Tag: nevin manimala

Infect Chemother. 2024 Dec;56(4):502-509. doi: 10.3947/ic.2024.0083.

ABSTRACT

BACKGROUND: Wound infections significantly impact morbidity, mortality, and healthcare costs globally. The Kashmir Valley’s unique geographical and climatic conditions, coupled with resource constraints and antibiotic misuse, complicate managing these infections effectively. This study aimed to identify predominant bacterial pathogens in wound infections at a tertiary care hospital in Kashmir, determine their antibiotic susceptibility profiles, and estimate the prevalence of multidrug-resistant (MDR) strains.

MATERIALS AND METHODS: A prospective cross-sectional study was conducted from January to June 2023 at the Government Medical College, Srinagar. Pus samples from wound infections were aseptically collected and processed following standard microbiological protocols. Antibiotic susceptibility testing utilized the Kirby-Bauer disk diffusion method, adhering to Clinical and Laboratory Standards Institute guidelines. Data were analyzed using IBM SPSS statistics.

RESULTS: Out of 4,378 samples analyzed, bacterial growth was observed in 1,921 samples, representing 43.9% of the total. Among the bacterial isolates, Gram-negative bacilli accounted for 73.5%, with Escherichia coli being the most prevalent at 27.9%. Among Gram-positive cocci, Staphylococcus aureus predominated, comprising 25.9% of the isolates. Methicillin-resistant S. aureus exhibited 100% susceptibility to linezolid but low susceptibility to erythromycin (27.0%) and clindamycin (24.0%). E. coli demonstrated high susceptibility to tigecycline (97.4%) and amikacin (75.0%), but lower susceptibility to imipenem (45.0%) and piperacillin-tazobactam (57.8%).

CONCLUSION: The substantial wound infection burden and high MDR prevalence in Kashmir necessitate comprehensive antimicrobial stewardship and infection control programs. Regular surveillance, education, and research are crucial to address antibiotic resistance and ensure effective wound infection management in the region.

PMID:39762926 | DOI:10.3947/ic.2024.0083

J Anim Sci Biotechnol. 2025 Jan 6;16(1):5. doi: 10.1186/s40104-024-01135-z.

ABSTRACT

BACKGROUND: Meat goat production is a worldwide industry with products such as meat, milk, soap, and fiber being produced. There are approximately 2.6 million meat goats in the United States. For breeding female ruminants, early pregnancy loss is estimated to be 30% within the first month of gestation. Extracellular L-citrulline (a precursor to L-arginine) is not degraded by ruminal microbes due to the lack of uptake. L-Arginine and thus L-citrulline, have beneficial impacts on placentation and, subsequently, fetal-placental development and survival. This study aimed to determine the impact of feeding L-citrulline to meat goats during gestation to improve reproductive success. Meat goats were fed either a control (CON) or L-citrulline (CIT) supplemented diet from d 12 to 82 of gestation. Blood samples were collected and sera were subjected to high-performance liquid chromatography analyses to quantify the abundance of amino acids. Pregnancy rates were determined on d 30, 61, and 90 of gestation, and litter weight, individual birth weights, and 90 d adjusted weaning weights were collected.

RESULTS: The concentrations of citrulline, ornithine, and arginine were greater in CIT does compared to CON does, but there was no difference in pregnancy rates between CON and CIT does. Birth weight was greater for male kids born as singles when compared to females, but this phenotype was not observed for kids born as twins or triplets. Further, males born to CON does had greater 90 d adjusted weaning weights than females, but this was not observed in the CIT group. Female kids born to CON and CIT Boer goats had heavier 90 d adjusted weaning weights than those born to Spanish or F1 Boer-Spanish does.

CONCLUSION: This study provides proof of concept that feeding dietary L-citrulline increases concentrations of citrulline and arginine in blood of gestating meat goats. However, further studies are needed to understand the cellular mechanisms impacted by feeding this supplement. Regardless, this study demonstrated that feeding L-citrulline has the potential to increase reproductive performance in gestating ruminants.

PMID:39762898 | DOI:10.1186/s40104-024-01135-z

Trials. 2025 Jan 6;26(1):6. doi: 10.1186/s13063-024-08713-6.

ABSTRACT

BACKGROUND: Leptospirosis is a zoonotic bacterial infection occurring worldwide. It is of particular public health concern due to its global distribution, epidemic potential and high mortality without appropriate treatment. The method for the management of leptospirosis, particularly in severe disease, is clouded by methodological inconsistency and a lack of standardized outcome measures. The study this protocol details aims to develop a core outcome set (COS) for leptospirosis research. A COS is a set of outcomes with international consensus as a minimum for reporting in future studies focusing on leptospirosis. Establishing a COS will contribute to harmonizing Leptospirosis treatment research and will be instrumental in constructing a high-quality evidence base to feed into a planned future rigorous international clinical trial on leptospirosis.

