Tag: nevin manimala

Prehosp Emerg Care. 2021 Jun 1:1-13. doi: 10.1080/10903127.2021.1936314. Online ahead of print.

ABSTRACT

ObjectiveWe sought to identify current Emergency Medical Services (EMS) practitioner comfort levels and communication strategies when caring for the Deaf American Sign Language (ASL) user. Additionally, we created and evaluated the effect of an educational intervention and visual communication tool on EMS practitioner comfort levels and communication.MethodsThis was a descriptive study assessing communication barriers at baseline and after the implementation of a novel educational intervention with cross-sectional surveys conducted at three time points (pre-, immediate-post, and three months post-intervention). Descriptive statistics characterized the study sample and we quantified responses from the baseline survey and both post-intervention surveys.ResultsThere were 148 EMS practitioners who responded to the baseline survey. The majority of participants (74%; 109/148) previously responded to a 9-1-1 call for a Deaf patient and 24% (35/148) reported previous training regarding the Deaf community.The majority felt that important details were lost during communication (83%; 90/109), reported that the Deaf patient appeared frustrated during an encounter (72%; 78/109), and felt that communication limited patient care (67%; 73/109). When interacting with a Deaf person, the most common communication strategies included written text (90%; 98/109), friend/family member (90%; 98/109), lip reading (55%; 60/109), and spoken English (50%; 55/109).Immediately after the training, most participants reported that the educational training expanded their knowledge of Deaf culture (93%; 126/135), communication strategies to use (93%; 125/135), and common pitfalls to avoid (96%; 129/135) when caring for Deaf patients.At 3 months, all participants (100%, 79/79) reported that the educational module was helpful. Some participants (19%, 15/79) also reported using the communication tool with other non-English speaking patients.ConclusionsThe majority of EMS practitioners reported difficulty communicating with Deaf ASL users and acknowledged a sense of patient frustration. Nearly all participants felt the educational training was beneficial and clinically relevant; three months later, all participants found it to still be helpful. Additionally, the communication tool may be applicable to other populations that use English as a second language.

PMID:34060987 | DOI:10.1080/10903127.2021.1936314

Curr Neurovasc Res. 2021 May 31. doi: 10.2174/1567202618666210531122239. Online ahead of print.

ABSTRACT

OBJECTIVE: Major depressive disorder (MDD) is a major health problem worldwide. Estrogen interacts with the central nervous system and has been shown to affect anxiety and depressive behavior. Estrogen mediates its effects by connecting its receptors, estrogen receptors 1 and 2. The purpose of this case-control study was to clarify the association between MDD risk and estrogen receptor 1 (ESR1) gene variants.

METHODS: This study included 245 individuals (125 MDD patients and 120 healthy controls). Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) technics were used for genotyping ESR1 XbaI (rs9340799) and PvuII (rs22346939) variants.

RESULTS: There were statistically significant differences between the groups in terms of genotype frequencies of the ESR1 PvuII (-397 T > C) variant (p = 0.049) but not for the XbaI (-351 A > G) variant (p > 0.05). However, a correlation was observed between MDD and ESR1 XbaI variant after male participants were excluded (p = 0.028). Also, the high pain score of MDD patients was associated with the ESR1 PvuII variant, especially in female patients (p = 0.021). According to the results of combined genotype analysis, AA-TC combined genotype was correlated with a decreased risk in patients with MDD compared to controls (p = 0.016), while the combined genotype of GG-CC was associated with increased risk in the patients with MDD compared to controls (p = 0.042).

CONCLUSION: The two ESR1 variants were associated with MDD risk and its features in both individual and combined forms.

PMID:34060989 | DOI:10.2174/1567202618666210531122239

Curr Neurovasc Res. 2021 May 31. doi: 10.2174/1567202618666210531130711. Online ahead of print.

ABSTRACT

BACKGROUND: Many factors including genetic and environmental are responsible for the incidence of age-related macular degeneration (AMD). However, its pathogenesis has not been clearly elucidated yet.

