Tag: nevin manimala

Orthop Nurs. 2021 May-Jun 01;40(3):182-188. doi: 10.1097/NOR.0000000000000758.

ABSTRACT

General anesthesia, prolonged immobilization, and pain may adversely affect pulmonary function in patients undergoing prosthetic surgery. The aim of this study was to evaluate the effect of balloon-blowing exercises on pulmonary functions in patients undergoing total hip arthroplasty. The patients in the experimental group performed three sets of balloon-blowing exercises in the morning, at noon, and in the evening on the first to third days postoperatively. The increase in forced vital capacity (FVC) values between the control and experimental groups in the postoperative period was statistically significant (p < .001), in favor of the experimental group. The increase in forced expiratory volume during the first second (FEV1)/FVC ratio was found to be significantly higher in the experimental group than in the control group (p < .001). Patients who performed balloon-blowing exercises increased their FVC and FEV1/FVC ratio.

PMID:34004618 | DOI:10.1097/NOR.0000000000000758

Forensic Sci Int. 2021 May 7;324:110823. doi: 10.1016/j.forsciint.2021.110823. Online ahead of print.

ABSTRACT

Calls for blind proficiency testing in forensic science disciplines intensified following the 2009 National Academy of Sciences report and were echoed in the 2016 report by the President’s Council of Advisors on Science and Technology. Both practitioners and scholars have noted that “open” proficiency tests, in which analysts know they are being tested, allow for test-taking behavior that is not representative of behavior in routine casework. This study reports the outcomes of one laboratory’s blind quality control (BQC) program. Specifically, we describe results from approximately 2.5 years of blind cases in the latent print section (N = 376 latent prints submitted as part of 144 cases). We also used a widely available quality metrics software (LQMetrics) to explore relationships between objective print quality and case outcomes. Results revealed that nearly all BQC prints (92.0%) were of sufficient quality to enter into AFIS. When prints had a source present in AFIS, 41.7% of print searches resulted in a candidate list containing the true source. Examiners committed no false positive errors but other types of errors were more common. Average print quality was in the midpoint of the range (53.4 on a 0-to-100 scale), though prints were evenly distributed across the Good, Bad, and Ugly categories. Quality metrics were significantly associated with sufficiency determinations, examiner conclusions, and examiner accuracy. Implications for blind testing and the use of quality metrics in routine casework as well as proficiency testing are discussed.

PMID:34004529 | DOI:10.1016/j.forsciint.2021.110823

Sci Total Environ. 2021 May 6;787:147554. doi: 10.1016/j.scitotenv.2021.147554. Online ahead of print.

ABSTRACT

Antibiotic levels in black-odor water could reflect the usage amount of antibiotics in population. On the other hand, these antibiotics are the source of antibiotics in the environmental water. Currently, researches on antibiotics in black-odor sediments are still lacking. In this study, 174 black and odor sediment samples from 74 cities in 28 provinces in China were collected for analysis. Among 44 targeted antibiotics, 13 antibiotics were detected in more than 30% of sediment samples. Fluoroquinolones and tetracyclines were the predominant antibiotics in these field samples, with average concentrations of up to 2074 and 1902 ng/g dry weight (dw), respectively, followed by macrolides (87.9 ng/g dw), lincosamides (8.06 ng/g dw) and sulfonamides (8.38 ng/g dw). High antibiotic contamination levels were almost always detected in black-odor sludges from economically less developed small cities; however, the difference in antibiotic concentrations between well-developed and small cities in China was not statistically significant. In addition, among the seven regions within China, no significant difference in concentrations was observed for the most antibiotics. Variances in antibiotic composition patterns in the 28 provinces of China may be due to differences in bacterial resistance, prescription habits, efficacy, and sediment carbon concentrations among various regions. There were significant positive correlations among some antibiotics in the same or different classes.

PMID:34004531 | DOI:10.1016/j.scitotenv.2021.147554

Sci Total Environ. 2021 May 11;787:147671. doi: 10.1016/j.scitotenv.2021.147671. Online ahead of print.