METHODS: The COS-LEP study will employ a COS development methodology standardized by the COMET initiative framework. This includes (1) a systematic review of available quantitative and qualitative literature reporting therapeutic response and safety outcomes and measures; (2) focused interviews with healthcare professional and people treated for leptospirosis exploring outcomes of interests using qualitative methodology; (3) narrowing the choice of outcomes by international consensus using a Delphi survey process; and (4) undertaking a hybrid consensus meeting with key stakeholders to build the final COS.

DISCUSSION: This protocol describes the method to develop the first core outcome set for use in human leptospirosis studies. This will not only be a key feature in the design of a future definitive randomized controlled trial, but also provide a structure for clinicians and researchers collecting treatment cohort data in the various settings where leptospirosis is a public health issue.

PMID:39762892 | DOI:10.1186/s13063-024-08713-6

BMC Nurs. 2025 Jan 6;24(1):9. doi: 10.1186/s12912-024-02581-w.

ABSTRACT

BACKGROUND: Negotiating is a common occurrence and a significant part of everyday tasks for head nurses. The ability of the head nurse to effectively negotiate is a crucial management tool for work management in healthcare facilities.

AIM: The present study aimed to assess the effect of negotiation skills training program on head nurses’ knowledge and behavior.

METHODS: A pretest-posttest, one-group quasi-experimental design was conducted at Menoufia University Hospitals. It is located in Shebeen, Elkom City, Cairo, Egypt. All head nurses and their assistants and their number 64 head nurses.

RESULTS: The results indicated that a minority of head nurses had satisfactory knowledge regarding negotiation in the pretest phase and obviously increased in the posttest to be more than three quarters and slightly decreased in the follow-up phase. Also, a minority had a high negotiation behavior level in the pretest phase and increased to be more than half in the posttest with a slight decrease in the follow-up stage. There was a highly statistically significant difference between pre-, post-, and follow-up results regarding negotiation knowledge and behavior.

CONCLUSION: The study revealed that the head nurse’s knowledge and behavior increased markedly after implementing the negotiation skills training program.

RECOMMENDATIONS: Conduct continuous education and training programs for stimulating and developing head nurses’ knowledge, behavior regarding negotiation, and hospital administration should support the importance of negotiation skills to both head nurses and organizations. TRIAL REGISTRATION NUMBER [TRN]: The study protocol was approved by the Research Ethics Committee of the Faculty of Nursing, Ain Shams University (code number: NUR 23.10.131).

PMID:39762889 | DOI:10.1186/s12912-024-02581-w

BMC Health Serv Res. 2025 Jan 6;25(1):32. doi: 10.1186/s12913-024-11782-7.

ABSTRACT

BACKGROUND: Voice barriers among frontline healthcare workers hinder safety related to work and patients. Understanding these barriers and practices is crucial to improve voice behavior in healthcare settings. Therefore, this study aims to identify the voice barriers and practices among healthcare workers in Pakistan.

RESEARCH METHOD: The study has adopted a mixed-method research design. Data was collected from 15 frontline healthcare workers through semi-structured interviews to achieve study objectives. Descriptives and content analysis were conducted to explore voice barriers and alternative practices to solve their concerns. After that, a quantitative study was conducted to determine the statistical significance of the identified voice barriers and the magnitude of their effect. For this purpose, data was collected from 480 frontline healthcare workers in the primary, secondary, and territory healthcare units. A questionnaire survey was used for data collection. Then, multistage hierarchical regression analysis was employed for data analysis.

RESULTS: Study findings highlight the determinants of two key factors: withholding patient safety concerns and withholding worker safety concerns. First, the study identifies several factors that increase the likelihood of healthcare workers withholding concerns about patient safety. These factors include professional designation, work experience, blackmailing, overconfidence, longer work tenure, feelings of insult, early career stage, fear of patient reactions, bad past experiences, job insecurity, and uncooperative management. Fear of increased workload also plays a significant role. Second, when it comes to work-related safety concerns, factors such as gender, shyness, lack of confidence, fear of duty changes, management issues, interpersonal conflicts, and resource shortages contribute to the withholding of concerns. To navigate these challenges, healthcare workers often resort to strategies such as seeking political connections, personal settlements, transfers, union protests, quitting, using social media, engaging in private practice, or referring patients to other hospitals.

CONCLUSION: Findings demonstrates that healthcare workers in Pakistan often withhold safety concerns due to hierarchical pressures, personal insecurities, and fear of repercussions. Their reliance on external mechanisms, such as political influence or social media, underscores the need for significant reforms to improve safety culture and management support. Addressing these issues is crucial for ensuring both patient and worker safety.

PMID:39762886 | DOI:10.1186/s12913-024-11782-7

Health Res Policy Syst. 2025 Jan 6;23(1):5. doi: 10.1186/s12961-024-01260-1.

