Tag: nevin manimala

Arch Gynecol Obstet. 2023 Nov 6. doi: 10.1007/s00404-023-07253-9. Online ahead of print.

ABSTRACT

PURPOSE: To investigate the association of minimal levator ani hiatus area with age in female adults without pelvic floor dysfunction.

METHODS: 532 female subjects aged 18 ~ 90 years without pelvic floor dysfunction, divided into four groups (Group A, 18 ~ 29 years old; Group B, 30 ~ 39 years old; Group C, 40 ~ 49 years old; Group D, ≥ 50 years old) based on age, underwent traditional pelvic two-dimensional (2D) T2-weighted imaging (T2WI) axial to the body (AxB) for measuring the minimal levator ani hiatus area. 39 female volunteers were re-recruited to undergo both traditional pelvic 2D T2WI AxB and three-dimensional (3D) T2WI. An axial plane parallel to the direction of the puborectalis muscle (AxPRM) was acquired based on 3D T2WI. The difference of levator ani hiatus area measured on AxB and AxPRM images in 39 female volunteers was compared by one-sample t test, to verify if minimal levator ani hiatus area can be acquired on the traditional pelvic 2D T2WI AxB images. Spearman analysis evaluated the association of minimal levator ani hiatus area with age and the rank-sum test analyzed the area differences among four age groups.

RESULTS: Female age was positively correlated with minimal levator ani hiatus area (r = 0.23; p < 0.001). The minimal levator ani hiatus areas of 532 subjects were: 15.17 ± 1.77 cm² in Group A, 15.52 ± 2.21 cm² in Group B, 16.03 ± 2.16 cm² in Group C, and 16.40 ± 2.10 cm² in Group D. ANOVA showed significant statistical differences among four age groups (F = 7.519, p < 0.0001). Significant differences in minimal levator ani hiatus areas were found between Group A and Group C (p = 0.0491), Group A and Group D (p = 0.0007), and Group B and Group D (p < 0.001). There was no statistical difference in minimal levator ani hiatus areas measured on AxB and AxPRM images in 39 female volunteers (p = 0.1000). There were no statistical difference in minimal levator ani hiatus areas between nulliparous and multiparous group for each age group (all p > 0.05).

CONCLUSIONS: Based on a large sample, this study summarized the minimum levator ani hiatus area of female adults without pelvic floor dysfunction in different age groups. We found significant differences among different age groups. In addition, a positive correlation was found between age and the minimum levator ani hiatus area. These findings can provide reference criteria for diagnosing pelvic organ prolapse in female adults of different age groups.

PMID:37926730 | DOI:10.1007/s00404-023-07253-9

Schizophr Res. 2023 Nov 3;262:67-75. doi: 10.1016/j.schres.2023.10.012. Online ahead of print.

ABSTRACT

INTRODUCTION: Social functioning is often impaired during the ultra-high risk (UHR) phase for psychosis, but group-level studies regarding the role of social functioning in transition to psychosis are inconsistent. Exploring the inter-individual differences which underlie the association between social functioning and psychotic symptoms in this phase could yield new insights.

OBJECTIVE: To examine the idiographic and dynamic association between social activation and suspiciousness in individuals at UHR for psychosis using time-series analysis.

METHODS: Twenty individuals at UHR for psychosis completed a diary application every evening for 90 days. Two items on social activation (quantity: ‘time spent alone’ and quality: ‘feeling supported’) and two items on suspiciousness (‘feeling suspicious’ and ‘feeling disliked’) were used. Time series (T = 90) of each individual were analyzed using vector auto regression analysis (VAR), to estimate the lagged (over 1 day) effect of social activation on suspiciousness, and vice versa, as well as their contemporaneous associations.

RESULTS: Heterogeneous person-specific associations between social activation and suspiciousness were found in terms of strength, direction and temporal aspects.

CONCLUSIONS: The association between social activation and suspiciousness differs amongst individuals who are at UHR for psychosis. These findings underline the importance of tailoring psychosocial interventions to the individual. Future studies may examine whether using results of single-subject studies in clinical practice to personalize treatment goals leads to better treatment outcomes.