ABSTRACT

A dedicated extremely low frequency (ELF) detector has been constructed and used successfully for Schumann Resonance (SRs) measurements in N.W. Greece. The main objective of this work was to investigate the effect of local lightning activity on the signal of our ELF detector and consequently on the estimated SRs parameters, namely the power, the frequency and the quality factor of each mode. Therefore, several measurements were taken into account for the ELF signal continuously recorded and the lightning intensity in a specific range around the ELF detector. Additionally, a simple filtering technique was used, in order to reject the distorted SRs spectra. The statistical analysis performed showed a positive and statistically significant correlation between the lightning events and the recorded magnetic component of the ELF signal. It was found that local lightnings have a significant impact on the SRs measurements, and it is necessary to be removed from the background signal.

PMID:34004542 | DOI:10.1016/j.scitotenv.2021.147671

Atherosclerosis. 2021 Apr 27;327:5-12. doi: 10.1016/j.atherosclerosis.2021.04.009. Online ahead of print.

ABSTRACT

BACKGROUND AND AIMS: The association between hysterectomy and cardiovascular disease (CVD) remains controversial and research focusing on different types of CVD, especially ischemic heart disease, is scant.

METHODS: This observational study was conducted with the National Health and Nutrition Examination Survey (NHANES) 2007-2018 using propensity score matching, propensity score overlap weighting, and logistic regression.

RESULTS: Among 15,257 women, 3476 (22.78%) had hysterectomy. Compared with non-hysterectomized women, hysterectomized women are more likely to be older, obese, with lower education level, and lower annual family income. Less favorable outcomes often occurred in unadjusted analysis. In adjusted, matched, and weighted analyses, the associations between hysterectomy and all outcomes were consistent, including ischemic heart disease (OR_unadjusted = 3.18[95%CI, 2.76-3.66]; OR_adjusted = 1.38[95%CI, 1.09-1.73]; OR_matched = 1.37[95%CI, 1.07-1.75]; OR_weighted = 1.38[95%CI, 1.12-1.71]), coronary heart disease (OR_unadjusted = 3.31[95%CI, 2.71-4.05]; OR_adjusted = 1.43[95%CI, 1.04-1.98]; OR_matched = 1.46[95%CI, 1.04-2.05]; OR_weighted = 1.45[95%CI, 1.06-1.99]), heart attack (OR_unadjusted = 3.04[95%CI, 2.51-3.68]; OR_adjusted = 1.47[95%CI, 1.09-1.99]; OR_matched = 1.42[95%CI, 1.03-1.95]; OR_weighted = 1.45[95%CI, 1.10-1.91]) and angina pectoris (OR_unadjusted = 3.29[95%CI, 2.66-4.08]; OR_adjusted = 1.34[95%CI, 0.95-1.89]; OR_matched = 1.30[95%CI, 0.91-1.87]; OR_weighted = 1.33[95%CI, 0.98-1.81]). In hysterectomized women, there were no significant associations between bilateral ovariectomy and ischemic heart disease (OR_unadjusted = 1.24[95%CI, 0.99-1.54]; OR_adjusted = 1.05[95%CI, 0.80-1.38]; OR_matched = 1.16[95%CI, 0.86-1.55]; OR_weighted = 0.93[95%CI, 0.68-1.27]), female hormones use and ischemic heart disease (OR_unadjusted = 0.94[95%CI, 0.76-1.16]; OR_adjusted = 0.81[95%CI, 0.62-1.07]; OR_matched = 0.89[95%CI, 0.66-1.20]; OR_weighted = 1.14[95%CI, 0.88-1.49]).

CONCLUSIONS: Hysterectomy may increase the risk of ischemic heart disease, especially for coronary heart disease and heart attack, but not for angina pectoris. As for the hysterectomized women, bilateral ovariectomy and female hormones use do not affect ischemic heart disease.

PMID:34004485 | DOI:10.1016/j.atherosclerosis.2021.04.009

Neurobiol Aging. 2021 Apr 22;105:16-24. doi: 10.1016/j.neurobiolaging.2021.04.005. Online ahead of print.

ABSTRACT

Intracranial arteriosclerosis has been increasingly recognized as a risk factor for cognitive impairment and even dementia. A possible mechanism linking intracranial arteriosclerosis to cognitive impairment and dementia involves structural brain changes including cerebral small vessel disease (CSVD). To assess whether intracranial carotid artery calcification (ICAC) and vertebrobasilar artery calcification (VBAC), as proxies for intracranial arteriosclerosis, are related to CSVD. Within the population-based Rotterdam Study, between 2003 and 2006 a computed tomography (CT)-based measurement of ICAC and VBAC and at least one magnetic resonance imaging (MRI) measurement of structural brain changes were performed from 2005 onwards in 1,489 participants. To estimate the burden of calcification independent of age, we computed age-adjusted percentile curves for ICAC and VBAC separately, based on the calcification volumes. Using the longitudinal MRI data, we assessed whether a larger calcification burden accelerates structural brain changes using appropriate statistical models for repeated outcome measures. A larger burden of ICAC and VBAC was associated with an increase of CSVD markers accelerating over time. A larger burden of ICAC and VBAC was not significantly (p > 0.05) associated with accelerated brain atrophy. Arteriosclerosis is related to accelerating structural brain changes over time.

