Tag: nevin manimala

Eur Neurol. 2021 Jul 29:1-10. doi: 10.1159/000517584. Online ahead of print.

ABSTRACT

BACKGROUND: Previous studies have shown inconsistent results for associations between vitamin D and risk of stroke. We gathered the existing published articles and conducted this meta-analysis with the aim to explore the association between vitamin D and risk of stroke.

METHODS: We searched for articles exploring the association between vitamin D and risk of stroke and published before April 2021 in the following databases: PubMed, Web of Science, MEDLINE, EMBASE, and Google Scholar. All statistical analyses were made using STATA 12.0 software. Q test and I2 were applied to examine heterogeneities between studies.

RESULTS: For the association between serum levels of 25(OH) vitamin D and risks of stroke, the present analysis included 20 cohort studies (including 213,276 participants) and a case-control analysis (including 13,642 participants). Additionally, the analysis included 15 studies (including 41,146 participants given vitamin D supplementation and 41,163 participants given placebo) to evaluate the influence of vitamin D supplementation on risk of stroke. Higher circulating levels of 25(OH) vitamin D were associated with a reduced risk of stroke (odds ratio/relative risk = 0.78, 95% confidence interval [CI]: 0.70-0.86, I2 = 41.5%, p = 0.025). However, the present analysis showed that vitamin D supplementation did not influence the risk of stroke (hazard ratio = 1.05, 95% CI: 0.96-1.14, I2 = 2.3%, p = 0.425).

CONCLUSIONS: Our analysis indicated that lower circulating level of vitamin D was associated with an elevated risk of stroke, but extra supplement of vitamin D failed to show benefit in decreasing the risk of stroke. Further research and study are also needed to show the role of vitamin D in relation to stroke.

PMID:34325429 | DOI:10.1159/000517584

ORL J Otorhinolaryngol Relat Spec. 2021 Jul 29:1-8. doi: 10.1159/000516592. Online ahead of print.

ABSTRACT

INTRODUCTION: Thyroglossal duct cysts (TGDCs) are the most common form of congenital neck cysts. They may become infected causing dysphagia or respiratory distress. Accordingly, the treatment is always surgical removal.

OBJECTIVES: The objectives of this article were to examine complications following TGDC excision by surgical specialty, demographics, and comorbid conditions.

METHODS: A retrospective review of the National Surgical Quality Improvement Program database was performed. Pediatric cases from January 1, 2014 to November 1, 2015 with a current procedure terminology code of 60,280 (excision of TGDC or sinus) were included. Statistical analysis was performed to assess associations between complications and surgical specialty, demographics, and comorbidities.

RESULTS: Of the 867 cases that met inclusion criteria, the median age was 4 years. There were 448 males (52.3%) and 408 females (47.7%). Thirty-six patients (4.2%) experienced at least one 30-day complication. The most predominant complications were reoperation (19 patients, 2.2%), readmission (18 patients, 2.1%), and surgical site infection (16 patients, 1.9%). There was no statistically significant difference between complications and surgical specialty. In those experiencing a complication, there was a statistically significant difference between males (86.1%) and females (13.9%). Of patients with at least one comorbidity, 36.67% had a complication, while 17.22% did not have a complication. There was also a statistically significant difference in the percentage of patients with a past medical history of asthma between those with at least one complication (16.67%) compared to those without any complications (4.76%).

CONCLUSIONS: excision is a generally safe procedure across surgical specialties. There is a higher complication rate in males compared to females as well as those with a history of at least one medical comorbidity and those with asthma. The most common 30-day complications are reoperation, readmission, and surgical site infection.

PMID:34325433 | DOI:10.1159/000516592

Curr Opin Pharmacol. 2021 Jul 26;60:34-39. doi: 10.1016/j.coph.2021.06.006. Online ahead of print.

ABSTRACT

Biophysically realistic computer modeling of neuronal microcircuitry has served as a testing ground for hypotheses related to the structure and function of different brain microcircuits. Recent advances in single-cell transcriptomics provide snapshots of a neuron’s molecular state and have demonstrated that cell-specific genetic markers engineer the electrophysiological properties of a neuron. Integrating these molecular details with biophysical modeling can allow unprecedented mechanistic insights. In this opinion review, we consider systems biology-based strategies involving statistical deconvolution and gene ontology to integrate the two approaches. We foresee that this integration will infer the nonlinear interactions between the transcriptomically detailed neurons in different brain states. For an initial assessment of these integrative strategies, we recommend testing them on a penetrant phenotype such as epilepsy or a basic organism model such as Caenorhabditis elegans.

