more frequently in patients with additional comorbidities. This novel data provides information clinicians can use when initiating treatment for NOE and counsel patients appropriately.

PMID:35194951 | DOI:10.1111/coa.13921

Angew Chem Int Ed Engl. 2022 Feb 22. doi: 10.1002/anie.202201700. Online ahead of print.

ABSTRACT

A strategy for the generation of heterotrimetallic double cavity (DC) cages [PdnPtmL4]6+ (DC1: n = 1, m = 2; and DC2: n = 2, m = 1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and Pd(II) ions. 1H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2, were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of the 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities was found to interact with two different guests, 5-FU and cisplatin, selectively.

PMID:35194905 | DOI:10.1002/anie.202201700

HIV Med. 2022 Feb 22. doi: 10.1111/hiv.13255. Online ahead of print.

ABSTRACT

OBJECTIVES: We aimed to assess prevalence and age at menopause, identify factors associated with early menopause and explore the provision and utilization of healthcare in women living with HIV in Switzerland.

METHODS: This was a retrospective Swiss HIV Cohort Study analysis from January 2010 to December 2018. Descriptive statistics to characterise the population and menopause onset. Logistic regression analysis to identify risk factors for early menopause.

RESULTS: Of all women in the SHCS, the proportion of postmenopausal women tripled from 11.5% (n = 274) in 2010 to 36.1% (n = 961) in 2018. The median age at menopause was 50 years. Early menopause (< 45 years) occurred in 115 (10.2%) women and premature ovarian insufficiency (POI) (< 40 years) in 23 (2%) women. Early menopause was associated with black ethnicity (52.2% vs. 21.6%, p < 0.001), but not with HIV acquisition mode, CDC stage, viral suppression, CD4 cell count, hepatitis C, smoking or active drug use. While 92% of the postmenopausal women underwent a gynaecological examination during the 36 months before menopause documentation, only 27% received a bone mineral density measurement within 36 months after the last bleed and 11% were on hormone replacement therapy at the time of menopause documentation.

CONCLUSIONS: The median age of women living with HIV at menopause is around 2 years lower than that reported for HIV-negative women in Switzerland. HIV care providers need to adapt their services to the requirements of the increasing number of women living with HIV transitioning through menopause. They should be able to recognize menopause-associated symptoms and improve access to bone mineral density measurement as well as hormone replacement therapy.

PMID:35194949 | DOI:10.1111/hiv.13255

Psychooncology. 2022 Feb 22. doi: 10.1002/pon.5909. Online ahead of print.

ABSTRACT

OBJECTIVE: The diagnosis of cancer in a child is a profoundly stressful experience. The impact on parents’ somatic health, including lifestyle-related diseases, however, is unresolved.

METHODS: We conducted a nationwide population- and register-based study with parents of all children under age 20 diagnosed with cancer in Denmark between 1998 – 2013 and parents of cancer-free children, matched (1:10) on child’s age and family type. We estimated hazard ratios (HR) with 95% confidence intervals (CI) in Cox proportional hazard models for thirteen major International Classification of Diseases-10 disease-groups, selected stress- and lifestyle-related disease-groups and investigated moderation by time since diagnosis, parental sex, and cancer type.

RESULTS: Among n=7797 parents of children with cancer compared with n=74,388 parents of cancer-free children (51% mothers, mean age 42), we found no overall pattern of increased risk for 13 broad disease-groups. We found increases in digestive system diseases (HR1.06, 95% CI1.01-1.12), genitourinary system diseases (HR 1.08, 95% CI 1.02-1.14), and neoplasms (HR 1.20, 95% CI 1.13-1.27), the latter attributable mostly to increased rates of tobacco-related cancers and mothers’ diet-related cancers.

CONCLUSIONS: This is the first attempt to document the impact of childhood cancer on parents’ somatic health. With the exception of increased risk for neoplasms, likely due to shared genetic or lifestyle factors, our findings offer the reassuring message, that the burden of caring for a child with cancer does not in general increase parents’ risk for somatic diseases. This article is protected by copyright. All rights reserved.