PMID:34004492 | DOI:10.1016/j.neurobiolaging.2021.04.005

Respir Med. 2021 May 4;184:106441. doi: 10.1016/j.rmed.2021.106441. Online ahead of print.

ABSTRACT

AIM: to investigate the relation of pulmonary function impairment with mortality and the possible mediation by low-grade inflammation in a general adult population.

METHODS: A prospective investigation was conducted on 14,503 individuals from the Moli-sani study (apparently free from lung disease and acute inflammatory status at baseline; 2005-2010). The 2012 Global Lung Function Initiative percent predicted (% pred) value of forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% of FVC (FEF25-75) and FEV1 quotient (FEV1Q) index were used. C-reactive protein and blood cell counts were measured and a score of subclinical inflammation (INFLA-score) was calculated.

RESULTS: Over a median follow-up of 8.6y, 503 deaths (28.9% cardiovascular) were ascertained. Total mortality increased by 19% for each decrease in 1 standard deviation of FEV1% pred or FVC% pred (Hazard Ratio:1.19; 95% CI:1.11-1.28 and 1.19; 1.10-1.28, respectively). Comparable findings for FEV1Q (1.30; 1.15-1.47) were observed. A statistically significant increased risk in cardiovascular mortality of 23%, 32% and 49% was observed for 1 standard deviation decrease of FEV1% pred, FVC% pred and FEV1Q, respectively. INFLA-score mediated the association of FEV1% pred and FEV1Q with cardiovascular mortality by 22.3% and 20.1%, respectively. Subjects with FEV1, FVC lower than normal limit showed increased risk both in total and cardiovascular mortality. Abnormal FEF25-75 values were associated with 33% (1.33; 1.02-1.74) total mortality risk.

CONCLUSIONS: Obstructive lung function impairment was associated with decreased survival. Low-grade inflammation mainly mediated the association of FEV1 with cardiovascular mortality.

PMID:34004499 | DOI:10.1016/j.rmed.2021.106441

Am J Emerg Med. 2021 May 5;48:255-260. doi: 10.1016/j.ajem.2021.04.085. Online ahead of print.

ABSTRACT

PURPOSE: To determine if aztreonam as initial empiric treatment of adult septic shock is associated with increased mortality compared to the use of anti-pseudomonal beta-lactam agents.

METHODS: This was a multicenter, retrospective cohort study of 582 adult emergency department patients admitted to 12 acute care facilities within a single health system from January 2014 to December 2017 with septic shock receiving either aztreonam or an anti-pseudomonal beta-lactam for empiric treatment and discharged with an infection-related ICD-9 or ICD-10 code. The primary endpoint was in-hospital mortality.

RESULTS: Initial exposure to aztreonam was associated with increased hospital mortality compared to treatment with an anti-pseudomonal beta-lactam agent (22.7% vs. 12.9%, OR = 1.98, 95% CI: 1.27-3.11). When adjusted for APACHE II score, the treatment group effect on mortality remained statistically significant (OR = 1.74, 95% CI: 1.08-2.80). Aztreonam use was also associated with increased utilization of aminoglycosides (28.9% vs. 12.4%, p < 0.0001) and fluoroquinolones (50.5% vs. 25.8%, p < 0.01). There was no difference in hospital or intensive care unit length of stay in surviving patients between the two groups.

CONCLUSIONS: Compared to anti-pseudomonal beta-lactams, empiric treatment with aztreonam is associated with increased mortality and greater antibiotic exposure among patients with acute septic shock. These findings suggest that treatment with anti-pseudomonal beta-lactams should be prioritized over allergy avoidance whenever feasible.

PMID:34004470 | DOI:10.1016/j.ajem.2021.04.085

Nutrition. 2021 Apr 20;90:111273. doi: 10.1016/j.nut.2021.111273. Online ahead of print.