ABSTRACT

BACKGROUND: An increasing number of people live with chronic disease or multi-morbidity. Current consensus is that their care requires an integrated model bringing different professionals together to provide person-centred care. Although primary care has a central role in managing chronic disease, and integration may be important in strengthening this role, previous research has shown insufficient attention to the relationships between primary care and integration. This review summarizes primary care involvement in integrated care interventions and assesses the effect of those interventions on a range of measures of primary care functions and wider outcomes.

METHODS: We searched Medline and Embase using terms for “integrated care”, “chronic disease” and “multimorbidity”. We included integrated care interventions involving different levels of care organizations or different care sectors. Risk of bias was appraised, and the contents of integrated care interventions assessed using the Sustainable intEgrated care modeLs for multi-morbidity: delivery, FInancing and performancE (SELFIE) conceptual framework. Effectiveness of integrated care interventions was assessed using meta-analysis of primary care functions (access, continuity, comprehensiveness and coordination) and wider outcomes (patient health and mortality, hospital admissions and costs). Sub-group analyses were conducted for different types of primary care involvement.

RESULTS: From 17,752 studies screened, 119 studies on integrated care were identified, of which 69 interventions (58%) involved primary care. Meta-analyses showed significant beneficial effects on two measures of primary care function: access (effect size: 0.17, 95% CI 0.05-0.29) and continuity (effect size: 0.32, 95% CI 0.14-0.50). For wider outcomes, the only statistically significant effect was found on costs (effect size: 0.02, 95% CI 0.02-0.03).

CONCLUSIONS: Integrated care interventions involving primary care can have positive effects on strengthening primary care functions, but these benefits do not necessarily translate consistently to wider outcomes.

PMID:39762867 | DOI:10.1186/s12961-024-01260-1

BMC Nurs. 2025 Jan 6;24(1):12. doi: 10.1186/s12912-024-02605-5.

ABSTRACT

BACKGROUND: Compassion Competence and the ability to strive to understand the suffering of patients in psychiatric ward is essential for nurses to establish effective therapeutic communication in the process of their recovery. Patient Safety Competency is of great importance for nurses to prevent adverse events and minimize errors. This study aimed to investigate the relationship between Compassion Competence and Patient Safety Competency in nurses working in psychiatric wards of Shiraz University of Medical Sciences affiliated hospitals in 2024.

METHOD: This descriptive-analytical study was conducted on 184 nurses working in the psychiatric wards of Shiraz University of Medical Sciences affiliated hospitals from January 2024 to April 2024 as a census. Data were collected using the Compassion Competence, Patient Safety Competency and Demographic Survey questionnaires and were then analyzed using descriptive and analytical statistics. The analyses were performed using SPSS 22 statistical software.

RESULTS: The results showed that the compassion competence score of psychiatric nurses was 3.98 ± 0.46, with subscales of sensitivity (4.05 ± 0.56), insight (3.79 ± 0.62), and communication (4.04 ± 0.48). Additionally, the patient safety competency score of psychiatric nurses was 3.56 ± 0.44, with subscales of attitude (3.67 ± 0.34), knowledge (3.06 ± 0.77), and skill (3.63 ± 0.58). A statistically significant correlation was also found between Compassion Competence and Patient Safety Competency (r = 0.458, p < 0.001). Regression results showed that the sensitivity (p = 0.012) and insight (p = 0.026) dimensions predict Patient Safety Competency. Among the demographic variables, only the completion of a communication skills course was significantly associated with both Compassion Competence (p = 0.04) and Patient Safety Competency (p = 0.02).

CONCLUSION: The findings of this study revealed a statistically significant correlation between Compassion Competence and Patient Safety Competency among psychiatric nurses. It is recommended that educational programs be designed to consider these two components and their dimensions to help enhance the competencies of nurses.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:39762865 | DOI:10.1186/s12912-024-02605-5

BMC Ophthalmol. 2025 Jan 6;25(1):5. doi: 10.1186/s12886-024-03818-7.

ABSTRACT

BACKGROUND: Primary acquired nasolacrimal duct obstruction (PANDO) is a condition in which tear ducts are blocked, leading to epiphora and dacryocystitis. This systematic review and meta-analysis aimed to measure the ability of transcanalicular dacryocystorhinostomy (TC-DCR) as an alternative approach to PANDO compared to traditional external dacryocystorhinostomy (EX-DCR).

METHODS: Our search included Embase, Medline, and the Cochrane Central Register of Controlled Trials (CENTRAL). We included only observational studies, randomized controlled trials (RCTs), and quasi-experimental studies that compared TC-DCR and EX-DCR. The outcomes measured were anatomical and functional success rates, intraoperative complications, postoperative complications, and surgical time. Statistically significant results were determined as a p value of less than 0.05; thus, a confidence interval of 95% was used. Dichotomous outcomes were reported via risk ratios (RR), whereas continuous outcomes were reported using standardized mean differences (SMD).