PMID:34325379 | DOI:10.1016/j.coph.2021.06.006

Parkinsonism Relat Disord. 2021 Jul 24;90:8-14. doi: 10.1016/j.parkreldis.2021.07.021. Online ahead of print.

ABSTRACT

INTRODUCTION: Levodopa-induced dyskinesia is a complication of levodopa therapy and negatively impacts the quality of life of patients. We aimed to elucidate white matter alterations in Parkinson’s disease with levodopa-induced dyskinesia using advanced diffusion magnetic resonance imaging techniques.

METHODS: The enrolled subjects included 26 clinically confirmed Parkinson’s disease patients without levodopa-induced dyskinesia, 25 Parkinson’s disease patients with levodopa-induced dyskinesia, and 23 healthy controls. Subjects were imaged using a 3-T magnetic resonance scanner. Diffusion tensor imaging, diffusion kurtosis imaging, and neurite orientation dispersion and density imaging findings were compared between groups with a group-wise whole brain approach and a region-of-interest analysis for each white matter tract. Additionally, logistic regression analysis was used to calculate odds ratios for levodopa-induced dyskinesia.

RESULTS: Group-wise tract-based spatial statistical analysis revealed significant white matter differences in isotropic diffusion, complexity, or heterogeneity, and neurite density between healthy controls and Parkinson’s disease patients without levodopa-induced dyskinesia and between patients with and without levodopa-induced dyskinesia. Region-of-interest analysis revealed similar alterations using a group-wise whole-brain approach in the external capsule, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus. These tracts had an odds ratio of approximately 2.3 for the presence of levodopa-induced dyskinesia.

CONCLUSIONS: Our findings suggest that Parkinson’s disease with levodopa-induced dyskinesia produces less white matter microstructural disruption, especially in temporal lobe fibers, than Parkinson’s disease without levodopa-induced dyskinesia. These fibers has a more than 2-fold odds ratio for the presence of levodopa-induced dyskinesia and might be associated with the pathogenesis of the sequela.

PMID:34325387 | DOI:10.1016/j.parkreldis.2021.07.021

Lung Cancer. 2021 Jul 17;159:111-116. doi: 10.1016/j.lungcan.2021.07.003. Online ahead of print.

ABSTRACT

OBJECTIVE: The association between the morphological characteristics and survival outcome of lung cancer associated with cystic airspaces (LCCAs) is unclear due to rarity of this disease. The current study attempted to compare the survival outcome between LCCAs and non-LCCAs and investigate the correlation between imaging features and prognosis of LCCA.

METHOD: Of 10,835 patients diagnosed with non-small cell lung carcinoma (NSCLC) between January 2015 and December 2016, 123 patients with LCCA were included. The non-LCCA group comprised 3136 patients with primary solitary adenocarcinoma or squamous cell lung cancer. Propensity score matching (PSM) was performed for age, sex, tumor size, tumor stage, and lymph node involvement in a 1:1 ratio between the LCCAs and non-LCCAs, and the correlation between radiological features and recurrence-free survival (RFS) was analyzed.

RESULT: The computed tomography (CT) lesion size was found to be higher in all LCCA subtypes, particularly in Type III (a cystic airspace with a mural nodule) and Type IV (mixed) LCCAs (3.09 and 3.65 cm, respectively), than in non-LCCAs (2 cm) after PSM. Three-year RFS in the LCCA group was higher than in the non-LCCA group (Type I- IV LCCAs: 100%, 84%, 77% and 83%, respectively vs. non-LCCAs: 77%). However, statistically significant difference was only found in comparison between LCCA Type I (thin-walled) and non-LCCA groups (P = 0.026). Type III lung cancer exhibited the worst survival among all four LCCA subtypes.

CONCLUSIONS: The CT lesion size and pathologic tumor size varied significantly across LCCAs. Type I LCCAs exhibited better survival than non-LCCAs, whereas Type III LCCAs exhibited the worst survival rate among the four LCCA subtypes.

PMID:34325317 | DOI:10.1016/j.lungcan.2021.07.003

Clin Neurol Neurosurg. 2021 Jul 10;208:106818. doi: 10.1016/j.clineuro.2021.106818. Online ahead of print.

ABSTRACT

OBJECTIVE: The aim of the study is to compare the efficacy and safety of angioplasty alone with acute stenting for acute tandem occlusions (TO) due to internal carotid artery atherosclerotic.