PMID:35194898 | DOI:10.1002/pon.5909

Eur J Neurol. 2022 Feb 23. doi: 10.1111/ene.15293. Online ahead of print.

ABSTRACT

BACKGROUND: Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short and long-term outcome of the disease.

METHODS: This is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the EAN NEuro-covid ReGistrY. The outcome at discharge was measured using the modified Rankin Scale (mRS) and defined as: “stable/improved” if mRS score was equal or lower than pre-morbid score; “worse” if the score was higher than pre-morbid score. Status at 6 months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6 months.

RESULTS: From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and ICU admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6 months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6 months of follow-up.

CONCLUSIONS: Neuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.

PMID:35194889 | DOI:10.1111/ene.15293

Phytochem Anal. 2022 Feb 22. doi: 10.1002/pca.3104. Online ahead of print.

ABSTRACT

INTRODUCTION: Forsythia suspensa (Thunb.) Vahl (FS), the fruit of Oleaceae plants, as a large part of traditional Chinese medicine, is classified as “Qingqiao (Q)” and “Laoqiao (L)” based on the harvest time. Because the maturation of FS is a gradual process, its accurate identification based on different maturity levels is an important issue.

OBJECTIVES: We suggest colorimetric, electronic tongue, and high-performance liquid chromatography (HPLC) characteristic fingerprints to discriminate FS in different harvest periods.

MATERIAL AND METHODS: First, FS fruits from different harvest times were collected, and then, their colour parameters, E-tongue sensory properties, HPLC characteristic fingerprints, and contents of nominal ingredients were determined. Finally, multivariate statistical analyses, including three-dimensional scatter plots, hierarchical cluster, principal component, linear discriminant, similarity, and partial least squares discriminant analyses were performed.

RESULTS: The results demonstrated that the three experimental techniques could effectively discriminate FS based on different harvest times with 100% accuracy. Under the qualitative conditions, nine common peaks were identified in the HPLC fingerprints of 60 samples, among which, six peaks [variable importance in projection (VIP) > 1] could be used as index peaks for qualitative identification. In fact, the contents of quality marker components, including forsythin, phillygenin, rutin and forsythoside A, were significant different (P < 0.001) at different harvest times. Interestingly, the quality markers not only accurately reflected the maturity of FS but also showed close correlations with the colour parameters and sensory E-tongue responses.

CONCLUSION: In our present investigation, bionic technologies, including a colorimeter, E-tongue analysis, and HPLC characteristic fingerprints, combined with chemometrics, were employed to develop a novel and accurate method for discriminating FS based on different harvest times.

PMID:35194875 | DOI:10.1002/pca.3104

Psychooncology. 2022 Feb 22. doi: 10.1002/pon.5908. Online ahead of print.

ABSTRACT

OBJECTIVE: To determine whether the existing MICRA scale, which assesses impact of receiving genetic test results on individuals being assessed for cancer risk, can be successfully adapted to cancer patients experiencing prolonged waiting for results of germline genome sequencing (GS).

METHODS: Patients previously diagnosed with likely hereditary cancer (n=250) who were waiting for germline GS results completed questionnaires 3 months after baseline. We adapted the MICRA to measure anxiety associated with waiting for results, and assessed factor structure, internal consistency, test-retest reliability and construct validation.

RESULTS: Factor analysis revealed 4 factors: distress, positive experience, family support and uncertainty. Internal consistency for each sub-scale was high with the values of Cronbach’s alpha for the distress, positive experiences, family support, and uncertainty sub-scales 0.92, 0.88, 0.92, and 0.87, respectively. Test-retest reliability was poor, with intra-class correlations of 0.53, 0.13, 0.33 and .52 for the four factors, respectively. Construct validation showed large correlations between the MICRA distress and uncertainty sub-scale scores and the IES intrusion (0.42 and 0.62, respectively) and IES avoidant thinking sub-scales (0.40 and 0.58, respectively) but not the HADS sub-scales.

CONCLUSIONS: The adapted MICRA identified test-related anxiety and uncertainty in a population of cancer patients waiting for germline GS results. Results suggest that the distress and uncertainty sub-scales of the adapted measure are most useful in this context. This article is protected by copyright. All rights reserved.