RESULTS: There was a statistically significant difference in anatomical success (RR = 0.84, 95% CI 0.72-0.97; P = 0.02), favoring EX-DCR; functional success (RR = 0.87, 95% CI 0.78-0.97; P = 0.01), favoring EX-DCR; operative (OR) time (SMD = -2.42, 95% CI -2.92 – -1.91; P < 0.00001) favoring TC-DCR; and intraoperative complications (RR = 0.16, 95% CI 0.06-0.43; P = 0.0003), favoring TC-DCR. Moreover, the subgroup analysis comparing single-diode TC-DCR to EX-DCR revealed a statistically significant difference in terms of anatomical success and functional success; however, the comparison of multidiode TC-DCR to EX-DCR revealed no statistically significant difference.

CONCLUSIONS: More research should be conducted to compare the anatomical and functional success of muli-diode TC-DCR with EX-DCR because the analysis performed comparing them revealed no statistical significance.

PMID:39762863 | DOI:10.1186/s12886-024-03818-7

BMC Med Educ. 2025 Jan 6;25(1):23. doi: 10.1186/s12909-024-06362-6.

ABSTRACT

BACKGROUND: Health literacy (HL) is crucial for making informed health decisions. Over one-third of US adults have limited HL, leading to adverse health outcomes. Despite its importance, HL education lacks standardization in medical training. This study evaluates medical learners’ confidence and experiences with HL at the University of South Carolina School of Medicine Greenville’s (USCSOMG) and the Family Medicine Residency Program Greenville (FMRGVL) to propose recommendations for HL instruction.

METHODS: A convergent parallel mixed methods design was used to assess the learners’ experiences with HL training through a student survey and faculty interviews. The study utilized thematic analysis for qualitative data and statistical analysis for quantitative data, focusing on prior and current HL training, confidence in HL application, and perceptions of HL education.

RESULTS: The curriculum at USCSOMG and FMRGVL incorporate active learning strategies, emphasizing HL and patient communication. Most participants reported high confidence in their HL knowledge and skills. The preferred teaching methods were hands-on clinical interactions, observing clinical interactions, and interactive lessons. Barriers to using HL interventions included time constraints and lack of real-world experience. Faculty recommended time prioritization and collaborative strategies to overcome these barriers.

CONCLUSIONS: This study highlights the impact of curricular approaches at USCSOMG and FMLGVL on learners’ confidence in engaging with patients facing low health literacy (LHL). To overcome barriers like time constraints and real-world challenges, medical educators should consider implementing competency-based exams, increasing practical opportunities for health literacy skills, and incorporating continuous curriculum evaluation based on faculty and student feedback. HL training and evaluation are essential to ensure that medical learners are adequately prepared to meet diverse patient literacy needs.

CLINICAL TRIAL NUMBER: Not Appliable.

PMID:39762861 | DOI:10.1186/s12909-024-06362-6

Int J Med Inform. 2024 Dec 31;195:105782. doi: 10.1016/j.ijmedinf.2024.105782. Online ahead of print.

ABSTRACT

BACKGROUND: Solid organ transplantation (SOT) is vital for end-stage organ failure but faces challenges like organ shortage and rejection. Artificial intelligence (AI) offers potential to improve outcomes through better matching, success prediction, and automation. However, the evolution of AI in SOT research remains underexplored. This study uses bibliometric analysis to identify trends, hotspots, and key contributors in the field.

METHODS: 821 articles from the Web of Science Core Collection were exported for analysis. Microsoft Excel 2021 was used for descriptive statistics. VOSviewer, CiteSpace, Scimago Graphica, and Biblioshiny were used for bibliometric analysis. The ggalluvial package in R was utilized to create Sankey diagrams, and top articles were selected based on citation count.

RESULTS: This analysis reveals the rapid expansion of AI in SOT. Key areas include robotic surgery, organ allocation, outcome prediction, immunosuppression management, and precision medicine. Robotic surgery has improved transplant outcomes. AI algorithms optimize organ matching and enhance fairness. Machine learning models predict outcomes and guide treatment, while AI-based systems advance personalized immunosuppression. AI in precision medicine, including diagnostics and imaging, is crucial for transplant success.

CONCLUSION: This study highlights AI’s transformative potential in SOT, with significant contributions from countries like the USA, Canada, and the UK. Key institutions such as the University of Toronto and the University of Pittsburgh have played vital roles. However, practical challenges like ethical issues, bias, and data integration remain. Fostering international and interdisciplinary collaborations is crucial for overcoming these challenges and accelerating AI’s integration into clinical practice, ultimately improving patient outcomes.

PMID:39761617 | DOI:10.1016/j.ijmedinf.2024.105782