Tag: nevin manimala

Rev Esc Enferm USP. 2021 Jul 26;55:e03757. doi: 10.1590/S1980-220X2020019503757. eCollection 2021.

ABSTRACT

OBJECTIVE: To analyze factors associated with diabetic foot risk in patients with diabetes mellitus assisted in Primary Care.

METHOD: Observational, analytic, and transversal study took place in Teresina, Piauí, with diabetic patients who are assisted in Primary Care. Data collection took place through interviews, foot clinical exams, and medical record analysis. We used the Mann-Whitney, Pearson’s Chi-square and multiple logistic regression statistics tests to analyze the data. The association power among categorical variables was measured by Odds Ratio .

RESULTS: 322 patients participated. Marital status with a partner presented a protection factor (p = 0.007). Risk factors for the development of the diabetic foot are: arterial hypertension (p = 0.045), obesity (p = 0.011), smoking (p = 0.027), not being submitted to follow ups (p = 0.046), inadequate control of capillary blood glucose (p < 0.001), indisposition to the care of the foot (p=0.014), and foot self-exam less frequently (p = 0.040).

CONCLUSION: Sociodemographic, clinical, and self-care aspects interfere in diabetic foot development, highlighting the necessity of effective follow up tracking and educational interventions for patients with diabetes mellitus in Primary Care.

PMID:34320142 | DOI:10.1590/S1980-220X2020019503757

Rev Bras Enferm. 2021 Jul 26;74(6):e20210044. doi: 10.1590/0034-7167-2021-0044. eCollection 2021.

ABSTRACT

OBJECTIVE: to analyze the relationship between exposure to workloads and presenteeism among nursing workers in the socio-environmental context of university hospitals.

METHOD: this is a quantitative, cross-sectional and analytical study with 355 nursing workers from two university hospitals in southern Brazil. Data were collected from November 2019 to February 2020. The Workload Scale in Nursing Activities and the Work Limitations Questionnaire were used. Descriptive statistics, variance analysis and Pearson’s correlation test were used.

RESULTS: there was a significant correlation between chemical loads and time management; biological loads and time management, physical demand and productivity loss; physiological loads and mental and interpersonal demand, production demand and loss of productivity; psychological loads and production demand.

CONCLUSIONS: there is a relationship between workloads and nursing presenteeism, verified by limitations and loss of productivity.

PMID:34320145 | DOI:10.1590/0034-7167-2021-0044

Codas. 2021 Jul 23;33(5):e20200174. doi: 10.1590/2317-1782/20202020174. eCollection 2021.

ABSTRACT

PURPOSE: To identify and correlate vocal fatigue and voice-related quality of life in university professors and verify possible differences between genders.

METHODS: This is a cross-sectional, observational, and analytical study approved by the Research Ethics Committee of the institution under number 1,708,786. The Voice Fatigue Index (VFI) and the Voice Related Quality of Life (VRQOL) were applied to 126 university professors, 71 women and 55 men, with an average age of 43 years. Scores were calculated using the formula for each protocol and statistical analysis was performed using Spearman’s Correlation.

RESULTS: Regarding the VFI, the average score found for factors 1, 2 and 3 were 13.78, 4.05 and 7.93, respectively. As for VRQOL, professors had an average global score of 91.90; 88.49 for the physical domain and 97.02 for the socioemotional domain. There was a negative weak to strong correlation between the protocols. There was no statistical difference between genders for both VFI and VRQOL.

CONCLUSION: University professors have good levels of voice related quality of life, but self-reported vocal fatigue, with no differences between genders. The lower the vocal fatigue is, the higher is the voice related quality of life, and vice versa.

PMID:34320139 | DOI:10.1590/2317-1782/20202020174

Codas. 2021 Jul 23;33(5):e20200197. doi: 10.1590/2317-1782/20202020197. eCollection 2021.

ABSTRACT

PURPOSE: To analyze which method of judgment, auditory- perceptual (PAJ) of audios or perceptual-visual judgment (PVJ) (ultrasound images), is more sensitive to detect gradual productions between the class of deaf coronal fricatives and check if there is a correlation between these forms of judgment.

METHOD: Audio and video files of language ultrasound (LUS) related to the production of the words “frog” and “key”, of 11 children, between 6 and 12 years old, with atypical speech production, were selected from a bank data and edited for judgments. After instruction and prior training, 20 judges should choose, immediately upon presentation of the stimulus (auditory or visual), one of three options arranged on the computer screen. In PAJ the options were: correct, incorrect or gradient production, while in PVJ the options were images corresponding to the production of [s], [∫] or undifferentiated. The presentation time of the stimuli and the reaction time were automatically controlled by the PERCEVAL software.

RESULTS: PVJ provided a higher percentage of identification of gradient stimuli and a shorter reaction time in performing the task compared to PAJ, both statistically significant. Spearman’s correlation test did not show statistical significance between PAJ and PVJ responses, nor for reaction time.

CONCLUSION: PVJ using US images proved to be the most sensitive method for detecting gradient production in the production of fricatives [s] and [∫], and can be used as a complementary method to PAJ in speech analysis.

