Tag: nevin manimala

J Strength Cond Res. 2021 Mar 31. doi: 10.1519/JSC.0000000000004016. Online ahead of print.

ABSTRACT

Coogan, SM, Hansen-Honeycutt, J, Fauntroy, V, and Ambegaonkar, JP. Upper-body strength endurance and power norms in healthy collegiate dancers: A 10-year prospective study. J Strength Cond Res XX(X): 000-000, 2021-Dance is physically demanding and requires dancers to have adequate upper body (UB), core, and lower-body fitness to perform successfully. 50-85% of dancers suffer injury during a performance season. Although a large number of dancer’s injuries are to the lower body, several dance genres (e.g., modern, hip hop, and salsa) use UB motions such as partner lifts and holds, which may result in a higher risk for UB injury. Health care practitioners often use baseline physical performance normative values to determine their clients’ fitness levels and when planning training programs to prevent or rehabilitate postinjury. Still, little information exists regarding UB fitness norms among collegiate dancers. Thus, our purpose was to determine UB strength endurance and power norms in healthy collegiate dancers. We recorded UB muscular fitness in 214 healthy collegiate dancers (males: n = 26, 174.0 ± 6.7 cm, 71.3 ± 9.2 kg and females: n = 188, 163.0 ± 6.1 cm, 59.3 ± 6.8 kg) prospectively over a 10-year period (2008-2018) in a dance program that emphasizes modern and ballet dance. For UB strength endurance, we recorded the number of push-ups a dancer was able to perform without forcibly straining or losing form for 2 consecutive repetitions. For UB power, dancers sat with legs outstretched, backs flat against a wall, and threw a 3-kg ball horizontally from their chest as far as possible (distance thrown normalized to body height, *BH). The best attempt of 3 trials was used for statistical analyses. We report descriptive statistics, interquartile ranges (IQRs), and percentiles for both outcome measures. Dancers performed 20.4 ± 10.6 (range: 2-70, IQR: 12-24; males: 32.5 ± 14.4; females: 18.4 ± 8.4) push-ups and threw the medicine ball 1.8 ± 0.5 *BH (range: 45-3.9, IQR: 1.4-2.1; females: 1.7 ± 0.5; males: 2.3 ± 0.7). Overall, in this long-term prospective study, we developed UB fitness norms for dancers. The push-up test and medicine ball throw test are simple, low-tech, and inexpensive to test dancers UB fitness. Although dancers’ UB muscular fitness was lower than previous reports among traditional sport athletes, these values may not necessarily indicate problems, as subjects were all healthy collegiate-level dancers. Rather, our findings reinforce the need to develop dance-specific norms so that practitioners can use these values to assess dancers’ UB fitness and devise interventions appropriately. These results provide baseline UB muscular fitness norms among collegiate modern and ballet dancers, and further support the notion that differing norms are needed for different sports and dance genres. Specifically, future researchers should similarly develop norms across different dance genres for preprofessional and professional dancers and also examine whether these norms can predict dancers’ injury risk or performance.

PMID:33795604 | DOI:10.1519/JSC.0000000000004016

Dermatol Surg. 2021 Apr 1;47(4):e111-e116. doi: 10.1097/DSS.0000000000002835.

ABSTRACT

BACKGROUND: Nail psoriasis is a common and potentially debilitating condition for which no effective and safe nonsystemic therapy is currently available. Recently, laser-assisted drug delivery (LADD) is being increasingly used to facilitate transcutaneous penetration of topical treatments.

OBJECTIVES: We set to assess the efficacy and safety of combined pulse-dye laser and fractional CO2 laser-assisted betamethasonecalcipotriol gel delivery for the treatment of nail psoriasis.

MATERIAL AND METHODS: We conducted a prospective, intrapatient comparative study in a series of 22 patients with bilateral fingernail psoriasis. Nails on the randomized hand were treated with 3 monthly sessions of pulse-dye laser to the proximal and lateral nail folds followed by fractional ablative CO2 laser to the nail plate. Between treatments and one month following the last treatment, the participants applied betamethasone propionate-calcipotriol gel once daily to the nail plate. Clinical outcome was ascertained using nails photography, the Nail Psoriasis Severity Index (NAPSI) and patient satisfaction.