PMID:37925753 | DOI:10.1016/j.schres.2023.10.012

Schizophr Res. 2023 Nov 3;262:60-66. doi: 10.1016/j.schres.2023.10.017. Online ahead of print.

ABSTRACT

Schizophrenia is associated with early mortality of 15 to 20 years, and 80 % of deaths are due to cardiovascular disease with a three-times greater risk of sudden-cardiac-death. While lifestyle, medications, genetics, and healthcare disparities are contributing factors, the etiology of this complex process is not fully understood. The aim of this study is to examine cardiac-related healthcare utilization and electrocardiogram (ECG) outcomes in schizophrenia at the end of life (EOL). A cohort of individuals with schizophrenia (SG) (n = 610, ≥50 years) were identified retrospectively from a unified clinical data platform and measures of cardiovascular healthcare utilization were evaluated within a 12-month period prior to death. Similarly, a control group (n = 610) was randomly identified and matched by gender (53 % females) and age of death (72.8 ± 12.4 years). Statistical methods included Cochran-Mantel-Haenszel and mixed-effects logistic & linear regression tests with adjustments for match strata and marital status, race, age, and gender as covariates. Results indicate that SG was more likely to be unmarried, unemployed, or from minority groups (all p < 0.001), and more likely to have diabetes and/or cardiovascular disease (p < 0.001). SG was less likely to receive an ECG (p = 0.001) or cardiac catheterization procedure (p < 0.001). SG had a greater mean QTc (447.2 ms vs. 434.6 ms; p = 0.001) and were twice as likely to have “prolonged QT” on ECG report (p = 0.006). In conclusion, SG had reduced likelihood of cardiac-related healthcare interventions, and despite greater likelihood of prolonged QTc, a recognized biomarker of cardiac risk, ECG was less likely at EOL. Given greater cardiac comorbidity and risk of sudden cardiac death in schizophrenia, improved practice guidelines are needed.

PMID:37925752 | DOI:10.1016/j.schres.2023.10.017

Sex Health. 2023 Nov 6. doi: 10.1071/SH23093. Online ahead of print.

ABSTRACT

BACKGROUND: School-based sexuality education is a core component of securing young people’s right to attain health equity regarding sexual and reproductive health and rights. This paper aims to explore how perceived knowledge (sufficient or insufficient) of taking care of one’s sexual health is associated with knowledge gained from school-based sexuality education and social determinants.

METHODS: The data material is drawn from a population-based survey conducted in Sweden in 2015. The survey had 7755 respondents and a response rate of 26%. To explore the aim descriptive statistics and logistic regression models were used.

RESULTS: Our results show that perceived insufficient knowledge from school-based sexuality education was associated with higher odds of reporting not being able to take care of one’s sexual health. The highest significant excess risk for insufficient knowledge was found among young people from sexual minorities.

CONCLUSIONS: Young people in Sweden do not have equal abilities to receive knowledge needed to take care of their sexual health and thus attain sexual health literacy. There is an unequal distribution of perceived knowledge, and LGBTQI+ youth particularly face barriers in using school-based sexuality education as a resource for sexual health literacy.

PMID:37925747 | DOI:10.1071/SH23093

Phys Rev Lett. 2023 Oct 20;131(16):166701. doi: 10.1103/PhysRevLett.131.166701.

ABSTRACT

Under certain boundary conditions, the square ice model exhibits a phase separation in which the core of the system is disordered while its outer region remains ordered. This phenomenon, known as the “arctic circle,” has been studied theoretically in combinatorial mathematics and statistical mechanics. Here, we realize the physics of the arctic circle experimentally for the first time, using a programmable lattice of superconducting qubits, and investigate its properties under the prism of a highly frustrated magnet. Our work reveals two unexpected properties. First, the disordered spin manifold confined within the arctic curve is a spin liquid whose average spin texture resembles that of an antivortex, i.e., it is a topologically charged Coulomb phase. Second, monopole quasiparticle excitations, which are totally absent in theoretical works, can be isolated in a phase-separated system. Remarkably, a monopole segregation mechanism is observed, in which the monopoles are sorted according to the magnetic charge and magnetic moment they carry, without the application of an external driving force.