PMID:34320140 | DOI:10.1590/2317-1782/20202020197

Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2303-2310. doi: 10.31557/APJCP.2021.22.7.2303.

ABSTRACT

INTRODUCTION: Women undergoing breast cancer treatment experience a number of changes, including loss or deformity of one or both breasts, surgical wounds, skin changes, and weight gain. These changes are very closely related to physical appearance and body image and often lead to reduced mental health, marital quality and psychological stress. Objective: This study aimed to determine the effect of Good Enough Sex (GES) model-based counseling intervention on the body image in women surviving breast cancer.

PATIENTS AND METHODS: This randomized clinical trial was a kind of quantitative study with control group carried out on 100 women (50 women in the intervention group and 50 women in the control group) who randomly entered into the study after completing the informed consent form. The intervention included 4 sessions of 120-190 minute sexual counseling with 2 and 3 months follow-up. The data were collected consisting of demographic characteristics and disease-related information, Body Image Scale (BIS) and analyzed using ANOVA repeated measures.

RESULTS: The results showed a statistically significant difference between the mean of body image in the intervention and control groups (P <0.001).

CONCLUSION: The educational and counseling intervention program based on a socio-psychological model was effective in improving the body image among women surviving breast cancer. The inclusion of educational and counseling programs in service centers in this regard has an effective role in the reproductive health of women with breast cancer.

TRIAL REGISTRATION: Registration of trial protocol has been approved in Iranian registry of clinical trials (IRCT20120609009975N8, https://en.irct.ir/trial/42030, ethical code; IR.TUMS.FNM.REC.1396.4865).<br />.

PMID:34319056 | DOI:10.31557/APJCP.2021.22.7.2303

Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2267-2272. doi: 10.31557/APJCP.2021.22.7.2267.

ABSTRACT

BACKGROUND: Acute myeloid leukemia (AML) is a malignancy arising within the bone marrow (BM), in which leukemic cells proliferate uncontrollably in association with a disruption of normal hematopoiesis.Aim of the work to evaluate the expression of LCN and BCL2L2, in newly diagnosed bone marrow samples from adult with AML and to correlate their expression levels with clinical and Laboratory data of the patients especially that known to have a prognostic feature.

METHODS: This study was carried out on 87 consecutive newly diagnosed adult AML patients of which 75 are evaluated for both LCN, BCL2L12 (All 87 are evaluated for LCN). In addition, 20 donors of matched age and sex healthy individuals from donors for bone marrow transplantation were included as a control group.

RESULTS: No statistical significant correlation was found between LCN over-expression and the control group , there was no statistical significance between its expression and age, sex, hepatomegally, splenomegally and lymphadenopathy, also there was no statistical significance regarding peripheral blood and bone marrow findings, immunophenotyping, cytogenetics or molecular findings and MRD at day 15.No statistical significance was found between BCL2L12 expression and the control group again there was no statistical significance between its expression and age, sex, hepatomegally, splenomegally and lymphadenopathy, also there was no statistical significance regarding peripheral blood and bone marrow findings, immunophenotyping, cytogenetics or molecular findings and MRD at day 15.

CONCLUSION: LCN and BCL2L12 were found to be expressed with non significant difference in AML as in normal subjects; however studies on large number of cases are needed to confirm our finding. The role of LCN and BCL2L12 need to be verified by further large-scale sample and further studies.<br />.

PMID:34319051 | DOI:10.31557/APJCP.2021.22.7.2267

Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2279-2288. doi: 10.31557/APJCP.2021.22.7.2279.

ABSTRACT

BACKGROUND: Three molecular pathways are described as the genetic basis of colorectal tumorigenesis. Among these, microsatellite instability (MSI) has shown greatest promise in serving as a biomarker to determine disease aggression by tumour biology, recurrence, and response to chemotherapy.

METHODOLOGY: This prospective observational pilot study included patients of colorectal cancers, in a population subset coming to a tertiary care hospital in northern India, who were operated with curative or palliative intent over a period of one year and followed up for a maximum of 55 months. The post-operative pathological assessment was done for MSI status using PCR technique, and an attempt was made to evaluate its correlation with conventional clinical and histological parameters, early recurrences, disease-free survival and overall survival in comparison to MSS type tumours in sporadic cases of colorectal malignancies.

RESULTS: Out of 38 patients of colorectal cancer, 26 were included in the study. Male to female ratio was 7:6 (n=14:12). Mean age of presentation was 48±14.2 years. Incidence of MSI was n=4 (15.4%). On subgroup analysis, age of presentation (p=0.044) and evidence of perineural invasion (p=0.017) was found to have significant statistical association with MSI tumour biology. Recurrence was seen in seven of the seventeen patients who previously had no synchronous or metastatic disease (41.2%). The mean disease-free survival for MSS was 21.32 months and was 25.25 months for MSI group which was statistically insignificant (p = 0.277). Out of four MSI tumour biology patients one was alive and without recurrence at 47 months. While the other two were alive and without recurrence till 27 months of follow-up. Conclusion: Age and perineural invasion showed statistically significant association with MSI tumour biology. Due to the small sample size statistical significance was not established with site, recurrence rate, DFS and OS.