RESULTS: Seventeen completed the study. Three participants withdrew from the study because of treatment-associated pain. Treatment was associated with a statistically significant improvement of the NAPSI scale (p < .002). Patient satisfaction was high.

CONCLUSION: Combined PDL and fractional ablative CO2-LADD of betamethasone-calcipotriol gel should be considered for the treatment of nail psoriasis.

PMID:33795567 | DOI:10.1097/DSS.0000000000002835

Am J Clin Oncol. 2021 Apr 1. doi: 10.1097/COC.0000000000000817. Online ahead of print.

ABSTRACT

OBJECTIVES: Low-dose computed tomography (LDCT) screening is an important tool for reducing lung cancer mortality. This study describes a single center’s experience with LDCT and attempts to identify any barriers to compliance with standard guidelines.

MATERIALS AND METHODS: This is a retrospective review of a single university-based hospital system from 2015 to 2019. All individuals who met eligibility for lung cancer screening were entered into a database. The definition of adherence with the screening program was determined by the recommended timeline for the follow-up LDCT. Cohorts were split by adherence and demographics were compared.

RESULTS: A total of 203 LDCTs were performed in 121 patients who met eligibility for LDCT and had appropriate surveillance from 2015 to 2019. The average age was 64 years old. The overall adherence rate for prescribed LDCTs was 59.1%. Patients with Lung-RADS score 2 had 2.43 times higher odds of adherence relative to patients with Lung-RADS score 1 (odds ratio [OR]=2.43; 95% confidence interval [CI]: 1.23-4.83; P=0.011). African American patients had 42% lower odds of adherence relative to white patients (OR=0.58; 95% CI: 0.32-1.06; P=0.076). Patients with non-District of Columbia zip codes had 57% higher odds of adherence relative to those with District of Columbia zip codes, although this did not reach statistical significance (OR=1.57; 95% CI: 0.87-2.82; P=0.136).

CONCLUSIONS: Despite the implementation of a multidisciplinary, academic LDCT screening program, overall adherence rate to prescribed follow-up scans was suboptimal. Socioeconomic disparities and African American race may negatively affect adherence to lung cancer screening LDCT guidelines. Patients with concerning findings on initial LDCT had a higher association of adherence to guidelines.

PMID:33795600 | DOI:10.1097/COC.0000000000000817

J Strength Cond Res. 2021 Mar 31. doi: 10.1519/JSC.0000000000004022. Online ahead of print.

ABSTRACT

Thomas, C, Dos’Santos, T, Warmenhoven, J, and Jones, PA. Between-limb differences during 180° turns in female soccer players: application of statistical parametric mapping. J Strength Cond Res XX(X): 000-000, 2021-This study was exploratory in nature and investigated the ability of statistical parametric mapping (SPM) to assess between-limb differences in lower-extremity movement change of direction. Fourteen female soccer players (mean ± SD; age = 20.6 ± 0.6 years; height = 1.65 ± 0.07 m; and body mass = 56.04 ± 6.20 kg). For comparisons between preferred and nonpreferred limbs, vertical (Fz) and horizontal (Fx) ground reaction force were determined along with hip, knee, and ankle angles and moments in the sagittal plane during weight acceptance during the final contact. In addition, frontal plane knee abduction angles and moments were calculated during the final contact. Statistical parametric mapping software was then used to assess for differences between the entire weight acceptance phase of preferred and nonpreferred limbs. There were no differences between limbs in all variables using SPM. These results demonstrate that female soccer players exhibit little side-to-side differences in certain lower-limb biomechanics when performing a turn maneuver. These findings can be utilized by practitioners and clinicians when developing injury prevention and rehabilitation programs.

PMID:33795602 | DOI:10.1519/JSC.0000000000004022

Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2023141118. doi: 10.1073/pnas.2023141118.

