Tag: nevin manimala

BMC Psychol. 2025 Jun 5;13(1):615. doi: 10.1186/s40359-025-02927-2.

ABSTRACT

BACKGROUND: One of the problems of infertility is damage to the genital self-image, which is one of the essential components of sexual health and is associated with sexual satisfaction and all dimensions of sexual function. Recently, narrative therapy has been used to treat a wide range of sexual disorders and marital incompatibility. The present study aimed to determine the effect of online narrative therapy on the genital self-image and sexual satisfaction of infertile women.

METHODS: This randomized controlled trial was conducted with 64 women with infertility, who were selected through the convenience sampling method from gynaecologists with infertility fellowship and family physician clinics. Genital self-image score and sexual satisfaction of the participants were evaluated using the Female Genital Self-Image Scale (FGSIS) and the Hudson sexual satisfaction questionnaire, respectively. The participants were randomly assigned to two narrative therapy and control groups of 32 women using the RANDBETWEEN software. The intervention group received five sessions of weekly 90-minute online narrative therapy sessions using the WhatsApp platform, and the control group received routine care. The data of the two groups, before the intervention, immediately after, and 45 days after the completion of the intervention, were collected and assessed. SPSS version 22 software and statistical tests such as Mann-Whitney U, Friedman, Bonferroni test, and repeated measures ANOVA were used for data analysis.

RESULTS: The Mann-Whitney U test showed that the mean score of the genital self-image in infertile women in the intervention and control groups showed no significant differences before the intervention (p = 0.312). The study results immediately and 45 days after the intervention demonstrated significant differences regarding the mean score of genital self-image compared to the control group (p < 0.001). In addition, according to the Bonferroni test, the mean sexual satisfaction score immediately and 45 days after the intervention had a significant difference from before the intervention (p < 0.001).

CONCLUSIONS: Online narrative therapy can be a suitable approach to improving genital self-image score and sexual satisfaction in infertile women.

TRIAL REGISTRATION: The protocol of this research was registered in the Iranian Registry of Clinical Trials (IRCT20161126031117N11) on 15/11/2021.

PMID:40474302 | DOI:10.1186/s40359-025-02927-2

Orphanet J Rare Dis. 2025 Jun 5;20(1):277. doi: 10.1186/s13023-025-03805-1.

ABSTRACT

Rare diseases present critical challenges to healthcare systems, patients, and caregivers due to their low prevalence and unique characteristics. Designing clinical trials and developing statistical methodologies for evaluating interventions in rare diseases face several challenges. The “EBStatMax” project, part of the European Joint Programme on Rare Diseases’ Demonstration Projects, aimed to address one of these challenges, namely: designing and analyzing longitudinal cross-over data in rare diseases, like Epidermolysis bullosa simplex (EBS). Although the main findings of the project have been published elsewhere, this manuscript reflects on additional hurdles encountered during the project, particularly regarding outcomes and methodological considerations. It explores issues surrounding outcome measurement, statistical methodology, and clinical considerations, emphasizing their broader relevance to methodological advancements in rare disease research beyond this specific case. This manuscript highlights the critical role of international collaboration in rare disease research to enhance evidence quality and aims to inspire further advancements in the field.

PMID:40474287 | DOI:10.1186/s13023-025-03805-1

Scand J Trauma Resusc Emerg Med. 2025 Jun 5;33(1):102. doi: 10.1186/s13049-025-01399-y.

ABSTRACT

BACKGROUND: Severe pelvic injuries with ISS > 15 is associated with a high degree of morbidity and mortality. We aimed to describe the demography, emergency interventions and outcome of patients with these injuries and analyze changes in practice occurring in this timeframe.

METHODS: Stavanger University Hospital (SUH) is located in South-Western Norway. All patients registered in the Stavanger University Hospital Trauma registry between 2004-2022 with a pelvic injury and concomitant ISS > 15 were included in this study.

RESULTS: In total 2283 patients with a pelvic injury were included in the trauma registry between 2004-2022. There were 160 patients with an ISS > 15, with 115 (72%) men and 45 (28%) women. Median age of men was 45 years, while women were slightly older at 52 years of age. The 30-day mortality in men (25/115) and women (10/45) was identical at 22%. Emergency intervention was performed in 33/160 (20.1%%) patients. In 27 patients a laparotomy, an EPP or an angioembolization was the primary hemostatic emergency procedure. All but one pelvic packing were done in the years 2010-2014, with one packing also performed in 2021. A significant decline both in number of patients receiving crystalloids and the amount of crystalloids administered, both prehospitally and in the ER were seen when comparing period 1-3. The mortality in the EPP group was very high at 6/8 (75%) while only 1/9 in the laparotomy group succumbed and 2/10 (20%) in the AE group. These discrepancies may be related to the high median ISS of 50 in the pelvic packing group, vs 40 in the angioembolization group vs 38 in the laparotomy group, reflected by a statistically significant difference in probability of survival (TRISS score) between emergency intervention groups (p < 0.001).