PMID:34319053 | DOI:10.31557/APJCP.2021.22.7.2279

Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2135-2141. doi: 10.31557/APJCP.2021.22.7.2135.

ABSTRACT

BACKGROUND: Visual inspection methods for cervical cancer screening are widely used in low resource settings. Fluorescent sodium could improve accuracy of cancer screening. This study aimed to assess diagnostic accuracy of fluorescein sodium (FNa) to detect cervical neoplasia.

METHODS: Seventy consecutive patients referred for colposcopy were enrolled prospectively. Acetic acid, Lugol’s iodine, and FNa were used sequentially. Biopsies were taken from all abnormal areas. If there was no obvious abnormality, two random biopsies and endocervical curettage were done. Reference standard was the highest grade lesion on cervical biopsy with a threshold of CIN2+. The patterns of each staining agent were recorded as absent, faint, or distinct. Diagnostic accuracy estimates with 95% confidence intervals were calculated. Correlation between the various tests were also determined using the kappa statistic.

RESULTS: There were 27 cases of CIN2+ (38.6%). The sensitivity of any fluorescence for CIN2+ was 82% (62, 94) and for distinct fluorescence was 59% (39, 78). The specificity was 65% (49, 79) for any fluorescence and 95% (84, 99) for distinct fluorescence, the same as for Swede score > 7. For any fluorescence, the positive likelihood ratio was 2.34 (1.5, 3.65) and the negative likelihood ratio was 0.28 (0.13, 0.65). For distinct fluorescence, the positive likelihood ratio was 12.74 (3.18, 51.1) and the negative likelihood ratio was 0.43 (0.27, 0.68). There was moderate correlation between FNa and the other tests.

CONCLUSION: Distinct fluorescence with FNa was very specific, low cost, and easy to perform and may contribute to confirm CIN2+ disease.

PMID:34319036 | DOI:10.31557/APJCP.2021.22.7.2135

Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2237-2241. doi: 10.31557/APJCP.2021.22.7.2237.

ABSTRACT

OBJECTIVE: The aim of the study is to analyse the Immuno-histochemical expression of Ki-67 and P16INK4a in CIN and cervical cancer cases and their utility to determine the accuracy of histological diagnosis and prediction of biological behavior of cervical lesion.

METHODOLOGY: A retrospective cross-sectional study was carried in 110 numbers of cervical biopsy that included 25 CIN1, 21 CIN2, 12 CIN3, 26 SCC and 01 adenocarcinoma and 25 non neoplastic lesion. The tissue sections were stained with Ki-67 and P16INK4a.

RESULTS: Ki-67 expression was seen in 55.5% (61/110) cases of cervical lesion., out of which 3.6% (4/110; cervicitis -2/110 and metaplasia-2/110) cases were non dysplaia, 51.8% (57/110) cases were dysplasia /CIN of varying grade including invasive cancer. P16INK4a expression was noted 51.8% (57/110). There was an increasing trend of the intensity of Ki-67 and P16INK4a from focal positivity in low grade lesion to diffuse intensity in higher grade lesion and is statistically significant. There was strong association between the two variables Ki-67 and P16INK4a positive cases with their histologic grade.

CONCLUSION: Though histopathology remains the ”gold standard” for the diagnosis of CIN, both low and high-grade, biomarkers like Ki-67 and P16INK4a have emerged as helpful adjuncts. Their combined use may assist in the histopathologic classification of preinvasive lesions and facilitate the distinction from nondysplasia.

PMID:34319047 | DOI:10.31557/APJCP.2021.22.7.2237

Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2243-2249. doi: 10.31557/APJCP.2021.22.7.2243.

ABSTRACT

BACKGROUND: Papanicolaou test is widely used to screening cervical cancer but low attend rate. There is one mountainous area found high participation rate.

OBJECTIVE: This study aimed to determine the factors associated with successful Pap test among Lahu hill tribe women.

MATERIALS AND METHODS: The quantitative cross-sectional study was used in this study. Data were collected from 650 Lahu hill tribe women by simple random sampling. The interview forms with reliability coefficient and validity of 0.78 and 0.91 were administered to participants. The data were analyzed by using descriptive statistics and Chi-square test.

RESULTS: The 96.15% of the Lahu hill tribe women had taken Pap test and 74.31% obtained the screening more than once. The contraceptive use and frequency of Pap test obtaining significantly associated with cervical cancer screening (p <0.001). The participants showed good level of knowledge in cervical cancer and the screening test (64.31% and 76.46% respectively). Most of participants received the cervical cancer disease information (87.17%) and screening information (66.92%) from health care professionals, which may influence on well cervical screening co-operation. Conclusions: The suitable health promotion model should provide to promote knowledge, attitude and motivate continuous cooperation in cervical cancer screening among hill tribe women.

PMID:34319048 | DOI:10.31557/APJCP.2021.22.7.2243