ABSTRACT

Subclasses of lymphocytes carry different functional roles to work together and produce an immune response and lasting immunity. Additionally to these functional roles, T and B cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens. The lymphocyte subclasses emerge from common ancestors generated with the same diversity of receptors during selection processes. Here, we leverage biophysical models of receptor generation with machine learning models of selection to identify specific sequence features characteristic of functional lymphocyte repertoires and subrepertoires. Specifically, using only repertoire-level sequence information, we classify CD4⁺ and CD8⁺ T cells, find correlations between receptor chains arising during selection, and identify T cell subsets that are targets of pathogenic epitopes. We also show examples of when simple linear classifiers do as well as more complex machine learning methods.

PMID:33795515 | DOI:10.1073/pnas.2023141118

Vasc Specialist Int. 2021 Mar 31;37(1):29-36. doi: 10.5758/vsi.210003.

ABSTRACT

PURPOSE: Native arteriovenous fistula (AVF) is the first choice for hemodialysis access; however, the maturation failure rate remains high. Hence, balloon-assisted maturation (BAM) is increasingly being used to overcome maturation failure. This study evaluated the outcomes of BAM and compared the differences between radial-cephalic (RC) and brachial-cephalic (BC) AVF.

MATERIALS AND METHODS: Between January 2013 and December 2017, 1,622 new AVFs were created. BAM was considered if the AVF did not satisfy the criteria for hemodynamic maturation (6-mm diameter and 500-mL/min flow rate within 8 weeks after the operation).

RESULTS: Of the 1,622 AVFs, BAM was performed in 142 patients (8.75%). There were 92 RC and 50 BC AVFs. Multivariate analyses revealed that ipsilateral central vein catheter history was the sole risk factor for maturation failure after BAM. Oneyear functional primary patency (FPP) and functional secondary patency (FSP) in RC AVFs were higher than those in BC AVFs without statistical significance (FPP, RC vs. BC: 70.9% vs. 50.9%, P=0.099; FSP, 95.5% vs. 81.1%, P=0.146). Further, based on the multivariate analysis, the independent risk factors for FPP in the RC and BC AVFs were the number of BAMs (odds ratio [OR], 3.05; 95% confidence interval [CI], 1.11-8.37; P=0.03) and age (OR, 1.04; 95% CI, 1.00-1.07; P=0.04), respectively.

CONCLUSION: BAM is a relatively good salvage method with tolerable patency. However, the risk factors for patency and the outcomes of BAM differ between RC and BC AVFs.

PMID:33795551 | DOI:10.5758/vsi.210003

Dermatol Surg. 2021 Apr 1;47(4):462-466. doi: 10.1097/DSS.0000000000002787.

ABSTRACT

BACKGROUND: Preoperative patient screening has been evaluated in many surgical specialties as a way to improve the overall patient experience. Current data are limited regarding patient screening for dermatologic procedures. The goal of preoperative screening is to identify patients at risk for poor outcomes and tailor the treatment plan to ensure a greater overall patient experience.

OBJECTIVE: To investigate the association between psychological comorbidities and acute postoperative pain in patients treated with Mohs micrographic surgery (MMS).

MATERIALS AND METHODS: Subjects were recruited from a single center, single provider, uniformed service MMS practice, and asked to complete preoperative and postoperative questionnaires for scheduled MMS. Outcome variables included anticipated pain, actual pain after MMS, duration of pain, and medications used for pain.

RESULTS: Mohs micrographic surgery was well tolerated. There were no significant differences in anticipated or reported pain, or in medication use between cohorts. Significant differences in pain were noted with closure technique with complex surgical repairs generating the greatest pain across groups.

CONCLUSION: Mohs micrographic surgery is well tolerated by patients, both with and without psychological comorbidities. Our results show no statistically significant differences, suggesting a limited role for preoperative screening as a tool to guide pain management after MMS.

PMID:33795564 | DOI:10.1097/DSS.0000000000002787

Dermatol Surg. 2021 Apr 1;47(4):e106-e110. doi: 10.1097/DSS.0000000000002815.

