Tag: pubmed

Environ Monit Assess. 2025 May 10;197(6):646. doi: 10.1007/s10661-025-14081-8.

ABSTRACT

In the past five decades, Dhaka city, the capital of Bangladesh experienced urbanization in an unprecedented manner. The city has grown spatially in all directions to accommodate the urban population that resulted in accelerated growth of the construction and demolished floor areas in Dhaka and its surroundings, commonly known as the Greater Dhaka. As a result, the quantities of construction and demolition waste have increased significantly within this region. Through an onsite field investigation of 21 construction and 12 demolition project sites in Greater Dhaka, the study identified the waste generation rate to be approximately 463.67 kg and 90.31 kg per m² floor area of demolition and construction projects, respectively. Projection based on this waste generation rate; the annual waste amount has been calculated for the eight districts of the Greater Dhaka region. The recycling potential identified through this study also estimated the economic benefits of the studied construction and demolition waste (CDW) materials for these eight districts for years 2022 to 2030. The findings of the present study are expected to assist the relevant stakeholders and policymakers to devise business development and legislative measures for the successful implementation of the sustainable waste management plan for the construction industry.

PMID:40347400 | DOI:10.1007/s10661-025-14081-8

Clin Oral Investig. 2025 May 10;29(6):294. doi: 10.1007/s00784-025-06368-4.

ABSTRACT

OBJECTIVE: Since relapse after orthodontic treatment and stability and failure of CAD/CAM fabricated and Conventional fixed retainers are widely discussed, this study investigated and compared two-year post-treatment stability after insertion of a CAD/CAM fabricated or Conventional fixed retainer in the lower jaw.

MATERIALS AND METHODS: Digitized dental casts or intraoral scans of n = 60 patients were used for data acquisition. The patients were divided into two groups according to the retention protocol: CAD/CAM fabricated fixed retainer (n = 30, mean age 16.97 ± 5.74 years) and Conventional fixed retainer (n = 30, mean age 15.70 ± 4.19 years). The evaluation included established procedures for dental measurements of the mandible (Intercanine Distance and Little´s Irregularity Index) before orthodontic treatment, at the end of orthodontic treatment, when the fixed retainer was inserted and two years after the insertion of the fixed retainer. All retainers were inserted by the same practitioner. Complications were recorded. Statistics included Shapiro-Wilk-, T- and Friedman-Tests. The level of significance was set at p < 0.05.

RESULTS: In patients with Conventional fixed retainers the change of the Intercanine Distance between insertion of the fixed retainer and two years afterwards was significantly more pronounced than in patients with CAD/CAM fabricated fixed retainers (ICD: Δ CAD/CAM_t1-t2: -0.03 ± 0.22 mm; Δ Conventional_t1-t2: 0.12 ± 0.29 mm). Stability of Intercanine Distance was less in patients with Conventional fixed retainers. The change of Little´s Irregularity Index was not significant between the groups. In two patients with a Conventional fixed retainer a bonding surface was renewed within the first three months.

CONCLUSIONS: Within two years, CAD/CAM fabricated fixed retainers showed less relapse of Intercanine Distance and fewer complications than Conventional fixed retainers.

CLINICAL RELEVANCE: Considering the amount of relapse and the differences in complications, CAD/CAM fabricated fixed retainers and Conventional fixed retainers are useful appliances for stabilization of treatment results with favorable stability. Fabrication of CAD/CAM based fixed retainers is aside from that timesaving compared to Conventional fixed retainers.

PMID:40347399 | DOI:10.1007/s00784-025-06368-4

Int Ophthalmol. 2025 May 10;45(1):188. doi: 10.1007/s10792-025-03556-9.

ABSTRACT

PURPOSE: To assess the macular vascular effects of prolonged use of latanoprost compared to the dorzolamide-timolol fixed combination in patients with very early-stage glaucoma, where glaucoma-specific damage has been minimized.

METHODS: The retinal vascular effects of latanoprost versus the dorzolamide-timolol fixed combination were evaluated using Optical Coherence Tomography Angiography (OCT-A) in a case-control study design. A total of 71 eyes from 71 individuals were included in the study: 28 eyes receiving latanoprost (Group 1), 20 eyes receiving the dorzolamide-timolol combination (Group 2), and 23 eyes from healthy individuals (Group 3). Superficial, deep, and radial peripapillary capillary plexus vascular density (SCP-vd, DCP-vd, RPCP-vd) and foveal avascular zone (FAZ) measurements were taken with OCT-A. The comparative analysis between groups was performed with SPSS V.26.