PMID:37925737 | DOI:10.1103/PhysRevLett.131.166701

Phys Rev Lett. 2023 Oct 20;131(16):160601. doi: 10.1103/PhysRevLett.131.160601.

ABSTRACT

We introduce a method that allows one to infer many properties of a quantum state-including nonlinear functions such as Rényi entropies-using only global control over the constituent degrees of freedom. In this protocol, the state of interest is first entangled with a set of ancillas under a fixed global unitary, before projective measurements are made. We show that when the unitary is sufficiently entangling, a universal relationship between the statistics of the measurement outcomes and properties of the state emerges, which can be connected to the recently discovered phenomeonon of emergent quantum state designs in chaotic systems. Thanks to this relationship, arbitrary observables can be reconstructed using the same number of experimental repetitions that would be required in classical shadow tomography [Huang et al., Nat. Phys. 16, 1050 (2020)NPAHAX1745-247310.1038/s41567-020-0932-7]. Unlike previous approaches to shadow tomography, our protocol can be implemented using only global Hamiltonian evolution, as opposed to qubit-selective logic gates, which makes it particularly well suited to analog quantum simulators, including ultracold atoms in optical lattices and arrays of Rydberg atoms.

PMID:37925705 | DOI:10.1103/PhysRevLett.131.160601

J Phys Chem Lett. 2023 Nov 5:10166-10172. doi: 10.1021/acs.jpclett.3c02823. Online ahead of print.

ABSTRACT

Single-molecule spectroscopy (SMS) is a unique and competent technique to study molecule dynamics and sense biomolecules precisely. The design of an ultrahigh-stability single fluorophore probe with excellent photostability and long-lived dark transient states for single-molecule fluorescence microscopy is challenging. Here, we found that the photostability of bimetallic AuAg₂₈ nanoclusters is better than monometallic Ag₂₉ nanoclusters. The photon antibunching experiments unveiled exceptional brightness and remarkable photostability with high survival times of up to 218 s with minimal blinking. AuAg₂₈ NCs exhibited longer “on” times and shorter “off” times as compared to Ag₂₉ NCs. The statistical analysis was performed on at least 100 molecules that showed single-step photobleaching and almost a 5-fold enhancement in intensity on Au doping in Ag₂₉ NCs. The distinctive and tunable photophysics of metal NCs can offer huge potential in pushing single-molecule dynamic measurements to be carried out biologically.

PMID:37925663 | DOI:10.1021/acs.jpclett.3c02823

Paediatr Anaesth. 2023 Nov 4. doi: 10.1111/pan.14793. Online ahead of print.

ABSTRACT

BACKGROUND AND AIMS: Virtual reality has been shown to be an effective non-pharmacological intervention for reducing anxiety of pediatric patients. A newer immersive technology, that of augmented reality, offers some practical advantages over virtual reality, and also seems to show beneficial effects on anxiety. The main objective of this study was to determine whether augmented reality could reduce preoperative anxiety in pediatric patients undergoing elective day surgeries. A secondary outcome was to document the level of satisfaction from pediatric patients toward augmented reality intervention.

METHODS: Children and adolescents aged between 5 and 17 years old scheduled for elective day surgery under general anesthesia were randomly divided into two groups. Patients in the control group received standard care, whereas patients in the augmented reality group were accompanied by two virtual characters who taught them relaxation techniques and provided emotional and informational support. Anxiety was measured at the time of admission and at the time of induction using the short version of the modified Yale Preoperative Anxiety Scale.