PMID:35194887 | DOI:10.1002/pon.5908

NMR Biomed. 2022 Feb 22:e4717. doi: 10.1002/nbm.4717. Online ahead of print.

ABSTRACT

OBJECTIVE: To optimize the post-processing pipeline of 7 T chemical exchange saturation transfer imaging for reproducibility. To prove this optimization for the detection of age differences and differences between Parkinson patients versus normal subjects.

METHODS: The following 7 T CEST MRI experiments were analyzed: Repeated measurements of a healthy subject, subjects of two age cohorts (14 older, 7 younger subjects), and measurements of 12 Parkinson patients. A slab-selective, B1+ -homogeneous parallel transmit protocol was used. The post-processing consisting of motion correction, smoothing, B0 -correction, normalization, denoising, B1+ -correction and Lorentzian fitting was optimized regarding the intra- and inter-subject coefficient of variation (CoV) of the amplitudes of the amide pool and the aliphatic rNOE pool within the brain.

RESULTS: Seven ‘tricks’ for post-processing accomplished an improvement of the mean voxel CoV of the amide pool and the aliphatic rNOE pool amplitudes below 5 % and 3 %, respectively. These post-processing steps are, image-based: 1)motion correction with interpolation of the motion of low-signal-offsets, 2)using the amide pool frequency offset image as reference; Z-spectrum-based, 3)normalization of the Z-spectrum using the outermost saturated measurements, 4) B0 correction of the Z-spectrum with moderate spline smoothing, 5)denoising using principal component analysis preserving the 11 highest intensity-components, 6) B1+ correction using a linear fit, and 7)Lorentzian fitting using the 5-pool fit model. It turns out that that with the optimized post-processing pipeline, a significant age effect in the amide pool can be detected. Additionally, for the first time, an aliphatic rNOE contrast between subjects suffering from Parkinson’s disease and age-matched healthy controls in the substantia nigra is detected. Interpretation We propose an optimized post-processing pipeline for CEST multi-pool evaluation. It is shown that by the use of these seven ‘tricks’, the reproducibility and, thus, the statistical power of a CEST measurement can be greatly improved and subtle changes can be detected.

PMID:35194865 | DOI:10.1002/nbm.4717

Clin Oral Implants Res. 2022 Feb 23. doi: 10.1111/clr.13908. Online ahead of print.

ABSTRACT

AIM: To assess the frequency and quantity of interproximal contact loss (ICL) between implant restorations and adjacent teeth after at least 10 years of follow-up (FU).

METHODS: Thirty-nine patients (median age 57.3 years) with 80 implants were re-examined at least 10 years after insertion of final restorations (single-crowns or fixed dental prostheses (FDPs)). Baseline (insertion of the restorations) and FU examinations encompassed: stone casts were scanned and superimposed for metric assessment of tooth movements, radiographs and clinical measurements. Outcome measures at implant sites were: the extent of tooth movement and the frequency of interproximal contact loss [ICL], peri-implant marginal bone levels [MBLs], and clinical measurements (plaque control record [PCR], bleeding on probing [BOP] and probing depth [PD]). Data were analyzed statistically with generalized regression modelling with robust standard errors to account for within-patient clustering at 5%.

RESULTS: ICL for at least one contact point after 10 years was observed in 50% of all implants (with open interproximal spaces up to 1.64 mm). Mesial contact points were significantly more prone to ICL than distal ones (relative risk [RR]=1.79; 95% confidence interval [CI]=1.07-2.99; p=0.03). The type of restoration had a significant effect on ICL, with FDPs of 2 implants being significantly more prone to mesial ICL than single crowns (RR=1.52; 95% CI=1.02-2.25; p=0.04). ICL was also associated with a significant increase in PD (+0.46 mm (95% CI=0.04-0.88 mm; P=0.03)) compared to implant sites without ICL. BOP, MBLs and PCR were not significantly influenced by ICL.

CONCLUSION: ICL was a common finding in 50% of the implant sites and was significantly associated with an increase in PD.

PMID:35194854 | DOI:10.1111/clr.13908