CONCLUSION: Severe pelvic injuries are quite rare, with about 1 incident per month. About 2/3 are men and transport related injuries are the most common mechanism of injury. Patients in need of emergency intervention are characterized by a high median ISS and concomitant high mortality. A significant decline in emergency interventions were seen over time, which may be related to declining infusions of crystalloids and better transfusion protocols.

PMID:40474283 | DOI:10.1186/s13049-025-01399-y

J Health Popul Nutr. 2025 Jun 5;44(1):190. doi: 10.1186/s41043-025-00785-7.

ABSTRACT

BACKGROUND: In this study, it was aimed to investigate whether engagement in healthy aging differs according to gender and whether the factors affecting the participation of men and women in healthy aging are different.

METHODS: The data of the cross-sectional study were collected between April-July 2024 with the participation of 381 elderly individuals through a questionnaire form. The questionnaire included a socio-demographic data form and the Engagement in Healthy Ageing Scale. The data of the study were analyzed using Standard Package of Statistical System package program 23. Descriptive statistics, t-test, Anova test and Forward Linear Regression analysis were used to evaluate the data.

RESULTS: Being female decreases the level of engagement in healthy ageing (OR = 3.220; CI:, -2.904/-0.702). Education status affects the level of engagement in healthy ageing in both men and women. In addition to educational level, income status, presence of COPD, musculoskeletal diseases and previous MI were found to be factors affecting engagement in healthy ageing in women.

CONCLUSIONS: Gender affects engagement in healthy ageing in individuals over 65 years of age. Gender differences should be taken into consideration in studies to be carried out for the promotion of healthy ageing. Public Health Programs should be carried out to increase physical activity in women and to rehabilitate chronic diseases.

PMID:40474265 | DOI:10.1186/s41043-025-00785-7

Biomed Eng Online. 2025 Jun 5;24(1):70. doi: 10.1186/s12938-025-01402-8.

ABSTRACT

BACKGROUND: Sedentary lifestyles can lead to musculoskeletal disorders, but proper sitting posture, particularly maintaining a slight anterior pelvic tilt, helps prevent issues like lower back pain and spinal misalignment. Samsung Electronics wearable robot ‘Bot Fit’ improves posture by enhancing core muscle tension, reducing trapezius muscle tension, and improving spinal alignment, which can alleviate pain and improve overall musculoskeletal health.

OBJECTIVE: This study was conducted to evaluate the effectiveness of Samsung’s wearable robot, ‘Bot Fit’, in promoting proper sitting posture.

METHODS: This study involved 37 participants, including healthy adults, elderly individuals. Participants were evaluated under two conditions, with and without the Bot Fit device, while seated on a Bobath table. Muscle tension, spinal angles, sitting height, and gluteal pressure distribution were measured under both conditions, and statistical analysis was conducted using paired t-tests with a significance level of p = 0.05.

RESULTS: Participants showed a significant increase in sitting height and rectus abdominis muscle tone, while upper trapezius muscle tone significantly decreased (p < 0.05). Additionally, hip pressure increased across all regions, and pressure differences between the left and right hips decreased significantly (p < 0.01).

CONCLUSION: Wearing the Bot Fit with its posture correction function improved muscle tone and sitting posture in adults and the elderly, potentially helping to prevent secondary musculoskeletal disorders from poor posture. Future research should explore the optimal torque settings of the Bot Fit based on individual factors like weight and gender.

PMID:40474262 | DOI:10.1186/s12938-025-01402-8

BMC Psychol. 2025 Jun 5;13(1):607. doi: 10.1186/s40359-025-02957-w.

ABSTRACT

BACKGROUND: Besides learning theoretical knowledge in class, participating in extracurricular activities is vital to students’ life development. Interpersonal trust is the basis for university students to establish a good social network. However, there is little discussion on the mechanism analysis that affects university students’ participation in the second classroom.