ABSTRACT

BACKGROUND: Wide excision (WE) is generally considered to be the most common treatment for recurrent hidradenitis suppurativa. When performed, excision is followed by decisions regarding best options for management of the surgical defect. Different reconstructive strategies (RSs) have been used, with varying rates of recurrence.

OBJECTIVE: To provide an up-to-date systematic review of the complete literature for different RS after WE and their recurrence rates.

METHODS: A systematic literature search of the complete available literature and a meta-analysis of proportions were performed on the included studies.

RESULTS: Of a total of 1,813 retrieved articles, 79 were included in the analysis. Most were retrospective analyses, with only one randomized controlled trial (RCT) and 7 prospective analyses. The RS described were divided into primary closure (PC), secondary intention healing (SIH), skin graft (SG), and fasciocutaneous flaps (FCF). The average estimated recurrence for PC was 22.0% (95% confidence interval [CI], 8.0%-40.0%), for SIH 11.0% (95% CI, 5.0%-20.0%), for SG 2.0% (95% CI, 0.0%-5.0%), and for FCF 2.0% (95% CI, 1.0%-5.0%) (p < .001). Hidradenitis suppurativa below the umbilicus was significantly associated with overall recurrence (p = .006). Quality of evidence was poor, and the reporting of results was mostly heterogeneous.

CONCLUSION: After WE, PC has the highest recurrence rates, whereas SG and FCF have the lowest rates. There is a need for more RCTs and guidelines, to be able to report uniformly on treatment outcomes.

PMID:33795566 | DOI:10.1097/DSS.0000000000002815

Saudi Med J. 2021 Apr;42(4):411-418. doi: 10.15537/smj.2021.42.4.20200674.

ABSTRACT

OBJECTIVES: To determine the relationship between fear of falling (FOF) and upper extremity muscle strength.

METHODS: This cross-sectional study included 112 hospitalized, mobile patients. Forty-seven (42%) were males and 65 (58%) were females, and the mean age was 72.3. The study was carried out between September 2018 and September 2019 at Balikli Rum Hospital Nursing Homes, Istanbul, Turkey. Patients were tested using geriatric tools (such as Mini-Mental State Examination) and physical tests such as handgrip, key pinch and 6-meter up and go tests.

RESULTS: The average annual falling number of elderly people with FOF was statistically significantly higher than that in those without FOF (p=0.001). Right handgrip, left handgrip, right key pinch, and left key-pinch mean values in elderly individuals with FOF were statistically significantly lower than those without FOF (p< 0.001, p< 0.001, p< 0.001, p< 0.001, respectively).

CONCLUSION: The measurement of upper extremity strength could be a predicting parameter of FOF.

PMID:33795497 | DOI:10.15537/smj.2021.42.4.20200674

Saudi Med J. 2021 Apr;42(4):419-427. doi: 10.15537/smj.2021.42.4.20200630.

ABSTRACT

OBJECTIVES: To assess the prevalence and characteristics of Autism Spectrum Disorder (ASD)-affected children attending autistic centers in 2 major cities in Saudi Arabia.

METHODS: A cross-sectional study, including ASD centers and schools (37 centers) in Makkah and Jeddah, Saudi Arabia was conducted between January and March 2020. Data were collected from records and parents of children with ASD using a questionnaire on sociodemographic, family history, consanguinity, severity, and maternal risk factors.

RESULTS: All centers in Makkah and Jeddah participated, with a total of 1,023 ASD children. The prevalence of ASD was 2.618 per 1,000 children for Jeddah, 3.68 per 1,000 children for Makkah and 2.81 per 1,000 children for both Jeddah and Makkah. There was no statistically significant relationship between the severity of ASD and sociodemographic, family and maternal risk factors. However, there was statistically significant relationship between severe ASD and ASD family history (p=0.029, OR: 3.46 and 95% CI 1.14 to 10.5).

CONCLUSIONS: The prevalence of ASD in Makkah and Jeddah was lower than the global prevalence of ASD. Individuals with a family history of ASD were more likely to have more severe ASD.

PMID:33795498 | DOI:10.15537/smj.2021.42.4.20200630