ABSTRACT

OBJECTIVE: Promising evidence suggests beneficial health effects of arabinogalactan, but little is known about the effect of this non-digestible carbohydrate on the gut microbiota, a crucial mediator of human health. The objective of this study was to investigate the effect of an arabinogalactan product (ResistAid) on the fecal microbiome and short-chain fatty acids and gastrointestinal tolerance in healthy adults in a randomized, double-blind, crossover trial.

METHODS: Thirty adults were randomly assigned to consume 15 g/d maltodextrin (control) or ResistAid for 6 wk.

RESULTS: At week 6, compared to placebo, ResistAid supplementation led to a significant decrease in the ratio of fecal Firmicutes to Bacteroidetes, driven by an increase in Bacteroidetes and a decrease in Firmicutes. Moreover, the relative abundance of Bifidobacterium tended to increase with ResistAid supplementation. Additionally, ResistAid significantly decreased the α-diversity of the fecal microbiome. Predicted functional abundances based on 16S rRNA sequences showed that ResistAid supplementation increased the gene abundance of the gut microbiome for α-l-rhamnosidase, β-fructosidase, and levanase, as well as tricarboxylic acid and vitamin B₆ biosynthesis pathways. Fecal isovaleric, valeric, and hexanoic acids were significantly lower after ResistAid consumption. There were no statistically significant changes in bowel habit, stool consistency, gastrointestinal tolerance symptoms, chemistry profile, metabolic panel, or vitals, suggesting that consumption of 15 g daily ResistAid over 6 wk is safe.

CONCLUSION: These results demonstrate that the gut microbiome composition and predicted functions can be modulated by ResistAid consumption, perhaps suggesting a mechanistic explanation on its reported benefits in metabolic parameters and the immune system.

PMID:34004416 | DOI:10.1016/j.nut.2021.111273

Int J Nurs Stud. 2021 Apr 24;119:103949. doi: 10.1016/j.ijnurstu.2021.103949. Online ahead of print.

ABSTRACT

BACKGROUND: Sexual and reproductive health of young people is an international concern with the increasing interest in healthy pregnancy and childbirth. mHealth interventions involve the use of mobile technologies for health support, have wide applications in clinical nursing practice, and play an increasingly important role in disseminating sexual and reproductive health-related information in emerging adulthood. However, there is a lack of evidence on the effects of mHealth intervention programs.

OBJECTIVES: This meta-analysis systematically assessed the effects of mHealth interventions on contraceptive use and pregnancy occurrence in emerging adulthood to identify the characteristics of a successful mHealth intervention program.

DESIGN: We conducted a systematic review and meta-analysis of randomized controlled trials.

DATA SOURCES: Four central electronic databases (PubMed, Embase, CINAHL complete, and the Cochrane Library) were searched for relevant articles published from inception to May 2020.

REVIEW METHODS: Data extraction and quality appraisal were performed independently by two reviewers. Eleven papers on the effects of mHealth interventions on sexual and reproductive health in emerging adulthood were selected. The included studies were assessed for the risk of bias with the Risk of Bias 2 (RoB 2) tool. Overall and subgroup meta-analyses were conducted using STATA 16.0. Heterogeneity within studies was calculated using I².

RESULTS: We tested the effect of mHealth interventions on contraceptive use and pregnancy occurrence to identify the impact of sexual and reproductive health. mHealth interventions improved the use of contraception (OR 1.21; 95% CI: 1.02-1.43, I² = 20.7%; p = 0.234) although the effect on pregnancy occurrence was not significant (OR 0.80, 95% CI: 0.61-1.05, I² = 0.0%, p = 0.950). In subgroup analysis, mHealth interventions especially improved oral contraceptive use (OR 1.43, 95% CI: 1.15-1.77, I² = 0.0%, p = 0.784). Regarding the communication type, two-way communication showed statistically significant results with the mHealth intervention in the experimental group (OR 1.28, 95% CI: 1.06-1.54, I² = 0.0%, p = 0.872).

CONCLUSION: This meta-analysis found a positive effect of mHealth intervention on contraception, whereas the impact on pregnancy occurrences was limited. We also confirmed the factors underlying effective mHealth interventions from the results of our review. Our findings demonstrate that mHealth interventions may be suggested as a useful strategy to promote sexual and reproductive health in emerging adulthood.

PMID:34004469 | DOI:10.1016/j.ijnurstu.2021.103949