METHODS: To explore the impact of interpersonal trust on university students’ participation in extracurricular activities, this study uses self-acceptance and self-esteem as mediating variables to make it a complete chain mediation model. Through a sample survey of university students, the chain mediation model is used to analyze the data.

RESULTS: The results show that interpersonal trust, self-acceptance, and self-esteem significantly and positively impact university students’ participation in extracurricular activities. In the chain mediation model, interpersonal trust positively affects university students’ second-classroom participation through the sequential mediators of self-acceptance and self-esteem. This hypothesized pathway was statistically supported by robust model fit indices, including Akaike’s Information Criterion (AIC) and Bayesian Information Criterion (BIC), derived from structural equation modeling (SEM).

CONCLUSION: Universities should create an excellent interpersonal trust environment for students and cultivate their self-acceptance and self-esteem. Improving students’ participation in the second classroom is conducive to promoting university students’ physical and mental health and all-around development.

PMID:40474261 | DOI:10.1186/s40359-025-02957-w

Eur J Med Res. 2025 Jun 5;30(1):457. doi: 10.1186/s40001-025-02721-1.

ABSTRACT

OBJECTIVES: This study aims to investigate the application strategy of “single point-point pressure method” and multi-point injection techniques for carbon nanoparticle injection in laparoscopic radical resection of rectal cancer. The focus is on evaluating the efficacy and efficiency of both methods in sentinel lymph node mapping and tumor localization.

PATIENTS AND METHODS: A prospective analysis was conducted on a total of 119 rectal cancer cases treated our center from January 2020 to December 2021. The cases were divided into two groups: multi-point group and single-point group. In the multi-point group, multiple points of 1:1 diluted nano-carbon suspension were injected into the submucosa around the lesions. In the single-spot group, the tumor lesions were identified using electronic colonoscopy, followed by manual pressure applied to the corresponding abdominal wall. A single point of the stock solution of nano-carbon suspension was injected into the submucosa around the lesions upon observing the external pressure “bouncing sign” under the microscope.

RESULTS: No significant differences were observed between the multi-point group and the single-point group in terms of the number of detected lymph nodes, lesion location, distal resection margin (time to locate the tumor), carbon nanoparticles injection spatter event, operation time for middle and high rectal cancer, intraoperative blood loss, and postoperative exhaust time (P > 0.05). However, the injection time of nano-carbon and operation time for low rectal cancer were significantly shorter in the single point group, with statistically significant differences observed between the two groups (P < 0.05).

CONCLUSIONS: Identifying the distal resection margin clinically contributes to reducing operation time, simplifying surgical procedures, and enhancing efficiency. Sentinel lymph node mapping is crucial in colorectal cancer as it helps in accurate staging and treatment planning. This study aligns with previous research highlighting the effectiveness of carbon nanoparticles in improving lymph node detection and reducing operative time. In addition, this study contributes to the literature by demonstrating the efficiency of the “single point-point pressure method” in laparoscopic radical resection of rectal cancer, offering a simpler and faster alternative to multi-point injection techniques.

PMID:40474254 | DOI:10.1186/s40001-025-02721-1

BMC Psychol. 2025 Jun 5;13(1):614. doi: 10.1186/s40359-025-02880-0.

ABSTRACT

Positive psychological attributes, such as mindfulness, grit, and adaptability, have been increasingly recognized for their role in promoting mental health and academic success among students. However, the extent to which these traits influence emotional stability and protect against academic burnout remains understudied, particularly in undergraduate populations. This cross-sectional study aimed to address a gap in literature by examining the impact of positive psychological attributes on emotional stability, and academic burnout among undergraduate students. A sample of 275 undergraduate students from various disciplines across two public and two private universities in Lahore, Pakistan, completed validated self-report questionnaire. Data were analyzed employing descriptive statistics and structural equation modeling (PLS-SEM). Study findings showed that positive psychological attributes has significant associations with higher emotional stability and lower levels of academic burnout. Specifically, mindfulness and grit emerged as the strongest predictors of reduced academic burnout. Additionally, emotional stability partially mediated the relationship between positive psychological traits and academic burnout, highlighting its critical role in student well-being. These findings not only enrich the theoretical understanding of psychological resilience in academic contexts but also offer practical implications. Specifically, they suggest that enhancing emotional stability could be an effective strategy to reduce academic burnout and improve students’ sense of personal accomplishment. These insights hold implications for educational policies and mental health promotion programs in higher education settings.