RESULTS: The analysis included 37 pediatric patients in the augmented reality group and 64 in the control group. Anxiety scores were statistically significantly lower in the augmented reality group than those in the control group at the time of admission (median difference [95% CI]: 6.3 [0-10.4], p = .01), while no difference was observed between groups at the time of induction (median difference [95% CI]: -4.2 [-5.2-4.2], p = .58). Most patients in the augmented reality group wished to wear the glasses again and reported to be very satisfied with the intervention.

CONCLUSION: To our knowledge, this study is the first large randomized controlled trial to provide empirical evidence of reduction in anxiety for children and adolescents using augmented reality prior to induction of general anesthesia.

PMID:37925608 | DOI:10.1111/pan.14793

Spec Care Dentist. 2023 Nov 4. doi: 10.1111/scd.12939. Online ahead of print.

ABSTRACT

OBJECTIVE: This cross-sectional study analyzed the socio-psychological need for orthodontic treatment in children and adolescents with and without Autism Spectrum Disorder (ASD) and its association with deleterious oral habits.

METHODS: Children/adolescents aged 6-14 years old, with and without ASD, and their respective caregivers were included. Caregivers completed a questionnaire addressing children and adolescents’ deleterious oral habits. To assess the socio-psychological need for orthodontic treatment, we utilized the aesthetic component of the Index of Orthodontic Treatment Needs (IOTN). Caregivers and an orthodontist independently used the standardized IOTN aesthetic attractiveness scale containing ten intraoral photographs and compared them with the most similar condition of the child/adolescent. Data collection occurred at two universities in northeastern Brazil and at an ASD referral center. Statistical analyses encompassed descriptive statistics, Shapiro-Wilk, Kruskal-Wallis, Mann-Whitney, and Chi-squared tests with linear trend (α5%).

RESULTS: The study involved 144 participants, evenly divided into two groups (ASD and non-ASN). The ASD group showed higher average IOTN-AC scores as evaluated by both professionals (mean score = 4.78 [± 2.34], p = .182) and caregivers (mean score = 4.31 [± 2.71], p = .992). Caregivers reported notably elevated IOTN-AC scores in cases where onychophagy was absent (p = .049).

CONCLUSIONS: Patients with ASD are indicated as having a relatively higher socio-psychological need for orthodontic treatment.

PMID:37925601 | DOI:10.1111/scd.12939

Sci Rep. 2023 Nov 4;13(1):19070. doi: 10.1038/s41598-023-45531-3.

ABSTRACT

Migraine is a complex disorder with multigenic inheritance and is characterized by the cardinal symptom of unilateral headache. Many genes are responsible for increasing the susceptibility of disease within different populations. Therefore, our primary aim in this review was to catalog the many genes that have been studied in India and after collecting the necessary information, we calculated a more precise risk relationship between an identified variation and migraine. The gene and its associated risk variant were discovered in the Indian population using a PRISMA-based systematic literature review guideline from online databases such as PubMed & Google Scholar. We constructed pooled odds ratios with 95% confidence intervals using multiple genetic models. Also, we looked for heterogeneity using Cochran’s Q Test and the I2 statistic. Publication bias was analyzed using Begg’s and Egger’s tests. A p-value less than 0.05 was judged to be statistically significant for all tests. After a critical analysis, a total of 24 studies explored about 21 genes with 31 variants out of which only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis. It has been found, that the ACE-DD variant (allele model: OR: 1.37 [1.11-1.69], I² = 0%/ fixed model), ESR1-PvuII (allele model: OR: 1.47 [1.24-1.74], I² = 0%/ fixed model) significantly increases the risk of migraine in Indian population. Also, a protective role of the LRP1-rs11172113variant was observed for both migraine and its clinical subtype i.e., MA (allelic model: OR of 0.65 [0.50-0.83] I² = 44% and allele: OR: 0.54 [0.37-0.78], I² = 52%) respectively. Overall, the results of this meta-analysis indicated that the ACE-DD variant and the ESR1-PvuII were associated with an increased risk of migraine in the Indian community, while the LRP1-rs11172113 variant was associated with protection from migraine in this population.

PMID:37925562 | DOI:10.1038/s41598-023-45531-3