RESULTS: Across the groups (from 1 to 3), whole image vascular density (vd) measurements were as follows: SCP-vd: 45.86 ± 3.99, 44.58 ± 4.58, 48.35 ± 4.04; DCP-vd: 44.86 ± 5.75, 44.02 ± 6.87, 49.74 ± 4.84; and RPCP-vd: 46.97 ± 3.81, 47.07 ± 5.49, 49.90 ± 2.43. All these measurements were significantly decreased in both glaucoma groups (groups 1 and 2) compared to healthy subjects (group 3). In subgroup analyses of the macular region, including the fovea, parafovea, and perifovea, vd measurements were decreased in all areas except the fovea in glaucoma patients. However, no statistically significant differences were found between the latanoprost and dorzolamide-timolol groups regarding retinal vascular structure. In FAZ measurements, no significant differences were found in any anatomical location among the three groups.

CONCLUSION: This study demonstrates that latanoprost, the first prostaglandin analog known for its edema-inducing effect on the macula, does not have a long-term impact on macular vascularity. However, this result should be supported with longer and larger studies.

PMID:40347381 | DOI:10.1007/s10792-025-03556-9

Lasers Med Sci. 2025 May 10;40(1):219. doi: 10.1007/s10103-025-04470-3.

ABSTRACT

The purpose of this research was to evaluate the impact of an 810 nm high-power diode laser on decontaminating both surface and intradentinal biofilm, as well as removing the smear layer. Forty human mandibular premolars were contaminated with a biofilm composed of Enterococcus faecalis and Streptococcus mutans. The teeth were divided into groups and treated with NaOCl 2.5% + PUI, saline solution + 810 nm laser, NaOCl 2.5% + PUI + 810 nm laser, and a control group. The samples were then evaluated using a confocal laser scanning microscope (CLSM). Another 40 teeth, prepared as dentin discs, were contaminated with the same biofilm to assess surface decontamination. Additionally, 80 bovine dentin discs with an induced smear layer, placed in the apical third of mesial root canals of 3D-printed teeth, underwent similar treatments. Pre- and post-treatment images were obtained using an environmental scanning electron microscope. Data were statistically analyzed with ANOVA test and Tukey’s test, respectively. Intradentinal disinfection rates were 67,33% for PUI, 51,50% for the 810 nm laser, and 55,32% for the PUI + 810 nm laser, with no statistically significant differences (p > 0.05). Surface decontamination rates were 39,52%, 51,27%, and 45,20% for the respective groups, also without significant differences (p > 0.05). No significant differences were found regarding smear layer removal (p > 0.05). The 810 nm diode laser with saline achieved disinfection similar to 2.5% sodium hypochlorite with ultrasound. Combining laser and PUI didn’t improve disinfection. None of the studied protocol removed the smear layer.

PMID:40347363 | DOI:10.1007/s10103-025-04470-3

Discov Oncol. 2025 May 10;16(1):717. doi: 10.1007/s12672-025-02553-9.

ABSTRACT

BACKGROUND: This retrospective study aimed to evaluate the safety and effectiveness of hepatic arterial infusion chemotherapy with raltitrexed and oxaliplatin (RALOX-HAIC) combined with radiotherapy, tyrosine kinase inhibitors, and immune checkpoint inhibitors in patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).

METHODS: A propensity score-matching (PSM) cohort study was conducted. The tumor response, treatment-related adverse events, survival outcomes were compared. Univariate and multivariate analyses were conducted to explore the risk factors of overall survival (OS).

RESULTS: Twenty-one pairs of patients were evaluated after PSM. No statistical differences were found in the tumor response, objective response rate, disease control rate, PVTT response, surgical resection rate, metastasis, and mortality between the two groups before and after PSM. Compared with the FOLFOX-HAIC group, the incidences of abdominal pain and fever was lower in the RALOX-HAIC group (P = 0.028, P = 0.029). These differences still had statistical significance after PSM (P = 0.013, P = 0.014). No statistical differences were found in OS and progression-free survival (PFS) between the two groups before and after PSM (Before [OS: hazard ratio(HR) = 1.138; 95%CI 0.569-2.276, P = 0.715; PFS: HR = 0.549; 95%CI 0.195-1.548, P = 0.257; After [OS: HR = 0.998; 95%CI 0.438-2.274, P = 0.995; PFS: HR = 0.792; 95%CI 0.359-1.748, P = 0.564]). The prealbumin < 170 mg/L before therapy was an independent risk factor for OS (HR = 2.234; 95%CI 1.051-4.751; P = 0.037).