OBJECTIVE: This study aimed to estimate the Age-Related Maculopathy Susceptibility 2 (ARMS2), Collagen type VIII Alpha 1 chain (COL8A1), Rad 51 paralog(RAD51B), and Vascular Endothelial Growth Factor (VEGF) protein levels in serum of AMD and control participants and to further investigate their correlation to understand AMD pathogenesis.

METHODS: For this cross-sectional study, 31 healthy control and 57 AMD patients were recruited from Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India. A blood sample was taken and serum was isolated from it. ELISA(enzyme-linked immunosorbent assay)was used for the estimation of proteins in the serum of patients.

RESULTS: ARMS2 and COL8A1 levels were significantly elevated in the AMD group than in the control group. The highest levels of ARMS2, COL8A1, and VEGF proteins were recorded for the wet AMD sub-group. The study results endorsed significant positive correlation between these following molecules; ARMS2 and COL8A1 (r=0.933, p<0.0001), ARMS2 and RAD51B (r=0.704, p<0.0001), ARMS2 and VEGF (r=0.925, p<0.0001), COL8A1 and RAD51B (r=0.736, p<0.0001), COL8A1 and VEGF (r=0.879, p<0.0001),and RAD51B and VEGF (r=0.691, p<0.0001).

CONCLUSION: The ARMS2 and COL8A1 levels were significantly higher and RAD51B was significantly lower in the AMD group than controls. Also, a significant statistical correlation was detected between these molecules, indicating that their interaction may be involved in the pathogenesis of AMD.

PMID:34060991 | DOI:10.2174/1567202618666210531130711

Thyroid. 2021 Jun 1. doi: 10.1089/thy.2021.0158. Online ahead of print.

ABSTRACT

BACKGROUND Noninvasive follicular neoplasm with papillary like nuclear features (NIFTP) reclassification has significantly influenced the field of thyroidology. However, the extent of this impact depends upon the incidence of NIFTP in a given population. In this meta-analysis, we aimed to obtain robust information about the actual incidence of NIFTP worldwide by reviewing the published data. METHODS Comprehensive literature search was performed using electronic databases of PubMed and Web of Science over a 5-year period (01.01.2016-30.01.2021). The incidence of NIFTP was calculated by dividing the number of NIFTP by the number of papillary thyroid carcinoma (PTC). Meta-analysis of proportion and their 95% confidence interval (CI) were pooled using the random-effect model. Heterogeneity across the included studies was assessed using I2 statistics. Egger’s regression test and funnel plot of estimates were used to evaluate the publication bias. P-value < 0.05 was considered significant. RESULTS From 505 publications, we finally included 50 studies, all retrospective, with 100,780 PTC and 3,990 NIFTP from 92 institutions worldwide. Our results demonstrated that the overall incidence of NIFTP was 6.0% (95% confidence interval [CI] = 4.4-8.2) among PTCs or thyroid malignancies with a high level of heterogeneity among the included studies (I2 = 98.6%). NIFTP incidence was largely similar in North America and Europe (9.3% vs. 9.6%) with a significantly lower overall rate from Asia (2.1%). There was a significant decline in the reported incidence of NIFTP in non-Asian studies published after 2017 (p = 0.002). On applying our data on global thyroid cancer statistics, this reclassification would affect ~30,881 patients annually with lower impact in Asia compared to North America and Europe. CONCLUSION This comprehensive meta-analysis confirms that the worldwide NIFTP incidence is much lower than estimated initially. The NIFTP rates are significantly lower in Asian continent as compared to North American and European countries. Apart from geography, NIFTP rates are significantly influenced by the nature of study, type of database used for sample collection and the diagnostic criteria used. Introduction of NIFTP may potentially spare over 30 thousand patients worldwide annually from clinical and psychological consequences of cancer diagnosis.

PMID:34060946 | DOI:10.1089/thy.2021.0158

J Psychosoc Nurs Ment Health Serv. 2021 Jun;59(6):31-36. doi: 10.3928/02793695-20210218-01. Epub 2021 Jun 1.