PMID:40474250 | DOI:10.1186/s40359-025-02880-0

J Health Popul Nutr. 2025 Jun 5;44(1):189. doi: 10.1186/s41043-025-00931-1.

ABSTRACT

BACKGROUND: Childhood cancer is a growing public health concern in low- and middle-income countries (LMICs), where over two-thirds of global pediatric cancer cases occur. Despite advances in diagnosis and treatment, malnutrition remains a major barrier to achieving better outcomes. This study aimed to assess the magnitude of undernutrition and identify barriers to optimal nutrition among pediatric patients with cancer receiving treatment at a major referral hospital in Tanzania.

METHODS: Two study populations were recruited: pediatric patients with cancer and their primary caregivers. Children were assessed for undernutrition using anthropometric indicators, including mid-upper arm circumference, weight-for-age, height-for-age, body mass index-for-age Z-score, and triceps skinfold thickness. Nutritional biomarkers, including serum albumin, total protein, hemoglobin, and mean corpuscular volume, were also evaluated. Caregivers completed structured questionnaires adapted from the Hunger Vital Sign™ and the United Nations Food and Agriculture Organization Nutrition-related Knowledge, Attitude, and Practices Questionnaire to assess the risk of food insecurity and caregiver nutrition knowledge and perceptions. Binary logistic regression was used to explore predictors of undernutrition.

RESULTS: A total of 65 pediatric patients were enrolled, of whom 41.54% were classified as undernourished based on at least one anthropometric indicator below age-specific thresholds. Although 44.62% had low serum albumin and 30.77% had low total protein, these biomarkers may reflect overall illness rather than nutritional deficiency alone. Anemia was observed in 53.85% of children under 5 and 38.46% of those aged 5 and older. Logistic regression showed that undernutrition was more likely among children aged 5-10 and > 10 years compared to those < 5 years (OR: 1.80; 95% CI: 0.88-3.68; p = 0.109), while anemia showed an inverse and unexpected association (OR: 0.15; 95% CI: 0.02-1.44; p = 0.100); however, neither was statistically significant. The risk of food insecurity was identified in 78.4% of households. Caregivers not at risk demonstrated significantly better nutrition knowledge and more positive perceptions than those at risk.

CONCLUSION: Undernutrition is common among pediatric patients with cancer and may be influenced by clinical and socioeconomic factors, including anemia, caregiver knowledge, and household food insecurity.

TRIAL REGISTRATION: This study is not a clinical trial and does not require registration.

CLINICAL TRIAL NUMBER: not applicable.

PMID:40474244 | DOI:10.1186/s41043-025-00931-1

BMC Med Genomics. 2025 Jun 5;18(1):103. doi: 10.1186/s12920-025-02172-x.

ABSTRACT

PURPOSE: To investigate chromosomal instability (CIN) in tumor tissue from radical bladder resection and to evaluate whether it can be used as a biomarker for the molecular typing of (BC).

METHODS: DNA was extracted from formalin-fixed paraffin-embedded samples of 50 BC patients who were followed up to March 23 2023 using the Qiagen nucleic acid kits. We analyzed CIN in tumor of bladder by low-coverage whole genome sequencing (LC-WGS). Kaplan-Meier log-rank test was used to perform survival analysis. The association between variables and overall and progression-free survival was analyzed using the Cox proportional hazards model.

RESULTS: There were 44 genome segments with statistically significant changes in copy number. CIN was significantly correlated with tumor stage, lymph node metastasis, relapse and survival status. Patients with high CIN were found to have a worse survival, with a median overall survival (OS) of 15 months. In addition, patients with high CIN were more likely to relapse, with a median progression-free survival (PFS) of 7 months. Patients with low CIN showed better OS and PFS. However, there was no significant difference in OS and PFS between T2 and T3-T4 patients. Multivariate cox regression analysis showed that high CIN was an independent predictor of OS, and high CIN and muscle invasion were independent predictors of PFS. Furthermore, patients with abnormal copy number of a single chromosome also had a poor prognosis, with a median survival of 14-30 months for OS and 5-10 months for PFS, while negative patients had a better prognosis.

CONCLUSION: CIN was significantly correlated with tumor stage, lymph node metastasis, relapse and survival status of BC. Patients with high CIN or abnormal copy numbers of a single chromosome have a poor prognosis. CIN might be better than T stage in predicting the prognosis of patients with BC. Molecular typing of CIN can be used as an independent prognostic factor for BC.

PMID:40474232 | DOI:10.1186/s12920-025-02172-x