CONCLUSIONS: The RALOX-HAIC combined radiotherapy, TKI, and ICI may provide similar survival advantages with fewer treatment-related abdominal pain and fever compared to FOLFOX-HAIC for HCC patients with PVTT. The prealbumin < 170 mg/L before therapy is an independent risk factor for OS.

PMID:40347357 | DOI:10.1007/s12672-025-02553-9

J Gambl Stud. 2025 May 10. doi: 10.1007/s10899-025-10391-1. Online ahead of print.

ABSTRACT

Loss chasing is a defining clinical criterion for Gambling Disorder. Using actual player records, we investigated the potential for a multidimensional loss chasing concept (based on bet size, betting odds, and time between bets) to predict potential gambling harm among online sports bettors (N = 36,331) and daily fantasy sports (DFS) players (N = 34,596). Our main focus was whether optimized thresholds (derived from ROC analysis) for loss chasing yielded greater predictive value than both median-derived thresholds and a natural continuous form. Compared to the other tested forms of chasing, optimized thresholds of loss chasing showed the most promise (i.e., positive and statistically significant effects and improved model fit) for two out of three dimensions (i.e., bet size and odds) for one outcome (i.e., loss trajectory) among sports bettors. For these bettors and outcomes, all three loss chasing dimensions predicted the outcome in isolation; however, grouping all three expressions into a single model yielded poor model fit. Loss chasing effects were less apparent (generally non-significant or in the negative direction) for another outcome (i.e., percent change in net loss) and among DFS players. Still, this study demonstrates the promise of a multidimensional concept of loss chasing, and the potential for optimized thresholds to improve prediction of potential harm-related outcomes.

PMID:40347356 | DOI:10.1007/s10899-025-10391-1

Patient. 2025 May 10. doi: 10.1007/s40271-025-00737-7. Online ahead of print.

ABSTRACT

INTRODUCTION: Like in many countries, coverage of sexual and reproductive health (SRH) services among adolescents and young people (AYP) aged 15-24 remains low in Zambia. Increasing coverage of SRH services requires interventions that are responsive to the needs and preferences of AYP. We conducted a discrete choice experiment (DCE) to elicit AYP’s preferences for SRH service delivery in Lusaka, Zambia.

METHODS: A cross-sectional DCE was conducted with AYP aged 15-24 years. Consenting participants were presented with alternative SRH service delivery strategies represented by six attributes, namely: location, type of provider, type of services, service differentiation by sex, availability of edutainment, and opening hours. Multinomial logit and random parameters logit models were used to analyse the data. All variables were effect coded.

RESULTS: A total of 423 AYP aged 15-24 years (61% female) completed the DCE. Respondents preferred SRH services that were integrated with other healthcare services (b = 0.65, p < 0.001), delivered by medical staff and peer support workers (b = 0.44, p < 0.001), and provided at a hub within a health facility (b = 0.62, p < 0.001). AYP also preferred services to be available on weekends during the daytime (b = 0.37, p < 0.001). Participants also preferred alternatives which included edutainment (b = 0.22, p < 0.001). Service differentiation by sex had little effect on the preference for SRH service delivery (b = – 0.05, p = 0.08). The coefficient for the “neither” option was negative and statistically significant (b = – 5.31, p < 0.001), implying that AYP did not favor routine SRH service delivery in an outpatient department.

CONCLUSION: Efforts to increase SRH service utilization among AYP should focus on providing comprehensive SRH services that are integrated with other healthcare services. These services should be delivered by a combination of medical staff and peer supporter workers in youth-friendly spaces. Careful attention should be paid to opening times to ensure that these are convenient to AYP.

PMID:40347324 | DOI:10.1007/s40271-025-00737-7

Odontology. 2025 May 10. doi: 10.1007/s10266-025-01121-5. Online ahead of print.