ABSTRACT

The current descriptive study investigated the correlation between psychological resilience and quality of professional life in clinic nurses. Nurses should have psychological resilience to have high compassion satisfaction and low burnout and compassion fatigue. The sample comprised 280 hospital nurses in Istanbul. Data were analyzed using descriptive statistics and Pearson correlation coefficient. Psychological resilience was positively correlated with compassion satisfaction (r = 0.372; p < 0.01) and negatively correlated with burnout (r = -0.379; p < 0.01) and compassion fatigue (r = -0.336; p < 0.01). Psychological resilience was positively correlated with professional quality of life. Managerial interventions and training should be developed and implemented to help nurses develop psychological resilience to create a positive organizational culture. [Journal of Psychosocial Nursing and Mental Health Services, 59(6), 31-36.].

PMID:34060959 | DOI:10.3928/02793695-20210218-01

Psychiatr Rehabil J. 2021 Jun;44(2):166-175. doi: 10.1037/prj0000462. Epub 2020 Oct 12.

ABSTRACT

Objective: The Internalized Stigma of Mental Illness (ISMI) scale is widely used to examine internalized stigma among people with mental illness. However, an Indonesian version does not yet exist. We developed an Indonesian translation of the ISMI scale and assessed its psychometric properties. Method: We included 280 inpatients with mental illness diagnoses in 2 hospitals and a rehabilitation center. We followed the guidelines proposed by Sousa and Rojjanasrirat (2011) to translate the questionnaire. The reliability was evaluated by measuring the internal consistency (Cronbach’s alpha) and test-retest reliability. Test validity was measured through exploratory factor analysis (EFA) to examine the structure of the scale and confirmatory factor analysis (CFA) to determine the model fits. Results: The EFA yielded 5 factors with Cronbach’s alpha coefficients of .96 for the total scale and .95, .95, .93, .94, and .82 for the 5 subscales. The test-retest reliability indicated excellent results, demonstrated by the interclass correlation coefficient ranging between .76 and .92 for all ISMI scale items. The Kaiser-Meyer-Olkin test statistic was 0.95, and Bartlett’s test of sphericity value was significant. Conclusions and Implications for Practice: The CFA indicated that the ISMI scale has an acceptable model fit. The Indonesian version of the ISMI scale demonstrated good psychometric properties for measuring internalized stigma of psychiatric patients in Indonesia. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:34060890 | DOI:10.1037/prj0000462

J Fam Psychol. 2021 May 31. doi: 10.1037/fam0000875. Online ahead of print.

ABSTRACT

Joint physical custody (JPC), a parental care arrangement in which children live with each parent about equally after separation or divorce, is an increasingly common phenomenon in many countries. This is a major shift away from the standard of sole physical custody (SPC), in which children live primarily with one parent (usually their mother) after family dissolution. Although attention to JPC by social scientists is growing, and the effects of this arrangement on children’s well-being are the subject of highly ideological debates, there is currently little empirical evidence with statistical power on JPC. Using data from Family Models in Germany (FAMOD), a survey of postseparation families conducted in 2019, we estimated four linear regression models for children aged 2-14 in SPC and JPC families, with analytic samples of up to 1,161 cases. We investigated the association between physical custody arrangements after separation or divorce and four dimensions of children’s well-being: psychological, physical, social, and cognitive/educational. The bivariate results provided support for the hypothesis that children living in JPC families fare significantly better than children living in SPC families on all four dimensions of well-being. However, after controlling for a set of child, parent, and separation characteristics, as well as for the quality of family relationships, the differences between children from SPC and JPC families disappeared. Additional analyses revealed that the parent-child relationships fully mediated this association. In sum, the quality of family relationships accounted for the positive association between JPC and children’s well-being in this study. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:34060891 | DOI:10.1037/fam0000875

Antimicrob Agents Chemother. 2021 Jun 1:AAC0079321. doi: 10.1128/AAC.00793-21. Online ahead of print.