METHODS: We identified 112 patients who underwent an endovascular treatment (EVT) for acute tandem internal carotid artery occlusions from the prospectively maintained registries 5 comprehensive stroke centers. The study cohort included 75 patients with underlying atherosclerotic lesion of the extracranial internal carotid artery, forty-five in the balloon angioplasty (BA) alone group and 30 in the acute stenting (AS) group. Using propensity score matching analysis, forty-four patients were matched. Clinical characteristics and outcome data were compared between two groups.

RESULTS: The successful reperfusion immediately post procedure [72.7% (16/22) vs. 77.3% (17/22), P = 1.0] and 90-days good functional outcome [54.5% (12/22) vs. 59.1% (13/22), P = 0.761] were not significantly different between the BA group and AS group. There was also no significant difference in the rate of symptomatic intracranial hemorrhage [13.6% (3/22) vs. 9.1% (2/22), P = 1.00] and restenosis of ICA (>50%)[27.3% (6/22) vs. 22.7% (5/22), P = 0.728] between 2 groups. Patients in the BA group appear to have a numerically lower rate of asymptomatic intracranial hemorrhage [40.9% (9/22) vs. 50% (11/22), P = 0.545] and mortality [0 vs. 9.1% (2/22), P = 0.488] than in the AS group, although there were not statistically significant.

CONCLUSION: Among TO patients with etiology of large vessel atherosclerosis, no statistical differences in outcome are identified between balloon angioplasty alone versus acute stenting. Future randomized controlled trials are warranted.

PMID:34325333 | DOI:10.1016/j.clineuro.2021.106818

J Mech Behav Biomed Mater. 2021 Jun 26;122:104654. doi: 10.1016/j.jmbbm.2021.104654. Online ahead of print.

ABSTRACT

AIM: The aim of this study was to evaluate the fracture resistance of cervical lesion centered access cavity restored with short glass fibre reinforced resin materials in human mandibular premolars.

MATERIALS AND METHODS: Sixty freshly extracted human mandibular premolars were collected and assigned to positive control group (G1- Intact teeth) and other experimental groups (G2, G3. G4, G5, G6), Traditional Access Cavity(TAC) and Cervical Lesion Centered Access Cavity(CLCAC). Following endodontic therapy, samples were grouped accordingly, G2-CLCAC without restoration (Negative Control), G3-CLCAC restored with conventional nano-hybrid composite (Tetric-N-Ceram), G4-TAC restored with short glass fibre reinforced resin composite (Ever-X Posterior), G5-CLCAC restored with short glass fibre reinforced resin composite (Ever-X Posterior), G6- CLCAC restored with individually formed unidirectional fibre-reinforced post (Everstick post) and short glass fibre-reinforced resin composite (Ever-X Posterior). The samples were thermocycled (35 °C/28s, 15 °C/2s, 35 °C/28s, 45 °C/2s/10,000 cycles) and cyclically fatigued(2,50,000 cycles/15-30N/2 Hz) and then subsequently loaded to failure. The mean load to fracture (Newtons) were statistically analyzed using one-way ANOVA and Tukey’s post HOC test and failure mode analysis was also done.

RESULTS: The mean fracture resistance of the CLCAC design restored with fibre reinforced materials was higher when compared to the TAC design but the difference was not statistically significant. The negative control group (CLCAC without restoration) showed significantly the least fracture resistance (P < 0.05) when compared to all the other groups except for group 3 (CLCAC restored with conventional composites).

CONCLUSIONS: Within the limitations of the study, it can be concluded that short glass fibre reinforced resin composites improved the fracture resistance of endodontically treated mandibular premolars irrespective of the type of access cavity designs. Favourable fractures were seen more in cervical lesion centered access cavity restored with short glass fibre reinforced composite materials. Nevertheless, the applicability of this design in multirooted teeth, canal cleanliness efficacy, and long term clinical performance are yet to be explored to complement this new access design.

PMID:34325237 | DOI:10.1016/j.jmbbm.2021.104654

J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jul 3;1179:122820. doi: 10.1016/j.jchromb.2021.122820. Online ahead of print.