ABSTRACT

This study aimed to investigate the prognosis of adolescent patients with anterior disk displacement without reduction (ADDwoR) who were treated with disk repositioning through suturing or arthrocentesis plus hyaluronic acid (HA) combined with stabilization splint (SS). A total of 96 ADDwoR patients aged ranging from 12 to 18 years, were divided into two groups, including 52 patients in Group A (underwent disk repositioning by suturing) and 44 patients in Group B (underwent arthrocentesis plus HA combined with SS). Condylar height, disk length, maximum mouth opening (MMO), maximal protrusive movement (PM), left/right maximal lateral movement (LLM/RLM) and visual analogue scale (VAS) pain scores were comparatively analyzed between the two groups before and after treatment. Baselined data analysis showed there was no statistical significance in condylar height, disk length, MMO, PM, LLM, RLM, and VAS values between two groups preoperatively. Postoperatively, values of condylar height and disk length in Group A were larger than those in Group B (all P < 0.001); whereas PM, LLM, and RLM values of Group B were all significantly larger than those of Group A (all P < 0.001). However, no statistical difference was obtained in MMO and VAS score between two groups after treatment (all P > 0.05). Both two surgical techniques can effectively relieve pain and improve MMO of adolescent patients with ADDwoR. The maximal protrusive and lateral movement of Group B were superior to those of Group A, while the latter can effectively enhance condylar development and prevent mandibular deformities.

PMID:40347314 | DOI:10.1007/s10266-025-01121-5

Support Care Cancer. 2025 May 10;33(6):466. doi: 10.1007/s00520-025-09517-3.

ABSTRACT

PURPOSE: This study evaluated how frequently patients with early onset colorectal cancer received fertility counseling and whether patient characteristics affected the likelihood of receiving such counseling.

METHODS: We conducted a single-center retrospective review of all new patients seen by medical oncology for colorectal cancer who were age 55 years or younger for men and 50 years or younger for women. Associations between patient demographics and clinical characteristics with receipt of fertility counseling were explored using univariate analyses and multivariable logistical regression analyses.

RESULTS: A total of 194 patients were included, of whom 15.5% received fertility counseling. Using multivariate analysis, we found that age < 40 (OR 15.587, p < 0.0001, 95% CI 4.841-50.191) and female sex (OR 3.979, p = 0.0292, 95% CI 1.150-13.770) were correlated with increased likelihood of fertility counseling. Patients living in areas of higher household income were more likely to receive fertility counseling, with a statistically significant difference between the 3rd and 1st quartiles of income (p = 0.0369, 95% CI 1.161-115.940).

CONCLUSION: A majority of patients with EOCRC did not receive fertility counseling despite the known toxicities of CRC treatment modalities on fertility. Older age, male sex, and residence in areas of lower income were associated with decreased likelihood of receiving fertility counseling.

PMID:40347312 | DOI:10.1007/s00520-025-09517-3

CNS Drugs. 2025 May 10. doi: 10.1007/s40263-025-01188-2. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: Baclofen, a traditional treatment for spasticity, is gaining interest for its use in alcohol use disorder (AUD). To assist clinicians in using baclofen for effective and safe treatment of AUD, we investigated the optimal target dosage of baclofen through a systematic review and dose-response meta-analysis.

METHODS: We searched Cochrane, EMBASE, MEDLINE via PubMed, PsycINFO, ClinicalTrials.gov, and the International Clinical Trials Registry Platform for randomized controlled trials on 1 and 2 April 2024. Inclusion criteria were patients aged ≥ 18 years diagnosed with AUD according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV, DSM-IV-TR, or International Classification of Diseases (ICD)-10, and treated with baclofen monotherapy. Continuous outcomes-percent days abstinent, drinks per drinking day, heavy drinking days (HDDs), craving, and anxiety-were analyzed as mean or standardized mean differences. Binary outcomes-relapse and dropout, including due to adverse events-were analyzed as odds ratios. Each outcome was assessed using the Cochrane Risk of Bias 2.0 tool. A one-stage random-effects dose-response meta-analysis was performed using restricted cubic splines with fixed knots at 10%, 50%, and 90% percentiles.

RESULTS: A total of 14 trials (1344 patients) were included. Increasing the dose of baclofen up to 50-60 mg/day was associated with a higher percent days abstinent and reduced craving. However, a higher baclofen dose increases the risk of dropout due to adverse events. Commonly observed adverse events were drowsiness, sedation, somnolence and fatigue. Baclofen up to 50-60 mg/day did not significantly affect drinks per drinking day, HDDs, anxiety, relapse or dropout. Doses > 60 mg/day lacked reliable evaluation due to limited data and study heterogeneity.

CONCLUSIONS: Baclofen up to 50-60 mg/day may increase percent days abstinent and reduce craving, but may increase dropout due to adverse events. Clinicians should carefully consider individual patient factors when prescribing baclofen to patients with AUD.

PMID:40347309 | DOI:10.1007/s40263-025-01188-2