ABSTRACT

Background: Stenotrophomonas maltophilia bloodstream infections (BSI) are associated with considerable mortality in the hematologic malignancy population. Trimethoprim-sulfamethoxazole (TMP-SMX) is the treatment of choice, however, it is not routinely included in empiric treatment regimens both because of its adverse event profile and the relative rarity of S. maltophilia infections. We developed a risk score to predict hematologic malignancy patients at increased risk for S. maltophilia BSI to guide early (TMP-SMX) therapy. Methods: Patients ≥12 years of age admitted to five hospitals between 7/2016 and 12/2019 were included. Two separate risk scores were developed: (1) a “knowledge-driven” risk score based upon previously identified risk factors in the literature in addition to variables identified by regression analysis using the current cohort and (2) a risk score based upon automatic variable selection. For both scores, discrimination (ROC curves and C statistics) and calibration (Hosmer-Lemeshow goodness of fit test and graphical calibration plots) were assessed. Internal validation was assessed using leave-one-out cross-validation. Results: 337 unique patients were included; 21 (6.2%) had S. maltophilia BSI. The knowledge-driven risk score (acute leukemia, absolute neutrophil count category, mucositis, central line, and ≥3 days of carbapenem therapy) had superior performance (C-statistic=0.75; 0.71 after cross-validation) compared to the risk score utilizing automatic variable selection (C-statistic=0.63; 0.38 after cross-validation). Conclusions: A user-friendly risk score incorporating five variables easily accessible to clinicians performed moderately well to predict hematologic malignancy patients at increased risk for S. maltophilia BSI. External validation using a larger cohort is necessary to create a refined risk score before broad clinical application.

PMID:34060899 | DOI:10.1128/AAC.00793-21

ACS Chem Neurosci. 2021 Jun 1. doi: 10.1021/acschemneuro.1c00115. Online ahead of print.

ABSTRACT

Depression has drawn increasing attention from the public around the world in recent years. Studies have shown that liver injury caused by chronic stress is relevant to depression and neurotransmitter changes. It is essential to clarify the relationship between neurotransmitter changes and hepatic gene expression in depression. In this study, we used the chronic unpredictable mild stress (CUMS) model combined with UHPLC-MS to explore the changes of neurotransmitters in serum and hippocampus and to decipher the differential gene expression in the liver by using the RNA-Seq combined with multivariate statistical analysis. Compared with the control group, the levels of neurotransmitters including 5-hydroxytryptamine (5-HT), acetylcholine, glutamate (Glu), and dopamine (DA) in the hippocampus and 5-HT, norepinephrine, γ-aminobutyric acid (GABA), and 5-hydroxyindoleacetic acid in serum were significantly changed in the CUMS rats. The results of liver transcriptomic analysis and correlation analysis showed that the Glu, DA, 5-HT, and GABA were impacted by 68 liver genes which were mainly enriched in three pathways including circadian rhythm, serotonergic synapse, and p53 signaling pathway. The expressive levels of clock genes and serotonergic synapse genes were validated by using q-PCR, and the diurnal rhythms of neurotransmitters were validated by in vivo hippocampus microdialysis. The CUMS stressors might cause phase advance of Glu and GABA by adjusting clock genes. The transcriptomic technique combined with correlation analysis and in vivo microdialysis could be used to discover comprehensive pathways of depression. It provides a new strategy for the rational assessment of the mechanism of disease.

PMID:34060807 | DOI:10.1021/acschemneuro.1c00115

J Exp Psychol Gen. 2021 May 31. doi: 10.1037/xge0001069. Online ahead of print.

ABSTRACT

When researchers choose to identify and exclude outliers from their data, should they do so across all the data, or within experimental conditions? A survey of recent papers published in the Journal of Experimental Psychology: General shows that both methods are widely used, and common data visualization techniques suggest that outliers should be excluded at the condition-level. However, I highlight in the present paper that removing outliers by condition runs against the logic of hypothesis testing, and that this practice leads to unacceptable increases in false-positive rates. I demonstrate that this conclusion holds true across a variety of statistical tests, exclusion criterion and cutoffs, sample sizes, and data types, and shows in simulated experiments and in a reanalysis of existing data that by-condition exclusions can result in false-positive rates as high as 43%. I finally demonstrate that by-condition exclusions are a specific case of a more general issue: Any outlier exclusion procedure that is not blind to the hypothesis that researchers want to test may result in inflated Type I errors. I conclude by offering best practices and recommendations for excluding outliers. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:34060886 | DOI:10.1037/xge0001069