ABSTRACT

Untargeted metabolomics approach based on ultra high performance liquid chromatography coupled with high resolution mass spectrometry (UHPLC-HRMS) was used to investigate the differences in cage duck eggs and sea duck eggs that from different poultry breeding system, which could help to combat fraud within the egg industry. High dimensions and complex data collected by UHPLC-HRMS were analyzed by multivariate statistical analysis. Identification model of sea duck eggs based on was established. After matching with the chemical databases, four potential markers were putatively matched. Further analysis showed that three of them were confirmed by reference standards. All these three markers (n-behenoyl-d-erythro-sphingosine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and n-nervonoyl-d-erythro-sphingosine) have higher content in sea duck eggs. The quantitative analysis showed that the content difference of three markers in farm samples were in highly consistent with the concentration changes measured in experimental samples, which indicate that these three markers are reliable.

PMID:34325310 | DOI:10.1016/j.jchromb.2021.122820

J Environ Radioact. 2021 Jul 26;237:106704. doi: 10.1016/j.jenvrad.2021.106704. Online ahead of print.

ABSTRACT

The source term of ¹³⁷Cs from the Fukushima Dai-ichi Nuclear Power Station (FDNPS) accident was estimated from the results of local-scale atmospheric dispersion simulations and measurements. To confirm the source term’s validity for reproducing the large-scale atmospheric dispersion of ¹³⁷Cs, this study conducted hemispheric-scale atmospheric and oceanic dispersion simulations. In the dispersion simulations, the atmospheric-dispersion database system Worldwide version of System for Prediction of Environmental Emergency Dose Information (WSPEEDI)-DB and oceanic dispersion model SEA-GEARN-FDM that were developed by the Japan Atomic Energy Agency were used. Compared with the air concentrations of ¹³⁷Cs measured by the Comprehensive Nuclear-Test-Ban Treaty Organization, overall, the WSPEEDI-DB simulations well reproduced the measurements, whereas the simulation results partly overestimated some measurements. Furthermore, the validity of the deposition of ¹³⁷Cs by WSPEEDI-DB was investigated using SEA-GEARN-FDM and concentrations of ¹³⁷Cs in seawater sampled from the North Pacific. Seawater concentrations of ¹³⁷Cs by the oceanic dispersion simulation, in which the deposition flux of ¹³⁷Cs by WSPEEDI-DB was used as input from the atmosphere to oceans, were statistically consistent to the measurement. However, the simulated seawater concentrations of ¹³⁷Cs were underestimated regionally in the North Pacific. Both the overestimation of air concentrations and underestimation of seawater concentrations could be attributed to the less amounts of ¹³⁷Cs deposition by less precipitation over the North Pacific. The overestimation and underestimation could be improved without contradiction between the air and seawater concentrations of ¹³⁷Cs using more realistic precipitation in atmospheric dispersion simulations. This shows that the source term validated in this study could reproduce the spatiotemporal distribution of ¹³⁷Cs from the FDNPS accident in both local and large-scale atmospheric dispersion simulations.

PMID:34325219 | DOI:10.1016/j.jenvrad.2021.106704

Comput Biol Med. 2021 Jul 22;136:104679. doi: 10.1016/j.compbiomed.2021.104679. Online ahead of print.

ABSTRACT

BACKGROUND: The appearance of high-density root obturating materials, such as gutta-percha and intracanal posts, on cone-beam computed tomography (CBCT) scans is substantially different from that seen in the specimen. This study evaluated the effectiveness of different CBCT software in the reduction of blooming artifacts when examining teeth with intracanal posts.

METHOD: The sample included 42 human single-rooted teeth with two types of posts: G1 – low-fusion alloy posts; G2 – gold alloy posts. CBCT scans were obtained using two scanners, PreXion 3D Elite® and Carestream 9000C 3D®. First, the posts were measured using a digital micrometer (standard reference, control). Post diameters were determined using the Blooming Artifact Reduction (BAR) tool of the e-Vol DX software and of the PreXion3D Image Analysis System. Statistical data were evaluated using the van Der Waerden nonparametric analysis of variance and, after that, normalized data were analyzed using the Tukey test. The level of significance was set at α = 5 %.

RESULTS: There were no significant differences (p > 0.05) between the diameters of intracanal posts on the CT scans when the e-Vol DX was used, or when these results were compared with those obtained using a micrometer. There were significant differences in post diameters determined using the PreXion3D Image Analysis System when compared with the e-Vol DX and the micrometer values (p < 0.05).

CONCLUSIONS: The use of the e-Vol DX BAR filter eliminated blooming artifacts. There were no dimensional changes in the CBCT images of the low-fusion and gold alloy intracanal posts using the e-Vol DX BAR filter.

PMID:34325229 | DOI:10.1016/j.compbiomed.2021.104679